ZNF182

Summary

ZNF182 (zinc finger protein 182, HGNC:13001) is a protein-coding gene on chromosome Xp11.23, encoding Zinc finger protein 182 (P17025). May be involved in transcriptional regulation.

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Source: NCBI Gene 7569 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 44 total — 1 likely-pathogenic
• MANE Select transcript: NM_001007088

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13001
Approved symbol	ZNF182
Name	zinc finger protein 182
Location	Xp11.23
Locus type	gene with protein product
Status	Approved
Aliases	KOX14, HHZ150, Zfp182
Ensembl gene	ENSG00000147118
Ensembl biotype	protein_coding
OMIM	314993
Entrez	7569

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000376943, ENST00000396965, ENST00000897864, ENST00000897865, ENST00000934376, ENST00000934377, ENST00000960814

RefSeq mRNA: 3 — MANE Select: NM_001007088 NM_001007088, NM_001178099, NM_006962

CCDS: CCDS35235, CCDS35236

Canonical transcript exons

ENST00000376943 — 6 exons

Exon	Start	End
ENSE00001472203	47982949	47983038
ENSE00001765627	47983285	47983411
ENSE00001868952	48003909	48003989
ENSE00001926044	47974851	47977797
ENSE00003489846	48002595	48002653
ENSE00003586340	48003508	48003702

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 93.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.9201 / max 36.0833, expressed in 1464 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199146	3.2513	1392
199148	0.4295	222
199147	0.2393	91

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	93.05	gold quality
pancreatic ductal cell	CL:0002079	87.43	silver quality
vena cava	UBERON:0004087	86.92	silver quality
cerebellar vermis	UBERON:0004720	85.96	silver quality
kidney epithelium	UBERON:0004819	85.77	silver quality
thymus	UBERON:0002370	85.37	gold quality
oocyte	CL:0000023	85.08	gold quality
nasal cavity epithelium	UBERON:0005384	84.07	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	83.58	gold quality
trabecular bone tissue	UBERON:0002483	83.34	gold quality
pylorus	UBERON:0001166	82.96	gold quality
pericardium	UBERON:0002407	81.04	gold quality
middle temporal gyrus	UBERON:0002771	81.04	gold quality
body of tongue	UBERON:0011876	80.96	gold quality
epithelial cell of pancreas	CL:0000083	80.94	gold quality
cardia of stomach	UBERON:0001162	80.66	gold quality
tendon of biceps brachii	UBERON:0008188	80.66	gold quality
parotid gland	UBERON:0001831	80.63	silver quality
Brodmann (1909) area 23	UBERON:0013554	80.47	gold quality
heart right ventricle	UBERON:0002080	80.33	gold quality
visceral pleura	UBERON:0002401	80.26	gold quality
cerebellar cortex	UBERON:0002129	80.25	gold quality
cerebellar hemisphere	UBERON:0002245	80.24	gold quality
superior surface of tongue	UBERON:0007371	80.08	gold quality
cerebellum	UBERON:0002037	80.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.92	gold quality
tongue	UBERON:0001723	79.74	gold quality
granulocyte	CL:0000094	79.59	gold quality
pons	UBERON:0000988	79.52	gold quality
inferior vagus X ganglion	UBERON:0005363	79.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting ZNF182, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-2116-3P	99.74	64.32	889
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-6892-3P	99.68	66.40	1178
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-3685	99.62	68.83	1621
HSA-MIR-497-3P	99.61	69.71	1990
HSA-MIR-488-3P	99.61	68.79	1731
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-549A-3P	99.54	68.17	825
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-4770	99.49	69.09	1451
HSA-MIR-20A-3P	99.44	69.10	1575
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-6088	99.29	68.45	1284
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-4279	99.19	66.70	2437

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp182	ENSMUSG00000054737
rattus_norvegicus	Zfp182	ENSRNOG00000047132

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 182 — P17025 (reviewed: P17025)

Alternative names: Zinc finger protein 21, Zinc finger protein KOX14

All UniProt accessions (1): P17025

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
P17025-1	1	yes
P17025-2	2

RefSeq proteins (3): NP_001007089, NP_001171570, NP_008893 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050717	C2H2-ZF_Transcription_Reg	Family

Pfam: PF00096, PF01352

UniProt features (20 total): zinc finger region 15, chain 1, domain 1, region of interest 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P17025-F1	70.89	0.38

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 49 (showing top): AAGTCCA_MIR422B_MIR422A, GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, AAACCAC_MIR140, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, chrXp11, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, RAO_BOUND_BY_SALL4, BREDEMEYER_RAG_SIGNALING_VIA_ATM_NOT_VIA_NFKB_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ZNF274_TARGET_GENES, ZNF322_TARGET_GENES, ZNF350_TARGET_GENES

GO Biological Process (4): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of biosynthetic process (GO:0009891), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nuclear lumen (GO:0031981)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
biosynthetic process	1
regulation of biosynthetic process	1
positive regulation of metabolic process	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nucleus	1
intracellular organelle lumen	1

Protein interactions and networks

STRING

682 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF182	ARAF	P07557	853
ZNF182	TIMP1	P01033	695
ZNF182	TBC1D25	Q3MII6	587
ZNF182	OR10H2	O60403	506
ZNF182	CXorf38	Q8TB03	491
ZNF182	SPACA5B	Q96QH8	446
ZNF182	C1GALT1C1L	P0DN25	443
ZNF182	WDR13	Q9H1Z4	419
ZNF182	ZC4H2	Q9NQZ6	411
ZNF182	POGZ	Q7Z3K3	399
ZNF182	RNF113A	O15541	395
ZNF182	MTMR11	A4FU01	385
ZNF182	LIPT1	Q9Y234	369
ZNF182	ABRACL	Q9P1F3	367
ZNF182	DYM	Q7RTS9	359

IntAct

4 interactions, top by confidence:

A	B	Type	Score
SLC9A8	ZNF432	psi-mi:“MI:0914”(association)	0.530
SLC9A8	AP1G1	psi-mi:“MI:0914”(association)	0.350
TRIM54	ZNF182	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (6): ZNF182 (Affinity Capture-MS), ZNF182 (Two-hybrid), ZNF182 (Affinity Capture-MS), ZNF182 (Affinity Capture-MS), ZNF182 (Affinity Capture-MS), ZNF182 (Affinity Capture-MS)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	27
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
394569	GRCh37/hg19 Xp11.23(chrX:47705458-47863717)x3	Likely pathogenic

SpliceAI

393 predictions. Top by Δscore:

Variant	Effect	Δscore
X:47977795:CTT:C	acceptor_gain	1.0000
X:47977796:TT:T	acceptor_gain	0.9900
X:47977798:C:CC	acceptor_gain	0.9900
X:47983280:CT:C	donor_loss	0.9900
X:47983283:AC:A	donor_gain	0.9900
X:47983283:ACCC:A	donor_loss	0.9900
X:47983284:CC:C	donor_gain	0.9900
X:47983284:CCCA:C	donor_gain	0.9900
X:47983408:GCCCC:G	acceptor_loss	0.9900
X:47983411:CCTG:C	acceptor_loss	0.9900
X:47983412:C:A	acceptor_loss	0.9900
X:47983413:T:A	acceptor_loss	0.9900
X:47988520:ATACC:A	donor_loss	0.9900
X:47988521:TACCT:T	donor_loss	0.9900
X:47988522:ACCTG:A	donor_loss	0.9900
X:47988523:C:CG	donor_loss	0.9900
X:47977797:TC:T	acceptor_loss	0.9800
X:47977798:C:T	acceptor_loss	0.9800
X:47977799:T:C	acceptor_loss	0.9800
X:47982942:CACTT:C	donor_loss	0.9800
X:47982943:ACTTA:A	donor_loss	0.9800
X:47982944:CTTAC:C	donor_loss	0.9800
X:47982945:TTA:T	donor_loss	0.9800
X:47982946:TA:T	donor_loss	0.9800
X:47983409:CCC:C	acceptor_gain	0.9800
X:47983410:CCC:C	acceptor_gain	0.9800
X:47983412:C:CC	acceptor_gain	0.9800
X:47983414:G:C	acceptor_loss	0.9800
X:47988519:CATA:C	donor_loss	0.9800
X:47983283:A:AC	donor_gain	0.9700

AlphaMissense

4129 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:47977106:G:C	F327L	0.999
X:47977106:G:T	F327L	0.999
X:47977108:A:G	F327L	0.999
X:47976417:A:G	L557P	0.998
X:47976434:A:C	F551L	0.998
X:47976434:A:T	F551L	0.998
X:47976436:A:G	F551L	0.998
X:47976765:T:G	Q441P	0.998
X:47976825:T:G	Q421P	0.998
X:47976854:G:C	F411L	0.998
X:47976854:G:T	F411L	0.998
X:47976856:A:G	F411L	0.998
X:47977190:G:C	F299L	0.998
X:47977190:G:T	F299L	0.998
X:47977192:A:G	F299L	0.998
X:47977242:C:G	R282P	0.998
X:47977274:A:C	F271L	0.998
X:47977274:A:T	F271L	0.998
X:47977276:A:G	F271L	0.998
X:47976266:A:C	F607L	0.997
X:47976266:A:T	F607L	0.997
X:47976268:A:G	F607L	0.997
X:47976350:G:C	F579L	0.997
X:47976350:G:T	F579L	0.997
X:47976352:A:G	F579L	0.997
X:47976501:A:G	L529P	0.997
X:47976518:G:C	F523L	0.997
X:47976518:G:T	F523L	0.997
X:47976520:A:G	F523L	0.997
X:47976602:A:C	F495L	0.997

dbSNP variants (sampled 300 via entrez): RS1000073254 (X:47994559 T>A), RS1000119540 (X:47986985 C>T), RS1000209631 (X:47975562 T>C), RS1000475562 (X:47975880 T>C,G), RS1000683804 (X:47997146 G>A), RS1000746958 (X:47996693 A>T), RS1001218577 (X:47978066 C>T), RS1001329240 (X:47988849 G>C), RS1001479749 (X:47978628 C>T), RS1001752104 (X:47998823 T>C), RS1002182059 (X:47991524 C>A), RS1002441709 (X:47980362 A>C,T), RS1002684782 (X:48001176 T>C), RS1002703035 (X:47991129 A>G), RS1002753505 (X:48000618 A>G)

Disease associations

OMIM: gene MIM:314993 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Leflunomide	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Estradiol	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	decreases expression	1
Lead	increases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Dronabinol	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.