ZNF234

Summary

ZNF234 (zinc finger protein 234, HGNC:13027) is a protein-coding gene on chromosome 19q13.31, encoding Zinc finger protein 234 (Q14588). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 10780 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 87 total
• MANE Select transcript: NM_006630

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13027
Approved symbol	ZNF234
Name	zinc finger protein 234
Location	19q13.31
Locus type	gene with protein product
Status	Approved
Aliases	HZF4
Ensembl gene	ENSG00000263002
Ensembl biotype	protein_coding
OMIM	604750
Entrez	10780

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 26 protein_coding, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000426739, ENST00000590748, ENST00000590795, ENST00000592437, ENST00000896265, ENST00000896266, ENST00000896267, ENST00000896268, ENST00000896269, ENST00000896270, ENST00000896271, ENST00000896272, ENST00000896273, ENST00000896274, ENST00000896275, ENST00000896276, ENST00000896277, ENST00000896278, ENST00000896279, ENST00000896280, ENST00000929192, ENST00000929193, ENST00000929194, ENST00000971544, ENST00000971545, ENST00000971546, ENST00000971547, ENST00000971548

RefSeq mRNA: 2 — MANE Select: NM_006630 NM_001144824, NM_006630

CCDS: CCDS46101

Canonical transcript exons

ENST00000426739 — 6 exons

Exon	Start	End
ENSE00001309205	44156252	44160313
ENSE00001640854	44142314	44142367
ENSE00001676261	44144557	44144647
ENSE00001799792	44141554	44141733
ENSE00002501033	44148771	44148897
ENSE00003618504	44150413	44150505

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 84.49.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.9078 / max 86.1217, expressed in 1501 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176251	2.4353	1291
176250	1.4725	891

Top tissues by expression

274 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.49	gold quality
adrenal tissue	UBERON:0018303	80.99	gold quality
calcaneal tendon	UBERON:0003701	80.35	gold quality
apex of heart	UBERON:0002098	79.12	gold quality
stromal cell of endometrium	CL:0002255	79.05	gold quality
cortical plate	UBERON:0005343	78.50	gold quality
right adrenal gland cortex	UBERON:0035827	78.32	gold quality
right adrenal gland	UBERON:0001233	78.27	gold quality
left adrenal gland	UBERON:0001234	77.84	gold quality
left adrenal gland cortex	UBERON:0035825	77.71	gold quality
adrenal gland	UBERON:0002369	77.38	gold quality
adrenal cortex	UBERON:0001235	76.70	gold quality
ventricular zone	UBERON:0003053	76.61	gold quality
left ovary	UBERON:0002119	75.83	gold quality
ganglionic eminence	UBERON:0004023	75.35	gold quality
right ovary	UBERON:0002118	75.30	gold quality
descending thoracic aorta	UBERON:0002345	75.27	gold quality
right atrium auricular region	UBERON:0006631	74.96	gold quality
right coronary artery	UBERON:0001625	74.86	gold quality
lower esophagus	UBERON:0013473	74.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	74.75	gold quality
colonic epithelium	UBERON:0000397	74.60	gold quality
rectum	UBERON:0001052	74.57	gold quality
ovary	UBERON:0000992	74.54	gold quality
heart left ventricle	UBERON:0002084	74.52	gold quality
gall bladder	UBERON:0002110	74.49	gold quality
metanephros cortex	UBERON:0010533	74.49	gold quality
sural nerve	UBERON:0015488	74.45	gold quality
monocyte	CL:0000576	74.36	gold quality
left lobe of thyroid gland	UBERON:0001120	74.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.37

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2549.1	ZNF234	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605530

Upstream regulators (CollecTRI, top): MYC

miRNA regulators (miRDB)

83 targeting ZNF234, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-3671	99.90	73.04	3897

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 234 — Q14588 (reviewed: Q14588)

Alternative names: Zinc finger protein 269, Zinc finger protein HZF4

All UniProt accessions (2): Q14588, K7ELL2

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001138296, NP_006621* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (26 total): zinc finger region 19, sequence variant 2, sequence conflict 2, chain 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14588-F1	74.75	0.20

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 57 (showing top): LIAO_METASTASIS, DODD_NASOPHARYNGEAL_CARCINOMA_UP, DANG_BOUND_BY_MYC, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, JOHNSTONE_PARVB_TARGETS_3_DN, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, H1_6_TARGET_GENES, RYBP_TARGET_GENES, ZNF8_TARGET_GENES, ZNF92_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR5688, MIR548AZ_5P

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleoplasm (GO:0005654), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
regulation of DNA-templated transcription	1
transcription regulator activity	1
transition metal ion binding	1
DNA binding	1
nucleic acid binding	1
cation binding	1
nuclear lumen	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

486 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF234	SH2D5	Q6ZV89	479
ZNF234	WRAP73	Q9P2S5	348
ZNF234	DOCK6	Q96HP0	348
ZNF234	PROKR1	Q8TCW9	311
ZNF234	A0A096LNH4	A0A096LNH4	302
ZNF234	SLC6A5	Q9Y345	300
ZNF234	MALRD1	Q5VYJ5	297
ZNF234	SLC38A4	Q969I6	296
ZNF234	TIMM29	Q9BSF4	290
ZNF234	SYT15	Q9BQS2	290
ZNF234	CEACAM19	Q7Z692	288
ZNF234	OR2L13	Q8N349	287
ZNF234	KIF26A	Q9ULI4	285
ZNF234	SNAPC1	Q16533	284
ZNF234	ZNF618	Q5T7W0	273

IntAct

4 interactions, top by confidence:

