ZKSCAN8

Summary

ZKSCAN8 (zinc finger with KRAB and SCAN domains 8, HGNC:12983) is a protein-coding gene on chromosome 6p22.1, encoding Zinc finger protein with KRAB and SCAN domains 8 (Q15776). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 7745 — RefSeq curated summary.

At a glance

• GWAS associations: 23
• Clinical variants (ClinVar): 84 total
• MANE Select transcript: NM_006298

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12983
Approved symbol	ZKSCAN8
Name	zinc finger with KRAB and SCAN domains 8
Location	6p22.1
Locus type	gene with protein product
Status	Approved
Aliases	LD5-1, ZSCAN40
Ensembl gene	ENSG00000198315
Ensembl biotype	protein_coding
OMIM	602240
Entrez	7745

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 2 nonsense_mediated_decay

ENST00000330236, ENST00000457389, ENST00000536028, ENST00000606198, ENST00000885351, ENST00000885352, ENST00000885353, ENST00000918693, ENST00000948324, ENST00000948325

RefSeq mRNA: 4 — MANE Select: NM_006298 NM_001278119, NM_001278121, NM_001278122, NM_006298

CCDS: CCDS4645

Canonical transcript exons

ENST00000330236 — 6 exons

Exon	Start	End
ENSE00000848518	28148316	28148824
ENSE00001372567	28153056	28159460
ENSE00003496787	28152261	28152384
ENSE00003597300	28151845	28151936
ENSE00003680014	28149483	28149624
ENSE00003843412	28141883	28142029

Expression profiles

Bgee: expression breadth ubiquitous, 251 present calls, max score 87.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.4939 / max 237.4867, expressed in 1792 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66613	17.9451	1788
66614	0.4005	200
66615	0.1483	52

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	87.14	gold quality
ventricular zone	UBERON:0003053	86.74	gold quality
calcaneal tendon	UBERON:0003701	86.39	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.73	gold quality
mucosa of stomach	UBERON:0001199	85.73	gold quality
colonic epithelium	UBERON:0000397	85.13	gold quality
sural nerve	UBERON:0015488	85.05	gold quality
cortical plate	UBERON:0005343	84.89	gold quality
body of uterus	UBERON:0009853	84.62	gold quality
left ovary	UBERON:0002119	84.51	gold quality
ovary	UBERON:0000992	84.28	gold quality
right ovary	UBERON:0002118	84.11	gold quality
tibial artery	UBERON:0007610	83.78	gold quality
popliteal artery	UBERON:0002250	83.75	gold quality
descending thoracic aorta	UBERON:0002345	83.69	gold quality
right lung	UBERON:0002167	83.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.57	gold quality
caput epididymis	UBERON:0004358	83.53	gold quality
lower esophagus	UBERON:0013473	83.53	gold quality
adrenal tissue	UBERON:0018303	83.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	83.47	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.38	gold quality
stromal cell of endometrium	CL:0002255	83.33	gold quality
corpus callosum	UBERON:0002336	83.26	gold quality
cauda epididymis	UBERON:0004360	83.14	gold quality
left uterine tube	UBERON:0001303	83.08	gold quality
body of pancreas	UBERON:0001150	82.93	gold quality
aorta	UBERON:0000947	82.81	gold quality
endocervix	UBERON:0000458	82.70	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.48

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

283 targeting ZKSCAN8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zkscan8	ENSMUSG00000063894
rattus_norvegicus	Zkscan8	ENSRNOG00000053635

