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ZMIZ2

gene
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Also known as KIAA1886hZIMP7ZIMP7DKFZp761I2123NET27

Summary

ZMIZ2 (zinc finger MIZ-type containing 2, HGNC:22229) is a protein-coding gene on chromosome 7p13, encoding Zinc finger MIZ domain-containing protein 2 (Q8NF64). Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.

ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).

Source: NCBI Gene 83637 — RefSeq curated summary.

At a glance

  • GWAS associations: 11
  • Clinical variants (ClinVar): 171 total
  • MANE Select transcript: NM_031449

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:22229
Approved symbolZMIZ2
Namezinc finger MIZ-type containing 2
Location7p13
Locus typegene with protein product
StatusApproved
AliasesKIAA1886, hZIMP7, ZIMP7, DKFZp761I2123, NET27
Ensembl geneENSG00000122515
Ensembl biotypeprotein_coding
OMIM611196
Entrez83637

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 24 protein_coding, 5 retained_intron, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000265346, ENST00000309315, ENST00000413916, ENST00000416856, ENST00000433667, ENST00000441627, ENST00000457123, ENST00000463056, ENST00000463931, ENST00000478045, ENST00000480964, ENST00000482322, ENST00000492001, ENST00000492558, ENST00000884706, ENST00000884707, ENST00000884708, ENST00000884709, ENST00000884710, ENST00000884711, ENST00000884712, ENST00000884713, ENST00000884714, ENST00000931484, ENST00000931485, ENST00000931486, ENST00000931487, ENST00000931488, ENST00000931489, ENST00000931490, ENST00000931491, ENST00000944840

RefSeq mRNA: 3 — MANE Select: NM_031449 NM_001300959, NM_031449, NM_174929

CCDS: CCDS43576, CCDS43577, CCDS75591

Canonical transcript exons

ENST00000309315 — 19 exons

ExonStartEnd
ENSE000011918404476015144760228
ENSE000012182704475694744757149
ENSE000015358044474884744748991
ENSE000016012644475642544756539
ENSE000017106234475784844758108
ENSE000017272404476042544760593
ENSE000017812414475928144759460
ENSE000034595224476642144766663
ENSE000034776234475618844756299
ENSE000035033614476533544765579
ENSE000035057864476494144765009
ENSE000035208304476288144762986
ENSE000035363744476616444766333
ENSE000035461014476441944764486
ENSE000035535984476169544761905
ENSE000035779834475737844757561
ENSE000036155834476325644763413
ENSE000036941984476144944761593
ENSE000037539154476751644769881

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 98.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.4822 / max 204.4060, expressed in 1821 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter IDTPM avgSamples expressed
7843731.92411815
784349.28511774
784351.7450866
784380.7868492
784420.4564257
784360.4428196
784410.4384230
2044270.2954115
784400.108125

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
endothelial cellCL:000011598.54gold quality
right uterine tubeUBERON:000130298.51gold quality
right lobe of thyroid glandUBERON:000111998.06gold quality
metanephros cortexUBERON:001053397.88gold quality
left lobe of thyroid glandUBERON:000112097.85gold quality
right frontal lobeUBERON:000281097.63gold quality
thyroid glandUBERON:000204697.43gold quality
adenohypophysisUBERON:000219697.29gold quality
CA1 field of hippocampusUBERON:000388197.29gold quality
pituitary glandUBERON:000000796.90gold quality
cervix squamous epitheliumUBERON:000692296.86gold quality
body of pancreasUBERON:000115096.84gold quality
right hemisphere of cerebellumUBERON:001489096.66gold quality
granulocyteCL:000009496.62gold quality
minor salivary glandUBERON:000183096.61gold quality
apex of heartUBERON:000209896.58gold quality
cortical plateUBERON:000534396.56gold quality
spermCL:000001996.38gold quality
amygdalaUBERON:000187696.38gold quality
left adrenal gland cortexUBERON:003582596.37gold quality
spleenUBERON:000210696.28gold quality
male germ cellCL:000001596.09gold quality
left adrenal glandUBERON:000123496.03gold quality
lower esophagus mucosaUBERON:003583496.03gold quality
right adrenal glandUBERON:000123396.01gold quality
small intestine Peyer’s patchUBERON:000345496.00gold quality
right lungUBERON:000216795.99gold quality
skin of abdomenUBERON:000141695.98gold quality
skin of legUBERON:000151195.97gold quality
left uterine tubeUBERON:000130395.94gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes8.92

