ZNF195

gene
On this page

Summary

ZNF195 (zinc finger protein 195, HGNC:12986) is a protein-coding gene on chromosome 11p15.5, encoding Zinc finger protein 195 (O14628). May be involved in transcriptional regulation.

This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms’ tumors. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 7748 — RefSeq curated summary.

At a glance

  • GWAS associations: 3
  • Clinical variants (ClinVar): 67 total
  • MANE Select transcript: NM_001130520

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:12986
Approved symbolZNF195
Namezinc finger protein 195
Location11p15.5
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000005801
Ensembl biotypeprotein_coding
OMIM602187
Entrez7748

Gene structure

Transcript identifiers

Ensembl transcripts: 36 — 22 protein_coding, 5 nonsense_mediated_decay, 5 retained_intron, 4 protein_coding_CDS_not_defined

ENST00000005082, ENST00000330692, ENST00000343338, ENST00000354599, ENST00000399602, ENST00000427810, ENST00000429541, ENST00000438262, ENST00000524857, ENST00000525313, ENST00000525502, ENST00000526501, ENST00000526540, ENST00000526598, ENST00000526601, ENST00000527386, ENST00000528218, ENST00000528410, ENST00000528636, ENST00000528796, ENST00000529085, ENST00000529228, ENST00000529678, ENST00000529789, ENST00000530643, ENST00000532539, ENST00000533036, ENST00000534569, ENST00000618467, ENST00000620374, ENST00000649622, ENST00000859310, ENST00000928995, ENST00000928996, ENST00000941946, ENST00000941947

RefSeq mRNA: 9 — MANE Select: NM_001130520 NM_001130519, NM_001130520, NM_001242841, NM_001242842, NM_001242843, NM_001256823, NM_001256824, NM_001256825, NM_007152

CCDS: CCDS41604, CCDS44521, CCDS44522, CCDS55736, CCDS55737, CCDS58111

Canonical transcript exons

ENST00000399602 — 6 exons

ExonStartEnd
ENSE0000188601233579273360565
ENSE0000354716933709753371070
ENSE0000354740733607203360788
ENSE0000357723533790383379146
ENSE0000358653633617433361889
ENSE0000368542933715773371703

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 96.30.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.0515 / max 126.8765, expressed in 1806 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
11829118.11711804
1182920.6458391
2061640.2886137

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
buccal mucosa cellCL:000233696.30gold quality
cortical plateUBERON:000534394.66gold quality
ganglionic eminenceUBERON:000402393.34gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099189.02gold quality
embryoUBERON:000092287.92gold quality
cerebellar hemisphereUBERON:000224587.56gold quality
rectumUBERON:000105287.53gold quality
cerebellar cortexUBERON:000212987.41gold quality
right hemisphere of cerebellumUBERON:001489087.24gold quality
islet of LangerhansUBERON:000000686.70gold quality
body of pancreasUBERON:000115086.61gold quality
ventricular zoneUBERON:000305386.52gold quality
mucosa of transverse colonUBERON:000499186.15gold quality
pancreasUBERON:000126485.53gold quality
small intestine Peyer’s patchUBERON:000345484.96gold quality
cerebellumUBERON:000203784.95gold quality
monocyteCL:000057684.79gold quality
transverse colonUBERON:000115784.75gold quality
granulocyteCL:000009484.62gold quality
C1 segment of cervical spinal cordUBERON:000646984.60gold quality
mononuclear cellCL:000084284.53gold quality
adrenal tissueUBERON:001830384.50gold quality
leukocyteCL:000073884.49gold quality
spleenUBERON:000210684.30gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047384.26gold quality
right frontal lobeUBERON:000281084.22gold quality
gastrocnemiusUBERON:000138884.06gold quality
minor salivary glandUBERON:000183083.94gold quality
hindlimb stylopod muscleUBERON:000425283.89gold quality
metanephros cortexUBERON:001053383.60gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes4.77
E-MTAB-6386no748.70

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

TargetRegulation
JUN

miRNA regulators (miRDB)

56 targeting ZNF195, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-548AW99.9972.573559
HSA-MIR-6870-5P99.9968.552115
HSA-MIR-302C-5P99.9772.563642
HSA-MIR-4723-5P99.9768.702034
HSA-MIR-569899.9768.492029
HSA-MIR-7111-5P99.9768.482062
HSA-MIR-1468-3P99.9672.743797
HSA-MIR-314399.9371.963104
HSA-MIR-153-5P99.8973.866317
HSA-MIR-450399.8571.451869
HSA-MIR-383-3P99.8565.841359
HSA-MIR-4728-5P99.8569.394718
HSA-MIR-6785-5P99.8268.684428
HSA-MIR-7110-5P99.8067.841712
HSA-MIR-4766-5P99.7569.232662
HSA-MIR-3913-3P99.7466.53938
HSA-MIR-149-3P99.7268.223963
HSA-MIR-128399.6972.423009
HSA-MIR-6883-5P99.6968.053785
HSA-MIR-7154-5P99.6970.521900
HSA-MIR-580-3P99.6769.231841
HSA-MIR-1249-5P99.6166.552049
HSA-MIR-6797-5P99.6166.552084
HSA-MIR-427699.5667.662514
HSA-MIR-6751-5P99.5664.991145
HSA-MIR-6733-3P99.5467.801281
HSA-MIR-65799.4866.02848
HSA-MIR-122B-5P99.4670.811457
HSA-MIR-1211399.3267.541072
HSA-MIR-126499.2566.811317

Literature-anchored findings (GeneRIF, showing 1)

  • ZNF195 and SBF1 are potential biomarkers for gemcitabine sensitivity in head and neck squamous cell carcinoma cell lines. (PMID:24817947)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 195O14628 (reviewed: O14628)

All UniProt accessions (13): O14628, A0A087WT67, C9JG37, E9PIN4, E9PIT0, E9PIY8, E9PLF5, E9PLW9, E9PMX5, E9PNM0, E9PPF8, E9PSE6, H0YDV1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Tissue specificity. Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (8)

UniProt IDNamesCanonical?
O14628-11, Ayes
O14628-22, B
O14628-33, C
O14628-44
O14628-55
O14628-66
O14628-77
O14628-88

RefSeq proteins (9): NP_001123991, NP_001123992, NP_001229770, NP_001229771, NP_001229772, NP_001243752, NP_001243753, NP_001243754, NP_009083 (=MANE)

Domains & families (InterPro)

IDNameType
IPR001909KRABDomain
IPR013087Znf_C2H2_typeDomain
IPR036051KRAB_dom_sfHomologous_superfamily
IPR036236Znf_C2H2_sfHomologous_superfamily

Pfam: PF00096, PF01352, PF13912

UniProt features (25 total): zinc finger region 10, splice variant 5, sequence conflict 4, cross-link 2, chain 1, domain 1, region of interest 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-O14628-F155.000.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 408, 383, 492

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-212436Generic Transcription Pathway

MSigDB gene sets: 113 (showing top): PUJANA_CHEK2_PCC_NETWORK, BROWNE_HCMV_INFECTION_24HR_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, BILD_E2F3_ONCOGENIC_SIGNATURE, MODULE_123, DODD_NASOPHARYNGEAL_CARCINOMA_UP, MODULE_98, MODULE_48, MODULE_95, CHEN_HOXA5_TARGETS_9HR_UP, JAIN_NFKB_SIGNALING, MODULE_198, BENPORATH_ES_1, HAMAI_APOPTOSIS_VIA_TRAIL_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING

GO Biological Process (2): regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
RNA Polymerase II Transcription1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
RNA polymerase II transcription regulatory region sequence-specific DNA binding2
DNA-templated transcription1
regulation of gene expression1
regulation of RNA biosynthetic process1
regulation of DNA-templated transcription1
transcription by RNA polymerase II1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
regulation of transcription by RNA polymerase II1
transition metal ion binding1
nucleic acid binding1
cation binding1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

648 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZNF195SS18L2Q9UHA2516
ZNF195SMCO4Q9NRQ5491
ZNF195SLC66A1LPA1A4F0446
ZNF195TRIM28Q13263429
ZNF195BEND2Q8NDZ0407
ZNF195MRGPREQ86SM8398
ZNF195AASDHQ4L235379
ZNF195NEK4P51957374
ZNF195USP19O94966363
ZNF195SLC3A2P08195353
ZNF195LIN28BQ6ZN17350
ZNF195DLGAP5Q15398349
ZNF195ZNF474Q6S9Z5349
ZNF195CXorf38Q8TB03348
ZNF195FAM90A1Q86YD7348

