ZNF236
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Summary
ZNF236 (zinc finger protein 236, HGNC:13028) is a protein-coding gene on chromosome 18q23, encoding Zinc finger protein 236 (Q9UL36). May be involved in transcriptional regulation. It is a selective cancer dependency (DepMap: 17.4% of cell lines).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glucose stimulus. Predicted to be active in nucleus.
Source: NCBI Gene 7776 — RefSeq curated summary.
At a glance
- GWAS associations: 6
- Clinical variants (ClinVar): 279 total
- Cancer dependency (DepMap): dependent in 17.4% of screened cell lines
- Transcription factor: yes — 14 downstream targets (CollecTRI)
- MANE Select transcript:
NM_001306089
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:13028 |
| Approved symbol | ZNF236 |
| Name | zinc finger protein 236 |
| Location | 18q23 |
| Locus type | gene with protein product |
| Status | Approved |
| Ensembl gene | ENSG00000130856 |
| Ensembl biotype | protein_coding |
| OMIM | 604760 |
| Entrez | 7776 |
Gene structure
Transcript identifiers
Ensembl transcripts: 9 — 3 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron, 2 protein_coding_CDS_not_defined
ENST00000253159, ENST00000320610, ENST00000543926, ENST00000579322, ENST00000583095, ENST00000583488, ENST00000584565, ENST00000645888, ENST00000706008
RefSeq mRNA: 2 — MANE Select: NM_001306089
NM_001306089, NM_007345
CCDS: CCDS42447, CCDS77201
Canonical transcript exons
ENST00000320610 — 31 exons
| Exon | Start | End |
|---|---|---|
| ENSE00000894918 | 76851775 | 76851939 |
| ENSE00000894937 | 76878009 | 76878152 |
| ENSE00000894939 | 76880113 | 76880316 |
| ENSE00001179496 | 76875492 | 76875664 |
| ENSE00001179502 | 76871701 | 76871825 |
| ENSE00001280714 | 76910660 | 76910811 |
| ENSE00001280724 | 76910068 | 76910169 |
| ENSE00001280732 | 76908320 | 76908573 |
| ENSE00001280745 | 76904380 | 76904521 |
| ENSE00001280757 | 76895013 | 76895285 |
| ENSE00001280856 | 76912244 | 76912347 |
| ENSE00001280886 | 76905155 | 76905415 |
| ENSE00001280898 | 76899019 | 76899222 |
| ENSE00001299490 | 76927277 | 76927517 |
| ENSE00001300789 | 76925189 | 76925554 |
| ENSE00001309083 | 76919776 | 76920058 |
| ENSE00001325501 | 76923071 | 76923174 |
| ENSE00001326724 | 76927037 | 76927182 |
| ENSE00001330668 | 76927927 | 76928106 |
| ENSE00001383033 | 76849526 | 76849668 |
| ENSE00002702314 | 76822557 | 76822662 |
| ENSE00002712372 | 76968215 | 76972901 |
| ENSE00003461570 | 76868685 | 76868863 |
| ENSE00003471855 | 76937156 | 76937343 |
| ENSE00003521981 | 76959687 | 76959816 |
| ENSE00003569780 | 76955985 | 76956182 |
| ENSE00003591609 | 76960679 | 76960855 |
| ENSE00003609826 | 76913747 | 76913898 |
| ENSE00003626243 | 76881284 | 76881512 |
| ENSE00003680587 | 76915647 | 76915859 |
| ENSE00003690442 | 76947521 | 76947652 |
Expression profiles
Bgee: expression breadth ubiquitous, 277 present calls, max score 93.08.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.3388 / max 22.3062, expressed in 1209 samples.