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HNF4A

miRNA regulators (miRDB)

86 targeting ZMIZ2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4533100.0069.482758
HSA-MIR-4692100.0067.322066
HSA-MIR-4481100.0066.421669
HSA-MIR-5193100.0067.261744
HSA-MIR-6867-5P100.0082.213464
HSA-MIR-6870-5P99.9968.552115
HSA-MIR-451499.9967.101870
HSA-MIR-4723-5P99.9768.702034
HSA-MIR-569899.9768.492029
HSA-MIR-7111-5P99.9768.482062
HSA-MIR-448799.9664.581252
HSA-MIR-185-3P99.9567.011743
HSA-MIR-6721-5P99.9368.922981
HSA-MIR-218-5P99.9372.222103
HSA-MIR-1211999.8768.351653
HSA-MIR-449299.8768.253611
HSA-MIR-76599.8468.242442
HSA-MIR-6764-5P99.7567.892304
HSA-MIR-11181-3P99.7566.382205
HSA-MIR-613299.6065.831554
HSA-MIR-6836-5P99.6065.621538
HSA-MIR-76299.5866.611994
HSA-MIR-1915-3P99.5866.791988
HSA-MIR-1207-5P99.4969.112983
HSA-MIR-444199.4966.563216
HSA-MIR-468899.4864.68828
HSA-MIR-6743-5P99.4863.60721
HSA-MIR-127599.4767.902749
HSA-MIR-449899.4767.422360
HSA-MIR-766-5P99.4767.912225

Literature-anchored findings (GeneRIF, showing 4)

  • hZimp7 modulates androgen receptor and/or other nuclear receptor-mediated transcription, possibly through alteration of chromatin structure by SWI/SNF-like BAF complexes. (PMID:16051670)
  • there is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription (PMID:20159969)
  • LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of beta-catenin. (PMID:31527801)
  • Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer. (PMID:39266996)

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
danio_reriozmiz2ENSDARG00000098683
mus_musculusZmiz2ENSMUSG00000041164
rattus_norvegicusZmiz2ENSRNOG00000025923
drosophila_melanogastertnaFBGN0026160
caenorhabditis_elegansWBGENE00011259

Paralogs (5): PIAS1 (ENSG00000033800), PIAS2 (ENSG00000078043), PIAS4 (ENSG00000105229), ZMIZ1 (ENSG00000108175), PIAS3 (ENSG00000131788)

Protein

Protein identifiers

Zinc finger MIZ domain-containing protein 2 — Q8NF64 (reviewed: Q8NF64)

Alternative names: PIAS-like protein Zimp7

All UniProt accessions (4): C9JDA5, E7EWM3, Q8NF64, F8WC48

UniProt curated annotations — full annotation on UniProt →

Function. Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.

Subunit / interactions. Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.

Subcellular location. Nucleus.

Tissue specificity. Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.

