ZNF14

Summary

ZNF14 (zinc finger protein 14, HGNC:12924) is a protein-coding gene on chromosome 19p13.11, encoding Zinc finger protein 14 (P17017). May be involved in transcriptional regulation.

The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins.

Source: NCBI Gene 7561 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 105 total
• MANE Select transcript: NM_021030

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12924
Approved symbol	ZNF14
Name	zinc finger protein 14
Location	19p13.11
Locus type	gene with protein product
Status	Approved
Aliases	KOX6, GIOT-4
Ensembl gene	ENSG00000105708
Ensembl biotype	protein_coding
OMIM	194556
Entrez	7561

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000344099

RefSeq mRNA: 1 — MANE Select: NM_021030 NM_021030

CCDS: CCDS12409

Canonical transcript exons

ENST00000344099 — 4 exons

Exon	Start	End
ENSE00000691432	19714091	19714151
ENSE00001407032	19710472	19713089
ENSE00001428460	19732956	19733112
ENSE00001593566	19714361	19714487

Expression profiles

Bgee: expression breadth ubiquitous, 267 present calls, max score 93.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.6888 / max 108.5483, expressed in 1455 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180166	5.6888	1455

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	93.48	gold quality
oocyte	CL:0000023	87.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.95	gold quality
buccal mucosa cell	CL:0002336	84.59	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.38	gold quality
endothelial cell	CL:0000115	80.62	gold quality
middle temporal gyrus	UBERON:0002771	79.95	gold quality
cortical plate	UBERON:0005343	79.81	gold quality
calcaneal tendon	UBERON:0003701	79.65	gold quality
Brodmann (1909) area 23	UBERON:0013554	79.27	gold quality
ganglionic eminence	UBERON:0004023	79.00	gold quality
hair follicle	UBERON:0002073	78.65	silver quality
ventricular zone	UBERON:0003053	78.08	gold quality
parotid gland	UBERON:0001831	77.45	gold quality
renal glomerulus	UBERON:0000074	77.37	gold quality
nephron tubule	UBERON:0001231	76.51	gold quality
metanephric glomerulus	UBERON:0004736	76.49	gold quality
caput epididymis	UBERON:0004358	75.75	gold quality
corpus epididymis	UBERON:0004359	75.74	gold quality
ovary	UBERON:0000992	75.67	gold quality
kidney epithelium	UBERON:0004819	75.45	gold quality
germinal epithelium of ovary	UBERON:0001304	74.88	gold quality
lymph node	UBERON:0000029	74.84	gold quality
islet of Langerhans	UBERON:0000006	74.81	gold quality
primary visual cortex	UBERON:0002436	74.81	gold quality
cauda epididymis	UBERON:0004360	74.58	gold quality
endometrium	UBERON:0001295	74.29	gold quality
parietal pleura	UBERON:0002400	74.16	gold quality
left ovary	UBERON:0002119	74.15	gold quality
palpebral conjunctiva	UBERON:0001812	74.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
FSHB

miRNA regulators (miRDB)

53 targeting ZNF14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-3156-3P	99.76	66.72	939
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-1260A	99.61	66.67	1098
HSA-MIR-1260B	99.61	66.67	1098
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-892C-5P	99.16	70.56	2116

Cross-species orthologs

0 orthologs

Paralogs (15): ZNF57 (ENSG00000171970), ZNF791 (ENSG00000173875), ZNF443 (ENSG00000180855), ZNF101 (ENSG00000181896), ZNF563 (ENSG00000188868), ZNF799 (ENSG00000196466), ZNF700 (ENSG00000196757), ZNF441 (ENSG00000197044), ZNF433 (ENSG00000197647), ZNF44 (ENSG00000197857), ZNF823 (ENSG00000197933), ZNF442 (ENSG00000198342), ZNF844 (ENSG00000223547), ZNF709 (ENSG00000242852), ZNF878 (ENSG00000257446)

Protein

Protein identifiers

Zinc finger protein 14 — P17017 (reviewed: P17017)

Alternative names: Gonadotropin-inducible ovary transcription repressor 4, Zinc finger protein KOX6

All UniProt accessions (1): P17017

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_066358* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050636	C2H2-ZF_domain-containing	Family

Pfam: PF00096, PF01352, PF13912

UniProt features (23 total): zinc finger region 19, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P17017-F1	78.62	0.26

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 95 (showing top): PID_ERB_GENOMIC_PATHWAY, MODULE_205, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP, CHEN_HOXA5_TARGETS_9HR_UP, chr19p13, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, LU_EZH2_TARGETS_DN, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP, MTOR_UP.N4.V1_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, HES2_TARGET_GENES, GSE10240_CTRL_VS_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN, SNAI1_TARGET_GENES, ZNF711_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

442 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF14	C8orf48	Q96LL4	446
ZNF14	BORCS8	Q96FH0	391
ZNF14	YJEFN3	A6XGL0	377
ZNF14	ATP13A1	Q9HD20	365
ZNF14	GMIP	Q9P107	355
ZNF14	PRDM2	Q13029	325
ZNF14	ENPP5	Q9UJA9	324
ZNF14	JHY	Q6NUN7	323
ZNF14	ZNF474	Q6S9Z5	322
ZNF14	TMEM121B	Q9BXQ6	322
ZNF14	NR2C2AP	Q86WQ0	317
ZNF14	SEC22C	Q9BRL7	316
ZNF14	NPAS1	Q99742	310
ZNF14	MZT2A	Q6P582	305
ZNF14	USP49	Q70CQ1	290

IntAct

5 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
FAM50A	SNRNP200	psi-mi:“MI:0914”(association)	0.350
MARK3	ZNF14	psi-mi:“MI:0914”(association)	0.350

BioGRID (9): ZNF14 (Affinity Capture-RNA), ZNF14 (Affinity Capture-RNA), ZNF14 (Affinity Capture-MS), ZNF14 (Affinity Capture-MS), ZNF14 (Affinity Capture-MS), ZNF14 (Affinity Capture-MS), ZNF14 (Affinity Capture-MS), ZNF14 (Affinity Capture-RNA), ZNF14 (Affinity Capture-RNA)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

105 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	93
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

784 predictions. Top by Δscore:

Variant	Effect	Δscore
19:19713085:GACAT:G	acceptor_gain	1.0000
19:19713087:CAT:C	acceptor_gain	1.0000
19:19713088:AT:A	acceptor_gain	1.0000
19:19713089:TC:T	acceptor_loss	1.0000
19:19713090:C:CC	acceptor_gain	1.0000
19:19713090:CTGT:C	acceptor_loss	1.0000
19:19713091:T:A	acceptor_loss	1.0000
19:19714086:CTCA:C	donor_loss	1.0000
19:19714087:TCA:T	donor_loss	1.0000
19:19714088:CA:C	donor_loss	1.0000
19:19714157:A:AC	acceptor_gain	1.0000
19:19714166:C:T	acceptor_gain	1.0000
19:19714358:TACCT:T	donor_loss	1.0000
19:19714359:A:AG	donor_loss	1.0000
19:19714485:GTCC:G	acceptor_loss	1.0000
19:19714486:TC:T	acceptor_gain	1.0000
19:19714487:CC:C	acceptor_gain	1.0000
19:19714488:C:CC	acceptor_gain	1.0000
19:19714488:CT:C	acceptor_loss	1.0000
19:19732952:TCA:T	donor_loss	1.0000
19:19732953:CA:C	donor_loss	1.0000
19:19732954:A:AG	donor_loss	1.0000
19:19713086:ACAT:A	acceptor_gain	0.9900
19:19713087:CATC:C	acceptor_gain	0.9900
19:19714090:CCTT:C	donor_gain	0.9900
19:19714147:TTTTC:T	acceptor_gain	0.9900
19:19714149:TTCC:T	acceptor_loss	0.9900
19:19714150:TC:T	acceptor_gain	0.9900
19:19714151:CC:C	acceptor_gain	0.9900
19:19714151:CCT:C	acceptor_loss	0.9900

AlphaMissense

4288 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:19712501:G:C	F260L	0.987
19:19712501:G:T	F260L	0.987
19:19712503:A:G	F260L	0.987
19:19712417:G:C	F288L	0.986
19:19712417:G:T	F288L	0.986
19:19712419:A:G	F288L	0.986
19:19711997:G:C	F428L	0.984
19:19711997:G:T	F428L	0.984
19:19711999:A:G	F428L	0.984
19:19712081:G:C	F400L	0.982
19:19712081:G:T	F400L	0.982
19:19712083:A:G	F400L	0.982
19:19711661:G:C	F540L	0.980
19:19711661:G:T	F540L	0.980
19:19711663:A:G	F540L	0.980
19:19712165:G:C	F372L	0.980
19:19712165:G:T	F372L	0.980
19:19712167:A:G	F372L	0.980
19:19712585:A:C	F232L	0.978
19:19712585:A:T	F232L	0.978
19:19712587:A:G	F232L	0.978
19:19711409:G:C	F624L	0.977
19:19711409:G:T	F624L	0.977
19:19711411:A:G	F624L	0.977
19:19712333:G:C	F316L	0.976
19:19712333:G:T	F316L	0.976
19:19712335:A:G	F316L	0.976
19:19712249:G:C	F344L	0.974
19:19712249:G:T	F344L	0.974
19:19712251:A:G	F344L	0.974

dbSNP variants (sampled 300 via entrez): RS1000068576 (19:19731982 T>C), RS1000145008 (19:19715917 G>A), RS1000194803 (19:19718329 G>A), RS1000227738 (19:19718024 AT>A), RS1000408433 (19:19728869 G>A), RS1000454342 (19:19715544 C>T), RS1000738715 (19:19729131 C>T), RS1000796363 (19:19729495 T>C), RS1000937505 (19:19720595 G>A), RS1000988119 (19:19720952 C>A,T), RS1001061391 (19:19714188 T>G), RS1001194813 (19:19732036 A>C), RS1001249875 (19:19729793 T>C), RS1001290661 (19:19730603 C>T), RS1001554854 (19:19714450 G>A,T)

Disease associations

OMIM: gene MIM:194556 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002671_14	Toenail selenium levels	5.000000e-06
GCST010002_52	Refractive error	4.000000e-29
GCST012020_59	Serum metabolite levels	8.000000e-11

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
potassium chromate(VI)	affects cotreatment, increases expression	1
ferrous chloride	decreases expression	1
resorcinol	decreases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
chloropicrin	increases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
jinfukang	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Arsenicals	increases methylation	1
Formaldehyde	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Valproic Acid	decreases expression	1
Aflatoxin M1	decreases expression	1
Asbestos, Crocidolite	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	increases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.