FANTOM5 promoters (1 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 170803 | 2.3388 | 1209 |
Top tissues by expression
287 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| sural nerve | UBERON:0015488 | 93.08 | gold quality |
| gingival epithelium | UBERON:0001949 | 92.83 | gold quality |
| calcaneal tendon | UBERON:0003701 | 92.83 | gold quality |
| buccal mucosa cell | CL:0002336 | 92.69 | silver quality |
| germinal epithelium of ovary | UBERON:0001304 | 91.58 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 88.60 | gold quality |
| mucosa of urinary bladder | UBERON:0001259 | 88.36 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 88.35 | gold quality |
| corpus callosum | UBERON:0002336 | 87.35 | gold quality |
| olfactory bulb | UBERON:0002264 | 85.20 | silver quality |
| mucosa of paranasal sinus | UBERON:0005030 | 85.19 | gold quality |
| type B pancreatic cell | CL:0000169 | 84.68 | gold quality |
| gingiva | UBERON:0001828 | 84.25 | gold quality |
| superficial temporal artery | UBERON:0001614 | 84.16 | gold quality |
| hair follicle | UBERON:0002073 | 83.99 | silver quality |
| tendon | UBERON:0000043 | 83.34 | gold quality |
| epithelium of nasopharynx | UBERON:0001951 | 82.16 | gold quality |
| diaphragm | UBERON:0001103 | 82.06 | gold quality |
| tibia | UBERON:0000979 | 82.00 | gold quality |
| visceral pleura | UBERON:0002401 | 81.79 | gold quality |
| pleura | UBERON:0000977 | 81.18 | gold quality |
| medial globus pallidus | UBERON:0002477 | 80.36 | gold quality |
| parietal pleura | UBERON:0002400 | 80.25 | gold quality |
| adrenal tissue | UBERON:0018303 | 79.96 | gold quality |
| cortical plate | UBERON:0005343 | 79.50 | gold quality |
| bone marrow cell | CL:0002092 | 79.47 | gold quality |
| thymus | UBERON:0002370 | 79.17 | gold quality |
| tonsil | UBERON:0002372 | 78.67 | gold quality |
| globus pallidus | UBERON:0001875 | 77.90 | gold quality |
| epithelial cell of pancreas | CL:0000083 | 77.80 | silver quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 5.79 |
Regulation
Is transcription factor: yes
Downstream targets (CollecTRI)
14 targets.
| Target | Regulation |
|---|---|
| ADH1B | |
| CHMP4A | |
| CSNK2A2 | |
| CXCL9 | |
| FERMT2 | |
| GCGR | |
| INS | |
| MAPK3 | |
| NEUROD1 | |
| PC | |
| PDX1 | |
| PKLR | |
| SLC2A2 | |
| VPS4B |
miRNA regulators (miRDB)
226 targeting ZNF236, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-3163 | 100.00 | 77.23 | 8605 |
| HSA-MIR-5692A | 100.00 | 74.40 | 6850 |
| HSA-LET-7A-3P | 100.00 | 74.03 | 3932 |
| HSA-LET-7B-3P | 100.00 | 74.08 | 3913 |
| HSA-LET-7F-1-3P | 100.00 | 74.02 | 3928 |
| HSA-MIR-98-3P | 100.00 | 74.08 | 3907 |
| HSA-MIR-190A-3P | 100.00 | 80.35 | 5520 |
| HSA-MIR-6740-5P | 100.00 | 65.64 | 932 |
| HSA-MIR-340-5P | 100.00 | 72.50 | 4437 |
| HSA-MIR-9-5P | 100.00 | 72.28 | 2361 |
| HSA-MIR-3613-3P | 100.00 | 76.36 | 7965 |
| HSA-MIR-656-3P | 100.00 | 72.15 | 2788 |
| HSA-MIR-4795-3P | 100.00 | 74.62 | 4024 |
| HSA-MIR-5011-5P | 100.00 | 83.46 | 5820 |
| HSA-MIR-1252-5P | 100.00 | 69.80 | 2774 |
| HSA-MIR-4682 | 100.00 | 68.89 | 1258 |
| HSA-MIR-3662 | 99.99 | 73.82 | 5684 |
| HSA-MIR-196A-1-3P | 99.99 | 72.15 | 2772 |
| HSA-MIR-4282 | 99.99 | 75.36 | 6408 |
| HSA-MIR-513B-5P | 99.99 | 69.96 | 2150 |
| HSA-MIR-548C-3P | 99.99 | 74.01 | 7587 |
| HSA-MIR-4775 | 99.98 | 75.00 | 6394 |
| HSA-MIR-12136 | 99.98 | 72.81 | 5713 |
| HSA-MIR-520D-5P | 99.98 | 73.34 | 4883 |
| HSA-MIR-524-5P | 99.98 | 73.43 | 4882 |
| HSA-MIR-3148 | 99.97 | 75.06 | 6478 |
| HSA-MIR-548AN | 99.97 | 70.91 | 2817 |
| HSA-MIR-302C-5P | 99.97 | 72.56 | 3642 |
| HSA-MIR-607 | 99.97 | 73.62 | 5593 |
| HSA-MIR-3065-5P | 99.97 | 71.56 | 3281 |
Functional genomics
DepMap (CRISPR cell-line fitness): dependent in 17.4% of screened cell lines.
