ZNF189

Summary

ZNF189 (zinc finger protein 189, HGNC:12980) is a protein-coding gene on chromosome 9q31.1, encoding Zinc finger protein 189 (O75820). May be involved in transcriptional regulation.

Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.

Source: NCBI Gene 7743 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_003452

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12980
Approved symbol	ZNF189
Name	zinc finger protein 189
Location	9q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000136870
Ensembl biotype	protein_coding
OMIM	603132
Entrez	7743

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000259395, ENST00000339664, ENST00000374861, ENST00000615466

RefSeq mRNA: 5 — MANE Select: NM_003452 NM_001278231, NM_001278232, NM_001278240, NM_003452, NM_197977

CCDS: CCDS65096, CCDS6754, CCDS6755, CCDS75867

Canonical transcript exons

ENST00000339664 — 3 exons

Exon	Start	End
ENSE00001733032	101399884	101400010
ENSE00003665756	101398851	101399189
ENSE00003919561	101407929	101410654

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 97.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.2566 / max 200.9506, expressed in 1712 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
97753	7.2566	1712

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	97.73	gold quality
cauda epididymis	UBERON:0004360	95.95	gold quality
caput epididymis	UBERON:0004358	95.40	gold quality
adrenal tissue	UBERON:0018303	95.16	gold quality
CA1 field of hippocampus	UBERON:0003881	94.92	gold quality
inferior vagus X ganglion	UBERON:0005363	94.85	gold quality
subthalamic nucleus	UBERON:0001906	94.15	gold quality
corpus callosum	UBERON:0002336	94.11	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.50	gold quality
medulla oblongata	UBERON:0001896	93.48	gold quality
superior vestibular nucleus	UBERON:0007227	93.06	gold quality
middle temporal gyrus	UBERON:0002771	92.79	gold quality
germinal epithelium of ovary	UBERON:0001304	92.54	gold quality
ventral tegmental area	UBERON:0002691	92.02	gold quality
substantia nigra pars reticulata	UBERON:0001966	91.75	gold quality
cranial nerve II	UBERON:0000941	91.64	gold quality
body of pancreas	UBERON:0001150	91.52	gold quality
pons	UBERON:0000988	91.49	gold quality
spinal cord	UBERON:0002240	91.37	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.37	gold quality
lateral globus pallidus	UBERON:0002476	91.14	gold quality
parietal lobe	UBERON:0001872	91.04	gold quality
inferior olivary complex	UBERON:0002127	91.01	gold quality
heart right ventricle	UBERON:0002080	90.92	gold quality
superficial temporal artery	UBERON:0001614	90.88	gold quality
postcentral gyrus	UBERON:0002581	90.76	gold quality
mucosa of paranasal sinus	UBERON:0005030	90.59	gold quality
dorsal plus ventral thalamus	UBERON:0001897	90.44	gold quality
epithelium of nasopharynx	UBERON:0001951	90.43	gold quality
gall bladder	UBERON:0002110	90.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.62

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
CDKN2A

JASPAR motifs

Motif	Name	Family
MA1725.1	ZNF189	More than 3 adjacent zinc fingers
MA1725.2	ZNF189	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:27852650

miRNA regulators (miRDB)

71 targeting ZNF189, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-548AZ-3P	99.82	70.56	3549

Literature-anchored findings (GeneRIF, showing 1)

• Maternal genes FLNB, HIC1 and ZNF189 were strongly associated with risk of clefting. (PMID:20634891)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp189	ENSMUSG00000039634
rattus_norvegicus	Zfp189	ENSRNOG00000006972

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 189 — O75820 (reviewed: O75820)

All UniProt accessions (2): A0A087X0K2, O75820

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Tissue specificity. Ubiquitous.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt ID	Names	Canonical?
O75820-1	1	yes
O75820-2	2
O75820-3	3, B2
O75820-4	4

RefSeq proteins (5): NP_001265160, NP_001265161, NP_001265169, NP_003443, NP_932094 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050826	Krueppel_C2H2_ZnFinger	Family

Pfam: PF00096, PF01352

UniProt features (28 total): zinc finger region 16, cross-link 5, splice variant 3, chain 1, domain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75820-F1	74.24	0.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 67, 88, 160, 434, 452

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 151 (showing top): RRAGTTGT_UNKNOWN, MODULE_493, TTGGGAG_MIR150, AACWWCAANK_UNKNOWN, GTGCCTT_MIR506, CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP, TGGNNNNNNKCCAR_UNKNOWN, CAIRO_HEPATOBLASTOMA_UP, ACTWSNACTNY_UNKNOWN, TCCCRNNRTGC_UNKNOWN, STAT1_02, YKACATTT_UNKNOWN, THUM_SYSTOLIC_HEART_FAILURE_DN, MATSUDA_NATURAL_KILLER_DIFFERENTIATION