Paralogs (30): ZNF263 (ENSG00000006194), ZNF213 (ENSG00000085644), ZNF500 (ENSG00000103199), ZKSCAN1 (ENSG00000106261), ZNF205 (ENSG00000122386), ZSCAN9 (ENSG00000137185), PGBD1 (ENSG00000137338), ZNF215 (ENSG00000149054), ZSCAN12 (ENSG00000158691), ZNF394 (ENSG00000160908), ZNF75A (ENSG00000162086), ZSCAN21 (ENSG00000166529), ZNF232 (ENSG00000167840), ZNF24 (ENSG00000172466), ZNF449 (ENSG00000173275), ZSCAN4 (ENSG00000180532), ZSCAN22 (ENSG00000182318), ZNF75D (ENSG00000186376), ZNF396 (ENSG00000186496), ZNF397 (ENSG00000186812), ZSCAN30 (ENSG00000186814), ZKSCAN4 (ENSG00000187626), ZSCAN23 (ENSG00000187987), ZKSCAN3 (ENSG00000189298), ZSCAN16 (ENSG00000196812), ZSCAN25 (ENSG00000197037), ZSCAN26 (ENSG00000197062), ZNF165 (ENSG00000197279), ZSCAN31 (ENSG00000235109), ZNF853 (ENSG00000236609)

Protein

Protein identifiers

Zinc finger protein with KRAB and SCAN domains 8 — Q15776 (reviewed: Q15776)

Alternative names: LD5-1, Zinc finger protein 192

All UniProt accessions (1): Q15776

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q15776-1	1	yes
Q15776-2	2

RefSeq proteins (4): NP_001265048, NP_001265050, NP_001265051, NP_006289* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily
IPR050527

Pfam: PF00096, PF01352, PF02023

UniProt features (37 total): cross-link 12, zinc finger region 9, sequence conflict 5, domain 2, region of interest 2, modified residue 2, splice variant 2, chain 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15776-F1	65.45	0.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (14): 12, 201, 26, 176, 199, 221, 272, 288, 374, 376, 413, 441, 502, 572

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 124 (showing top): WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN, HONMA_DOCETAXEL_RESISTANCE, BILD_HRAS_ONCOGENIC_SIGNATURE, CATRRAGC_UNKNOWN, DANG_BOUND_BY_MYC, SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC, TGGAAA_NFAT_Q4_01, SANSOM_APC_MYC_TARGETS, WGTTNNNNNAAA_UNKNOWN, BENPORATH_MYC_MAX_TARGETS, SCGGAAGY_ELK1_02, MGGAAGTG_GABP_B, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, JOHNSTONE_PARVB_TARGETS_2_DN, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
cellular anatomical structure	1

Protein interactions and networks

STRING

786 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZKSCAN8	NKAPL	Q5M9Q1	646
ZKSCAN8	PTAR1	Q7Z6K3	506
ZKSCAN8	PM20D2	Q8IYS1	453
ZKSCAN8	ZNF438	Q7Z4V0	408
ZKSCAN8	CCDC184	Q52MB2	390
ZKSCAN8	OR11G2	Q8NGC1	377
ZKSCAN8	SACS	Q9NZJ4	375
ZKSCAN8	GOLGA8J	A6NMD2	373
ZKSCAN8	MIER3	Q7Z3K6	357
ZKSCAN8	DOP1A	Q5JWR5	352
ZKSCAN8	LYSMD1	Q96S90	352
ZKSCAN8	ZNF512	Q96ME7	349
ZKSCAN8	DPH5	Q9H2P9	348
ZKSCAN8	TULP4	Q9NRJ4	348
ZKSCAN8	TBC1D32	Q96NH3	344

IntAct

187 interactions, top by confidence:

A	B	Type	Score
ZNF396	ZNF24	psi-mi:“MI:0914”(association)	0.700
ZKSCAN8	ZNF444	psi-mi:“MI:0915”(physical association)	0.670
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
MAGOH	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
TCEA2	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	ZNF587	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	DMWD	psi-mi:“MI:0915”(physical association)	0.560
ELAVL4	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
GRN	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8		psi-mi:“MI:0915”(physical association)	0.560
HLA-A	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
LMNA	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	NEFL	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	NF2	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	PPIA	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	PRPS1	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	WFS1	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	YWHAG	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	SETDB1	psi-mi:“MI:0915”(physical association)	0.560
KAT5	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	KIF1B	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	RNF11	psi-mi:“MI:0915”(physical association)	0.560
LMO3	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560
ZKSCAN8	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
HTT	ZKSCAN8	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (172): ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-Western), ZKSCAN8 (Reconstituted Complex), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS)

ESM2 similar proteins: A1YEP8, A1YEV9, A1YFW2, A1YG26, A1YG48, A1YG60, A2T6E3, A2T6V8, A2T712, A2T736, A2T7D2, A2T7F4, A2T7L7, A2T812, A6QNZ0, O14709, O15535, O43296, O43309, P10073, P17023, P17097, P49910, Q07231, Q12901, Q15776, Q16670, Q1LZ87, Q3MJ62, Q53GI3, Q571J5, Q5JNZ3, Q5RAE6, Q5RBX0, Q5RCD9, Q5RJ54, Q7Z7L9, Q86W11, Q8IZ26, Q8NF99

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 133 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	7	24.8×	3e-07
Cap-dependent Translation Initiation	7	24.8×	3e-07
SARS-CoV-1 modulates host translation machinery	7	24.8×	3e-07
Eukaryotic Translation Elongation	7	22.4×	6e-07
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	7	21.9×	7e-07
Nonsense-Mediated Decay (NMD)	8	21.4×	1e-07
SARS-CoV-2 modulates host translation machinery	7	18.0×	3e-06
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	13	17.6×	2e-10

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	12	18.1×	2e-09
ribosomal small subunit biogenesis	7	13.0×	2e-04
rRNA processing	8	9.2×	4e-04
translation	11	9.2×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

84 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	78
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1074 predictions. Top by Δscore:

Variant	Effect	Δscore
6:28142030:G:GG	donor_gain	1.0000
6:28148315:GAA:G	acceptor_gain	1.0000
6:28149620:GAGAG:G	donor_gain	1.0000
6:28149622:GAG:G	donor_gain	1.0000
6:28149625:G:GA	donor_loss	1.0000
6:28149626:T:G	donor_loss	1.0000
6:28151843:A:AG	acceptor_gain	1.0000
6:28151844:G:GG	acceptor_gain	1.0000
6:28151844:GCC:G	acceptor_gain	1.0000
6:28151844:GCCAT:G	acceptor_gain	1.0000
6:28152253:T:TA	acceptor_gain	1.0000
6:28152257:TCA:T	acceptor_loss	1.0000
6:28152258:CA:C	acceptor_loss	1.0000
6:28152259:A:AC	acceptor_loss	1.0000
6:28152259:A:AG	acceptor_gain	1.0000
6:28152260:G:A	acceptor_loss	1.0000
6:28152260:G:GA	acceptor_gain	1.0000
6:28152260:GA:G	acceptor_gain	1.0000
6:28152260:GAC:G	acceptor_gain	1.0000
6:28152260:GACT:G	acceptor_gain	1.0000
6:28152260:GACTT:G	acceptor_gain	1.0000
6:28152333:GATC:G	donor_gain	1.0000
6:28152383:GG:G	donor_gain	1.0000
6:28152384:GG:G	donor_gain	1.0000
6:28152384:GGTAA:G	donor_loss	1.0000
6:28152385:G:GG	donor_gain	1.0000
6:28152386:TAA:T	donor_loss	1.0000
6:28153052:TCAG:T	acceptor_loss	1.0000
6:28153053:CAG:C	acceptor_loss	1.0000
6:28142034:G:GG	donor_gain	0.9900

