ZNF143-AS1

Summary

ZNF143-AS1 (ZNF143 antisense RNA 1, HGNC:58073) is a long non-coding RNA gene on chromosome 11p15.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58073
Approved symbol	ZNF143-AS1
Name	ZNF143 antisense RNA 1
Location	11p15.4
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000268403
Ensembl biotype	lncRNA
Entrez	644656
RNAcentral	URS000075C10F — lncRNA, 1161 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000596206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000596206 — 1 exons

Exon	Start	End
ENSE00004128978	9459548	9460702

Expression profiles

Bgee: expression breadth ubiquitous, 189 present calls, max score 79.69.

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	79.69	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.59	silver quality
right uterine tube	UBERON:0001302	78.41	gold quality
middle temporal gyrus	UBERON:0002771	78.31	silver quality
tibia	UBERON:0000979	78.26	gold quality
epithelial cell of pancreas	CL:0000083	77.90	silver quality
germinal epithelium of ovary	UBERON:0001304	77.09	gold quality
Brodmann (1909) area 23	UBERON:0013554	76.74	silver quality
apex of heart	UBERON:0002098	75.20	gold quality
bronchial epithelial cell	CL:0002328	74.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.73	gold quality
metanephros cortex	UBERON:0010533	74.62	gold quality
mucosa of transverse colon	UBERON:0004991	73.89	gold quality
bronchus	UBERON:0002185	73.85	gold quality
cerebellar hemisphere	UBERON:0002245	73.76	gold quality
cerebellar cortex	UBERON:0002129	73.63	gold quality
primary visual cortex	UBERON:0002436	73.14	gold quality
cerebellum	UBERON:0002037	73.01	gold quality
jejunal mucosa	UBERON:0000399	72.69	gold quality
right coronary artery	UBERON:0001625	72.38	gold quality
bone marrow cell	CL:0002092	72.26	silver quality
monocyte	CL:0000576	71.97	gold quality
bone marrow	UBERON:0002371	71.97	gold quality
spleen	UBERON:0002106	71.82	gold quality
metanephros	UBERON:0000081	71.75	gold quality
granulocyte	CL:0000094	71.73	gold quality
right lobe of thyroid gland	UBERON:0001119	71.71	gold quality
esophagus squamous epithelium	UBERON:0006920	71.53	silver quality
left lobe of thyroid gland	UBERON:0001120	71.40	gold quality
pituitary gland	UBERON:0000007	71.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LOC644656 promotes cisplatin resistance in cervical cancer by recruiting ZNF143 and activating the transcription of E6-AP. (PMID:38395183)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.