ZNF177

Summary

ZNF177 (zinc finger protein 177, HGNC:12966) is a protein-coding gene on chromosome 19p13.2, encoding Zinc finger protein 177 (Q13360). May be involved in transcriptional regulation.

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in blood microparticle.

Source: NCBI Gene 7730 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 36 total
• MANE Select transcript: NM_001172651

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12966
Approved symbol	ZNF177
Name	zinc finger protein 177
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188629
Ensembl biotype	protein_coding
OMIM	601276
Entrez	7730

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000343499, ENST00000589262, ENST00000590616, ENST00000592912, ENST00000683217, ENST00000888362, ENST00000920310

RefSeq mRNA: 4 — MANE Select: NM_001172651 NM_001172651, NM_001384658, NM_001384659, NM_003451

CCDS: CCDS54214

Canonical transcript exons

ENST00000683217 — 8 exons

Exon	Start	End
ENSE00003459595	9376316	9376423
ENSE00003470201	9378259	9378344
ENSE00003479614	9364862	9364948
ENSE00003493511	9378962	9379088
ENSE00003533805	9380057	9380139
ENSE00003547674	9379527	9379619
ENSE00003916744	9380668	9382617
ENSE00003919489	9363013	9363084

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 89.62.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3452 / max 14.3536, expressed in 166 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173696	0.3452	166

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.02	gold quality
right uterine tube	UBERON:0001302	83.87	gold quality
cerebellar hemisphere	UBERON:0002245	80.20	gold quality
corpus callosum	UBERON:0002336	80.10	gold quality
cerebellar cortex	UBERON:0002129	80.04	gold quality
cerebellum	UBERON:0002037	79.91	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.74	gold quality
right testis	UBERON:0004534	79.28	gold quality
ventricular zone	UBERON:0003053	78.82	gold quality
testis	UBERON:0000473	78.78	gold quality
left testis	UBERON:0004533	78.66	gold quality
amygdala	UBERON:0001876	77.95	gold quality
temporal lobe	UBERON:0001871	77.77	gold quality
ganglionic eminence	UBERON:0004023	77.70	gold quality
left ovary	UBERON:0002119	77.66	gold quality
cortical plate	UBERON:0005343	77.59	gold quality
Ammon’s horn	UBERON:0001954	77.42	gold quality
right ovary	UBERON:0002118	77.38	gold quality
caudate nucleus	UBERON:0001873	77.29	gold quality
nucleus accumbens	UBERON:0001882	77.20	gold quality
ovary	UBERON:0000992	77.17	gold quality
apex of heart	UBERON:0002098	77.13	gold quality
substantia nigra	UBERON:0002038	77.12	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.11	gold quality
brain	UBERON:0000955	76.84	gold quality
hypothalamus	UBERON:0001898	76.66	gold quality
body of uterus	UBERON:0009853	76.56	gold quality
putamen	UBERON:0001874	76.50	gold quality
pituitary gland	UBERON:0000007	76.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

69 targeting ZNF177, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-4671-3P	99.88	72.46	1045
HSA-MIR-7845-5P	99.88	64.88	771
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-379-3P	99.69	69.60	1524
HSA-MIR-411-3P	99.69	69.63	1524

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 177 — Q13360 (reviewed: Q13360)

All UniProt accessions (3): Q13360, K7EK36, K7EQU1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q13360-1	1	yes
Q13360-2	2
Q13360-3	3

RefSeq proteins (4): NP_001166122, NP_001371587, NP_001371588, NP_003442 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096, PF01352, PF13465, PF13912

UniProt features (20 total): zinc finger region 10, splice variant 3, sequence variant 3, sequence conflict 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13360-F1	61.42	0.25

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 60 (showing top): SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5, MORF_ZNF10, MODULE_123, MORF_EPHA7, BROWNE_HCMV_INFECTION_10HR_UP, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP, MORF_DCC, NUYTTEN_EZH2_TARGETS_DN, GOCC_BLOOD_MICROPARTICLE, chr19p13, MORF_FRK, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, HATADA_METHYLATED_IN_LUNG_CANCER_UP, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II

GO Biological Process (3): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), blood microparticle (GO:0072562)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
extracellular region	1
cellular anatomical structure	1

Protein interactions and networks

STRING

400 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF177	SHKBP1	Q8TBC3	925
ZNF177	CDO1	P78513	581
ZNF177	BCAT1	P54687	571
ZNF177	TRIM58	Q8NG06	570
ZNF177	OR6S1	Q8NH40	474
ZNF177	SLC27A5	Q9Y2P5	412
ZNF177	CPXM1	Q96SM3	399
ZNF177	DEPDC4	Q8N2C3	396
ZNF177	ANKRD53	Q8N9V6	395
ZNF177	FSD1	Q9BTV5	366
ZNF177	ZC3H6	P61129	329
ZNF177	CCDC184	Q52MB2	311
ZNF177	DPYSL4	O14531	306
ZNF177	ADCY4	Q8NFM4	305
ZNF177	CLXN	Q9HAE3	301
ZNF177	CCDC181	Q5TID7	301

IntAct

8 interactions, top by confidence:

A	B	Type	Score
ZNF177	ARHGAP21	psi-mi:“MI:0915”(physical association)	0.560
ARHGAP21	ZNF177	psi-mi:“MI:0915”(physical association)	0.560
ZNF177	CANX	psi-mi:“MI:0915”(physical association)	0.400
ZNF177		psi-mi:“MI:0915”(physical association)	0.370
SLC37A3	ZNF177	psi-mi:“MI:0915”(physical association)	0.370
Cdca5	ATP5MF-PTCD1	psi-mi:“MI:0914”(association)	0.350

BioGRID (41): ARHGAP21 (Two-hybrid), ZNF177 (Affinity Capture-MS), ZNF177 (Reconstituted Complex), ZNF177 (Two-hybrid), ZNF559-ZNF177 (Two-hybrid), ZNF177 (Two-hybrid), ZNF559-ZNF177 (Two-hybrid), ZNF177 (Two-hybrid), ZNF559-ZNF177 (Two-hybrid), ZNF177 (Two-hybrid), ZNF559-ZNF177 (Two-hybrid), ZNF177 (Two-hybrid), ZNF559-ZNF177 (Two-hybrid), ZNF177 (Two-hybrid), ZNF559-ZNF177 (Two-hybrid)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1880 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9379504:A:AG	acceptor_gain	1.0000
19:9379505:T:G	acceptor_gain	1.0000
19:9379516:T:A	acceptor_gain	1.0000
19:9379518:C:CA	acceptor_gain	1.0000
19:9379525:AG:A	acceptor_gain	1.0000
19:9379525:AGG:A	acceptor_gain	1.0000
19:9379526:GG:G	acceptor_gain	1.0000
19:9379526:GGG:G	acceptor_gain	1.0000
19:9364475:GGAA:G	donor_gain	0.9900
19:9364476:G:T	donor_gain	0.9900
19:9364856:TTTCA:T	acceptor_loss	0.9900
19:9364857:TTCA:T	acceptor_loss	0.9900
19:9364858:TCA:T	acceptor_loss	0.9900
19:9364859:CAGGG:C	acceptor_loss	0.9900
19:9364860:A:AG	acceptor_gain	0.9900
19:9364860:A:AT	acceptor_loss	0.9900
19:9364860:AG:A	acceptor_gain	0.9900
19:9364861:G:GG	acceptor_gain	0.9900
19:9364861:GG:G	acceptor_gain	0.9900
19:9364861:GGGCT:G	acceptor_gain	0.9900
19:9364947:GG:G	donor_gain	0.9900
19:9364948:GG:G	donor_gain	0.9900
19:9378257:A:AG	acceptor_gain	0.9900
19:9378258:G:GG	acceptor_gain	0.9900
19:9378339:TCAC:T	donor_gain	0.9900
19:9379503:C:G	acceptor_gain	0.9900
19:9379509:T:A	acceptor_gain	0.9900
19:9379520:T:TA	acceptor_gain	0.9900
19:9379524:CAGGG:C	acceptor_loss	0.9900
19:9379525:A:AG	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000102397 (19:9362998 C>T), RS1000181985 (19:9379328 G>A), RS1000316701 (19:9379276 T>C), RS1000485563 (19:9380641 A>C,G), RS1000604933 (19:9379515 C>T), RS1000875858 (19:9369205 CT>C,CTT), RS1000926289 (19:9368952 C>T), RS1001023952 (19:9375079 C>T), RS1001246311 (19:9369655 C>T), RS1001297259 (19:9370122 A>G), RS1001312006 (19:9362791 C>A,G), RS1001432279 (19:9376117 T>C), RS1001772375 (19:9363355 T>C), RS1002116597 (19:9365277 T>G), RS1002149985 (19:9381898 G>T)

Disease associations

OMIM: gene MIM:601276 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	5
fluorene-9-bisphenol	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
Decitabine	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Cisplatin	decreases expression	1
Formaldehyde	increases expression	1
Lead	increases expression	1
Methyl Methanesulfonate	increases expression	1
Nickel	decreases expression	1
Phenylmercuric Acetate	affects cotreatment, decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1
Genistein	increases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.