ZNF106

Summary

ZNF106 (zinc finger protein 106, HGNC:12886) is a protein-coding gene on chromosome 15q15.1, encoding Zinc finger protein 106 (Q9H2Y7). RNA-binding protein.

Enables RNA binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in cytosol and membrane.

Source: NCBI Gene 64397 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 288 total
• MANE Select transcript: NM_001366845

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12886
Approved symbol	ZNF106
Name	zinc finger protein 106
Location	15q15.1
Locus type	gene with protein product
Status	Approved
Aliases	ZNF474, SH3BP3
Ensembl gene	ENSG00000103994
Ensembl biotype	protein_coding
OMIM	603988
Entrez	64397

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000263805, ENST00000564754, ENST00000565380, ENST00000565500, ENST00000565611, ENST00000565660, ENST00000565948, ENST00000567041, ENST00000567772, ENST00000568906, ENST00000569648, ENST00000570078

RefSeq mRNA: 12 — MANE Select: NM_001366845 NM_001284306, NM_001284307, NM_001366844, NM_001366845, NM_001366846, NM_001381993, NM_001381994, NM_001381995, NM_001381996, NM_001381997, NM_001381998, NM_022473

CCDS: CCDS32208, CCDS61602, CCDS61603, CCDS91986

Canonical transcript exons

ENST00000564754 — 22 exons

Exon	Start	End
ENSE00000679046	42417805	42417951
ENSE00000679055	42428018	42428134
ENSE00000884128	42435384	42435518
ENSE00000931129	42437232	42437377
ENSE00000931130	42438612	42438667
ENSE00000931132	42442073	42442414
ENSE00000931135	42446589	42446658
ENSE00001232049	42439033	42439813
ENSE00001342840	42412823	42417360
ENSE00002215322	42472236	42472321
ENSE00002274798	42466053	42466114
ENSE00002588520	42456958	42457158
ENSE00002608885	42490980	42491141
ENSE00003472556	42421061	42421132
ENSE00003510480	42423998	42424060
ENSE00003597018	42424834	42425025
ENSE00003629939	42421917	42421988
ENSE00003638668	42422501	42422620
ENSE00003641459	42448072	42448705
ENSE00003679571	42449771	42451954
ENSE00003697191	42444202	42444262
ENSE00003698266	42444827	42444981

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 99.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.2628 / max 1814.5796, expressed in 1796 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149563	15.0551	1776
149558	14.4245	889
149552	1.5073	664
149561	0.5777	263
207486	0.5541	244
149562	0.5209	281
149559	0.2415	94
149553	0.1286	37
149560	0.1271	34
149554	0.1260	37

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.47	gold quality
diaphragm	UBERON:0001103	99.41	gold quality
gluteal muscle	UBERON:0002000	99.40	gold quality
left ventricle myocardium	UBERON:0006566	99.39	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	99.37	gold quality
biceps brachii	UBERON:0001507	99.36	gold quality
vastus lateralis	UBERON:0001379	99.30	gold quality
quadriceps femoris	UBERON:0001377	99.24	gold quality
body of tongue	UBERON:0011876	99.24	gold quality
skeletal muscle tissue	UBERON:0001134	99.11	gold quality
deltoid	UBERON:0001476	99.11	gold quality
heart right ventricle	UBERON:0002080	99.04	gold quality
tibialis anterior	UBERON:0001385	98.90	gold quality
triceps brachii	UBERON:0001509	98.89	gold quality
myocardium	UBERON:0002349	98.88	gold quality
muscle organ	UBERON:0001630	98.73	gold quality
skeletal muscle organ	UBERON:0014892	98.73	gold quality
cardiac muscle of right atrium	UBERON:0003379	98.57	gold quality
gastrocnemius	UBERON:0001388	98.55	gold quality
muscle of leg	UBERON:0001383	98.53	gold quality
muscle tissue	UBERON:0002385	98.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.22	gold quality
tongue	UBERON:0001723	97.59	gold quality
cardiac ventricle	UBERON:0002082	97.17	gold quality
heart left ventricle	UBERON:0002084	97.11	gold quality
choroid plexus epithelium	UBERON:0003911	97.00	gold quality
vena cava	UBERON:0004087	96.79	gold quality
calcaneal tendon	UBERON:0003701	96.50	gold quality
superior surface of tongue	UBERON:0007371	96.46	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	96.16	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-135922	yes	485.78
E-ANND-3	yes	19.12
E-MTAB-7249	no	7502.78
E-ENAD-20	no	1891.19

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

185 targeting ZNF106, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-548AE-3P	99.93	72.66	4867

Literature-anchored findings (GeneRIF, showing 2)

• Study identified ZFP106 as a novel substrate for CBP-mediated acetylation, and showed that the fully disordered isolated ID3 in CREBBP transiently interacts with an IDR of ZFP106 in a fashion that both IDR regions are maintained. (PMID:28680062)
• Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis. (PMID:33427755)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf106a	ENSDARG00000016651
danio_rerio	znf106b	ENSDARG00000091947
mus_musculus	Zfp106	ENSMUSG00000027288
rattus_norvegicus	Zfp106	ENSRNOG00000052583

Protein

Protein identifiers

Zinc finger protein 106 — Q9H2Y7 (reviewed: Q9H2Y7)

Alternative names: Zinc finger protein 474

All UniProt accessions (8): A0A0C4DGM5, Q9H2Y7, H3BNJ4, H3BNX5, H3BRD4, H3BS99, H3BSS6, U3KQH7

UniProt curated annotations — full annotation on UniProt →

Function. RNA-binding protein. Specifically binds to 5’-GGGGCC-3’ sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.

Subunit / interactions. Interacts with KNOP1. Interacts with TARDBP and NUP107. Interacts (via N-terminus) with RBM39. Interacts with the SH3 domains of FYN and GRB2.

Subcellular location. Nucleus. Nucleolus. Nucleus speckle.

Post-translational modifications. Phosphorylated by FYN in vitro.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H2Y7-1	1	yes
Q9H2Y7-2	2

RefSeq proteins (12): NP_001271235, NP_001271236, NP_001353773, NP_001353774, NP_001353775, NP_001368922, NP_001368923, NP_001368924, NP_001368925, NP_001368926, NP_001368927, NP_071918 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR013087	Znf_C2H2_type	Domain
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR042622	Znf106	Family

Pfam: PF00400

UniProt features (120 total): cross-link 44, modified residue 22, compositionally biased region 21, region of interest 12, repeat 6, sequence conflict 6, sequence variant 4, splice variant 2, zinc finger region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H2Y7-F1	44.82	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (66): 1454, 1486, 1504, 1585, 1737, 1864, 6, 37, 422, 590, 641, 661, 859, 861, 864, 893, 937, 1021, 1025, 1026 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 230 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, HORIUCHI_WTAP_TARGETS_DN, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_DN, MARTINEZ_RB1_TARGETS_UP, MCBRYAN_PUBERTAL_BREAST_4_5WK_DN, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, GOBP_RESPONSE_TO_INSULIN, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5, MODULE_256, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_RESPONSE_TO_HORMONE

GO Biological Process (1): insulin receptor signaling pathway (GO:0008286)

GO Molecular Function (4): RNA binding (GO:0003723), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (5): nucleolus (GO:0005730), cytosol (GO:0005829), membrane (GO:0016020), nuclear speck (GO:0016607), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell surface receptor protein tyrosine kinase signaling pathway	1
cellular response to insulin stimulus	1
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
nuclear lumen	1
intracellular membraneless organelle	1
cytoplasm	1
nuclear ribonucleoprotein granule	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1314 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF106	ZNF91	Q05481	815
ZNF106	KNOP1	Q1ED39	643
ZNF106	PURA	Q00577	588
ZNF106	ADARB2	Q9NS39	574
ZNF106	ALYREF	Q86V81	562
ZNF106	TARDBP	Q13148	536
ZNF106	ZDHHC22	Q8N966	513
ZNF106	C1orf159	Q96HA4	507
ZNF106	DNHD1	Q96M86	473
ZNF106	RANGAP1	P46060	469
ZNF106	PTCD2	Q8WV60	459
ZNF106	NUCLEOLIN	P19338	455
ZNF106	ZNHIT2	Q9UHR6	455
ZNF106	PPFIA1	Q13136	447
ZNF106	FRMD8	Q9BZ67	447
ZNF106	TOPORS	Q9NS56	447

IntAct

77 interactions, top by confidence:

A	B	Type	Score
CSNK2A2	EIF3J	psi-mi:“MI:0914”(association)	0.790
SMARCD1	ARID1A	psi-mi:“MI:0914”(association)	0.790
CSNK2B	NMT2	psi-mi:“MI:0914”(association)	0.660
STAMBPL1	PIK3C2A	psi-mi:“MI:0914”(association)	0.640
CSNK2B	RPS6KA4	psi-mi:“MI:0914”(association)	0.640
NEURL4	APBB1	psi-mi:“MI:0914”(association)	0.530
KLHL40	CBX4	psi-mi:“MI:0914”(association)	0.530
KNOP1	DHX15	psi-mi:“MI:0914”(association)	0.530
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.530
FHL2	CNOT1	psi-mi:“MI:0914”(association)	0.530
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
Cep170	WDR62	psi-mi:“MI:0915”(physical association)	0.400
PCNA	ZNF106	psi-mi:“MI:0915”(physical association)	0.370
ZNF106	CFAP418	psi-mi:“MI:0915”(physical association)	0.370
ZNF106	SKIL	psi-mi:“MI:0915”(physical association)	0.370
Cep170	NEURL4	psi-mi:“MI:0914”(association)	0.350
MATR3	BCLAF3	psi-mi:“MI:0914”(association)	0.350
GTSE1	HIP1	psi-mi:“MI:0914”(association)	0.350
Kif18a	WASL	psi-mi:“MI:0914”(association)	0.350
Uso1	GOLGA2	psi-mi:“MI:0914”(association)	0.350
CAPZA2	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
EXOSC9	MPHOSPH6	psi-mi:“MI:0914”(association)	0.350
KIF21A	NCOA4	psi-mi:“MI:0914”(association)	0.350
PPP1CB	PLEKHG3	psi-mi:“MI:0914”(association)	0.350

BioGRID (106): ZNF106 (Affinity Capture-RNA), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS), ZNF106 (Affinity Capture-MS)

ESM2 similar proteins: A0A087WXM9, A0A2K1JJ00, A0JM83, A4IGL8, E1BC15, E9Q5F9, O14513, O35923, O60673, O88491, P46013, P97929, Q14B71, Q28DZ0, Q29RT4, Q3MHH3, Q3TNU4, Q3ZBP0, Q4QY64, Q4V7J0, Q5DTT3, Q5E9A0, Q5F2C3, Q5RD08, Q5VWN6, Q5VYV7, Q61493, Q69YH5, Q6NS59, Q703I1, Q80U59, Q86XD8, Q8IXS0, Q8IYL3, Q8L7I1, Q8N7Z5, Q8NFU7, Q8TEP8, Q92628, Q96BU1

Diamond homologs: A4RDD7, A6ZPA6, A7EF03, A7THX0, B3LJT5, B4HSL3, B4QHG6, B8P4B0, B8PD53, B9WD30, C4YPI7, C5DF48, C5DY07, C5FP68, C5MJE8, C7GWC1, C8ZH19, D3TLL6, D4AM37, D4D8P3, O00628, P39946, P97865, Q54WA3, Q5A7Q3, Q5A7Q6, Q6CJ50, Q6CU55, Q6DFC6, Q6FT96, Q6FWT9, Q759U7, Q7KNS3, Q7RXH4, Q8IWA0, Q8R537, Q8RXA7, Q9H2Y7, A6ZQL5, B0WC36

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 99 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	6	56.0×	3e-07
Activation of BAD and translocation to mitochondria	5	52.9×	3e-06
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	5	46.6×	4e-06
Activation of BH3-only proteins	5	34.5×	1e-05
RHO GTPases activate PKNs	6	26.4×	6e-06
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	5	20.9×	1e-04
Intrinsic Pathway for Apoptosis	5	20.3×	1e-04
SARS-CoV-1-host interactions	8	19.5×	2e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

288 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	239
Likely benign	22
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2654 predictions. Top by Δscore:

Variant	Effect	Δscore
15:42417280:T:TA	donor_gain	1.0000
15:42417280:TCCCA:T	donor_gain	1.0000
15:42417281:C:A	donor_gain	1.0000
15:42417304:T:TA	donor_gain	1.0000
15:42417819:T:A	donor_gain	1.0000
15:42417947:TGCCA:T	acceptor_gain	1.0000
15:42417949:CCA:C	acceptor_gain	1.0000
15:42417950:CA:C	acceptor_gain	1.0000
15:42417950:CAC:C	acceptor_gain	1.0000
15:42417952:C:CC	acceptor_gain	1.0000
15:42421055:CCTTA:C	donor_loss	1.0000
15:42421056:CTT:C	donor_loss	1.0000
15:42421057:TTACC:T	donor_loss	1.0000
15:42421058:T:TA	donor_loss	1.0000
15:42421059:A:AT	donor_loss	1.0000
15:42421059:AC:A	donor_gain	1.0000
15:42421060:C:CA	donor_loss	1.0000
15:42421060:CC:C	donor_gain	1.0000
15:42421060:CCCAA:C	donor_gain	1.0000
15:42421132:TCT:T	acceptor_loss	1.0000
15:42421133:C:CA	acceptor_loss	1.0000
15:42421909:ACACT:A	donor_loss	1.0000
15:42421912:CTCA:C	donor_loss	1.0000
15:42421913:TCA:T	donor_loss	1.0000
15:42421914:C:CG	donor_loss	1.0000
15:42421915:A:AC	donor_gain	1.0000
15:42421915:A:C	donor_loss	1.0000
15:42421916:C:CC	donor_gain	1.0000
15:42421916:CCATG:C	donor_gain	1.0000
15:42421984:TGAGA:T	acceptor_gain	1.0000

AlphaMissense

12593 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:42417858:A:G	C1848R	1.000
15:42421064:A:C	C1815W	1.000
15:42421066:A:G	C1815R	1.000
15:42421122:C:T	G1796D	1.000
15:42422517:C:G	R1763P	1.000
15:42422520:A:T	V1762D	1.000
15:42422529:T:A	D1759V	1.000
15:42422534:G:C	C1757W	1.000
15:42422547:A:C	M1753R	1.000
15:42422599:A:C	Y1736D	1.000
15:42422616:C:A	G1730V	1.000
15:42422616:C:T	G1730D	1.000
15:42424008:T:G	H1725P	1.000
15:42424009:G:C	H1725D	1.000
15:42424011:G:T	A1724D	1.000
15:42424012:C:G	A1724P	1.000
15:42424017:A:T	V1722D	1.000
15:42424021:A:G	S1721P	1.000
15:42424026:T:A	D1719V	1.000
15:42424026:T:G	D1719A	1.000
15:42424027:C:A	D1719Y	1.000
15:42424027:C:G	D1719H	1.000
15:42424035:C:T	G1716D	1.000
15:42424036:C:G	G1716R	1.000
15:42424037:A:C	S1715R	1.000
15:42424037:A:T	S1715R	1.000
15:42424039:T:G	S1715R	1.000
15:42424041:A:G	F1714S	1.000
15:42424044:A:T	V1713E	1.000
15:42424047:A:G	L1712P	1.000

dbSNP variants (sampled 300 via entrez): RS1000078351 (15:42482195 C>T), RS1000123021 (15:42486642 G>A), RS1000179648 (15:42434155 T>A), RS1000196673 (15:42437103 T>C), RS1000247504 (15:42437392 T>C), RS1000262218 (15:42445218 G>A), RS1000272601 (15:42479232 G>A), RS1000301520 (15:42438393 C>T), RS1000392045 (15:42431066 T>C), RS1000438414 (15:42438086 G>A), RS1000478445 (15:42473740 A>G), RS1000500105 (15:42488038 G>T), RS1000502293 (15:42458657 G>A), RS1000594683 (15:42446937 T>A), RS1000595042 (15:42444047 G>C)

Disease associations

OMIM: gene MIM:603988 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST010083_5	Hemoglobin levels	1.000000e-10
GCST010173_12	Triglyceride levels	7.000000e-24
GCST90002384_377	Hemoglobin	4.000000e-09
GCST90002397_254	Mean spheric corpuscular volume	3.000000e-09
GCST90002403_479	Red blood cell count	3.000000e-14

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004509	hemoglobin measurement
EFO:0004530	triglyceride measurement
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression, increases expression	2
FR900359	affects phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
bisphenol A	increases expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
nickel chloride	decreases expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
aflatoxin B2	increases methylation	1
coumarin	decreases phosphorylation	1
beta-methylcholine	affects expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Caffeine	decreases phosphorylation	1
Carbamazepine	affects expression	1
Doxorubicin	decreases expression	1
Lead	affects expression	1
Manganese	decreases expression, increases abundance, affects cotreatment	1
Ribonucleotides	affects binding	1
Testosterone	decreases expression	1
Thiram	increases expression	1
Tretinoin	increases expression	1
Valproic Acid	affects expression	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	increases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.