ZNF207

Summary

ZNF207 (zinc finger protein 207, HGNC:12998) is a protein-coding gene on chromosome 17q11.2, encoding BUB3-interacting and GLEBS motif-containing protein ZNF207 (O43670). Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. It is a common-essential gene (DepMap: required in 95.9% of cancer cell lines).

Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; nuclear chromosome segregation; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix.

Source: NCBI Gene 7756 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 64 total
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• Cancer dependency (DepMap): dependent in 95.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_001098507

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12998
Approved symbol	ZNF207
Name	zinc finger protein 207
Location	17q11.2
Locus type	gene with protein product
Status	Approved
Aliases	BuGZ
Ensembl gene	ENSG00000010244
Ensembl biotype	protein_coding
OMIM	603428
Entrez	7756

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 22 protein_coding, 5 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000321233, ENST00000342555, ENST00000394670, ENST00000394673, ENST00000394679, ENST00000577324, ENST00000577908, ENST00000578918, ENST00000579416, ENST00000579634, ENST00000579810, ENST00000580759, ENST00000581531, ENST00000582165, ENST00000582705, ENST00000584416, ENST00000584696, ENST00000868080, ENST00000868081, ENST00000868082, ENST00000868083, ENST00000914402, ENST00000914403, ENST00000914404, ENST00000914405, ENST00000914406, ENST00000914407, ENST00000970199, ENST00000970202

RefSeq mRNA: 3 — MANE Select: NM_001098507 NM_001032293, NM_001098507, NM_003457

CCDS: CCDS11271, CCDS32614, CCDS42294

Canonical transcript exons

ENST00000394670 — 12 exons

Exon	Start	End
ENSE00000360900	32360892	32360967
ENSE00000360902	32365330	32365487
ENSE00000360903	32366665	32366757
ENSE00000360905	32369295	32369454
ENSE00000712920	32367772	32368014
ENSE00001364975	32361468	32361515
ENSE00001825204	32369599	32381885
ENSE00002734466	32350157	32350326
ENSE00003479117	32362914	32362984
ENSE00003498509	32358503	32358641
ENSE00003511268	32351786	32351912
ENSE00003670974	32360598	32360765

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 98.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 149.3913 / max 2244.7374, expressed in 1828 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160228	148.9324	1828
160229	0.4589	190

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	98.41	gold quality
embryo	UBERON:0000922	98.19	gold quality
ventricular zone	UBERON:0003053	98.18	gold quality
lower esophagus mucosa	UBERON:0035834	98.17	gold quality
ganglionic eminence	UBERON:0004023	98.15	gold quality
esophagus mucosa	UBERON:0002469	98.10	gold quality
lymph node	UBERON:0000029	98.01	gold quality
monocyte	CL:0000576	97.98	gold quality
mononuclear cell	CL:0000842	97.96	gold quality
left ovary	UBERON:0002119	97.93	gold quality
ectocervix	UBERON:0012249	97.90	gold quality
leukocyte	CL:0000738	97.89	gold quality
rectum	UBERON:0001052	97.87	gold quality
tonsil	UBERON:0002372	97.86	gold quality
minor salivary gland	UBERON:0001830	97.85	gold quality
oral cavity	UBERON:0000167	97.79	gold quality
endocervix	UBERON:0000458	97.79	gold quality
body of uterus	UBERON:0009853	97.78	gold quality
endothelial cell	CL:0000115	97.76	gold quality
right ovary	UBERON:0002118	97.76	gold quality
vagina	UBERON:0000996	97.74	gold quality
mouth mucosa	UBERON:0003729	97.71	gold quality
smooth muscle tissue	UBERON:0001135	97.70	gold quality
right uterine tube	UBERON:0001302	97.68	gold quality
islet of Langerhans	UBERON:0000006	97.67	gold quality
skin of abdomen	UBERON:0001416	97.66	gold quality
skin of leg	UBERON:0001511	97.66	gold quality
bone marrow cell	CL:0002092	97.60	gold quality
esophagus	UBERON:0001043	97.60	gold quality
calcaneal tendon	UBERON:0003701	97.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

