ZKSCAN5

Summary

ZKSCAN5 (zinc finger with KRAB and SCAN domains 5, HGNC:12867) is a protein-coding gene on chromosome 7q22.1, encoding Zinc finger protein with KRAB and SCAN domains 5 (Q9Y2L8). May be involved in transcriptional regulation.

This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 23660 — RefSeq curated summary.

At a glance

• GWAS associations: 18
• Clinical variants (ClinVar): 100 total
• MANE Select transcript: NM_145102

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12867
Approved symbol	ZKSCAN5
Name	zinc finger with KRAB and SCAN domains 5
Location	7q22.1
Locus type	gene with protein product
Status	Approved
Aliases	ZNF914, ZSCAN37
Ensembl gene	ENSG00000196652
Ensembl biotype	protein_coding
OMIM	611272
Entrez	23660

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 19 protein_coding, 1 nonsense_mediated_decay

ENST00000326775, ENST00000394170, ENST00000451158, ENST00000454175, ENST00000864572, ENST00000864573, ENST00000864574, ENST00000864575, ENST00000864576, ENST00000864577, ENST00000925936, ENST00000925937, ENST00000925938, ENST00000925939, ENST00000925940, ENST00000925941, ENST00000925942, ENST00000925943, ENST00000970506, ENST00000970507

RefSeq mRNA: 5 — MANE Select: NM_145102 NM_001318082, NM_001318083, NM_001318084, NM_014569, NM_145102

CCDS: CCDS5667

Canonical transcript exons

ENST00000326775 — 7 exons

Exon	Start	End
ENSE00000708266	99519827	99519909
ENSE00001102972	99520169	99520304
ENSE00001289080	99504662	99504733
ENSE00001375021	99506005	99506458
ENSE00001385326	99512453	99512591
ENSE00001866398	99531108	99534700
ENSE00003496204	99525813	99526418

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 88.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8459 / max 78.0778, expressed in 1772 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
79883	4.6478	1664
79881	1.6068	1026
79882	1.5913	970

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	88.00	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.03	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.64	gold quality
ventricular zone	UBERON:0003053	83.47	gold quality
ganglionic eminence	UBERON:0004023	82.70	gold quality
cortical plate	UBERON:0005343	82.25	gold quality
sperm	CL:0000019	82.05	gold quality
stromal cell of endometrium	CL:0002255	80.06	gold quality
male germ cell	CL:0000015	79.37	gold quality
tendon	UBERON:0000043	78.82	gold quality
hindlimb stylopod muscle	UBERON:0004252	77.91	gold quality
adrenal tissue	UBERON:0018303	77.76	gold quality
islet of Langerhans	UBERON:0000006	77.61	gold quality
gastrocnemius	UBERON:0001388	77.50	gold quality
muscle of leg	UBERON:0001383	77.46	gold quality
calcaneal tendon	UBERON:0003701	76.74	gold quality
granulocyte	CL:0000094	76.48	gold quality
cerebellar hemisphere	UBERON:0002245	76.44	gold quality
endothelial cell	CL:0000115	76.42	silver quality
cerebellar cortex	UBERON:0002129	76.41	gold quality
embryo	UBERON:0000922	76.09	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.58	gold quality
prefrontal cortex	UBERON:0000451	75.34	gold quality
right adrenal gland cortex	UBERON:0035827	75.15	gold quality
cerebellum	UBERON:0002037	75.12	gold quality
right adrenal gland	UBERON:0001233	75.04	gold quality
leukocyte	CL:0000738	74.88	gold quality
testis	UBERON:0000473	74.65	gold quality
monocyte	CL:0000576	74.52	gold quality
secondary oocyte	CL:0000655	74.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.30

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA1652.1	ZKSCAN5	Factors with multiple dispersed zinc fingers
MA1652.2	ZKSCAN5	Factors with multiple dispersed zinc fingers

JASPAR matrix evidence (PMIDs): PMID:23354101

miRNA regulators (miRDB)

63 targeting ZKSCAN5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-187-5P	99.74	70.26	1404
HSA-MIR-3913-3P	99.74	66.53	938
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-670-5P	99.67	69.94	1565

Literature-anchored findings (GeneRIF, showing 2)

• Shorter telomeres increase chronic obstructive pulmonary disease (COPD) risk and the zinc finger protein 95 homolog ZFP95 (ZNF208) polymorphism affects telomere length in COPD patients. (PMID:30397981)
• ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma. (PMID:38018874)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zkscan5	ENSMUSG00000055991
rattus_norvegicus	Zkscan5	ENSRNOG00000059552

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein with KRAB and SCAN domains 5 — Q9Y2L8 (reviewed: Q9Y2L8)

Alternative names: Zinc finger protein 95 homolog

All UniProt accessions (2): Q9Y2L8, F8WBD4

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (5): NP_001305011, NP_001305012, NP_001305013, NP_055384, NP_659570* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF02023

