ZNF16

Summary

ZNF16 (zinc finger protein 16, HGNC:12947) is a protein-coding gene on chromosome 8q24.3, encoding Zinc finger protein 16 (P17020). Acts as a transcriptional activator.

The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 7564 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 110 total
• MANE Select transcript: NM_006958

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12947
Approved symbol	ZNF16
Name	zinc finger protein 16
Location	8q24.3
Locus type	gene with protein product
Status	Approved
Aliases	KOX9
Ensembl gene	ENSG00000170631
Ensembl biotype	protein_coding
OMIM	601262
Entrez	7564

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 9 protein_coding, 4 retained_intron

ENST00000276816, ENST00000394909, ENST00000527427, ENST00000527512, ENST00000527811, ENST00000529378, ENST00000532351, ENST00000532811, ENST00000611477, ENST00000871992, ENST00000871993, ENST00000871994, ENST00000957674

RefSeq mRNA: 6 — MANE Select: NM_006958 NM_001029976, NM_001413564, NM_001413565, NM_001413566, NM_001413567, NM_006958

CCDS: CCDS6437

Canonical transcript exons

ENST00000394909 — 3 exons

Exon	Start	End
ENSE00002160551	144930358	144932590
ENSE00003564928	144946011	144946215
ENSE00003850325	144950797	144950880

Expression profiles

Bgee: expression breadth ubiquitous, 229 present calls, max score 88.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0189 / max 27.0525, expressed in 1607 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95730	4.0189	1607

Top tissues by expression

270 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.91	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.07	gold quality
oocyte	CL:0000023	80.91	gold quality
ganglionic eminence	UBERON:0004023	79.68	gold quality
gastrocnemius	UBERON:0001388	79.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	79.36	gold quality
cortical plate	UBERON:0005343	79.22	gold quality
muscle of leg	UBERON:0001383	79.16	gold quality
secondary oocyte	CL:0000655	78.71	gold quality
ventricular zone	UBERON:0003053	78.44	gold quality
skin of leg	UBERON:0001511	78.30	gold quality
gingival epithelium	UBERON:0001949	78.19	gold quality
left ovary	UBERON:0002119	78.01	gold quality
cervix squamous epithelium	UBERON:0006922	77.92	gold quality
skin of abdomen	UBERON:0001416	77.90	gold quality
stromal cell of endometrium	CL:0002255	77.74	gold quality
body of pancreas	UBERON:0001150	77.55	gold quality
popliteal artery	UBERON:0002250	77.53	gold quality
tibial artery	UBERON:0007610	77.53	gold quality
metanephric glomerulus	UBERON:0004736	77.39	gold quality
zone of skin	UBERON:0000014	77.34	gold quality
ovary	UBERON:0000992	77.33	gold quality
muscle organ	UBERON:0001630	77.32	gold quality
pancreas	UBERON:0001264	77.27	gold quality
lower esophagus mucosa	UBERON:0035834	77.22	gold quality
gall bladder	UBERON:0002110	77.17	gold quality
endothelial cell	CL:0000115	76.76	silver quality
islet of Langerhans	UBERON:0000006	76.73	gold quality
muscle layer of sigmoid colon	UBERON:0035805	76.71	gold quality
renal glomerulus	UBERON:0000074	76.53	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6911	no	72.20
E-ANND-3	no	3.25

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
CDKN2A
KIT

JASPAR motifs

Motif	Name	Family
MA1654.1	ZNF16	More than 3 adjacent zinc fingers
MA1654.2	ZNF16	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:27852650

miRNA regulators (miRDB)