67 targeting ZNF207, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-323A-3P	99.79	70.30	1739
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-6516-3P	99.65	68.57	1238
HSA-MIR-6126	99.62	68.09	996

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 95.9% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 7)

• BuGZ forms temperature-dependent liquid droplets alone or on microtubules in physiological buffers. Coacervation in vitro or in spindle and spindle matrix depends on hydrophobic residues in BuGZ. BuGZ coacervation and its binding to microtubules and tubulin are required to promote assembly of spindle and spindle matrix in Xenopus egg extract and in mammalian cells. (PMID:26388440)
• the two zinc fingers of BuGZ directly bind to AurA and BuGZ coacervation appears to promote AurA activation during spindle assembly. (PMID:29074706)
• a distinct isoform of ZNF207 functions in hESCs at the nexus that balances pluripotency and differentiation to ectoderm. (PMID:30349051)
• ZNF207 expression is elevated in hepatocellular carcinoma (PMID:31113916)
• BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis. (PMID:32820050)
• System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma. (PMID:35246476)
• SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3. (PMID:37535603)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf207a	ENSDARG00000015538
danio_rerio	znf207b	ENSDARG00000101277
mus_musculus	Zfp207	ENSMUSG00000017421
rattus_norvegicus	Zfp207	ENSRNOG00000000236
caenorhabditis_elegans		WBGENE00007105

Protein

Protein identifiers

BUB3-interacting and GLEBS motif-containing protein ZNF207 — O43670 (reviewed: O43670)

Alternative names: Zinc finger protein 207

All UniProt accessions (9): O43670, H0Y3M2, J3KRB6, J3KRW6, J3KS31, J3KTL1, J3QRS9, J3QS27, X6R4W8

UniProt curated annotations — full annotation on UniProt →

Function. Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome.

Subunit / interactions. Interacts (via GLEBS region) with BUB3.

Subcellular location. Nucleus. Chromosome. Centromere. Kinetochore. Cytoplasm. Cytoskeleton. Spindle.

Tissue specificity. Ubiquitous.

Domain organisation. The GLEBS region mediates interaction with BUB3. The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis. Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.

Isoforms (4)

UniProt ID	Names	Canonical?
O43670-1	1	yes
O43670-2	2
O43670-3	3
O43670-4	4

RefSeq proteins (3): NP_001027464, NP_001091977, NP_003448 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain

UniProt features (22 total): compositionally biased region 8, region of interest 6, splice variant 3, zinc finger region 2, chain 1, sequence variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43670-F1	61.30	0.17

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

Position	Phenotype
373–374	in bugzaa: abolishes interaction with bub3.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 249 (showing top): GOBP_CHROMOSOME_ORGANIZATION, GOBP_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE, WWTAAGGC_UNKNOWN, GOBP_REGULATION_OF_NUCLEAR_DIVISION, GOBP_CHROMOSOME_LOCALIZATION, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GOBP_CELL_CYCLE_PHASE_TRANSITION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_CHROMOSOME_SEPARATION, chr17q11, GOLDRATH_ANTIGEN_RESPONSE, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_MITOTIC_SPINDLE_ASSEMBLY, GOBP_ORGANELLE_FISSION

GO Biological Process (10): mitotic sister chromatid segregation (GO:0000070), microtubule bundle formation (GO:0001578), mitotic spindle assembly checkpoint signaling (GO:0007094), attachment of spindle microtubules to kinetochore (GO:0008608), microtubule polymerization (GO:0046785), protein stabilization (GO:0050821), cell division (GO:0051301), regulation of chromosome segregation (GO:0051983), mitotic spindle assembly (GO:0090307), chromosome segregation (GO:0007059)

GO Molecular Function (7): DNA binding (GO:0003677), RNA binding (GO:0003723), microtubule binding (GO:0008017), heparin binding (GO:0008201), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (11): kinetochore (GO:0000776), nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), spindle (GO:0005819), microtubule (GO:0005874), spindle matrix (GO:1990047), chromosome, centromeric region (GO:0000775), chromosome (GO:0005694), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	5
cellular anatomical structure	3
mitotic nuclear division	2
cell cycle process	2
nucleic acid binding	2
nuclear lumen	2
microtubule cytoskeleton	2
sister chromatid segregation	1
mitotic cell cycle process	1
microtubule cytoskeleton organization	1
mitotic cell cycle	1
negative regulation of mitotic metaphase/anaphase transition	1
spindle assembly checkpoint signaling	1
mitotic spindle checkpoint signaling	1
microtubule binding	1
metaphase chromosome alignment	1
microtubule nucleation	1
microtubule polymerization or depolymerization	1
protein polymerization	1
supramolecular fiber organization	1
regulation of protein stability	1
cellular process	1
chromosome segregation	1
regulation of cell cycle process	1
mitotic sister chromatid segregation	1
mitotic spindle organization	1
spindle assembly	1
tubulin binding	1
glycosaminoglycan binding	1
sulfur compound binding	1
transition metal ion binding	1
binding	1
cation binding	1
condensed chromosome, centromeric region	1
supramolecular complex	1
intracellular membrane-bounded organelle	1
polymeric cytoskeletal fiber	1
cytoskeleton	1
chromosomal region	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1746 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF207	BUB3	O43684	962
ZNF207	SF3A3	Q12874	670
ZNF207	RAE1	P78406	548
ZNF207	CRLF3	Q8IUI8	497
ZNF207	CLVS2	Q5SYC1	470
ZNF207	MRPL3	P09001	436
ZNF207	ZMAT2	Q96NC0	427
ZNF207	ZNF319	Q9P2F9	416
ZNF207	SF3A2	Q15428	401
ZNF207	DCPS	Q96C86	400
ZNF207	BUB1	O43683	389
ZNF207	RNF149	Q8NC42	383
ZNF207	ZNF277	Q9NRM2	371
ZNF207	MDP1	Q86V88	366
ZNF207	ELAVL4	P26378	358

IntAct

85 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
BUB3	ZNF207	psi-mi:“MI:0915”(physical association)	0.690
ZNF207	BUB3	psi-mi:“MI:0403”(colocalization)	0.690
BUB3	ZNF207	psi-mi:“MI:0914”(association)	0.690
ZNF207	BUB3	psi-mi:“MI:0915”(physical association)	0.690
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
ZNF207	Dlg4	psi-mi:“MI:0407”(direct interaction)	0.440
SF3A2	ZNF207	psi-mi:“MI:0915”(physical association)	0.400
WBP4	ZNF207	psi-mi:“MI:0915”(physical association)	0.400
ZNF207	E7	psi-mi:“MI:0915”(physical association)	0.370
CCL1	ZNF207	psi-mi:“MI:0915”(physical association)	0.370
POLR1B	ZNF207	psi-mi:“MI:0915”(physical association)	0.370
ZNF207	MAP2K2	psi-mi:“MI:0915”(physical association)	0.370
HNRNPUL1	ZNF207	psi-mi:“MI:0915”(physical association)	0.370
WDR77	ZNF207	psi-mi:“MI:0915”(physical association)	0.370
HNRNPM	ZNF207	psi-mi:“MI:0915”(physical association)	0.370
SF1	U2SURP	psi-mi:“MI:0914”(association)	0.350
JUN		psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
USP7		psi-mi:“MI:0914”(association)	0.350

BioGRID (141): ZNF207 (Affinity Capture-RNA), ZNF207 (Affinity Capture-RNA), ZNF207 (Affinity Capture-RNA), ZNF207 (Affinity Capture-MS), ZNF207 (Affinity Capture-MS), BUB3 (Co-fractionation), ZNF207 (Affinity Capture-MS), ZNF207 (Proximity Label-MS), ZNF207 (Affinity Capture-MS), ZNF207 (Affinity Capture-MS), ZNF207 (Affinity Capture-MS), ZNF207 (Affinity Capture-MS), UBR5 (Affinity Capture-Western), ZNF207 (Reconstituted Complex), KPNB1 (Affinity Capture-Western)