Domain organisation. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Isoforms (3)

UniProt IDNamesCanonical?
Q8NF64-11yes
Q8NF64-22
Q8NF64-33

RefSeq proteins (3): NP_001287888, NP_113637, NP_777589 (=MANE)

Domains & families (InterPro)

IDNameType
IPR004181Znf_MIZDomain
IPR013083Znf_RING/FYVE/PHDHomologous_superfamily
IPR057847ZMIZ1/ZMIZ2_GBD-likeDomain

Pfam: PF02891, PF25527

UniProt features (34 total): compositionally biased region 7, region of interest 6, sequence conflict 6, binding site 4, modified residue 3, cross-link 3, splice variant 2, chain 1, zinc finger region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8NF64-F154.680.28

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 616; 618; 639; 642

Post-translational modifications (6): 111, 245, 262, 402, 457, 692

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 165 (showing top): GOBP_SMAD_PROTEIN_SIGNAL_TRANSDUCTION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, MODULE_182, GOCC_NUCLEAR_REPLICATION_FORK, GOBP_PEPTIDYL_LYSINE_MODIFICATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA, GOBP_PROTEIN_SUMOYLATION, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP, GOBP_RESPONSE_TO_GROWTH_FACTOR, chr7p13, PID_AR_TF_PATHWAY, GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), protein sumoylation (GO:0016925), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (5): transcription coactivator activity (GO:0003713), zinc ion binding (GO:0008270), SUMO ligase activity (GO:0061665), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (5): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), mitochondrion (GO:0005739), nuclear replication fork (GO:0043596)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
transcription by RNA polymerase II2
positive regulation of DNA-templated transcription2
cellular anatomical structure2
intracellular membrane-bounded organelle2
regulation of DNA-templated transcription1
peptidyl-lysine modification1
protein modification by small protein conjugation1
regulation of transcription by RNA polymerase II1
transcription coregulator activity1
transition metal ion binding1
SUMO transferase activity1
ubiquitin-like protein ligase activity1
binding1
cation binding1
chromosome1
nuclear lumen1
cytoplasm1
nuclear chromosome1
nucleus1
replication fork1
CMG complex1

Protein interactions and networks

STRING

1246 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZMIZ2SMARCE1Q969G3760
ZMIZ2BANF1O75531634
ZMIZ2TXNRD2Q9NNW7589
ZMIZ2SMARCA4P51532570
ZMIZ2BLTP1Q2LD37559
ZMIZ2ALS2CLQ60I27559
ZMIZ2THRBP10828554
ZMIZ2LACRTQ9GZZ8509
ZMIZ2USP7Q93009503
ZMIZ2TUBB1Q9H4B7475
ZMIZ2ARHGEF19Q8IW93471
ZMIZ2PEAR1Q5VY43449
ZMIZ2PLXNA1Q9UIW2442
ZMIZ2POLGP54098433
ZMIZ2TUBBP05218424

IntAct

44 interactions, top by confidence:

ABTypeScore
ZMIZ2PIN1psi-mi:“MI:0915”(physical association)0.670
PIN1ZMIZ2psi-mi:“MI:0915”(physical association)0.670
CRCPZMIZ2psi-mi:“MI:0915”(physical association)0.560
ZMIZ2ARSJpsi-mi:“MI:0915”(physical association)0.560
ZMIZ2CRCPpsi-mi:“MI:0915”(physical association)0.560
ARSJZMIZ2psi-mi:“MI:0915”(physical association)0.560
HIS2ZMIZ2psi-mi:“MI:0915”(physical association)0.560
ZMIZ2HIS2psi-mi:“MI:0915”(physical association)0.560
BANPZMIZ2psi-mi:“MI:0915”(physical association)0.560
ZMIZ2SLC39A7psi-mi:“MI:0915”(physical association)0.400
KPNA4ZMIZ2psi-mi:“MI:0915”(physical association)0.400
MVPZMIZ2psi-mi:“MI:0915”(physical association)0.370
ZMIZ2SOCS6psi-mi:“MI:0915”(physical association)0.370
ZMIZ2reppsi-mi:“MI:0915”(physical association)0.370

BioGRID (132): ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), ZMIZ2 (Two-hybrid), C2orf88 (Two-hybrid), INTS4 (Two-hybrid), LRRC37A11P (Two-hybrid), SELV (Two-hybrid)