Cross-species orthologs
4 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | znf236 | ENSDARG00000095890 |
| mus_musculus | Zfp236 | ENSMUSG00000041258 |
| rattus_norvegicus | Zfp236 | ENSRNOG00000016303 |
| drosophila_melanogaster | CG15073 | FBGN0034379 |
Protein
Protein identifiers
Zinc finger protein 236 — Q9UL36 (reviewed: Q9UL36)
All UniProt accessions (4): Q9UL36, A0A2R8YCW3, A0A994J512, J9JID5
UniProt curated annotations — full annotation on UniProt →
Function. May be involved in transcriptional regulation.
Subcellular location. Nucleus.
Tissue specificity. Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.
Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.
Isoforms (2)
| UniProt ID | Names | Canonical? |
|---|---|---|
| Q9UL36-1 | B | yes |
| Q9UL36-2 | A |
RefSeq proteins (2): NP_001293018, NP_031371 (=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR013087 | Znf_C2H2_type | Domain |
| IPR036236 | Znf_C2H2_sf | Homologous_superfamily |
| IPR051643 | Transcr_Reg_ZincFinger | Family |
Pfam: PF00096, PF12874, PF13465, PF13912
UniProt features (45 total): zinc finger region 30, sequence variant 5, region of interest 3, compositionally biased region 3, splice variant 2, chain 1, sequence conflict 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q9UL36-F1 | 55.21 | 0.04 |
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 161 (showing top):
GSE45365_NK_CELL_VS_CD8A_DC_UP, GSE45365_NK_CELL_VS_BCELL_UP, LEE_NEURAL_CREST_STEM_CELL_DN, TGCACTT_MIR519C_MIR519B_MIR519A, AAGCCAT_MIR135A_MIR135B, GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS, GCAAGGA_MIR502, TATTATA_MIR374, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, BLALOCK_ALZHEIMERS_DISEASE_UP, ACATTCC_MIR1_MIR206, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP, GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS, GOBP_CARBOHYDRATE_HOMEOSTASIS
GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), cellular response to glucose stimulus (GO:0071333)
GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)
GO Cellular Component (1): nucleus (GO:0005634)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | 2 |
| regulation of DNA-templated transcription | 1 |
| transcription by RNA polymerase II | 1 |
| intracellular glucose homeostasis | 1 |
| response to glucose | 1 |
| cellular response to hexose stimulus | 1 |
| cis-regulatory region sequence-specific DNA binding | 1 |
| chromatin | 1 |
| DNA-binding transcription factor activity | 1 |
| regulation of transcription by RNA polymerase II | 1 |
| transition metal ion binding | 1 |
| nucleic acid binding | 1 |
| binding | 1 |
| cation binding | 1 |
| intracellular membrane-bounded organelle | 1 |
Protein interactions and networks
STRING
1075 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| ZNF236 | CAPN15 | O75808 | 480 |
| ZNF236 | CCAR2 | Q8N163 | 477 |
| ZNF236 | MLLT3 | P42568 | 456 |
| ZNF236 | GALR1 | P47211 | 454 |
| ZNF236 | MED8 | Q96G25 | 443 |
| ZNF236 | ETV7 | Q9Y603 | 426 |
| ZNF236 | FOXP2 | O15409 | 422 |
| ZNF236 | ZNF594 | Q96JF6 | 417 |
| ZNF236 | CA8 | P35219 | 416 |
| ZNF236 | TFB2M | Q9H5Q4 | 406 |
| ZNF236 | PTGR3 | Q8N4Q0 | 397 |
| ZNF236 | TRDN | Q13061 | 379 |
| ZNF236 | PPAN | Q9NQ55 | 373 |
| ZNF236 | DOT1L | Q8TEK3 | 369 |
| ZNF236 | MAMLD1 | Q13495 | 366 |
IntAct
5 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| PRKAB2 | ZNF236 | psi-mi:“MI:0915”(physical association) | 0.560 |
| KRR1 | PES1 | psi-mi:“MI:0914”(association) | 0.350 |
BioGRID (12): ZNF236 (Affinity Capture-MS), ZNF236 (Affinity Capture-RNA), ZNF236 (Two-hybrid), ZNF236 (Affinity Capture-RNA), ZNF236 (Affinity Capture-RNA), PRKAB2 (Two-hybrid), ZNF236 (Positive Genetic), ZNF236 (Affinity Capture-MS), ZNF236 (Affinity Capture-MS), ZNF236 (Affinity Capture-RNA), ZNF236 (Affinity Capture-RNA), ZNF236 (Cross-Linking-MS (XL-MS))