GO Biological Process (4): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of biosynthetic process (GO:0009891), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
biosynthetic process	1
regulation of biosynthetic process	1
positive regulation of metabolic process	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

548 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF189	MRPL50	Q8N5N7	624
ZNF189	TMEM186	Q96B77	432
ZNF189	ZMAT5	Q9UDW3	432
ZNF189	NUDCD1	Q96RS6	409
ZNF189	HMG20A	Q9NP66	409
ZNF189	RSRC2	Q7L4I2	377
ZNF189	ALG9	Q9H6U8	368
ZNF189	ZNF277	Q9NRM2	339
ZNF189	PHF1	O43189	323
ZNF189	TPD52	P55327	303
ZNF189	FOXE1	O00358	296
ZNF189	APPBP2	Q92624	295
ZNF189	ROR2	Q01974	293
ZNF189	STRADB	Q9C0K7	280
ZNF189	ZMYM4	Q5VZL5	270

IntAct

41 interactions, top by confidence:

A	B	Type	Score
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
AURKA	ZNF189	psi-mi:“MI:0915”(physical association)	0.370
ZNF189	AXIN2	psi-mi:“MI:0915”(physical association)	0.370
ZNF189	BMPR1A	psi-mi:“MI:0915”(physical association)	0.370
ZNF189	BRAF	psi-mi:“MI:0915”(physical association)	0.370
BUB1	ZNF189	psi-mi:“MI:0915”(physical association)	0.370
ZNF189	CTNNA1	psi-mi:“MI:0915”(physical association)	0.370
ZNF189	DLC1	psi-mi:“MI:0915”(physical association)	0.370
ZNF189	ERBB2	psi-mi:“MI:0915”(physical association)	0.370
KRAS	ZNF189	psi-mi:“MI:0915”(physical association)	0.370
MCC	ZNF189	psi-mi:“MI:0915”(physical association)	0.370
PMS2	ZNF189	psi-mi:“MI:0915”(physical association)	0.370
SMAD4	ZNF189	psi-mi:“MI:0915”(physical association)	0.370
SRC	ZNF189	psi-mi:“MI:0915”(physical association)	0.370
ZNF189	STK11	psi-mi:“MI:0915”(physical association)	0.370
rl3_rl3l_human	NKRF	psi-mi:“MI:0914”(association)	0.350
NOP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL28	GTPBP10	psi-mi:“MI:0914”(association)	0.350
APOBEC3C	GTPBP10	psi-mi:“MI:0914”(association)	0.350
OASL	ZNF316	psi-mi:“MI:0914”(association)	0.350
GLI4	ZNF316	psi-mi:“MI:0914”(association)	0.350
RPS6	CCDC85C	psi-mi:“MI:0914”(association)	0.350
NOL12		psi-mi:“MI:0914”(association)	0.350
SURF6		psi-mi:“MI:0914”(association)	0.350
FGFBP1	ZNF724	psi-mi:“MI:0914”(association)	0.350
ZNF2	APOBEC3DE	psi-mi:“MI:0914”(association)	0.350
RPL17		psi-mi:“MI:0914”(association)	0.350

BioGRID (64): ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-RNA), ZNF189 (Affinity Capture-MS), ZNF189 (Affinity Capture-RNA), ZNF189 (Two-hybrid)

ESM2 similar proteins: A0JNB1, A6QLU5, O75123, O75820, P10076, P10755, P16374, P17031, P17097, P17141, P51814, Q02975, Q08ER8, Q14588, Q14590, Q32KN0, Q3V080, Q4V8A8, Q5CZA5, Q5R4K8, Q5R5Q6, Q5R9S5, Q5RBX0, Q61751, Q6GQR8, Q6P560, Q6ZMS4, Q7TSH9, Q7TSI0, Q7Z3I7, Q7Z3V5, Q8BLB0, Q8N141, Q8N184, Q8N823, Q8N8J6, Q8N9F8, Q8TBZ5, Q8TF47, Q96ND8

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 55 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	7	24.0×	1e-06
Viral mRNA Translation	7	24.0×	1e-06
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	7	23.7×	1e-06
Selenocysteine synthesis	7	22.7×	1e-06
Eukaryotic Translation Termination	7	22.7×	1e-06
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	7	22.3×	1e-06
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	7	22.3×	1e-06
Formation of a pool of free 40S subunits	7	21.2×	1e-06

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	7	25.9×	3e-06
rRNA processing	8	22.7×	1e-06
translation	7	14.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

609 predictions. Top by Δscore:

Variant	Effect	Δscore
9:101400009:GG:G	donor_gain	1.0000
9:101400010:GG:G	donor_gain	1.0000
9:101399186:GAAG:G	donor_gain	0.9900
9:101399188:AG:A	donor_gain	0.9900
9:101399189:GG:G	donor_gain	0.9900
9:101399189:GGTA:G	donor_loss	0.9900
9:101399190:G:GG	donor_gain	0.9900
9:101400008:TGGG:T	donor_loss	0.9900
9:101400011:G:C	donor_loss	0.9900
9:101400011:G:GG	donor_gain	0.9900
9:101400012:T:TC	donor_loss	0.9900
9:101407927:A:AG	acceptor_gain	0.9900
9:101407928:G:GG	acceptor_gain	0.9900
9:101407928:GAT:G	acceptor_gain	0.9900
9:101399187:AAG:A	donor_gain	0.9800
9:101399194:G:GG	donor_gain	0.9800
9:101407924:TCCA:T	acceptor_loss	0.9800
9:101407925:CCA:C	acceptor_loss	0.9800
9:101407926:CA:C	acceptor_loss	0.9800
9:101399882:AGG:A	acceptor_gain	0.9700
9:101399883:GGG:G	acceptor_gain	0.9700
9:101407927:AGAT:A	acceptor_gain	0.9700
9:101407928:GATG:G	acceptor_gain	0.9700
9:101407928:GATGT:G	acceptor_gain	0.9700
9:101399508:T:TA	acceptor_gain	0.9600
9:101407919:A:AG	acceptor_gain	0.9600
9:101399193:A:AG	donor_gain	0.9500
9:101399882:AG:A	acceptor_gain	0.9500
9:101399883:GG:G	acceptor_gain	0.9500
9:101399188:AGGT:A	donor_gain	0.9400

AlphaMissense

4242 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:101408573:T:C	F269L	0.998
9:101408575:C:A	F269L	0.998
9:101408575:C:G	F269L	0.998
9:101408657:T:C	F297L	0.998
9:101408659:T:A	F297L	0.998
9:101408659:T:G	F297L	0.998
9:101408741:T:C	F325L	0.998
9:101408743:T:A	F325L	0.998
9:101408743:T:G	F325L	0.998
9:101408825:T:C	F353L	0.998
9:101408827:C:A	F353L	0.998
9:101408827:C:G	F353L	0.998
9:101408909:T:C	F381L	0.998
9:101408911:C:A	F381L	0.998
9:101408911:C:G	F381L	0.998
9:101408405:T:C	F213L	0.997
9:101408407:T:A	F213L	0.997
9:101408407:T:G	F213L	0.997
9:101408489:T:C	F241L	0.997
9:101408491:C:A	F241L	0.997
9:101408491:C:G	F241L	0.997
9:101408993:T:C	F409L	0.997
9:101408995:T:A	F409L	0.997
9:101408995:T:G	F409L	0.997
9:101409245:T:C	F493L	0.997
9:101409247:C:A	F493L	0.997
9:101409247:C:G	F493L	0.997
9:101408321:T:C	F185L	0.995
9:101408323:T:A	F185L	0.995
9:101408323:T:G	F185L	0.995

dbSNP variants (sampled 300 via entrez): RS1000028563 (9:101397664 T>A,C), RS1000189078 (9:101403253 A>G), RS1000289701 (9:101397402 T>C), RS1000489863 (9:101402796 A>C,G), RS1000658529 (9:101407450 AAC>A), RS1000710475 (9:101407732 A>G), RS1000829027 (9:101401414 T>A,C), RS1001181821 (9:101396904 T>C,G), RS1001588711 (9:101401571 C>G), RS1001973419 (9:101407512 C>T), RS1002195319 (9:101400381 G>C), RS1002333255 (9:101406260 G>A), RS1002383964 (9:101406602 G>A), RS1002582345 (9:101397530 G>T), RS1002600774 (9:101399262 C>A,G)

Disease associations

OMIM: gene MIM:603132 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	4
Valproic Acid	affects expression, decreases expression, decreases methylation	4
Acetaminophen	decreases expression, increases expression	3
Cyclosporine	decreases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
geraniol	increases expression	1
beta-methylcholine	affects expression	1
abrine	increases expression	1
jinfukang	decreases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Azacitidine	decreases expression	1
Benzo(a)pyrene	decreases expression	1
Cadmium	increases expression, increases abundance	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Lead	affects expression	1
Quercetin	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	decreases expression	1
1-Methyl-3-isobutylxanthine	increases expression, affects cotreatment	1
Aflatoxin B1	decreases expression	1
Aflatoxin M1	decreases expression	1

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2PQ	HAP1 ZNF189 (-) 1	Cancer cell line	Male
CVCL_E2PR	HAP1 ZNF189 (-) 2	Cancer cell line	Male
CVCL_XW13	HEK293 eGFP-ZNF189	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.