ZNF155

Summary

ZNF155 (zinc finger protein 155, HGNC:12940) is a protein-coding gene on chromosome 19q13.31, encoding Zinc finger protein 155 (Q12901). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 7711 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 86 total
• MANE Select transcript: NM_198089

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12940
Approved symbol	ZNF155
Name	zinc finger protein 155
Location	19q13.31
Locus type	gene with protein product
Status	Approved
Aliases	pHZ-96
Ensembl gene	ENSG00000204920
Ensembl biotype	protein_coding
OMIM	604086
Entrez	7711

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 13 protein_coding, 2 retained_intron

ENST00000270014, ENST00000407951, ENST00000586454, ENST00000587302, ENST00000588531, ENST00000590411, ENST00000590615, ENST00000591532, ENST00000611002, ENST00000851203, ENST00000851204, ENST00000851205, ENST00000932768, ENST00000968381, ENST00000968382

RefSeq mRNA: 5 — MANE Select: NM_198089 NM_001260486, NM_001260487, NM_001260488, NM_003445, NM_198089

CCDS: CCDS12634, CCDS58668

Canonical transcript exons

ENST00000270014 — 5 exons

Exon	Start	End
ENSE00002487188	43991842	43991934
ENSE00002516458	43991548	43991674
ENSE00002802234	43984188	43984245
ENSE00003546200	43988459	43988558
ENSE00003842492	43996093	43998326

Expression profiles

Bgee: expression breadth ubiquitous, 201 present calls, max score 94.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2060 / max 91.0908, expressed in 1544 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176238	4.1677	1544
176239	0.0383	11

Top tissues by expression

266 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	94.33	gold quality
oocyte	CL:0000023	91.14	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.23	gold quality
calcaneal tendon	UBERON:0003701	81.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.98	gold quality
tendon	UBERON:0000043	78.67	gold quality
apex of heart	UBERON:0002098	78.09	gold quality
adrenal tissue	UBERON:0018303	78.06	gold quality
stromal cell of endometrium	CL:0002255	77.65	gold quality
mucosa of stomach	UBERON:0001199	77.59	gold quality
ganglionic eminence	UBERON:0004023	76.90	gold quality
granulocyte	CL:0000094	76.83	gold quality
cerebellar hemisphere	UBERON:0002245	76.82	gold quality
cerebellar cortex	UBERON:0002129	76.76	gold quality
right adrenal gland	UBERON:0001233	76.46	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.30	gold quality
rectum	UBERON:0001052	76.14	gold quality
right adrenal gland cortex	UBERON:0035827	76.14	gold quality
cortical plate	UBERON:0005343	75.75	gold quality
islet of Langerhans	UBERON:0000006	75.72	gold quality
left adrenal gland cortex	UBERON:0035825	75.50	gold quality
left adrenal gland	UBERON:0001234	75.42	gold quality
ventricular zone	UBERON:0003053	75.21	gold quality
cerebellum	UBERON:0002037	75.12	gold quality
right coronary artery	UBERON:0001625	74.94	gold quality
adrenal gland	UBERON:0002369	74.89	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.79	gold quality
right ovary	UBERON:0002118	74.73	gold quality
heart left ventricle	UBERON:0002084	74.57	gold quality
descending thoracic aorta	UBERON:0002345	74.24	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-124858	no	283.11
E-ANND-3	no	3.44

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

31 targeting ZNF155, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-623	99.76	68.16	1170
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-561-3P	99.64	70.90	3647
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-3616-5P	99.55	67.02	989
HSA-MIR-573	99.55	67.44	955
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-219A-1-3P	98.91	67.87	639
HSA-MIR-224-3P	98.91	68.42	1815
HSA-MIR-522-3P	98.91	68.56	1817
HSA-MIR-3944-5P	98.50	67.55	997
HSA-MIR-3179	98.22	65.90	1445
HSA-MIR-432-5P	98.00	68.13	989
HSA-MIR-4433A-3P	97.75	62.82	1435
HSA-MIR-495-5P	97.62	68.28	682
HSA-MIR-642B-5P	96.37	67.26	745
HSA-MIR-675-3P	95.77	69.27	675
HSA-MIR-4515	95.70	65.73	716

Cross-species orthologs

0 orthologs

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391)

Protein

Protein identifiers

Zinc finger protein 155 — Q12901 (reviewed: Q12901)

All UniProt accessions (4): Q12901, K7EJJ6, K7ELA0, K7ENV6

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q12901-1	1	yes
Q12901-2	2

RefSeq proteins (5): NP_001247415, NP_001247416, NP_001247417, NP_003436, NP_932355* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096, PF01352

UniProt features (26 total): zinc finger region 12, sequence conflict 6, sequence variant 5, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q12901-F1	66.82	0.16

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 50 (showing top): CHEN_HOXA5_TARGETS_9HR_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, IL21_UP.V1_DN, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, GOMF_DNA_BINDING_TRANSCRIPTION_REPRESSOR_ACTIVITY, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CSHL1_TARGET_GENES, E2F5_TARGET_GENES, ZNF223_TARGET_GENES, ZNF30_TARGET_GENES, ZNF33A_TARGET_GENES, ZNF350_TARGET_GENES, ZNF592_TARGET_GENES

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleoplasm (GO:0005654), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
negative regulation of transcription by RNA polymerase II	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transcription cis-regulatory region binding	1
regulation of DNA-templated transcription	1
transcription regulator activity	1
transition metal ion binding	1
DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
nuclear lumen	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

284 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF155	FLACC1	Q96Q35	431
ZNF155	ATP6AP1L	Q52LC2	418
ZNF155	FAM184A	Q8NB25	403
ZNF155	LRRC37A2	A6NM11	390
ZNF155	PRAMEF6	Q5VXH4	371
ZNF155	LRRC37A	A6NMS7	357
ZNF155	LRRC37A3	O60309	351
ZNF155	PRAMEF8	Q5VWM4	350
ZNF155	PRAMEF7	Q5VXH5	349
ZNF155	NGRN	Q9NPE2	348
ZNF155	TARBP1	Q13395	336
ZNF155	TRUB1	Q8WWH5	323
ZNF155	PRAMEF4	O60810	310
ZNF155	OSBP2	Q969R2	305
ZNF155	A0A096LNW4	A0A096LNW4	305

IntAct

14 interactions, top by confidence:

A	B	Type	Score
CCNDBP1	ZNF155	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-6	ZNF155	psi-mi:“MI:0915”(physical association)	0.560
ZNF155	MDFI	psi-mi:“MI:0915”(physical association)	0.560
GOLGA6L9	ZNF155	psi-mi:“MI:0915”(physical association)	0.560
PB2	SEC15L3	psi-mi:“MI:0914”(association)	0.350
ZNF155	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.000
ZNF155	KRTAP10-6	psi-mi:“MI:0915”(physical association)	0.000
ZNF155	MDFI	psi-mi:“MI:0915”(physical association)	0.000
ZNF155	GOLGA6L9	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (10): ZNF155 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZNF155 (Two-hybrid), ZNF155 (Two-hybrid), ZNF155 (Two-hybrid), ZNF155 (Two-hybrid), ZNF155 (Affinity Capture-RNA), ZNF155 (Affinity Capture-MS)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

86 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1053 predictions. Top by Δscore:

Variant	Effect	Δscore
19:43984241:GCCAA:G	donor_gain	1.0000
19:43984246:G:GG	donor_gain	1.0000
19:43991543:TGTA:T	acceptor_loss	1.0000
19:43991545:TA:T	acceptor_loss	1.0000
19:43991546:A:AC	acceptor_loss	1.0000
19:43991546:A:AG	acceptor_gain	1.0000
19:43991546:AG:A	acceptor_gain	1.0000
19:43991546:AGGAG:A	acceptor_gain	1.0000
19:43991547:G:GA	acceptor_gain	1.0000
19:43991547:GG:G	acceptor_gain	1.0000
19:43991547:GGA:G	acceptor_gain	1.0000
19:43991547:GGAGG:G	acceptor_gain	1.0000
19:43991658:G:GT	donor_gain	1.0000
19:43991671:G:GG	donor_gain	1.0000
19:43991672:TGG:T	donor_gain	1.0000
19:43991673:GGG:G	donor_gain	1.0000
19:43991675:G:GG	donor_gain	1.0000
19:43984213:G:GT	donor_gain	0.9900
19:43988457:A:AG	acceptor_gain	0.9900
19:43988458:G:GG	acceptor_gain	0.9900
19:43988458:GACT:G	acceptor_gain	0.9900
19:43988532:G:GG	donor_gain	0.9900
19:43988555:CAAGG:C	donor_loss	0.9900
19:43988557:AGG:A	donor_loss	0.9900
19:43988558:GGT:G	donor_loss	0.9900
19:43988559:G:T	donor_loss	0.9900
19:43988560:T:A	donor_loss	0.9900
19:43991540:T:TA	acceptor_gain	0.9900
19:43991543:T:A	acceptor_gain	0.9900
19:43991545:TAGG:T	acceptor_gain	0.9900

AlphaMissense

3598 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:43996578:T:C	F241L	0.997
19:43996580:C:A	F241L	0.997
19:43996580:C:G	F241L	0.997
19:43996662:T:C	F269L	0.995
19:43996664:C:A	F269L	0.995
19:43996664:C:G	F269L	0.995
19:43997082:T:C	F409L	0.993
19:43997084:T:A	F409L	0.993
19:43997084:T:G	F409L	0.993
19:43996494:T:C	F213L	0.992
19:43996496:T:A	F213L	0.992
19:43996496:T:G	F213L	0.992
19:43996830:T:C	F325L	0.991
19:43996832:T:A	F325L	0.991
19:43996832:T:G	F325L	0.991
19:43996681:T:C	L275P	0.990
19:43996579:T:C	F241S	0.989
19:43996746:T:C	F297L	0.989
19:43996748:C:A	F297L	0.989
19:43996748:C:G	F297L	0.989
19:43996914:T:C	F353L	0.989
19:43996916:T:A	F353L	0.989
19:43996916:T:G	F353L	0.989
19:43996998:T:C	F381L	0.989
19:43997000:C:A	F381L	0.989
19:43997000:C:G	F381L	0.989
19:43996585:G:C	R243P	0.988
19:43996513:T:C	L219P	0.986
19:43996551:T:C	F232L	0.986
19:43996553:C:A	F232L	0.986

dbSNP variants (sampled 300 via entrez): RS1000220369 (19:43983419 G>T), RS1000918203 (19:43986454 T>G), RS1000938995 (19:43994676 C>A,T), RS1001378175 (19:43993009 C>A), RS1002188621 (19:43995579 T>C), RS1002953865 (19:43986321 T>G), RS1003368225 (19:43990776 C>G,T), RS1003547470 (19:43984750 G>A), RS1003600520 (19:43997641 T>A,C,G), RS1004036742 (19:43990147 T>C), RS1004086976 (19:43997619 T>C,G), RS1004284322 (19:43984327 G>A), RS1004709848 (19:43986004 GGAAA>G), RS1004907434 (19:43992175 A>G), RS1005156017 (19:43989081 A>G,T)

Disease associations

OMIM: gene MIM:604086 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
ferrous chloride	decreases expression	1
aflatoxin B2	increases methylation	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
Amphotericin B	decreases expression	1
Benzene	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	increases abundance, increases expression	1
Tretinoin	increases expression	1
Urethane	affects expression	1
Valproic Acid	decreases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	increases abundance, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW09	HEK293 eGFP-ZNF155	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.