ESM2 similar proteins: A7EYK3, A7SEP9, A8NYM5, A8XW44, B0JYS7, B7Q2M2, C0NN85, C7YRT4, D3ZCL3, D5GDH4, E0VI98, E1C6F0, E2RGI3, E3X5D6, F6TFD9, F7ARS3, P09234, P33240, P90815, Q03369, Q15637, Q16IW3, Q1K7T5, Q1RLC9, Q298E0, Q32PA0, Q4WQM6, Q562A2, Q5BBX9, Q5RDA3, Q5U231, Q62241, Q64213, Q6GPM1, Q6P1E1, Q6PCR6, Q7PXU6, Q8BIQ5, Q8C7E9, Q8CIE2

Diamond homologs: A0A0A7EPL0, F4JYG0, O94451, Q04195, Q6P1E1, Q8CIE2, Q8N2W9, Q8NF64, Q94361, Q9JM05, Q9ULJ6, F1R4C4, O54714, O70260, O75925, O75928, O88907, Q12216, Q680Q4, Q6ASW7, Q6AZ28, Q6L4L4, Q8C5D8, Q9Y6X2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 29 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Deactivation of the beta-catenin transactivating complex555.5×3e-06
TCF dependent signaling in response to WNT528.0×3e-05
Signaling by WNT526.7×3e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

171 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance130
Likely benign5
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

3378 predictions. Top by Δscore:

VariantEffectΔscore
7:44756181:C:Aacceptor_gain1.0000
7:44756423:A:AGacceptor_gain1.0000
7:44756423:AGT:Aacceptor_gain1.0000
7:44756424:G:GGacceptor_gain1.0000
7:44756424:GTG:Gacceptor_gain1.0000
7:44756424:GTGAT:Gacceptor_gain1.0000
7:44756536:CCAGG:Cdonor_loss1.0000
7:44756538:AGGTA:Adonor_loss1.0000
7:44756540:G:Cdonor_loss1.0000
7:44757373:TGCA:Tacceptor_loss1.0000
7:44757375:CA:Cacceptor_loss1.0000
7:44757376:A:ACacceptor_loss1.0000
7:44757541:GAGC:Gdonor_gain1.0000
7:44757548:GCCA:Gdonor_gain1.0000
7:44757552:G:GGdonor_gain1.0000
7:44757557:GAGCG:Gdonor_gain1.0000
7:44757559:GCG:Gdonor_gain1.0000
7:44757562:G:GGdonor_gain1.0000
7:44757562:GTGA:Gdonor_loss1.0000
7:44757563:T:Gdonor_loss1.0000
7:44760217:GGCC:Gdonor_gain1.0000
7:44760218:GCC:Gdonor_gain1.0000
7:44760224:GTGGG:Gdonor_gain1.0000
7:44760423:A:AGacceptor_gain1.0000
7:44760424:G:GGacceptor_gain1.0000
7:44761448:GGAA:Gacceptor_gain1.0000
7:44761901:GCTGC:Gdonor_gain1.0000
7:44761902:C:Gdonor_gain1.0000
7:44761904:GC:Gdonor_gain1.0000
7:44761906:G:GGdonor_gain1.0000

AlphaMissense

5938 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
7:44757473:C:AA155D1.000
7:44757482:C:AA158D1.000
7:44757488:C:AA160D1.000
7:44757494:C:AA162D1.000
7:44757500:C:AA164D1.000
7:44757506:C:AA166D1.000
7:44761496:G:TG430W1.000
7:44761506:T:CL433P1.000
7:44761514:T:CF436L1.000
7:44761515:T:CF436S1.000
7:44761516:C:AF436L1.000
7:44761516:C:GF436L1.000
7:44761521:T:AL438Q1.000
7:44761521:T:CL438P1.000
7:44761526:C:GH440D1.000
7:44761527:A:TH440L1.000
7:44761528:C:AH440Q1.000
7:44761528:C:GH440Q1.000
7:44761533:T:CL442P1.000
7:44761541:A:CS445R1.000
7:44761543:C:AS445R1.000
7:44761543:C:GS445R1.000
7:44761553:T:CF449L1.000
7:44761554:T:CF449S1.000
7:44761555:C:AF449L1.000
7:44761555:C:GF449L1.000
7:44761560:T:CL451P1.000
7:44761584:T:CL459P1.000
7:44761703:T:CL465P1.000
7:44761709:T:AL467Q1.000