IntAct

63 interactions, top by confidence:

ABTypeScore
ZNF195BAG2psi-mi:“MI:0914”(association)0.530
TRIM28ZNF316psi-mi:“MI:0914”(association)0.530
TRIM28ZNF320psi-mi:“MI:0914”(association)0.530
IL13RA2METTL15psi-mi:“MI:0914”(association)0.530
SKP2DPYSL4psi-mi:“MI:0914”(association)0.530
ZNF764SH3PXD2Bpsi-mi:“MI:0914”(association)0.530
HSPB8VWA8psi-mi:“MI:0914”(association)0.530
PCBD1ZNF195psi-mi:“MI:0915”(physical association)0.370
ZNF195psi-mi:“MI:0915”(physical association)0.370
Mpsi-mi:“MI:0914”(association)0.350
CBX5ZNF568psi-mi:“MI:0914”(association)0.350
KRT2IFT56psi-mi:“MI:0914”(association)0.350
FBLN5ZNF320psi-mi:“MI:0914”(association)0.350
ZNF460ZNF320psi-mi:“MI:0914”(association)0.350
SPANXN2ZNF320psi-mi:“MI:0914”(association)0.350
ZNF677ZNF320psi-mi:“MI:0914”(association)0.350
CFAP184TARS3psi-mi:“MI:0914”(association)0.350
TRIM52MEIOCpsi-mi:“MI:0914”(association)0.350
RFPL4BKRBA1psi-mi:“MI:0914”(association)0.350
C6orf141KRBA1psi-mi:“MI:0914”(association)0.350
THSD4KRBA1psi-mi:“MI:0914”(association)0.350
KRT38KRBA1psi-mi:“MI:0914”(association)0.350
TEX19ZNF316psi-mi:“MI:0914”(association)0.350
RPL15ZSWIM8psi-mi:“MI:0914”(association)0.350
F9APBB1psi-mi:“MI:0914”(association)0.350
LYPD4PIK3C2Apsi-mi:“MI:0914”(association)0.350
MAP3K20MEIS1psi-mi:“MI:0914”(association)0.350
ZNF484ZNF195psi-mi:“MI:0914”(association)0.350

BioGRID (69): ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS), ZNF195 (Affinity Capture-MS)

ESM2 similar proteins: A0JPL0, A6NK53, E7ETH6, E9Q8G5, O14628, P21506, P51508, Q09FC8, Q13360, Q2M218, Q2M3X9, Q2VY69, Q3KQV3, Q3SY52, Q4R882, Q5HY98, Q5REN4, Q5RES8, Q68DI1, Q6NX49, Q6P280, Q6PG37, Q6V9R5, Q6ZMW2, Q7Z340, Q86XU0, Q8IYI8, Q8N587, Q8N720, Q8N859, Q8NB42, Q8NDW4, Q8NEK5, Q8WXB4, Q96MR9, Q96MU6, Q96NG8, Q96NJ3, Q96SR6, Q9BR84

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance59
Likely benign2
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1260 predictions. Top by Δscore:

VariantEffectΔscore
11:3368790:A:Cdonor_gain1.0000
11:3371554:C:CTdonor_gain1.0000
11:3371555:T:TTdonor_gain1.0000
11:3371560:A:ACdonor_gain1.0000
11:3371569:AT:Adonor_gain1.0000
11:3371576:CCAA:Cdonor_gain1.0000
11:3371616:C:Adonor_gain1.0000
11:3379033:CTCA:Cdonor_loss1.0000
11:3379036:A:ACdonor_gain1.0000
11:3379037:C:CCdonor_gain1.0000
11:3379037:CCAT:Cdonor_gain1.0000
11:3360561:CATAG:Cacceptor_gain0.9900
11:3360563:TAG:Tacceptor_gain0.9900
11:3368795:T:Cdonor_gain0.9900
11:3369355:AC:Adonor_gain0.9900
11:3369356:CC:Cdonor_gain0.9900
11:3369465:T:TCacceptor_gain0.9900
11:3370995:T:TAdonor_gain0.9900
11:3371071:CT:Cacceptor_loss0.9900
11:3371072:T:Gacceptor_loss0.9900
11:3371076:T:TCacceptor_gain0.9900
11:3371571:CCTCA:Cdonor_loss0.9900
11:3371572:CTCA:Cdonor_loss0.9900
11:3371573:TCA:Tdonor_loss0.9900
11:3371574:C:CGdonor_loss0.9900
11:3371575:A:ACdonor_gain0.9900
11:3371575:A:AGdonor_loss0.9900
11:3371576:C:Adonor_loss0.9900
11:3371576:C:CCdonor_gain0.9900
11:3371615:T:TAdonor_gain0.9900

AlphaMissense

4202 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
11:3359163:G:CF615L0.997
11:3359163:G:TF615L0.997
11:3359165:A:GF615L0.997
11:3359247:A:CF587L0.997
11:3359247:A:TF587L0.997
11:3359249:A:GF587L0.997
11:3359230:A:GL593P0.996
11:3359248:A:GF587S0.996
11:3359398:A:GL537P0.996
11:3359415:A:CF531L0.996
11:3359415:A:TF531L0.996
11:3359417:A:GF531L0.996
11:3359331:G:CF559L0.995
11:3359331:G:TF559L0.995
11:3359333:A:GF559L0.995
11:3359146:A:GL621P0.994
11:3359416:A:GF531S0.994
11:3359583:G:CF475L0.994
11:3359583:G:TF475L0.994
11:3359585:A:GF475L0.994
11:3359222:G:CH596D0.993
11:3359354:A:GC552R0.993
11:3359390:G:CH540D0.993
11:3359482:A:GL509P0.993
11:3359164:A:GF615S0.992
11:3359270:A:GC580R0.992
11:3359438:A:GC524R0.992
11:3371668:G:CF13L0.992
11:3371668:G:TF13L0.992
11:3371670:A:GF13L0.992

dbSNP variants (sampled 300 via entrez): RS1000085505 (11:3370288 A>G), RS1000116895 (11:3370029 C>A,T), RS1000129116 (11:3363384 T>C), RS1000148922 (11:3358218 G>A,C), RS1000420362 (11:3364664 A>G), RS1000735289 (11:3380816 C>G), RS1000765161 (11:3380396 G>A), RS1001333035 (11:3375349 C>G), RS1001444366 (11:3379636 G>A,T), RS1001470119 (11:3375643 C>G), RS1001585057 (11:3373838 G>A), RS1001711257 (11:3366892 C>T), RS1001892398 (11:3375049 T>TA), RS1002298380 (11:3369706 A>G), RS1002313399 (11:3363205 A>G)

Disease associations

OMIM: gene MIM:602187 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

StudyTraitp-value
GCST010725_20Malaria4.000000e-69
GCST010725_33Malaria2.000000e-67
GCST010725_51Malaria1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Aflatoxin B1increases expression, increases methylation3
Arsenicaffects methylation, decreases expression, increases abundance2
Benzo(a)pyrenedecreases expression, increases methylation2
Cisplatinincreases expression2
Formaldehydedecreases expression, increases expression2
Particulate Matterincreases expression, increases abundance2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamidedecreases expression1
GSK-J4decreases expression1
TAK-243increases sumoylation1
dicrotophosdecreases expression1
methylmercuric chlorideincreases expression1
triphenyl phosphateaffects expression1
geraniolincreases expression1
2-butenaldecreases expression1
beta-lapachonedecreases expression1
sodium arsenitedecreases expression, increases abundance1
zinc chromateincreases abundance, increases expression1
ochratoxin Adecreases expression1
chromium hexavalent ionincreases abundance, increases expression1
bisphenol Saffects cotreatment, decreases expression1
Sunitinibincreases expression1
Atrazinedecreases expression1
Vehicle Emissionsincreases abundance, increases expression1
Dexamethasoneaffects cotreatment, decreases expression1
Doxorubicindecreases expression1
Ethyl Methanesulfonateincreases expression1
Gallic Aciddecreases expression1
Indomethacinaffects cotreatment, decreases expression1
Methyl Methanesulfonateincreases expression1
Nickelincreases expression1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_XW15HEK293 eGFP-ZNF195Transformed cell lineFemale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): malaria