ESM2 similar proteins: A7EYK3, A7SEP9, A8NYM5, A8XW44, B0JYS7, B7Q2M2, C0NN85, C3Z1P5, C5XYW4, C5XZK6, C7YRT4, D0NHA2, D3B3B7, D3ZCL3, D5GDH4, E0VI98, E1C6F0, E2RGI3, E3KIY6, E3LAN7, E3X5D6, F6HQ26, F6TFD9, F7ARS3, O43670, P09234, P33240, P90815, Q03369, Q16IW3, Q1K7T5, Q1RLC9, Q298E0, Q32PA0, Q4N6K2, Q4WQM6, Q56XE4, Q5BBX9, Q5KC16, Q5R8K4

Diamond homologs: O43670, Q5R8K4, Q7ZXV8, Q9C5G0, Q9JMD0

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 85 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Polyadenylation	15	20.0×	9e-14
mRNA Splicing	12	20.0×	7e-11
Processing of Capped Intron-Containing Pre-mRNA	16	19.9×	1e-14
mRNA Splicing - Minor Pathway	5	17.0×	7e-04
mRNA Splicing - Major Pathway	19	15.7×	2e-15
CHD1 and CHD2 subfamily	7	11.5×	2e-04
Dengue Virus-Host Interactions	15	10.4×	9e-10
G2/M DNA damage checkpoint	5	9.1×	9e-03

GO biological processes:

GO term	Partners	Fold	FDR
U2-type prespliceosome assembly	5	42.2×	3e-05
mRNA splicing, via spliceosome	15	18.6×	1e-12

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1907 predictions. Top by Δscore:

Variant	Effect	Δscore
17:32358498:GTTA:G	acceptor_loss	1.0000
17:32358499:TTA:T	acceptor_loss	1.0000
17:32358501:A:AC	acceptor_loss	1.0000
17:32358501:A:AG	acceptor_gain	1.0000
17:32358501:AG:A	acceptor_gain	1.0000
17:32358502:G:A	acceptor_loss	1.0000
17:32358502:G:GA	acceptor_gain	1.0000
17:32358502:GG:G	acceptor_gain	1.0000
17:32358502:GGT:G	acceptor_gain	1.0000
17:32358502:GGTA:G	acceptor_gain	1.0000
17:32358502:GGTAC:G	acceptor_gain	1.0000
17:32358640:AG:A	donor_gain	1.0000
17:32358641:GG:G	donor_gain	1.0000
17:32358641:GGTA:G	donor_loss	1.0000
17:32358642:G:GG	donor_gain	1.0000
17:32358652:GGA:G	donor_gain	1.0000
17:32358653:GA:G	donor_gain	1.0000
17:32360593:A:AG	acceptor_gain	1.0000
17:32360594:A:G	acceptor_gain	1.0000
17:32360595:C:G	acceptor_gain	1.0000
17:32360596:A:AG	acceptor_gain	1.0000
17:32360597:G:GT	acceptor_gain	1.0000
17:32360597:GA:G	acceptor_gain	1.0000
17:32360597:GAA:G	acceptor_gain	1.0000
17:32360597:GAAA:G	acceptor_gain	1.0000
17:32360754:G:GT	donor_gain	1.0000
17:32360755:A:T	donor_gain	1.0000
17:32360761:TCCAG:T	donor_loss	1.0000
17:32360762:CCAGG:C	donor_loss	1.0000
17:32360763:CAGG:C	donor_loss	1.0000

AlphaMissense

3215 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:32350289:G:C	G2R	1.000
17:32350289:G:T	G2C	1.000
17:32350290:G:A	G2D	1.000
17:32350290:G:T	G2V	1.000
17:32350292:C:A	R3S	1.000
17:32350292:C:T	R3C	1.000
17:32350293:G:A	R3H	1.000
17:32350295:A:G	K4E	1.000
17:32350296:A:T	K4M	1.000
17:32350297:G:C	K4N	1.000
17:32350297:G:T	K4N	1.000
17:32350317:C:A	P11Q	1.000
17:32350317:C:G	P11R	1.000
17:32350319:T:A	W12R	1.000
17:32350319:T:C	W12R	1.000
17:32350320:G:C	W12S	1.000
17:32350320:G:T	W12L	1.000
17:32350321:G:C	W12C	1.000
17:32350321:G:T	W12C	1.000
17:32350322:T:A	C13S	1.000
17:32350322:T:C	C13R	1.000
17:32350323:G:A	C13Y	1.000
17:32350323:G:C	C13S	1.000
17:32350323:G:T	C13F	1.000
17:32350324:C:G	C13W	1.000
17:32350325:T:A	W14R	1.000
17:32350325:T:C	W14R	1.000
17:32351786:G:C	W14C	1.000
17:32351786:G:T	W14C	1.000
17:32351787:T:A	Y15N	1.000

dbSNP variants (sampled 300 via entrez): RS1000097005 (17:32378629 C>A,G), RS1000121677 (17:32357358 T>A), RS1000181486 (17:32376900 GCT>G), RS1000200727 (17:32373857 G>A), RS1000210740 (17:32370654 T>C), RS1000253203 (17:32362685 C>T), RS1000335444 (17:32368516 A>G), RS1000358694 (17:32355645 G>A,C,T), RS1000430204 (17:32368243 T>C), RS1000613224 (17:32360986 T>C), RS1000641267 (17:32353749 A>G), RS1000643863 (17:32367339 G>T), RS1000716910 (17:32367663 A>G,T), RS1000832518 (17:32352052 C>A,T), RS1000845860 (17:32374034 T>A,C,G)

Disease associations

OMIM: gene MIM:603428 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004485_43	Survival in pancreatic cancer	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0000638	overall survival

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5724610 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL1232461	MOLIBRESIB	2	1,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

5 potent at pChembl≥5 of 5 total, top 5 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.17	Kd	67	nM	CHEMBL5566563
6.49	Kd	325	nM	CHEMBL5653589
6.49	ED50	325	nM	CHEMBL5653589
5.83	IC50	1480	nM	MOLIBRESIB
5.62	Kd	2400	nM	CHEMBL5572679

PubChem BioAssay actives

4 with measured affinity, of 14 total; 4 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
N-[2-(1-benzylpiperidin-4-yl)ethyl]-8-bromo-15-cyanotetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide	2090207: Binding affinity to human ZNF207 assessed as dissociation constant by SPR analysis	kd	0.0670	uM
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149815: Binding affinity to human ZNF207 incubated for 45 mins by Kinobead based pull down assay	kd	0.3250	uM
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide	2178815: Inhibition of ZNF207 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	ic50	1.4800	uM
15-cyano-N-(4-nitrophenyl)tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide	2090207: Binding affinity to human ZNF207 assessed as dissociation constant by SPR analysis	kd	2.4000	uM

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
bisphenol A	affects cotreatment, increases methylation, decreases expression, increases expression	4
mercuric bromide	decreases expression, affects cotreatment	2
Cadmium	decreases reaction, increases abundance, increases palmitoylation, increases expression	2
Formaldehyde	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	increases expression	1
geldanamycin	decreases expression	1
methylmercuric chloride	decreases expression	1
geraniol	decreases expression	1
sodium arsenate	decreases expression	1
methylparaben	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
2-bromopalmitate	increases palmitoylation, decreases reaction, increases abundance	1
beta-methylcholine	affects expression	1
pinosylvin	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
nutlin 3	affects cotreatment, increases secretion	1
bisphenol B	increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
NSC 689534	affects binding, increases expression	1
bisphenol AF	increases expression	1
Irinotecan	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1

ChEMBL screening assays

12 unique, capped per target: 12 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5530938	Binding	Binding affinity to human ZNF207 assessed as dissociation constant by SPR analysis	Discovery of Novel N-(Anthracen-9-ylmethyl) Benzamide Derivatives as ZNF207 Inhibitors Promising in Treating Glioma. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.