UniProt features (57 total): strand 17, zinc finger region 13, helix 10, cross-link 9, turn 4, domain 2, chain 1, modified residue 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
2EM5	SOLUTION NMR
2EMM	SOLUTION NMR
2EMZ	SOLUTION NMR
2EN3	SOLUTION NMR
2EOM	SOLUTION NMR
2EON	SOLUTION NMR
2EOO	SOLUTION NMR
2YSO	SOLUTION NMR
2YTG	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2L8-F1	58.55	0.04

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 335, 216, 248, 270, 303, 317, 509, 513, 709, 785

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 131 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, GSE45365_NK_CELL_VS_CD8_TCELL_UP, TTTGTAG_MIR520D, HFH8_01, TGACATY_UNKNOWN, BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_UP, LEE_AGING_NEOCORTEX_DN, MODULE_207, DANG_BOUND_BY_MYC, CETS1P54_01, PARENT_MTOR_SIGNALING_UP, BENPORATH_OCT4_TARGETS, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, BENPORATH_MYC_MAX_TARGETS, SCGGAAGY_ELK1_02

GO Biological Process (3): regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of macromolecule biosynthetic process (GO:0010558)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription by RNA polymerase II	1
macromolecule biosynthetic process	1
negative regulation of biosynthetic process	1
regulation of macromolecule biosynthetic process	1
negative regulation of macromolecule metabolic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1042 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZKSCAN5	CNOT10	Q9H9A5	623
ZKSCAN5	FCF1	Q9Y324	559
ZKSCAN5	AMMECR1L	Q6DCA0	542
ZKSCAN5	USP39	Q53GS9	539
ZKSCAN5	TLK2	Q86UE8	499
ZKSCAN5	ARPC1A	Q92747	492
ZKSCAN5	DHX16	O60231	490
ZKSCAN5	NPIPB6	E9PJ23	480
ZKSCAN5	DDX50	Q9BQ39	473
ZKSCAN5	NOL7	Q9UMY1	465
ZKSCAN5	TMUB2	Q71RG4	463
ZKSCAN5	SLC4A1AP	Q9BWU0	460
ZKSCAN5	GPATCH3	Q96I76	444
ZKSCAN5	NUDCD3	Q8IVD9	429
ZKSCAN5	AGK	Q53H12	420

IntAct

28 interactions, top by confidence:

A	B	Type	Score
ZKSCAN5	GFAP	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN5	GLE1	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN5	ATXN10	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN5	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
SUV39H1	ZKSCAN5	psi-mi:“MI:0915”(physical association)	0.510
CRK	ZKSCAN5	psi-mi:“MI:0407”(direct interaction)	0.440
CCL1	ZKSCAN5	psi-mi:“MI:0915”(physical association)	0.370
ZKSCAN5	ZBTB9	psi-mi:“MI:0915”(physical association)	0.370
ZKSCAN5	ZSCAN1	psi-mi:“MI:0915”(physical association)	0.370
TNNT1	ZKSCAN5	psi-mi:“MI:0915”(physical association)	0.370
ZSCAN20	ZNF197	psi-mi:“MI:0914”(association)	0.350
ZNF232	ZNF197	psi-mi:“MI:0914”(association)	0.350
ZKSCAN5	DNAJB6	psi-mi:“MI:0914”(association)	0.350
ZSCAN21	IPO8	psi-mi:“MI:0914”(association)	0.350
fadL	ZKSCAN5	psi-mi:“MI:0915”(physical association)	0.000
ZKSCAN5		psi-mi:“MI:0915”(physical association)	0.000
RBM11	ZKSCAN5	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (19): ZKSCAN5 (Affinity Capture-MS), ZKSCAN5 (Affinity Capture-MS), ZKSCAN5 (Affinity Capture-MS), ZKSCAN5 (Affinity Capture-RNA), ZKSCAN5 (Affinity Capture-MS), ZKSCAN5 (Affinity Capture-MS), ZKSCAN5 (Affinity Capture-MS), ZKSCAN5 (Affinity Capture-MS), ZKSCAN5 (Reconstituted Complex), ZKSCAN5 (Protein-peptide), ZKSCAN5 (Two-hybrid), PPA1 (Cross-Linking-MS (XL-MS)), ZBTB9 (Two-hybrid), ZSCAN1 (Two-hybrid), ZKSCAN5 (Two-hybrid)

ESM2 similar proteins: A1YEP8, A1YEV9, A1YFW2, A1YG26, A1YG48, A1YG60, A2T6E3, A2T6V8, A2T712, A2T736, A2T7D2, A2T7F4, A2T7L7, A2T812, A6QNZ0, O14709, O15535, O43296, O43309, P10073, P17023, P17097, P49910, Q07231, Q12901, Q15776, Q16670, Q1LZ87, Q3MJ62, Q53GI3, Q571J5, Q5JNZ3, Q5RAE6, Q5RBX0, Q5RCD9, Q5RJ54, Q7Z7L9, Q86W11, Q8IZ26, Q8NF99

