ZNF205-AS1

Summary

ZNF205-AS1 (ZNF205 antisense RNA 1, HGNC:28586) is a long non-coding RNA gene on chromosome 16p13.3.

Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting.

Source: NCBI Gene 81854 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28586
Approved symbol	ZNF205-AS1
Name	ZNF205 antisense RNA 1
Location	16p13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC3771
Entrez	81854
RNAcentral	URS000075B159 — lncRNA, 1233 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• our study demonstrated that the positive feedback loop between ZNF205-AS1 and EGR4 promotes non-small cell lung cancer (NSCLC) growth, and implied that targeting this feedback loop may be promising therapeutic strategy for NSCLC (PMID:30556283)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000057340 (16:3117352 G>A), RS1000131613 (16:3111222 G>A,C), RS1000341512 (16:3115738 G>A,T), RS1000561731 (16:3113896 AGT>A,AGTGT,AGTGTGT), RS1001020560 (16:3115616 G>T), RS1001193096 (16:3111852 G>A), RS1002049966 (16:3113598 G>A,C,T), RS1002081075 (16:3113373 GC>G), RS1002401744 (16:3115981 G>A,T), RS1002665369 (16:3117489 C>A,G), RS1002738968 (16:3117194 G>C), RS1002938481 (16:3112681 C>T), RS1003250107 (16:3113892 G>A), RS1003318029 (16:3112909 G>A,C), RS1003568641 (16:3117105 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
GSK-J4	decreases expression	1
butyraldehyde	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Cisplatin	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.