ZMIZ1-AS1

Summary

ZMIZ1-AS1 (ZMIZ1 antisense RNA 1, HGNC:27433) is a long non-coding RNA gene on chromosome 10q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27433
Approved symbol	ZMIZ1-AS1
Name	ZMIZ1 antisense RNA 1
Location	10q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224596
Ensembl biotype	lncRNA
Entrez	283050
RNAcentral	URS000075ADF9 — lncRNA, 2450 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 48 — 48 lncRNA

ENST00000428862, ENST00000440151, ENST00000456353, ENST00000665190, ENST00000838110, ENST00000838111, ENST00000838112, ENST00000838113, ENST00000838114, ENST00000838115, ENST00000838116, ENST00000838117, ENST00000838118, ENST00000838119, ENST00000838120, ENST00000838121, ENST00000838122, ENST00000838123, ENST00000838124, ENST00000838125, ENST00000838126, ENST00000838127, ENST00000838128, ENST00000838129, ENST00000838130, ENST00000838131, ENST00000838132, ENST00000838133, ENST00000838134, ENST00000838135, ENST00000838136, ENST00000838137, ENST00000838138, ENST00000838139, ENST00000838140, ENST00000838141, ENST00000838142, ENST00000838143, ENST00000838144, ENST00000838145, ENST00000838146, ENST00000838147, ENST00000838148, ENST00000838149, ENST00000838150, ENST00000838151, ENST00000838152, ENST00000838153

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000428862 — 4 exons

Exon	Start	End
ENSE00001649317	78960505	78960716
ENSE00001661275	78961254	78962394
ENSE00001711606	78945912	78945989
ENSE00001741567	78943328	78944747

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 87.49.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4294 / max 43.0608, expressed in 187 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110232	0.3505	144
110233	0.0789	28

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.49	gold quality
sperm	CL:0000019	84.12	silver quality
bone marrow cell	CL:0002092	81.62	gold quality
right adrenal gland	UBERON:0001233	74.29	gold quality
left adrenal gland	UBERON:0001234	74.12	gold quality
left adrenal gland cortex	UBERON:0035825	73.95	gold quality
right adrenal gland cortex	UBERON:0035827	73.56	gold quality
adrenal cortex	UBERON:0001235	71.53	gold quality
left testis	UBERON:0004533	70.70	gold quality
right testis	UBERON:0004534	70.66	gold quality
right lobe of thyroid gland	UBERON:0001119	70.60	gold quality
adrenal gland	UBERON:0002369	70.48	gold quality
left lobe of thyroid gland	UBERON:0001120	70.09	gold quality
testis	UBERON:0000473	69.34	gold quality
thyroid gland	UBERON:0002046	69.30	gold quality
cortical plate	UBERON:0005343	68.90	gold quality
stromal cell of endometrium	CL:0002255	68.87	gold quality
mucosa of stomach	UBERON:0001199	67.70	gold quality
colonic epithelium	UBERON:0000397	65.69	silver quality
amniotic fluid	UBERON:0000173	65.60	silver quality
prefrontal cortex	UBERON:0000451	64.93	gold quality
skin of leg	UBERON:0001511	64.89	gold quality
ectocervix	UBERON:0012249	64.41	gold quality
cartilage tissue	UBERON:0002418	64.24	silver quality
body of uterus	UBERON:0009853	64.10	gold quality
islet of Langerhans	UBERON:0000006	63.93	gold quality
endocervix	UBERON:0000458	63.83	gold quality
skin of abdomen	UBERON:0001416	63.83	gold quality
minor salivary gland	UBERON:0001830	63.75	gold quality
zone of skin	UBERON:0000014	63.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA ZMIZ1-AS1 promotes osteosarcoma progression by stabilization of ZMIZ1. (PMID:34508303)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.