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

100 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	88
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1328 predictions. Top by Δscore:

Variant	Effect	Δscore
7:99504731:GAG:G	donor_gain	1.0000
7:99506455:GCAG:G	donor_gain	1.0000
7:99506457:AGGTG:A	donor_loss	1.0000
7:99506458:GGTG:G	donor_loss	1.0000
7:99506459:G:A	donor_loss	1.0000
7:99506460:T:A	donor_loss	1.0000
7:99512443:T:TA	acceptor_gain	1.0000
7:99512448:GTTA:G	acceptor_loss	1.0000
7:99512449:TTA:T	acceptor_loss	1.0000
7:99512450:TA:T	acceptor_loss	1.0000
7:99512451:A:AG	acceptor_gain	1.0000
7:99512452:G:GG	acceptor_gain	1.0000
7:99512452:GATT:G	acceptor_gain	1.0000
7:99519825:A:AG	acceptor_gain	1.0000
7:99519826:G:GG	acceptor_gain	1.0000
7:99520168:GAA:G	acceptor_gain	1.0000
7:99526414:GAGAT:G	donor_gain	1.0000
7:99529654:G:GT	donor_gain	1.0000
7:99531107:GGCA:G	acceptor_gain	1.0000
7:99504724:T:TA	donor_gain	0.9900
7:99504725:G:GA	donor_gain	0.9900
7:99504731:GAGGT:G	donor_loss	0.9900
7:99504733:GGT:G	donor_loss	0.9900
7:99504734:G:GA	donor_loss	0.9900
7:99504735:T:G	donor_loss	0.9900
7:99505365:A:T	donor_gain	0.9900
7:99506003:A:AG	acceptor_gain	0.9900
7:99506004:G:GG	acceptor_gain	0.9900
7:99506004:GT:G	acceptor_gain	0.9900
7:99506461:GAG:G	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000031988 (7:99524869 A>C), RS1000139139 (7:99526988 G>A), RS1000171680 (7:99508258 C>A,T), RS1000350807 (7:99520774 T>G), RS1000424408 (7:99514945 T>G), RS1000500159 (7:99512657 C>T), RS1000544518 (7:99531353 T>G), RS1000552235 (7:99512891 T>C), RS1000561038 (7:99507115 A>G), RS1000582612 (7:99525321 A>G), RS1000648285 (7:99526442 G>A,C,T), RS1000819719 (7:99520040 C>G,T), RS1000828054 (7:99507538 T>C), RS1001142836 (7:99533108 T>G), RS1001230513 (7:99519690 G>T)

Disease associations

OMIM: gene MIM:611272 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

18 associations (top):

Study	Trait	p-value
GCST001038_1	Dehydroepiandrosterone sulphate levels	3.000000e-36
GCST002925_11	Sex hormone levels	2.000000e-14
GCST002925_12	Sex hormone levels	2.000000e-07
GCST002925_6	Sex hormone levels	6.000000e-14
GCST004730_2	Facial emotion recognition (sad faces)	3.000000e-06
GCST005144_1	Tacrolimus trough concentration in kidney transplant patients	2.000000e-17
GCST005348_113	Total body bone mineral density	1.000000e-08
GCST005795_25	Femoral neck bone mineral density	8.000000e-06
GCST005796_12	Lumbar spine bone mineral density	1.000000e-08
GCST005830_30	Hand grip strength	2.000000e-08
GCST006249_21	Serum metabolite levels	4.000000e-11
GCST006249_22	Serum metabolite levels	2.000000e-12
GCST009163_1	Hormone measurements	2.000000e-08
GCST009163_2	Hormone measurements	2.000000e-09
GCST009733_105	Urinary metabolite levels in chronic kidney disease	6.000000e-18
GCST009733_120	Urinary metabolite levels in chronic kidney disease	2.000000e-12
GCST009733_239	Urinary metabolite levels in chronic kidney disease	6.000000e-12
GCST90002407_487	White blood cell count	1.000000e-09

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0004730	hormone measurement
EFO:0007001	dehydroepiandrosterone sulphate measurement
EFO:0004908	testosterone measurement
EFO:0008329	facial emotion recognition measurement
EFO:0008458	tacrolimus measurement
EFO:0007785	femoral neck bone mineral density
EFO:0007701	spine bone mineral density
EFO:0006941	grip strength measurement
EFO:0010239	cortisol:DHEAS ratio measurement
EFO:0010240	dehydroepiandrosterone measurement
EFO:0005116	urinary metabolite measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, decreases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
FR900359	decreases phosphorylation	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	decreases expression	1
4-nitroso-N-phenylaniline	affects response to substance	1
arsenic disulfide	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
abrine	increases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
PCI 5002	affects cotreatment, increases expression	1
Leflunomide	decreases expression	1
Copper	affects binding, decreases expression	1
Disulfiram	affects binding, decreases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	increases expression	1
Zinc	affects cotreatment, increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.