ESM2 similar proteins: A0JPB4, A1L1J6, A4IFJ6, D3ZUU2, E9Q8T2, G5E8B9, O08954, O15060, O42409, O43623, O57415, O70237, O75626, O95625, P19382, P25932, P36197, P37275, P97469, Q20082, Q2EI20, Q3MHQ4, Q3UH06, Q4VBD9, Q5DU09, Q5R9W9, Q5SVQ8, Q5T0B9, Q5ZLR2, Q60542, Q60636, Q62947, Q64318, Q6DCW1, Q6GNP2, Q6INV8, Q6NRM0, Q7TS63, Q7ZVR6, Q80X44
Diamond homologs: A0A9P4XV22, A2ANX9, B1H2Q6, O62836, P08048, P0CJ78, P10925, P17010, P17012, P20662, P27705, P28698, P52288, P80944, Q01611, Q03081, Q03125, Q0VDT2, Q29419, Q3U3I9, Q52V16, Q567C6, Q5U2Z0, Q6B4Z5, Q7RTV3, Q95LI3, Q966L8, Q96EG3, Q9UDV6, Q9UL36, Q9Y462, B0K011, B0X9H6, E9Q6W4, O75362, O77459, P31509, P60319, P86413, Q01798
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
279 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 207 |
| Likely benign | 23 |
| Benign | 13 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
5749 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 18:76849512:AT:A | acceptor_gain | 1.0000 |
| 18:76849513:T:G | acceptor_gain | 1.0000 |
| 18:76849513:T:TA | acceptor_gain | 1.0000 |
| 18:76849516:A:AG | acceptor_gain | 1.0000 |
| 18:76849524:A:AG | acceptor_gain | 1.0000 |
| 18:76849524:AGAT:A | acceptor_gain | 1.0000 |
| 18:76849525:G:GG | acceptor_gain | 1.0000 |
| 18:76849525:GATG:G | acceptor_gain | 1.0000 |
| 18:76849669:G:GG | donor_gain | 1.0000 |
| 18:76851769:A:AG | acceptor_gain | 1.0000 |
| 18:76851770:A:G | acceptor_gain | 1.0000 |
| 18:76851773:A:AG | acceptor_gain | 1.0000 |
| 18:76851774:G:GA | acceptor_gain | 1.0000 |
| 18:76851774:GCC:G | acceptor_gain | 1.0000 |
| 18:76851774:GCCAC:G | acceptor_gain | 1.0000 |
| 18:76851934:G:GT | donor_gain | 1.0000 |
| 18:76868682:CAGA:C | acceptor_loss | 1.0000 |
| 18:76868683:A:AG | acceptor_gain | 1.0000 |
| 18:76868683:A:C | acceptor_loss | 1.0000 |
| 18:76868684:G:GA | acceptor_gain | 1.0000 |
| 18:76868684:GA:G | acceptor_gain | 1.0000 |
| 18:76868843:G:GT | donor_gain | 1.0000 |
| 18:76868863:GGTA:G | donor_gain | 1.0000 |
| 18:76871696:ACTAG:A | acceptor_gain | 1.0000 |
| 18:76871822:ACAG:A | donor_loss | 1.0000 |
| 18:76871823:CAG:C | donor_loss | 1.0000 |
| 18:76871824:AG:A | donor_loss | 1.0000 |
| 18:76871825:GGTAT:G | donor_loss | 1.0000 |
| 18:76871826:G:GA | donor_loss | 1.0000 |
| 18:76871827:T:A | donor_loss | 1.0000 |
AlphaMissense
12232 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 18:76851784:T:C | C68R | 1.000 |
| 18:76851793:T:C | C71R | 1.000 |
| 18:76851824:T:C | L81P | 1.000 |
| 18:76871759:T:C | C199R | 1.000 |
| 18:76871807:C:G | H215D | 1.000 |
| 18:76871809:C:A | H215Q | 1.000 |
| 18:76871809:C:G | H215Q | 1.000 |
| 18:76875509:T:C | C227R | 1.000 |
| 18:76875518:T:C | C230R | 1.000 |
| 18:76875530:T:C | F234L | 1.000 |
| 18:76875531:T:C | F234S | 1.000 |
| 18:76875532:T:A | F234L | 1.000 |
| 18:76875532:T:G | F234L | 1.000 |
| 18:76875538:G:C | Q236H | 1.000 |
| 18:76875538:G:T | Q236H | 1.000 |
| 18:76875549:T:C | L240P | 1.000 |
| 18:76875557:C:G | H243D | 1.000 |
| 18:76875559:C:A | H243Q | 1.000 |
| 18:76875559:C:G | H243Q | 1.000 |
| 18:76875593:T:C | C255R | 1.000 |
| 18:76875594:G:A | C255Y | 1.000 |
| 18:76875595:T:G | C255W | 1.000 |
| 18:76875602:T:C | C258R | 1.000 |
| 18:76875603:G:A | C258Y | 1.000 |
| 18:76875604:T:G | C258W | 1.000 |
| 18:76875614:T:C | F262L | 1.000 |
| 18:76875615:T:C | F262S | 1.000 |
| 18:76875616:C:A | F262L | 1.000 |
| 18:76875616:C:G | F262L | 1.000 |
| 18:76875633:T:C | L268P | 1.000 |
