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ZNF226

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Summary

ZNF226 (zinc finger protein 226, HGNC:13019) is a protein-coding gene on chromosome 19q13.31, encoding Zinc finger protein 226 (Q9NYT6). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 7769 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 149 total
  • MANE Select transcript: NM_001032373

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:13019
Approved symbolZNF226
Namezinc finger protein 226
Location19q13.31
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000167380
Ensembl biotypeprotein_coding
Entrez7769

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 31 protein_coding, 1 retained_intron

ENST00000300823, ENST00000337433, ENST00000413984, ENST00000454662, ENST00000585560, ENST00000585678, ENST00000586203, ENST00000586286, ENST00000586914, ENST00000588127, ENST00000588742, ENST00000588795, ENST00000588883, ENST00000589160, ENST00000590089, ENST00000590467, ENST00000590524, ENST00000590578, ENST00000590759, ENST00000852800, ENST00000852801, ENST00000852802, ENST00000929407, ENST00000929408, ENST00000929409, ENST00000929410, ENST00000929411, ENST00000929412, ENST00000929413, ENST00000966188, ENST00000966189, ENST00000966190

RefSeq mRNA: 20 — MANE Select: NM_001032373 NM_001032372, NM_001032373, NM_001032374, NM_001146220, NM_001319088, NM_001319089, NM_001319090, NM_001388168, NM_001388169, NM_001388170, NM_001388171, NM_001388172, NM_001388173, NM_001388174, NM_001388175, NM_001388176, NM_001388177, NM_001388178, NM_015919, NM_016444

CCDS: CCDS46102, CCDS46103

Canonical transcript exons

ENST00000337433 — 6 exons

ExonStartEnd
ENSE000011124904417286044172952
ENSE000016665814416510044165142
ENSE000017306724416575744165807
ENSE000024538214417208844172214
ENSE000035744284417003544170095
ENSE000039182324417549844177685

Expression profiles

Bgee: expression breadth ubiquitous, 272 present calls, max score 93.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.9066 / max 200.9506, expressed in 1766 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
17625211.09221758
1762530.8144520

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
tendon of biceps brachiiUBERON:000818893.60gold quality
endothelial cellCL:000011593.42gold quality
calcaneal tendonUBERON:000370192.97gold quality
adrenal tissueUBERON:001830392.66gold quality
right adrenal glandUBERON:000123392.44gold quality
tendonUBERON:000004392.41gold quality
right adrenal gland cortexUBERON:003582792.41gold quality
left adrenal glandUBERON:000123491.65gold quality
left adrenal gland cortexUBERON:003582591.39gold quality
adrenal glandUBERON:000236991.02gold quality
adrenal cortexUBERON:000123590.89gold quality
adenohypophysisUBERON:000219690.72gold quality
pituitary glandUBERON:000000790.65gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099189.76gold quality
apex of heartUBERON:000209888.66gold quality
corpus callosumUBERON:000233688.51gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047388.41gold quality
right uterine tubeUBERON:000130288.35gold quality
palpebral conjunctivaUBERON:000181288.16gold quality
C1 segment of cervical spinal cordUBERON:000646987.85gold quality
medial globus pallidusUBERON:000247787.75gold quality
amniotic fluidUBERON:000017387.66gold quality
gall bladderUBERON:000211087.64gold quality
olfactory segment of nasal mucosaUBERON:000538687.41gold quality
mucosa of stomachUBERON:000119987.25gold quality
left lobe of thyroid glandUBERON:000112087.19gold quality
anterior cingulate cortexUBERON:000983587.10gold quality
cingulate cortexUBERON:000302786.97gold quality
stromal cell of endometriumCL:000225586.91gold quality
substantia nigraUBERON:000203886.79gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-GEOD-124858no216.06
E-ANND-3no0.00

Regulation

Is transcription factor: yes

JASPAR motifs

MotifNameFamily
MA2548.1ZNF226More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