dbSNP variants (sampled 300 via entrez): RS1000119424 (7:44756647 G>A,C), RS1000178890 (7:44760540 C>G,T), RS1000345049 (7:44750540 A>G), RS1000346062 (7:44750227 G>A,C), RS1000402711 (7:44756958 C>G,T), RS1000509989 (7:44759358 G>A), RS1000744660 (7:44768427 G>C,T), RS1000840838 (7:44766907 G>A), RS1000951859 (7:44752058 A>T), RS1000980050 (7:44770236 G>A), RS1001194247 (7:44765233 G>A), RS1001296965 (7:44769159 G>A), RS1001348862 (7:44748709 A>C), RS1001536468 (7:44768222 C>T), RS1001691353 (7:44753321 C>T)

Disease associations

OMIM: gene MIM:611196 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

StudyTraitp-value
GCST004601_96Red blood cell count1.000000e-17
GCST004630_258Mean corpuscular hemoglobin1.000000e-26
GCST005316_3Intelligence (MTAG)2.000000e-09
GCST005316_4Intelligence (MTAG)3.000000e-09
GCST005316_5Intelligence (MTAG)4.000000e-10
GCST006269_1211General cognitive ability4.000000e-08
GCST009524_111Household income (MTAG)3.000000e-08
GCST010241_228Apolipoprotein A1 levels2.000000e-09
GCST010988_154Adult body size4.000000e-12
GCST90002383_426Hematocrit7.000000e-10
GCST90013407_38Liver enzyme levels (gamma-glutamyl transferase)9.000000e-14

EFO canonical traits (7, from GWAS)

EFO IDTrait name
EFO:0004305erythrocyte count
EFO:0004527mean corpuscular hemoglobin
EFO:0004337intelligence
EFO:0009695household income
EFO:0004614apolipoprotein A 1 measurement
EFO:0004348hematocrit
EFO:0004532serum gamma-glutamyl transferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects expression, increases expression, increases methylation4
Cadmium Chloridedecreases expression, increases abundance2
TAK-243increases sumoylation1
dicrotophosincreases expression1
alpha-pineneaffects cotreatment, increases oxidation, increases abundance1
propionaldehydeincreases expression1
sodium arsenateincreases abundance, increases expression1
beta-lapachonedecreases expression1
tris(1,3-dichloro-2-propyl)phosphatedecreases expression1
sodium arseniteincreases expression1
butyraldehydeincreases expression1
manganese chloridedecreases expression, increases abundance1
methacrylaldehydeaffects cotreatment, increases oxidation, increases abundance1
testosterone-3-carboxymethyloxime-bovine serum albumin conjugateaffects expression1
2-palmitoylglycerolincreases expression1
ICG 001increases expression1
abrineincreases expression1
Grape Seed Proanthocyanidinsaffects cotreatment, decreases expression1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-oldecreases expression1
Acroleinaffects cotreatment, increases oxidation, increases abundance1
Air Pollutantsaffects cotreatment, increases abundance, increases oxidation1
Arsenicincreases abundance, increases expression1
Benzo(a)pyrenedecreases methylation, increases methylation1
Cadmiumdecreases expression, increases abundance1
Catechinaffects cotreatment, decreases expression1
Estradiolaffects cotreatment, decreases expression1
Formaldehydeincreases expression1
Manganesedecreases expression, increases abundance1
Ozoneaffects cotreatment, increases oxidation, increases abundance1
Progesteronedecreases expression, affects cotreatment1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_TZ22HAP1 ZMIZ2 (-) 1Cancer cell lineMale
CVCL_TZ23HAP1 ZMIZ2 (-) 2Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot