ZNF157

Summary

ZNF157 (zinc finger protein 157, HGNC:12942) is a protein-coding gene on chromosome Xp11.3, encoding Zinc finger protein 157 (P51786). May be involved in transcriptional regulation.

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23.

Source: NCBI Gene 7712 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 82 total
• MANE Select transcript: NM_003446

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12942
Approved symbol	ZNF157
Name	zinc finger protein 157
Location	Xp11.3
Locus type	gene with protein product
Status	Approved
Aliases	HZF22
Ensembl gene	ENSG00000147117
Ensembl biotype	protein_coding
OMIM	300024
Entrez	7712

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000377073

RefSeq mRNA: 1 — MANE Select: NM_003446 NM_003446

CCDS: CCDS14278

Canonical transcript exons

ENST00000377073 — 4 exons

Exon	Start	End
ENSE00001391178	47410680	47410775
ENSE00001472699	47412369	47414498
ENSE00001472701	47370578	47370740
ENSE00001790252	47410276	47410402

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 68.52.

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	68.52	gold quality
endometrium epithelium	UBERON:0004811	65.68	gold quality
ventricular zone	UBERON:0003053	64.69	gold quality
ganglionic eminence	UBERON:0004023	64.40	gold quality
right uterine tube	UBERON:0001302	61.83	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	61.66	gold quality
islet of Langerhans	UBERON:0000006	59.58	gold quality
cerebellar cortex	UBERON:0002129	59.14	gold quality
cerebellar hemisphere	UBERON:0002245	59.11	gold quality
embryo	UBERON:0000922	57.87	gold quality
cerebellum	UBERON:0002037	57.86	gold quality
right hemisphere of cerebellum	UBERON:0014890	57.72	gold quality
adenohypophysis	UBERON:0002196	55.19	gold quality
prefrontal cortex	UBERON:0000451	54.78	gold quality
pituitary gland	UBERON:0000007	54.14	gold quality
paraflocculus	UBERON:0005351	52.72	gold quality
fallopian tube	UBERON:0003889	52.26	gold quality
lymph node	UBERON:0000029	51.98	gold quality
nasal cavity mucosa	UBERON:0001826	51.20	gold quality
thymus	UBERON:0002370	51.16	silver quality
stromal cell of endometrium	CL:0002255	51.10	silver quality
smooth muscle tissue	UBERON:0001135	50.54	gold quality
frontal pole	UBERON:0002795	50.41	gold quality
middle frontal gyrus	UBERON:0002702	50.30	gold quality
Brodmann (1909) area 10	UBERON:0013541	50.18	gold quality
frontal cortex	UBERON:0001870	50.01	gold quality
quadriceps femoris	UBERON:0001377	49.95	gold quality
neocortex	UBERON:0001950	49.72	gold quality
vastus lateralis	UBERON:0001379	49.56	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.26
E-GEOD-83139	no	24.51

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2331.1	ZNF157	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:28273063

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

4 targeting ZNF157, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-640	98.44	66.93	644
HSA-MIR-3085-5P	97.72	65.43	544

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 157 — P51786 (reviewed: P51786)

Alternative names: Zinc finger protein HZF22

All UniProt accessions (1): P51786

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_003437* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (15 total): zinc finger region 12, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P51786-F1	76.24	0.39

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 102 (showing top): MORF_FLT1, MORF_MSH3, MORF_BRCA1, MORF_ESR1, MORF_RAD51L3, MORF_CTSB, MORF_IL4, MORF_PRKCA, CAR_MYST2, MODULE_123, MODULE_157, CAR_MLANA, MORF_THPO, MODULE_113, MORF_ATF2

GO Biological Process (3): regulation of DNA-templated transcription (GO:0006355), regulation of macromolecule metabolic process (GO:0060255), regulation of primary metabolic process (GO:0080090)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of metabolic process	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
macromolecule metabolic process	1
primary metabolic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

482 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF157	ARAF	P07557	813
ZNF157	CTSV	O60911	671
ZNF157	TIMP1	P01033	667
ZNF157	CD99	P14209	545
ZNF157	TMEM63A	O94886	509
ZNF157	UBA1	P22314	506
ZNF157	TIMP3	P35625	490
ZNF157	CTSS	P25774	473
ZNF157	GNB3	P16520	427
ZNF157	PRSS8	Q16651	426
ZNF157	DCAF12L2	Q5VW00	418
ZNF157	SCNN1A	P37088	418
ZNF157	SPANXN4	Q5MJ08	417
ZNF157	PPP1R1B	Q9UD71	391
ZNF157	PTGER3	P43115	387

IntAct

3 interactions, top by confidence:

A	B	Type	Score
ZNF157	EDF1	psi-mi:“MI:0915”(physical association)	0.400
ZNF157	ECHS1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (9): ZNF157 (Affinity Capture-MS), ZNF157 (Affinity Capture-MS), ZNF157 (Affinity Capture-MS), ZNF157 (Affinity Capture-MS), ZNF157 (Affinity Capture-MS), ZNF157 (Affinity Capture-MS), ZNF157 (Proximity Label-MS), ZNF157 (Proximity Label-MS), ZNF157 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2RRD8, A6NHJ4, B4DX44, O75346, P10077, P10755, P15621, P16372, P16373, P51786, P52737, P85977, Q0VGE8, Q14588, Q147U1, Q15928, Q15973, Q2M3X9, Q3KNS6, Q3MIS6, Q494X3, Q5HY98, Q5RBQ3, Q5REK1, Q5VIY5, Q60585, Q61751, Q6GQR8, Q7L2R6, Q7TSH9, Q8IYX0, Q8N782, Q8N823, Q8N988, Q8N9F8, Q8NA42, Q8NCK3, Q8NDP4, Q8NEP9, Q8TC21

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	54
Likely benign	4
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

1226 predictions. Top by Δscore:

Variant	Effect	Δscore
X:47370737:TGAGG:T	donor_loss	1.0000
X:47370740:GGTA:G	donor_loss	1.0000
X:47370741:GTA:G	donor_loss	1.0000
X:47370742:T:G	donor_loss	1.0000
X:47410274:A:AC	acceptor_loss	1.0000
X:47410274:A:AG	acceptor_gain	1.0000
X:47410274:AGG:A	acceptor_gain	1.0000
X:47410275:G:GA	acceptor_loss	1.0000
X:47410275:G:GG	acceptor_gain	1.0000
X:47410275:GGG:G	acceptor_gain	1.0000
X:47410363:G:GT	donor_gain	1.0000
X:47410398:TGTGG:T	donor_loss	1.0000
X:47410399:GTGG:G	donor_gain	1.0000
X:47410401:GG:G	donor_gain	1.0000
X:47410402:GG:G	donor_gain	1.0000
X:47410403:G:GG	donor_gain	1.0000
X:47410403:GT:G	donor_loss	1.0000
X:47410404:T:A	donor_loss	1.0000
X:47410408:G:GT	donor_gain	1.0000
X:47410771:CTCAG:C	donor_gain	1.0000
X:47410772:TCAG:T	donor_gain	1.0000
X:47410774:AG:A	donor_gain	1.0000
X:47410775:GG:G	donor_gain	1.0000
X:47410776:G:GG	donor_gain	1.0000
X:47370738:GAG:G	donor_gain	0.9900
X:47370741:G:GG	donor_gain	0.9900
X:47381250:G:GT	donor_gain	0.9900
X:47407208:C:G	donor_gain	0.9900
X:47410274:AG:A	acceptor_gain	0.9900
X:47410274:AGGG:A	acceptor_gain	0.9900

AlphaMissense

3355 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:47412836:T:C	F255L	0.999
X:47412838:T:A	F255L	0.999
X:47412838:T:G	F255L	0.999
X:47412752:T:C	F227L	0.998
X:47412754:T:A	F227L	0.998
X:47412754:T:G	F227L	0.998
X:47412855:T:C	L261P	0.998
X:47412668:T:C	F199L	0.997
X:47412670:C:A	F199L	0.997
X:47412670:C:G	F199L	0.997
X:47412771:T:C	L233P	0.997
X:47412863:C:G	H264D	0.997
X:47412867:A:C	Q265P	0.997
X:47412920:T:C	F283L	0.997
X:47412922:T:A	F283L	0.997
X:47412922:T:G	F283L	0.997
X:47413004:T:C	F311L	0.997
X:47413006:C:A	F311L	0.997
X:47413006:C:G	F311L	0.997
X:47412793:C:A	H240Q	0.996
X:47412793:C:G	H240Q	0.996
X:47412877:C:A	H268Q	0.996
X:47412877:C:G	H268Q	0.996
X:47412939:T:C	L289P	0.996
X:47412687:T:C	L205P	0.995
X:47412781:T:A	H236Q	0.995
X:47412781:T:G	H236Q	0.995
X:47412837:T:C	F255S	0.995
X:47412863:C:A	H264N	0.995
X:47412865:T:A	H264Q	0.995

dbSNP variants (sampled 300 via entrez): RS1000254993 (X:47385965 T>A), RS1000304895 (X:47370891 G>C), RS1000366766 (X:47370221 A>G), RS1000420853 (X:47373782 C>G), RS1000517864 (X:47393519 T>C), RS1000905952 (X:47369023 A>C,G), RS1000923321 (X:47410301 C>A), RS1000954104 (X:47410722 G>A), RS1001012921 (X:47395595 T>C), RS1001040503 (X:47396052 C>T), RS1001120175 (X:47409612 C>T), RS1001130608 (X:47401976 G>A,T), RS1001342391 (X:47386656 C>T), RS1001397734 (X:47381660 G>A), RS1001423035 (X:47376346 G>T)

Disease associations

OMIM: gene MIM:300024 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST000657_7	Optic nerve measurement (disc area)	4.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases expression	1
arsenite	increases methylation	1
sodium arsenite	decreases expression	1
Decitabine	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Dexamethasone	affects cotreatment, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Niclosamide	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Aflatoxin B1	decreases methylation	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW10	HEK293 eGFP-ZNF157	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.