Upstream regulators (CollecTRI, top): BRD1, RBAK, STAT1

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusZfp61ENSMUSG00000050605
rattus_norvegicusZfp94ENSRNOG00000019416

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 226 — Q9NYT6 (reviewed: Q9NYT6)

All UniProt accessions (11): Q9NYT6, K7EJ66, K7EK05, K7EKQ6, K7EL77, K7ELA3, K7ELM4, K7EPU4, K7EQC3, K7ERY1, K7ESM6

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt IDNamesCanonical?
Q9NYT6-11yes
Q9NYT6-22

RefSeq proteins (20): NP_001027544, NP_001027545, NP_001027546, NP_001139692, NP_001306017, NP_001306018, NP_001306019, NP_001375097, NP_001375098, NP_001375099, NP_001375100, NP_001375101, NP_001375102, NP_001375103, NP_001375104, NP_001375105, NP_001375106, NP_001375107, NP_057003, NP_057528 (=MANE)

Domains & families (InterPro)

IDNameType
IPR001909KRABDomain
IPR013087Znf_C2H2_typeDomain
IPR036051KRAB_dom_sfHomologous_superfamily
IPR036236Znf_C2H2_sfHomologous_superfamily

Pfam: PF00096, PF01352

UniProt features (26 total): zinc finger region 19, splice variant 2, chain 1, domain 1, region of interest 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9NYT6-F165.300.05

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-212436Generic Transcription Pathway

MSigDB gene sets: 68 (showing top): GOZGIT_ESR1_TARGETS_DN, PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP, KOYAMA_SEMA3B_TARGETS_UP, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, BASAKI_YBX1_TARGETS_DN, HAN_SATB1_TARGETS_DN, GEORGES_TARGETS_OF_MIR192_AND_MIR215, ONDER_CDH1_TARGETS_1_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN, WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS, KRIEG_KDM3A_TARGETS_NOT_HYPOXIA

GO Biological Process (3): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (4): zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
RNA Polymerase II Transcription1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
transcription by RNA polymerase II2
regulation of transcription by RNA polymerase II1
negative regulation of DNA-templated transcription1
regulation of DNA-templated transcription1
DNA-templated transcription1
regulation of gene expression1
regulation of RNA biosynthetic process1
transition metal ion binding1
DNA binding1
nucleic acid binding1
cation binding1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

502 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZNF226CCDC51Q96ER9480
ZNF226TMA7Q9Y2S6418
ZNF226ANKEF1Q9NU02379
ZNF226SHISAL1Q3SXP7371
ZNF226LRRC46Q96FV0370
ZNF226TSPYL4Q9UJ04348
ZNF226CCDC57Q2TAC2325
ZNF226IGFLR1Q9H665318
ZNF226CHAC2Q8WUX2314
ZNF226GXYLT1Q4G148313
ZNF226DNASE1L1P49184309
ZNF226EML2O95834308
ZNF226DNAJC9Q8WXX5300
ZNF226SMPDL3AQ92484298
ZNF226OTOP1Q7RTM1274

IntAct

6 interactions, top by confidence:

ABTypeScore
TRIM28ZNF320psi-mi:“MI:0914”(association)0.530
ZNF226MRPL58psi-mi:“MI:0915”(physical association)0.400
ZNF226SSBP3psi-mi:“MI:0915”(physical association)0.370
ATF4ZNF226psi-mi:“MI:0915”(physical association)0.370
H2BC10SMCHD1psi-mi:“MI:2364”(proximity)0.270

BioGRID (14): ZNF226 (Proximity Label-MS), ZNF226 (Affinity Capture-MS), ZNF226 (Proximity Label-MS), ZNF226 (Proximity Label-MS), ZNF226 (Proximity Label-MS), ZNF226 (Affinity Capture-MS), ZNF226 (Affinity Capture-MS), ZNF226 (Proximity Label-MS), ZNF226 (Proximity Label-MS), ZNF226 (Proximity Label-MS), ZNF226 (Affinity Capture-MS), ZNF226 (Affinity Capture-RNA), ZNF226 (Two-hybrid), SSBP3 (Two-hybrid)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