A	B	Type	Score
CDC42	ZNF234	psi-mi:“MI:0915”(physical association)	0.000
NDEL1	ZNF234	psi-mi:“MI:0915”(physical association)	0.000
CLIC6	ZNF234	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): ZNF234 (Biochemical Activity), ZNF234 (Affinity Capture-MS), ZNF234 (Two-hybrid), ZNF234 (Affinity Capture-MS), ZNF234 (Affinity Capture-RNA), ZNF234 (Two-hybrid), ZNF234 (Affinity Capture-RNA), ZNF234 (Affinity Capture-MS)

ESM2 similar proteins: A2RRD8, A6NHJ4, B4DX44, O75346, P10077, P10755, P15621, P16372, P16373, P51786, P52737, P85977, Q0VGE8, Q14588, Q147U1, Q15928, Q15973, Q2M3X9, Q3KNS6, Q3MIS6, Q494X3, Q5HY98, Q5RBQ3, Q5REK1, Q5VIY5, Q60585, Q61751, Q6GQR8, Q7L2R6, Q7TSH9, Q8IYX0, Q8N782, Q8N823, Q8N988, Q8N9F8, Q8NA42, Q8NCK3, Q8NDP4, Q8NEP9, Q8TC21

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	72
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1209 predictions. Top by Δscore:

Variant	Effect	Δscore
19:44141662:GGACT:G	donor_gain	1.0000
19:44142368:G:GG	donor_gain	1.0000
19:44144750:C:G	donor_gain	1.0000
19:44148769:AGGAG:A	acceptor_gain	1.0000
19:44148770:GGA:G	acceptor_gain	1.0000
19:44148770:GGAGG:G	acceptor_gain	1.0000
19:44148881:G:GT	donor_gain	1.0000
19:44148894:GTGG:G	donor_gain	1.0000
19:44148896:GG:G	donor_gain	1.0000
19:44148897:GG:G	donor_gain	1.0000
19:44148898:G:GG	donor_gain	1.0000
19:44148898:GTG:G	donor_loss	1.0000
19:44148899:T:G	donor_loss	1.0000
19:44148903:G:GT	donor_gain	1.0000
19:44141583:G:T	donor_gain	0.9900
19:44141663:G:T	donor_gain	0.9900
19:44141663:GACT:G	donor_gain	0.9900
19:44142366:ACGTG:A	donor_loss	0.9900
19:44142367:CGTG:C	donor_loss	0.9900
19:44142368:G:GA	donor_loss	0.9900
19:44142369:T:A	donor_loss	0.9900
19:44144553:ATAGT:A	acceptor_gain	0.9900
19:44144554:T:G	acceptor_gain	0.9900
19:44144555:A:AG	acceptor_gain	0.9900
19:44144556:G:GG	acceptor_gain	0.9900
19:44144556:GT:G	acceptor_gain	0.9900
19:44148768:TAGG:T	acceptor_gain	0.9900
19:44148769:A:AG	acceptor_gain	0.9900
19:44148769:AG:A	acceptor_gain	0.9900
19:44148769:AGGA:A	acceptor_gain	0.9900

AlphaMissense

4692 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:44156989:T:C	F325L	0.996
19:44156991:C:A	F325L	0.996
19:44156991:C:G	F325L	0.996
19:44157241:T:C	F409L	0.996
19:44157243:C:A	F409L	0.996
19:44157243:C:G	F409L	0.996
19:44157325:T:C	F437L	0.996
19:44157327:C:A	F437L	0.996
19:44157327:C:G	F437L	0.996
19:44157493:T:C	F493L	0.996
19:44157495:T:A	F493L	0.996
19:44157495:T:G	F493L	0.996
19:44157745:T:C	F577L	0.996
19:44157747:C:A	F577L	0.996
19:44157747:C:G	F577L	0.996
19:44156905:T:C	F297L	0.995
19:44156907:C:A	F297L	0.995
19:44156907:C:G	F297L	0.995
19:44157577:T:C	F521L	0.995
19:44157579:C:A	F521L	0.995
19:44157579:C:G	F521L	0.995
19:44157829:T:C	F605L	0.995
19:44157831:C:A	F605L	0.995
19:44157831:C:G	F605L	0.995
19:44156821:T:C	F269L	0.994
19:44156823:C:A	F269L	0.994
19:44156823:C:G	F269L	0.994
19:44157008:T:C	L331P	0.994
19:44157157:T:C	F381L	0.994
19:44157159:C:A	F381L	0.994

dbSNP variants (sampled 300 via entrez): RS1000282031 (19:44153031 C>A), RS1000418865 (19:44153283 G>A), RS1000711097 (19:44160360 A>G), RS1000738174 (19:44140507 C>T), RS1000803414 (19:44150867 C>T), RS1001252925 (19:44143088 C>T), RS1001390350 (19:44143333 G>A,T), RS1001640006 (19:44149760 C>A,T), RS1001871180 (19:44144726 C>T), RS1002087721 (19:44155012 C>T), RS1002242820 (19:44148113 T>G), RS1002641697 (19:44154251 C>T), RS1002701513 (19:44148477 G>A), RS1002843700 (19:44150992 G>A), RS1002946174 (19:44144477 G>A)

Disease associations

OMIM: gene MIM:604750 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation, affects methylation	3
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
2-butenal	decreases expression	1
sodium arsenite	increases abundance, increases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	decreases expression	1
bisphenol S	increases methylation	1
Temozolomide	increases expression	1
Air Pollutants	decreases expression	1
Arsenic	increases abundance, increases expression	1
Cadmium	increases abundance, increases expression	1
Doxorubicin	decreases expression	1
Methapyrilene	decreases methylation	1
Tetrachlorodibenzodioxin	affects expression	1
Urethane	decreases expression	1
Valproic Acid	decreases expression	1
Copper Sulfate	increases expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.