dbSNP variants (sampled 300 via entrez): RS1000048008 (18:76862900 A>G), RS1000054036 (18:76958673 T>C), RS1000060421 (18:76936476 T>C), RS1000078624 (18:76862699 A>G), RS1000121419 (18:76949701 C>A), RS1000141812 (18:76906749 A>C), RS1000147061 (18:76891215 T>A), RS1000151766 (18:76888350 G>A,C), RS1000154712 (18:76876692 A>C), RS1000159020 (18:76869849 G>A), RS1000171031 (18:76829396 C>T), RS1000205416 (18:76844198 C>T), RS1000208101 (18:76953402 C>T), RS1000218471 (18:76931559 G>A,T), RS1000228140 (18:76823789 C>A,T)
Disease associations
OMIM: gene MIM:604760 | disease phenotypes:
GenCC curated gene-disease
Mondo (1): neurodevelopmental disorder (MONDO:0700092)
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
6 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST002007_4 | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | 2.000000e-06 |
| GCST002701_38 | Verbal declarative memory | 2.000000e-06 |
| GCST004863_86 | Mosquito bite size | 6.000000e-06 |
| GCST009391_1470 | Metabolite levels | 1.000000e-06 |
| GCST009391_1826 | Metabolite levels | 6.000000e-06 |
| GCST011320_34 | Type 2 diabetes or prostate cancer (pleiotropy) | 2.000000e-08 |
EFO canonical traits (5, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0004874 | memory performance |
| EFO:0006805 | word list delayed recall measurement |
| EFO:0008378 | mosquito bite reaction size measurement |
| EFO:0010407 | triacylglycerol 48:4 measurement |
| EFO:0010411 | triacylglycerol 50:4 measurement |
MeSH disease descriptors (1)
| Descriptor | Name | Tree numbers |
|---|---|---|
| D065886 | Neurodevelopmental Disorders | F03.625 |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
22 total (human), top 22 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Phenylmercuric Acetate | affects cotreatment, decreases expression | 2 |
| aristolochic acid I | decreases expression | 1 |
| methylmercuric chloride | decreases expression | 1 |
| triphenyl phosphate | affects expression | 1 |
| beta-lapachone | decreases expression, increases expression | 1 |
| butyraldehyde | decreases expression | 1 |
| cupric oxide | increases expression | 1 |
| CGP 52608 | affects binding, increases reaction | 1 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | decreases expression, affects cotreatment | 1 |
| dorsomorphin | affects cotreatment, decreases expression | 1 |
| Sunitinib | increases expression | 1 |
| Amphotericin B | increases expression | 1 |
| Arsenic | affects methylation | 1 |
| Benzo(a)pyrene | increases methylation | 1 |
| Cadmium | decreases expression, increases abundance | 1 |
| Carbamazepine | affects expression | 1 |
| Formaldehyde | decreases expression | 1 |
| Hydrogen Peroxide | decreases expression | 1 |
| Valproic Acid | decreases methylation | 1 |
| Aflatoxin B1 | decreases methylation | 1 |
| Cadmium Chloride | decreases expression, increases abundance | 1 |
| Copper Sulfate | increases expression | 1 |
Clinical trials (associated diseases)
202 trials via MONDO — disease-level, not drug-specific.
| Trial | Phase | Status | Title |
|---|---|---|---|
| NCT04586348 | PHASE4 | UNKNOWN | Prenatal Iodine Supplementation and Early Childhood Neurodevelopment |
| NCT04873115 | PHASE4 | UNKNOWN | Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties, |
| NCT02559102 | PHASE3 | COMPLETED | Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants |
| NCT02757079 | PHASE3 | COMPLETED | Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders |
| NCT06915480 | PHASE3 | RECRUITING | Reducing Missed Appointments |
| NCT07377032 | PHASE3 | RECRUITING | TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders |
| NCT02909959 | PHASE2 | COMPLETED | Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder |
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Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): prostate carcinoma