149 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance130
Likely benign9
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1026 predictions. Top by Δscore:

VariantEffectΔscore
19:44165808:G:GGdonor_gain1.0000
19:44165810:GA:Gdonor_gain1.0000
19:44165812:G:GGdonor_gain1.0000
19:44170033:A:AGacceptor_gain1.0000
19:44170034:G:GAacceptor_gain1.0000
19:44170034:GTTC:Gacceptor_gain1.0000
19:44170034:GTTCA:Gacceptor_gain1.0000
19:44170092:CAAGG:Cdonor_loss1.0000
19:44170094:AGGT:Adonor_loss1.0000
19:44170097:T:Gdonor_loss1.0000
19:44172080:T:TAacceptor_gain1.0000
19:44172083:C:Aacceptor_gain1.0000
19:44172085:TAGGA:Tacceptor_loss1.0000
19:44172086:A:AGacceptor_gain1.0000
19:44172086:A:Cacceptor_loss1.0000
19:44172086:AG:Aacceptor_gain1.0000
19:44172087:G:GTacceptor_gain1.0000
19:44172087:GG:Gacceptor_gain1.0000
19:44172087:GGA:Gacceptor_gain1.0000
19:44172087:GGAA:Gacceptor_gain1.0000
19:44172162:G:GTdonor_gain1.0000
19:44172181:ATG:Adonor_gain1.0000
19:44172211:G:GGdonor_gain1.0000
19:44172211:GTGG:Gdonor_loss1.0000
19:44172213:GG:Gdonor_gain1.0000
19:44172214:GG:Gdonor_gain1.0000
19:44172214:GGTG:Gdonor_loss1.0000
19:44172215:G:GGdonor_gain1.0000
19:44172215:GTGAG:Gdonor_loss1.0000
19:44172220:G:GTdonor_gain1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000012879 (19:44166959 C>A,T), RS1000031956 (19:44175686 AT>A), RS1000082345 (19:44175467 C>CAAAAAAAAAA), RS1000113218 (19:44163870 A>G), RS1000198165 (19:44167068 A>G), RS1000321460 (19:44169479 C>T), RS1000329226 (19:44197975 A>T), RS1000395961 (19:44164104 C>T), RS1000491472 (19:44188610 G>A), RS1000630455 (19:44188994 C>T), RS1000632035 (19:44198390 C>G), RS1000708757 (19:44184089 G>A), RS1000710744 (19:44176926 T>C,G), RS1000790116 (19:44182355 A>G), RS1000791731 (19:44191713 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Aciddecreases expression, affects cotreatment6
Formaldehydedecreases expression, increases expression3
trichostatin Adecreases expression, affects cotreatment2
sodium arsenitedecreases expression, increases expression2
entinostatdecreases expression, affects cotreatment2
Estradiolaffects expression, decreases expression2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamidedecreases expression1
GSK-J4decreases expression1
TAK-243increases sumoylation1
methylmercuric chloridedecreases expression1
triphenyl phosphateaffects expression1
beta-lapachoneincreases expression1
methylparabenincreases expression1
tris(1,3-dichloro-2-propyl)phosphateincreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamidedecreases expression, affects cotreatment1
abrineincreases expression1
dorsomorphinaffects cotreatment, decreases expression1
Sunitinibdecreases expression1
Acetaldehydedecreases expression1
Air Pollutantsaffects expression, increases abundance1
Atrazineincreases expression1
Benzo(a)pyreneincreases expression1
Coumestroldecreases expression1
Ethyl Methanesulfonateincreases expression1
Folic Aciddecreases expression1
Methyl Methanesulfonateincreases expression1
Ozoneaffects expression, increases abundance1
Tobacco Smoke Pollutionincreases expression1
Urethanedecreases expression1
Aflatoxin B1decreases methylation1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot