ZNF132

Summary

ZNF132 (zinc finger protein 132, HGNC:12916) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 132 (P52740). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 7691 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 140 total
• MANE Select transcript: NM_003433

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12916
Approved symbol	ZNF132
Name	zinc finger protein 132
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	pHZ-12
Ensembl gene	ENSG00000131849
Ensembl biotype	protein_coding
OMIM	604074
Entrez	7691

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 2 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000254166, ENST00000599148, ENST00000703732, ENST00000950417

RefSeq mRNA: 1 — MANE Select: NM_003433 NM_003433

CCDS: CCDS12980

Canonical transcript exons

ENST00000254166 — 3 exons

Exon	Start	End
ENSE00000902267	58432814	58435211
ENSE00001005401	58437047	58437215
ENSE00001436835	58439759	58440153

Expression profiles

Bgee: expression breadth ubiquitous, 175 present calls, max score 78.03.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4733 / max 54.2742, expressed in 883 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182958	1.4733	883

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	78.03	gold quality
adrenal tissue	UBERON:0018303	77.71	gold quality
cortical plate	UBERON:0005343	77.66	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.92	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.50	gold quality
cerebellar hemisphere	UBERON:0002245	76.39	gold quality
cerebellar cortex	UBERON:0002129	76.20	gold quality
stromal cell of endometrium	CL:0002255	75.90	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.65	gold quality
ganglionic eminence	UBERON:0004023	75.55	gold quality
adenohypophysis	UBERON:0002196	75.16	gold quality
islet of Langerhans	UBERON:0000006	74.93	gold quality
right uterine tube	UBERON:0001302	74.28	gold quality
pituitary gland	UBERON:0000007	73.69	gold quality
heart left ventricle	UBERON:0002084	73.49	gold quality
apex of heart	UBERON:0002098	73.28	gold quality
right atrium auricular region	UBERON:0006631	73.28	gold quality
right lobe of thyroid gland	UBERON:0001119	73.23	gold quality
gastrocnemius	UBERON:0001388	73.18	gold quality
muscle of leg	UBERON:0001383	73.08	gold quality
cerebellum	UBERON:0002037	72.99	gold quality
left lobe of thyroid gland	UBERON:0001120	72.48	gold quality
left ovary	UBERON:0002119	72.47	gold quality
cardiac ventricle	UBERON:0002082	72.40	gold quality
right frontal lobe	UBERON:0002810	72.31	gold quality
right adrenal gland	UBERON:0001233	72.15	gold quality
right ovary	UBERON:0002118	71.99	gold quality
thyroid gland	UBERON:0002046	71.93	gold quality
right adrenal gland cortex	UBERON:0035827	71.79	gold quality
prefrontal cortex	UBERON:0000451	71.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.63

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

34 targeting ZNF132, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-1200	99.71	70.42	1838
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4524A-5P	99.57	71.73	1193
HSA-MIR-4524B-5P	99.57	71.68	1195
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-6071	99.16	67.77	1780
HSA-MIR-6809-5P	99.13	68.45	1223
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-6738-3P	99.03	67.14	1326
HSA-MIR-4699-5P	98.99	67.50	1210
HSA-MIR-5001-3P	98.91	67.28	1394
HSA-MIR-6804-5P	98.39	65.77	1084
HSA-MIR-4450	98.26	68.35	725
HSA-MIR-6511B-5P	97.98	65.64	823
HSA-MIR-6811-5P	97.98	64.96	848
HSA-MIR-3670	97.88	64.39	763
HSA-MIR-3173-5P	97.35	65.82	1282
HSA-MIR-6799-3P	97.35	65.60	1302

Literature-anchored findings (GeneRIF, showing 3)

• downregulation of ZNF132 is associated with aggressive prostate cancer. (PMID:21445975)
• results suggest that ZNF132 plays an important role in the development of esophageal squamous cell carcinoma as a tumor suppressor gene and support the underlying mechanism caused by the DNA hypermethylation-mediated Sp1-binding decay and gene silencing. (PMID:30578410)
• Downregulated ZNF132 predicts unfavorable outcomes in breast Cancer via Hypermethylation modification. (PMID:33827486)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 132 — P52740 (reviewed: P52740)

All UniProt accessions (1): P52740

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
P52740-1	1	yes
P52740-2	2

RefSeq proteins (1): NP_003424* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050527

Pfam: PF00096, PF01352

UniProt features (23 total): zinc finger region 18, sequence variant 2, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P52740-F1	68.84	0.22

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 55 (showing top): MORF_ITGA2, ROVERSI_GLIOMA_COPY_NUMBER_UP, MORF_RAD51L3, MORF_CTSB, MORF_IL4, MORF_PRKCA, MORF_THPO, MORF_ATF2, MORF_PTPRR, MORF_PAX7, MORF_MAP2K7, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MORF_DMPK, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, MORF_FSHR

GO Biological Process (4): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of biosynthetic process (GO:0009891), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
biosynthetic process	1
regulation of biosynthetic process	1
positive regulation of metabolic process	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

372 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF132	SLC27A5	Q9Y2P5	468
ZNF132	ZNF438	Q7Z4V0	407
ZNF132	KAT8	Q9H7Z6	395
ZNF132	OPRD1	P41143	356
ZNF132	NKAPL	Q5M9Q1	347
ZNF132	OPLAH	O14841	324
ZNF132	TIGD6	Q17RP2	310
ZNF132	FAM72C	H0Y354	302
ZNF132	CALY	Q9NYX4	298
ZNF132	FBXO39	Q8N4B4	298
ZNF132	ZNF646	O15015	294
ZNF132	TSPYL5	Q86VY4	293
ZNF132	C9orf50	Q5SZB4	287
ZNF132	ZBED4	O75132	282
ZNF132	BEND5	Q7L4P6	275

IntAct

3 interactions, top by confidence:

A	B	Type	Score
ZNF132	CBX3	psi-mi:“MI:0914”(association)	0.350
EPHA1	ZNF132	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A3KN32, B2RUI1, O43296, O75123, P10072, P17020, P17097, P51814, P52736, P52740, Q07230, Q08ER8, Q13398, Q14590, Q32KN0, Q3KQV3, Q3MIS6, Q4V8A8, Q5CZA5, Q5RBQ3, Q5RBX0, Q5RCD9, Q5RCX4, Q6GQR8, Q6NX45, Q6P9A3, Q6PK81, Q7TSH9, Q7TSI0, Q7Z7L9, Q86UD4, Q8BFS8, Q8BLB0, Q8IVP9, Q8IZ26, Q8N9F8

Diamond homologs: A2RRD8, A6NFI3, A6NM28, A8MUZ8, A8MWA4, B2RUI1, B4DU55, E9Q8G5, O43296, O43361, O75467, O75820, P0CH99, P0CI00, P10078, P16373, P16374, P17021, P17023, P17032, P17097, P17098, P21506, P51786, P52740, Q06732, Q08ER8, Q13106, Q13360, Q13398, Q14592, Q147U1, Q32M78, Q3KQV3, Q3MIS6, Q3SY52, Q571J5, Q5CZA5, Q5HY98, Q5R7I8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

140 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	133
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

428 predictions. Top by Δscore:

Variant	Effect	Δscore
19:58437214:TG:T	acceptor_gain	0.9900
19:58437021:A:AC	donor_gain	0.9800
19:58437041:CATTA:C	donor_loss	0.9800
19:58437042:ATT:A	donor_loss	0.9800
19:58437043:TTACC:T	donor_loss	0.9800
19:58437045:ACC:A	donor_loss	0.9800
19:58437079:A:AC	donor_gain	0.9800
19:58437073:T:TA	donor_gain	0.9700
19:58437084:A:AC	donor_gain	0.9700
19:58437085:C:CC	donor_gain	0.9700
19:58437086:TGTGG:T	donor_gain	0.9700
19:58437211:GTATG:G	acceptor_gain	0.9700
19:58437212:TATG:T	acceptor_gain	0.9700
19:58437213:A:C	acceptor_gain	0.9700
19:58437045:A:AC	donor_gain	0.9600
19:58437046:C:CC	donor_gain	0.9600
19:58437083:CA:C	donor_gain	0.9600
19:58437216:C:CC	acceptor_gain	0.9600
19:58439870:T:TA	donor_gain	0.9600
19:58439754:CTTA:C	donor_loss	0.9500
19:58439755:TTA:T	donor_loss	0.9500
19:58439756:T:TG	donor_loss	0.9500
19:58439757:A:AG	donor_loss	0.9500
19:58439758:C:CT	donor_loss	0.9500
19:58440084:C:CA	donor_gain	0.9500
19:58435208:GAACC:G	acceptor_loss	0.9400
19:58435209:AACC:A	acceptor_loss	0.9400
19:58435211:CCTG:C	acceptor_loss	0.9400
19:58435212:CTGAA:C	acceptor_loss	0.9400
19:58435213:T:A	acceptor_loss	0.9400

AlphaMissense

4746 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:58434040:G:C	F468L	0.999
19:58434040:G:T	F468L	0.999
19:58434042:A:G	F468L	0.999
19:58434124:A:C	F440L	0.999
19:58434124:A:T	F440L	0.999
19:58434126:A:G	F440L	0.999
19:58433956:G:C	F496L	0.998
19:58433956:G:T	F496L	0.998
19:58433958:A:G	F496L	0.998
19:58434023:A:G	L474P	0.998
19:58434292:G:C	F384L	0.998
19:58434292:G:T	F384L	0.998
19:58434294:A:G	F384L	0.998
19:58434097:G:C	H449Q	0.997
19:58434097:G:T	H449Q	0.997
19:58434208:G:C	F412L	0.997
19:58434208:G:T	F412L	0.997
19:58434210:A:G	F412L	0.997
19:58434376:G:C	F356L	0.997
19:58434376:G:T	F356L	0.997
19:58434378:A:G	F356L	0.997
19:58433788:A:C	F552L	0.996
19:58433788:A:T	F552L	0.996
19:58433790:A:G	F552L	0.996
19:58434013:A:C	H477Q	0.996
19:58434013:A:T	H477Q	0.996
19:58434015:G:C	H477D	0.996
19:58433536:A:C	F636L	0.995
19:58433536:A:T	F636L	0.995
19:58433538:A:G	F636L	0.995

dbSNP variants (sampled 300 via entrez): RS1000304254 (19:58435991 T>G), RS1000786057 (19:58438288 C>T), RS1000863909 (19:58441361 T>G), RS1001683642 (19:58440848 C>A), RS1002080233 (19:58435030 C>G,T), RS1002222900 (19:58437504 G>C), RS1002791494 (19:58440359 C>G,T), RS1003121673 (19:58441255 C>T), RS1003733674 (19:58433384 T>C), RS1003766048 (19:58433637 C>G), RS1004575533 (19:58440648 CT>C), RS1004637283 (19:58436537 A>G), RS1004678903 (19:58441303 G>A), RS1004752704 (19:58441511 A>C,G), RS1004796321 (19:58440783 C>A,T)

Disease associations

OMIM: gene MIM:604074 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	2
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
terbufos	increases methylation	1
arsenite	increases methylation	1
abrine	increases expression	1
Fonofos	increases methylation	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Parathion	increases methylation	1
Silicon Dioxide	decreases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Vanadates	increases expression	1
Magnetite Nanoparticles	decreases methylation	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW05	HEK293 eGFP-ZNF132	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.