ZKSCAN4

Summary

ZKSCAN4 (zinc finger with KRAB and SCAN domains 4, HGNC:13854) is a protein-coding gene on chromosome 6p22.1, encoding Zinc finger protein with KRAB and SCAN domains 4 (Q969J2). May be involved in the transcriptional activation of MDM2 and EP300 genes.

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm.

Source: NCBI Gene 387032 — RefSeq curated summary.

At a glance

• GWAS associations: 26
• Clinical variants (ClinVar): 66 total
• MANE Select transcript: NM_019110

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13854
Approved symbol	ZKSCAN4
Name	zinc finger with KRAB and SCAN domains 4
Location	6p22.1
Locus type	gene with protein product
Status	Approved
Aliases	p373c6.1, P1P373C6, FLJ32136, ZSCAN36
Ensembl gene	ENSG00000187626
Ensembl biotype	protein_coding
OMIM	611643
Entrez	387032

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000377294, ENST00000901698, ENST00000901699, ENST00000901700, ENST00000901701, ENST00000927145, ENST00000927146, ENST00000959508

RefSeq mRNA: 2 — MANE Select: NM_019110 NM_001304506, NM_019110

CCDS: CCDS4647

Canonical transcript exons

ENST00000377294 — 5 exons

Exon	Start	End
ENSE00001473458	28241697	28245975
ENSE00001836023	28251558	28252269
ENSE00001970341	28246969	28247092
ENSE00001977144	28248067	28248149
ENSE00003571983	28249687	28249834

Expression profiles

Bgee: expression breadth ubiquitous, 219 present calls, max score 87.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.4414 / max 48.7986, expressed in 1628 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72403	3.7792	1563
72402	0.5784	356
72405	0.0838	34

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	87.54	gold quality
male germ cell	CL:0000015	85.55	gold quality
hair follicle	UBERON:0002073	84.44	gold quality
oocyte	CL:0000023	83.54	gold quality
secondary oocyte	CL:0000655	83.08	gold quality
diaphragm	UBERON:0001103	82.50	gold quality
adult organism	UBERON:0007023	79.94	gold quality
epithelium of nasopharynx	UBERON:0001951	77.46	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.84	gold quality
germinal epithelium of ovary	UBERON:0001304	74.48	gold quality
gingival epithelium	UBERON:0001949	73.50	silver quality
spleen	UBERON:0002106	72.53	gold quality
granulocyte	CL:0000094	72.52	gold quality
stromal cell of endometrium	CL:0002255	72.49	gold quality
ganglionic eminence	UBERON:0004023	72.43	gold quality
cortical plate	UBERON:0005343	72.25	gold quality
ventricular zone	UBERON:0003053	72.07	gold quality
gingiva	UBERON:0001828	71.71	silver quality
embryo	UBERON:0000922	71.70	gold quality
pigmented layer of retina	UBERON:0001782	71.39	gold quality
epithelial cell of pancreas	CL:0000083	71.33	gold quality
trabecular bone tissue	UBERON:0002483	71.09	silver quality
tongue squamous epithelium	UBERON:0006919	70.99	gold quality
jejunal mucosa	UBERON:0000399	70.85	gold quality
leukocyte	CL:0000738	70.11	gold quality
palpebral conjunctiva	UBERON:0001812	69.77	gold quality
mononuclear cell	CL:0000842	69.72	gold quality
monocyte	CL:0000576	69.71	gold quality
lymph node	UBERON:0000029	69.63	gold quality
squamous epithelium	UBERON:0006914	69.61	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.85

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
EP300	Repression
MDM2	Repression

JASPAR motifs

Motif	Name	Family
MA2544.1	ZKSCAN4	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605530

miRNA regulators (miRDB)

115 targeting ZKSCAN4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-10527-5P	99.91	72.28	3754

Literature-anchored findings (GeneRIF, showing 4)

• ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation (PMID:17910948)
• The SCAN- and KRAB-domain-containing zinc finger protein 307 (ZKSCAN4) was co-precipitated with the receptor when both proteins were overexpressed in HEK293 cells. (PMID:19008334)
• ZNF307 ameliorates pressure overload-induced cardiac hypertrophy by inhibiting the activity of NF-kappaB-signaling pathway (PMID:28223477)
• our results indicate that ZNF307 may serve as a tumor suppressor and inhibits cell proliferation of hepatocellular carcinoma via inducing apoptosis (PMID:28765950)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zkscan3	ENSMUSG00000021327
mus_musculus	Zkscan4	ENSMUSG00000054931
rattus_norvegicus	Zkscan4	ENSRNOG00000051823
rattus_norvegicus	Zkscan3	ENSRNOG00000055000

Paralogs (30): ZNF263 (ENSG00000006194), ZNF213 (ENSG00000085644), ZNF500 (ENSG00000103199), ZKSCAN1 (ENSG00000106261), ZNF205 (ENSG00000122386), ZSCAN9 (ENSG00000137185), PGBD1 (ENSG00000137338), ZNF215 (ENSG00000149054), ZSCAN12 (ENSG00000158691), ZNF394 (ENSG00000160908), ZNF75A (ENSG00000162086), ZSCAN21 (ENSG00000166529), ZNF232 (ENSG00000167840), ZNF24 (ENSG00000172466), ZNF449 (ENSG00000173275), ZSCAN4 (ENSG00000180532), ZSCAN22 (ENSG00000182318), ZNF75D (ENSG00000186376), ZNF396 (ENSG00000186496), ZNF397 (ENSG00000186812), ZSCAN30 (ENSG00000186814), ZSCAN23 (ENSG00000187987), ZKSCAN3 (ENSG00000189298), ZSCAN16 (ENSG00000196812), ZSCAN25 (ENSG00000197037), ZSCAN26 (ENSG00000197062), ZNF165 (ENSG00000197279), ZKSCAN8 (ENSG00000198315), ZSCAN31 (ENSG00000235109), ZNF853 (ENSG00000236609)

Protein

Protein identifiers

Zinc finger protein with KRAB and SCAN domains 4 — Q969J2 (reviewed: Q969J2)

Alternative names: P373c6.1, Zinc finger protein 307, Zinc finger protein 427

All UniProt accessions (2): A0A0S2Z658, Q969J2

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in the transcriptional activation of MDM2 and EP300 genes.

Subcellular location. Nucleus.

Tissue specificity. Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001291435, NP_061983* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF02023

UniProt features (20 total): zinc finger region 7, cross-link 4, region of interest 3, domain 2, compositionally biased region 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q969J2-F1	62.00	0.05

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 26, 29, 178, 222

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 101 (showing top): PIT1_Q6, NAGASHIMA_NRG1_SIGNALING_DN, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, YAGI_AML_WITH_T_8_21_TRANSLOCATION, ZWANG_EGF_INTERVAL_UP, DCA_UP.V1_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ALKBH3_TARGET_GENES, DIDO1_TARGET_GENES, HMG20B_TARGET_GENES, SNIP1_TARGET_GENES, ZNF329_TARGET_GENES, ZNF561_TARGET_GENES, ZNF8_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), identical protein binding (GO:0042802), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleoplasm (GO:0005654), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
protein binding	1
nucleic acid binding	1
binding	1
cation binding	1
nuclear lumen	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

702 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZKSCAN4	NKAPL	Q5M9Q1	723
ZKSCAN4	MDM2	Q00987	564
ZKSCAN4	EP300	Q09472	506
ZKSCAN4	TSPAN18	Q96SJ8	400
ZKSCAN4	TP53	P04637	373
ZKSCAN4	ZNF804A	Q7Z570	367
ZKSCAN4	NKAP	Q8N5F7	355
ZKSCAN4	KRABD4	Q5JUW0	348
ZKSCAN4	TIAM1	Q13009	325
ZKSCAN4	CCDC15	Q0P6D6	322
ZKSCAN4	CCDC157	Q569K6	317
ZKSCAN4	L3MBTL2	Q969R5	302
ZKSCAN4	TCAIM	Q8N3R3	287
ZKSCAN4	KAT8	Q9H7Z6	286
ZKSCAN4	ZNF79	Q15937	285

IntAct

162 interactions, top by confidence:

A	B	Type	Score
ZNF24	ZKSCAN4	psi-mi:“MI:0915”(physical association)	0.880
ZKSCAN4	SCAND1	psi-mi:“MI:0915”(physical association)	0.870
SCAND1	ZKSCAN4	psi-mi:“MI:0915”(physical association)	0.870
ZKSCAN4	SCAND1	psi-mi:“MI:0914”(association)	0.870
ZKSCAN4	ZNF496	psi-mi:“MI:0915”(physical association)	0.850
ZNF496	ZKSCAN4	psi-mi:“MI:0915”(physical association)	0.850
ZKSCAN4	ZSCAN32	psi-mi:“MI:0915”(physical association)	0.800
ZSCAN32	ZKSCAN4	psi-mi:“MI:0915”(physical association)	0.800
CABP5	ZKSCAN4	psi-mi:“MI:0915”(physical association)	0.780
ZKSCAN4	CABP5	psi-mi:“MI:0915”(physical association)	0.780
ZKSCAN4	PGBD1	psi-mi:“MI:0915”(physical association)	0.740
ZKSCAN4	ZSCAN21	psi-mi:“MI:0915”(physical association)	0.740
LXN	ZKSCAN4	psi-mi:“MI:0915”(physical association)	0.720

BioGRID (134): ZKSCAN4 (Two-hybrid), ZKSCAN4 (Two-hybrid), ZKSCAN4 (Two-hybrid), ZKSCAN4 (Two-hybrid), ZKSCAN4 (Two-hybrid), ZKSCAN4 (Two-hybrid), ZKSCAN4 (Two-hybrid), ZKSCAN4 (Two-hybrid), ZKSCAN4 (Affinity Capture-MS), ZKSCAN4 (Affinity Capture-MS), ZKSCAN4 (Affinity Capture-MS), ZKSCAN4 (Affinity Capture-MS), ZKSCAN4 (Affinity Capture-MS), ZKSCAN4 (Affinity Capture-MS), ZKSCAN4 (Proximity Label-MS)

ESM2 similar proteins: A1YEQ3, A1YEV9, A1YFW6, A1YG26, A1YG48, A1YG60, A2T6W2, A2T712, A2T736, A2T7L7, A6QNZ0, O14978, O15535, O95125, P17022, P17029, P49910, P51815, P59923, Q07231, Q15776, Q16670, Q1LZ87, Q3MJ62, Q3URR7, Q4KLI1, Q4R8H9, Q53GI3, Q5R670, Q5R741, Q5RJ54, Q63HK3, Q642B9, Q6P9G9, Q810A1, Q86W11, Q8BGS3, Q8CF60, Q8NF99, Q92670

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 76 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
transcription by RNA polymerase II	7	7.0×	1e-02

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

772 predictions. Top by Δscore:

Variant	Effect	Δscore
6:28247091:CC:C	acceptor_gain	1.0000
6:28247092:CC:C	acceptor_gain	1.0000
6:28246963:TCTTA:T	donor_loss	0.9900
6:28246964:CTTA:C	donor_loss	0.9900
6:28246965:TTACC:T	donor_loss	0.9900
6:28246966:T:TG	donor_loss	0.9900
6:28246968:C:A	donor_loss	0.9900
6:28247094:TAAAA:T	acceptor_loss	0.9900
6:28251608:C:CT	donor_gain	0.9900
6:28251613:T:TA	donor_gain	0.9900
6:28251648:G:C	donor_gain	0.9900
6:28246967:A:AC	donor_gain	0.9800
6:28246968:C:CC	donor_gain	0.9800
6:28251543:A:C	donor_gain	0.9800
6:28251609:C:CT	donor_gain	0.9800
6:28245974:ACCTG:A	acceptor_loss	0.9700
6:28247505:C:CT	donor_gain	0.9700
6:28247506:T:TT	donor_gain	0.9700
6:28251467:CCTGG:C	donor_gain	0.9700
6:28245977:TGAAA:T	acceptor_loss	0.9600
6:28251466:TCCTG:T	donor_gain	0.9600
6:28251469:TGG:T	donor_gain	0.9600
6:28251685:TCCAG:T	donor_gain	0.9600
6:28251686:CCAGC:C	donor_gain	0.9600
6:28245972:CCAC:C	acceptor_gain	0.9500
6:28245973:CACC:C	acceptor_gain	0.9500
6:28247093:C:CC	acceptor_gain	0.9500
6:28251605:C:CT	donor_gain	0.9500
6:28247093:C:T	acceptor_gain	0.9400
6:28248148:AACT:A	acceptor_gain	0.9400

AlphaMissense

3598 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:28245431:A:C	F441L	0.999
6:28245431:A:T	F441L	0.999
6:28245433:A:G	F441L	0.999
6:28245515:G:C	F413L	0.999
6:28245515:G:T	F413L	0.999
6:28245517:A:G	F413L	0.999
6:28245599:G:C	F385L	0.999
6:28245599:G:T	F385L	0.999
6:28245601:A:G	F385L	0.999
6:28245683:G:C	F357L	0.999
6:28245683:G:T	F357L	0.999
6:28245685:A:G	F357L	0.999
6:28245182:G:C	F524L	0.998
6:28245182:G:T	F524L	0.998
6:28245184:A:G	F524L	0.998
6:28245572:G:C	H394Q	0.998
6:28245572:G:T	H394Q	0.998
6:28245582:A:G	L391P	0.998
6:28245600:A:G	F385S	0.998
6:28245658:G:C	H366D	0.998
6:28245767:A:C	F329L	0.998
6:28245767:A:T	F329L	0.998
6:28245769:A:G	F329L	0.998
6:28245432:A:G	F441S	0.997
6:28245574:G:C	H394D	0.997
6:28245654:T:G	Q367P	0.997
6:28245656:A:C	H366Q	0.997
6:28245656:A:T	H366Q	0.997
6:28245183:A:G	F524S	0.996
6:28245488:A:C	H422Q	0.996

dbSNP variants (sampled 300 via entrez): RS1000536019 (6:28241303 C>T), RS1000768753 (6:28248840 A>G), RS1000926885 (6:28249095 A>G), RS1000943690 (6:28256441 A>G), RS1001245941 (6:28257706 A>G), RS1001277670 (6:28255994 T>C), RS1001622637 (6:28242432 A>C), RS1001676006 (6:28258016 C>T), RS1001695204 (6:28249895 T>C), RS1001704871 (6:28250191 C>A,G), RS1001885007 (6:28248424 G>A), RS1001968701 (6:28241852 C>A,T), RS1002462807 (6:28255789 G>A), RS1002552094 (6:28244977 C>G,T), RS1002705275 (6:28260800 G>A)

Disease associations

OMIM: gene MIM:611643 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

26 associations (top):

Study	Trait	p-value
GCST004521_112	Autism spectrum disorder or schizophrenia	3.000000e-26
GCST004521_115	Autism spectrum disorder or schizophrenia	3.000000e-16
GCST004521_166	Autism spectrum disorder or schizophrenia	4.000000e-24
GCST004521_212	Autism spectrum disorder or schizophrenia	5.000000e-14
GCST004521_22	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_23	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_6	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_7	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_73	Autism spectrum disorder or schizophrenia	8.000000e-11
GCST004521_77	Autism spectrum disorder or schizophrenia	1.000000e-19
GCST007201_362	Schizophrenia	3.000000e-23
GCST008921_4	Asthma and major depressive disorder	2.000000e-11
GCST008921_6	Asthma and major depressive disorder	1.000000e-09
GCST009106_1	Basal metabolic rate variance	1.000000e-09
GCST009129_1	Basal metabolic rate	2.000000e-09
GCST010002_50	Refractive error	4.000000e-34
GCST010142_16	Fish- and plant-related diet	2.000000e-10
GCST010142_19	Fish- and plant-related diet	4.000000e-10
GCST010142_34	Fish- and plant-related diet	7.000000e-09
GCST010142_35	Fish- and plant-related diet	8.000000e-09
GCST010142_42	Fish- and plant-related diet	1.000000e-08
GCST010142_7	Fish- and plant-related diet	3.000000e-12
GCST010702_75	Subcortical volume (MOSTest)	3.000000e-11
GCST010703_272	Brain morphology (MOSTest)	7.000000e-16
GCST90020028_834	Hip circumference adjusted for BMI	1.000000e-08
GCST90020028_835	Hip circumference adjusted for BMI	2.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007777	base metabolic rate measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Plant Extracts	affects cotreatment, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	increases sumoylation	1
bisphenol A	affects expression	1
sodium arsenite	increases expression	1
ferrous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
indolo(3,2-b)carbazole	increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
Resveratrol	increases expression, affects cotreatment	1
Temozolomide	increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases expression	1
Formaldehyde	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases expression	1
Cyclosporine	decreases expression	1
Cadmium Chloride	increases expression	1
Okadaic Acid	decreases expression	1
Acrylamide	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A8D2	SEES3-1V human ZKSCAN4, clone1	Embryonic stem cell	Male
CVCL_A8D3	SEES3-1V human ZKSCAN4, clone2	Embryonic stem cell	Male
CVCL_A8D4	SEES3-1V human ZKSCAN4, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.