29 targeting ZNF16, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-5693	99.24	66.67	1106
HSA-MIR-4528	99.18	69.77	1936
HSA-MIR-499A-3P	99.18	69.20	1392
HSA-MIR-499B-3P	99.18	69.27	1391
HSA-MIR-371A-5P	99.08	66.51	1914
HSA-MIR-3926	98.95	69.26	1438
HSA-MIR-606	98.72	67.34	960
HSA-MIR-1537-5P	98.70	68.33	999
HSA-MIR-548S	98.50	67.17	1213
HSA-MIR-6867-3P	98.12	66.07	1305
HSA-MIR-618	97.62	67.46	861
HSA-MIR-4287	97.55	67.24	1247
HSA-MIR-4685-3P	97.55	67.35	1255
HSA-MIR-7108-5P	96.42	66.17	598
HSA-MIR-6806-5P	96.37	68.74	587
HSA-MIR-423-3P	95.99	67.75	62
HSA-MIR-571	95.38	66.54	671

Literature-anchored findings (GeneRIF, showing 3)

• study demonstrate that ZNF16 plays an important role in erythropoiesis and megakaryocytopoiesis via its regulation of the c-Kit/c-Raf/MEK/ERK/c-Jun/HEY1/GATA1 cascade (PMID:24180487)
• Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population. (PMID:32432340)
• Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. (PMID:32460791)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 16 — P17020 (reviewed: P17020)

Alternative names: Zinc finger protein KOX9

All UniProt accessions (3): P17020, E9PNT9, E9PQV1

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis.

Subunit / interactions. Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.

Subcellular location. Nucleus.

Tissue specificity. Ubiquitous.

Induction. Up-regulated by hemin during erythroid differentiation. Up-regulated by phorbol myristate acetate (PMA) during megakaryocytic differentiation. Up-regulated by the transcriptional activator MEF2A.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (6): NP_001025147, NP_001400493, NP_001400494, NP_001400495, NP_001400496, NP_008889* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050331	Zinc_finger_PRDM4/PRDM1/PRDM14	Family

Pfam: PF00096

UniProt features (28 total): zinc finger region 17, region of interest 5, sequence variant 2, chain 1, compositionally biased region 1, modified residue 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P17020-F1	69.30	0.13

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 487, 253

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 109 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_DN, GOBP_MYELOID_CELL_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION, GOBP_MYELOID_CELL_HOMEOSTASIS, MODULE_169, GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_ERYTHROCYTE_HOMEOSTASIS, GOBP_CELL_CYCLE_PHASE_TRANSITION, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY, GOBP_REGULATION_OF_HEMOPOIESIS, GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION, GOBP_POSITIVE_REGULATION_OF_CELL_DIVISION, GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION

GO Biological Process (12): regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of cell population proliferation (GO:0008284), positive regulation of kinase activity (GO:0033674), negative regulation of apoptotic process (GO:0043066), positive regulation of erythrocyte differentiation (GO:0045648), positive regulation of megakaryocyte differentiation (GO:0045654), cell division (GO:0051301), positive regulation of cell division (GO:0051781), cellular response to sodium dodecyl sulfate (GO:0072707), positive regulation of cell cycle phase transition (GO:1901989), positive regulation of metabolic process (GO:0009893), regulation of multicellular organismal process (GO:0051239)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of cellular process	3
positive regulation of myeloid cell differentiation	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
nuclear lumen	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cell population proliferation	1
regulation of cell population proliferation	1
kinase activity	1
positive regulation of phosphorylation	1
positive regulation of catalytic activity	1
regulation of kinase activity	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
erythrocyte differentiation	1
regulation of erythrocyte differentiation	1
megakaryocyte differentiation	1
regulation of megakaryocyte differentiation	1
cellular process	1
cell division	1
regulation of cell division	1
response to sodium dodecyl sulfate	1
cellular response to oxygen-containing compound	1
cell cycle phase transition	1
positive regulation of cell cycle process	1
regulation of cell cycle phase transition	1
metabolic process	1
regulation of metabolic process	1
multicellular organismal process	1
regulation of biological process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

586 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF16	NOX4	Q9NPH5	767
ZNF16	ZPR1	O75312	480
ZNF16	H1-10	Q92522	461
ZNF16	INCA1	Q0VD86	431
ZNF16	H1-1	Q02539	421
ZNF16	C8orf33	Q9H7E9	400
ZNF16	POP1	Q99575	396
ZNF16	SACK1H	Q6ZRV2	380
ZNF16	ZHX1-C8orf76	Q96EF9	375
ZNF16	ZBTB25	P24278	374
ZNF16	TIGD5	Q53EQ6	373
ZNF16	C8orf76	Q96K31	370
ZNF16	LRRC14	Q15048	350
ZNF16	COMMD5	Q9GZQ3	322
ZNF16	MROH1	Q8NDA8	311

IntAct

78 interactions, top by confidence:

A	B	Type	Score
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
ZNF16	ZNF101	psi-mi:“MI:0915”(physical association)	0.560
ZNF101	ZNF16	psi-mi:“MI:0915”(physical association)	0.560
ZNF16	AQP1	psi-mi:“MI:0915”(physical association)	0.560
ZNF16	FAIM	psi-mi:“MI:0915”(physical association)	0.560
ZNF16	ZBTB47	psi-mi:“MI:0915”(physical association)	0.560
ZNF16	ZCCHC17	psi-mi:“MI:0915”(physical association)	0.560
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
THAP3	CASC3	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
H1-4	RRP8	psi-mi:“MI:0914”(association)	0.530
INCA1	ZNF16	psi-mi:“MI:0915”(physical association)	0.510
GORAB	ZNF16	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	ACTA1	psi-mi:“MI:0915”(physical association)	0.370
FHL1	ZNF16	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	DEFA1	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	ZXDC	psi-mi:“MI:0915”(physical association)	0.370
S100A8	ZNF16	psi-mi:“MI:0915”(physical association)	0.370
PFN1	ZNF16	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	CEACAM8	psi-mi:“MI:0915”(physical association)	0.370
COL1A1	ZNF16	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	COL1A2	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	ACSL6	psi-mi:“MI:0915”(physical association)	0.370
FABP4	ZNF16	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	GMPS	psi-mi:“MI:0915”(physical association)	0.370
ZNF16	ATP5ME	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (40): ZNF101 (Two-hybrid), ZNF16 (Affinity Capture-MS), ZNF16 (Affinity Capture-MS), ZNF16 (Affinity Capture-MS), ZNF16 (Affinity Capture-MS), ZNF16 (Affinity Capture-MS), ZNF16 (Two-hybrid), ZNF16 (Two-hybrid), ZNF16 (Two-hybrid), AQP1 (Two-hybrid), ZNF16 (Affinity Capture-RNA), ZNF16 (Affinity Capture-MS), ZNF16 (Affinity Capture-MS), ZNF16 (Affinity Capture-MS), ZNF16 (Affinity Capture-MS)

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A6QLU5, B2RUI1, D3ZVT0, O14709, O43296, O75123, P10072, P15621, P17020, P17097, P51814, P85977, Q08ER8, Q0VGE8, Q14590, Q32KN0, Q3KQV3, Q4V8A8, Q5CZA5, Q5RBX0, Q5RCD9, Q5VIY5, Q61116, Q61967, Q6GQR8, Q6P9A3, Q6ZMS4, Q7TSH9, Q7TSI0, Q7Z3I7, Q86UD4, Q86WZ6, Q8BFS8, Q8IZ26, Q8N9F8, Q8TAF7

Diamond homologs: A1YF12, A1YG88, A2T759, P17020, Q96NJ6, Q1LZ87, Q8NF99

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 75 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	12	29.3×	2e-12
Viral mRNA Translation	11	26.8×	2e-11
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	11	26.6×	2e-11
Selenocysteine synthesis	11	25.4×	2e-11
Eukaryotic Translation Termination	11	25.4×	2e-11
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	11	24.9×	2e-11
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	11	24.9×	2e-11
Formation of a pool of free 40S subunits	11	23.7×	4e-11

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	12	30.4×	2e-12
translation	12	16.9×	1e-09
ribosomal small subunit biogenesis	5	15.6×	2e-03
rRNA processing	6	11.6×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

110 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

660 predictions. Top by Δscore:

Variant	Effect	Δscore
8:144932587:CAAT:C	acceptor_gain	1.0000
8:144932590:TCTGA:T	acceptor_loss	1.0000
8:144932591:C:CC	acceptor_gain	1.0000
8:144950793:TAACC:T	donor_loss	1.0000
8:144950794:AAC:A	donor_loss	1.0000
8:144932586:ACAAT:A	acceptor_gain	0.9900
8:144932587:CAATC:C	acceptor_gain	0.9900
8:144932588:AAT:A	acceptor_gain	0.9900
8:144932589:AT:A	acceptor_gain	0.9900
8:144932597:C:CT	acceptor_gain	0.9900
8:144932598:A:T	acceptor_gain	0.9900
8:144933349:CAATT:C	donor_gain	0.9900
8:144933357:A:AC	donor_gain	0.9800
8:144933358:C:CC	donor_gain	0.9800
8:144946070:C:CT	donor_gain	0.9800
8:144950795:A:AC	donor_gain	0.9800
8:144950796:C:CC	donor_gain	0.9800
8:144950796:CCT:C	donor_gain	0.9800
8:144932589:ATCT:A	acceptor_gain	0.9700
8:144950293:CAGAG:C	donor_gain	0.9700
8:144950294:AGAGA:A	donor_gain	0.9700
8:144950754:A:AT	donor_gain	0.9700
8:144932588:AATCT:A	acceptor_gain	0.9600
8:144946010:CCTGG:C	donor_gain	0.9600
8:144946040:T:TA	donor_gain	0.9600
8:144932599:A:AC	acceptor_gain	0.9300
8:144946214:ACCTG:A	acceptor_loss	0.9300
8:144946215:CCTGA:C	acceptor_loss	0.9300
8:144946216:CTGA:C	acceptor_loss	0.9300
8:144946217:T:G	acceptor_loss	0.9300

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000144827 (8:144936076 C>G), RS1000276905 (8:144950844 G>A,C), RS1000299480 (8:144941976 ATTTTTTTT>A,AT,ATTT,ATTTT,ATTTTT,ATTTTTT,ATTTTTTT,ATTTTTTTTT,ATTTTTTTTTT,ATTTTTTTTTTT,ATTTTTTTTTTTT,ATTTTTTTTTTTTT,ATTTTTTTTTTTTTT,ATTTTTTTTTTTTTTTT), RS1000537313 (8:144939405 G>A), RS1000860790 (8:144948684 C>T), RS1001138942 (8:144933386 G>A,C), RS1001166140 (8:144942715 C>A), RS1001217101 (8:144942921 T>C), RS1001372014 (8:144935890 A>G), RS1001780679 (8:144936181 T>G), RS1001896146 (8:144951765 C>A,G,T), RS1001946775 (8:144952061 T>A), RS1002005340 (8:144947723 T>A,C), RS1002290530 (8:144930161 A>G), RS1002464271 (8:144947965 G>A)

Disease associations

OMIM: gene MIM:601262 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003013_31	White matter hyperintensity burden	3.000000e-07
GCST007005_3	Logical memory (immediate recall) in normal cognition	5.000000e-07
GCST007005_4	Logical memory (immediate recall) in normal cognition	2.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005665	white matter hyperintensity measurement
EFO:0004874	memory performance

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Leflunomide	increases expression	1
Carbamazepine	affects expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tretinoin	decreases expression	1
Zinc	affects cotreatment, increases expression	1
Cyclosporine	increases expression	1
Cadmium Chloride	decreases expression	1
Magnetite Nanoparticles	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD11	HEK293 eGFP-ZNF16	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.