AlphaMissense

3806 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:28153607:T:C	F443L	1.000
6:28153609:C:A	F443L	1.000
6:28153609:C:G	F443L	1.000
6:28153355:T:C	F359L	0.999
6:28153357:C:A	F359L	0.999
6:28153357:C:G	F359L	0.999
6:28153439:T:C	F387L	0.999
6:28153441:C:A	F387L	0.999
6:28153441:C:G	F387L	0.999
6:28153523:T:C	F415L	0.999
6:28153525:C:A	F415L	0.999
6:28153525:C:G	F415L	0.999
6:28153626:T:C	L449P	0.999
6:28153691:T:C	F471L	0.999
6:28153693:C:A	F471L	0.999
6:28153693:C:G	F471L	0.999
6:28153710:T:C	L477P	0.999
6:28153775:T:C	F499L	0.999
6:28153777:C:A	F499L	0.999
6:28153777:C:G	F499L	0.999
6:28153859:T:C	F527L	0.999
6:28153861:C:A	F527L	0.999
6:28153861:C:G	F527L	0.999
6:28153888:C:A	H536Q	0.999
6:28153888:C:G	H536Q	0.999
6:28153943:T:C	F555L	0.999
6:28153945:T:A	F555L	0.999
6:28153945:T:G	F555L	0.999
6:28153271:T:C	F331L	0.998
6:28153273:T:A	F331L	0.998

dbSNP variants (sampled 300 via entrez): RS1000068062 (6:28150862 A>C), RS1000205924 (6:28141947 G>T), RS1000233662 (6:28144265 G>A), RS1000566792 (6:28143467 G>A,C,T), RS1000596222 (6:28143858 T>C), RS1000727827 (6:28151079 T>G), RS1000904404 (6:28158163 G>T), RS1000955718 (6:28150240 T>G), RS1001506469 (6:28145388 G>C), RS1001693494 (6:28142942 C>T), RS1001755740 (6:28145063 A>C), RS1001914159 (6:28142631 G>C), RS1001982713 (6:28140152 A>G), RS1002057206 (6:28158212 G>C), RS1002081968 (6:28158632 G>A)

Disease associations

OMIM: gene MIM:602240 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

23 associations (top):

Study	Trait	p-value
GCST004521_112	Autism spectrum disorder or schizophrenia	3.000000e-26
GCST004521_115	Autism spectrum disorder or schizophrenia	3.000000e-16
GCST004521_163	Autism spectrum disorder or schizophrenia	3.000000e-08
GCST004521_166	Autism spectrum disorder or schizophrenia	4.000000e-24
GCST004521_212	Autism spectrum disorder or schizophrenia	5.000000e-14
GCST004521_22	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_23	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_6	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_73	Autism spectrum disorder or schizophrenia	8.000000e-11
GCST004521_77	Autism spectrum disorder or schizophrenia	1.000000e-19
GCST004602_49	Mean corpuscular volume	2.000000e-21
GCST007327_58	Smoking status (ever vs never smokers)	3.000000e-08
GCST008921_6	Asthma and major depressive disorder	1.000000e-09
GCST010002_50	Refractive error	4.000000e-34
GCST010142_16	Fish- and plant-related diet	2.000000e-10
GCST010142_19	Fish- and plant-related diet	4.000000e-10
GCST010142_34	Fish- and plant-related diet	7.000000e-09
GCST010142_35	Fish- and plant-related diet	8.000000e-09
GCST010142_42	Fish- and plant-related diet	1.000000e-08
GCST010142_7	Fish- and plant-related diet	3.000000e-12
GCST010702_75	Subcortical volume (MOSTest)	3.000000e-11
GCST010703_272	Brain morphology (MOSTest)	7.000000e-16
GCST90011898_139	Alanine aminotransferase levels	3.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004318	smoking behavior
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	4
perfluorooctane sulfonic acid	decreases expression, increases expression	2
Air Pollutants	affects expression, increases abundance, increases expression	2
Cisplatin	decreases expression, affects response to substance	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases methylation	1
kojic acid	decreases expression	1
zinc chromate	increases abundance, increases expression	1
manganese chloride	increases abundance, increases expression	1
coumarin	increases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	increases expression	1
Caffeine	increases phosphorylation	1
Manganese	increases abundance, increases expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Urethane	affects expression	1
Aflatoxin B1	decreases methylation	1
Particulate Matter	increases abundance, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_GZ98	K562 eGFP-ZKSCAN8	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.