ZNF26

Summary

ZNF26 (zinc finger protein 26, HGNC:13053) is a protein-coding gene on chromosome 12q24.33, encoding Zinc finger protein 26 (P17031). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 7574 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 23 total
• MANE Select transcript: NM_019591

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13053
Approved symbol	ZNF26
Name	zinc finger protein 26
Location	12q24.33
Locus type	gene with protein product
Status	Approved
Aliases	KOX20, FLJ20755
Ensembl gene	ENSG00000198393
Ensembl biotype	protein_coding
OMIM	194537
Entrez	7574

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 3 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000328654, ENST00000534834, ENST00000537956, ENST00000540238, ENST00000544181, ENST00000545101, ENST00000627376, ENST00000943709

RefSeq mRNA: 5 — MANE Select: NM_019591 NM_001256279, NM_001256280, NM_001330513, NM_001330514, NM_019591

CCDS: CCDS31939

Canonical transcript exons

ENST00000328654 — 4 exons

Exon	Start	End
ENSE00001624558	133007042	133007168
ENSE00001695579	133010136	133027102
ENSE00001768259	133007437	133007532
ENSE00002279717	132986367	132986873

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 87.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.7888 / max 87.0869, expressed in 1742 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128847	7.1356	1699
128846	1.1991	658
128848	0.4541	236

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	87.14	silver quality
middle temporal gyrus	UBERON:0002771	82.35	gold quality
pancreatic ductal cell	CL:0002079	81.53	silver quality
epithelial cell of pancreas	CL:0000083	81.10	gold quality
Brodmann (1909) area 23	UBERON:0013554	81.10	gold quality
granulocyte	CL:0000094	79.50	gold quality
tibia	UBERON:0000979	79.30	gold quality
ventricular zone	UBERON:0003053	79.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.24	gold quality
choroid plexus epithelium	UBERON:0003911	78.20	gold quality
monocyte	CL:0000576	77.98	gold quality
hair follicle	UBERON:0002073	77.86	silver quality
germinal epithelium of ovary	UBERON:0001304	77.85	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.81	gold quality
leukocyte	CL:0000738	77.74	gold quality
mononuclear cell	CL:0000842	77.73	gold quality
cortical plate	UBERON:0005343	77.35	gold quality
visceral pleura	UBERON:0002401	76.79	gold quality
cartilage tissue	UBERON:0002418	76.64	gold quality
ganglionic eminence	UBERON:0004023	76.59	gold quality
sural nerve	UBERON:0015488	76.59	gold quality
cauda epididymis	UBERON:0004360	76.27	gold quality
CA1 field of hippocampus	UBERON:0003881	76.12	gold quality
pleura	UBERON:0000977	76.09	gold quality
spleen	UBERON:0002106	76.08	gold quality
tibial nerve	UBERON:0001323	76.05	gold quality
body of pancreas	UBERON:0001150	76.02	gold quality
stromal cell of endometrium	CL:0002255	75.86	gold quality
skin of abdomen	UBERON:0001416	75.77	gold quality
skin of leg	UBERON:0001511	75.69	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.79
E-CURD-10	no	343.75

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

50 targeting ZNF26, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-4658	99.77	64.94	514
HSA-MIR-6790-5P	99.77	65.24	505
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-6516-3P	99.65	68.57	1238
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-3682-3P	99.58	67.63	865

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 26 — P17031 (reviewed: P17031)

Alternative names: Zinc finger protein KOX20

All UniProt accessions (4): P17031, F5GZ77, F5H2P7, V9HW07

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (5): NP_001243208, NP_001243209, NP_001317442, NP_001317443, NP_062537* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (15 total): zinc finger region 13, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P17031-F1	73.81	0.24

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 42 (showing top): DODD_NASOPHARYNGEAL_CARCINOMA_UP, HAN_SATB1_TARGETS_DN, chr12q24, PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN, DIDO1_TARGET_GENES, ELF2_TARGET_GENES, NFE2L1_TARGET_GENES, ZBTB18_TARGET_GENES, ZNF30_TARGET_GENES, ZNF350_TARGET_GENES, ZNF708_TARGET_GENES, MIR1468_3P, LET_7C_3P, MIR548AV_5P_MIR548K, MIR4766_5P

GO Biological Process (1): regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (4): DNA binding (GO:0003677), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

412 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF26	DDX50	Q9BQ39	416
ZNF26	CTIF	O43310	410
ZNF26	MIF4GD	A9UHW6	371
ZNF26	LBX2	Q6XYB7	370
ZNF26	TREX2	Q9BQ50	369
ZNF26	CES4A	Q5XG92	348
ZNF26	SLBP	Q14493	278
ZNF26	CLVS1	Q8IUQ0	267
ZNF26	TLX2	O43763	266
ZNF26	GOLGA3	Q08378	262
ZNF26	POU6F1	Q14863	261
ZNF26	RPS20	P17075	253
ZNF26	HPSE2	Q8WWQ2	245
ZNF26	A0A2R8Y455	A0A2R8Y455	228
ZNF26	SNAPIN	O95295	222

IntAct

25 interactions, top by confidence:

A	B	Type	Score
TRIM39	ZNF26	psi-mi:“MI:0915”(physical association)	0.670
ZNF26	TRIM39	psi-mi:“MI:0915”(physical association)	0.670
KRTAP10-7	ZNF26	psi-mi:“MI:0915”(physical association)	0.560
TP53BP2	ZNF26	psi-mi:“MI:0915”(physical association)	0.560
KRT40	ZNF26	psi-mi:“MI:0915”(physical association)	0.560
ZNF26	TRIM41	psi-mi:“MI:0915”(physical association)	0.560
ZNF26		psi-mi:“MI:0915”(physical association)	0.560
TRIM41	ZNF26	psi-mi:“MI:0915”(physical association)	0.560
	ZNF26	psi-mi:“MI:0915”(physical association)	0.560
ZNF26	TP53BP2	psi-mi:“MI:0915”(physical association)	0.560
ZNF397	ZNF197	psi-mi:“MI:0914”(association)	0.530
ZNF26	MTCL2	psi-mi:“MI:0914”(association)	0.350
ZNF26	leuD	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (13): ZNF26 (Two-hybrid), TRIM39 (Two-hybrid), TRIM41 (Two-hybrid), KRT40 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZNF26 (Affinity Capture-MS), SORL1 (Affinity Capture-MS), SOGA1 (Affinity Capture-MS), TRIM28 (Affinity Capture-MS), MTCL1 (Affinity Capture-MS), ZNF26 (Affinity Capture-MS), ZNF26 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A3KN32, A3KN36, O14709, O43296, O75123, P15622, P16373, P17023, P17031, P17097, P52736, P85977, Q07230, Q12901, Q14929, Q29RZ4, Q4V8A8, Q571J5, Q5CZA5, Q5JNZ3, Q5R7I8, Q5RBX0, Q5RBY9, Q5RCD9, Q5RCX4, Q61751, Q61967, Q6GQR8, Q6IV72, Q6NX45, Q6PK81, Q6ZMS4, Q7TNU6, Q7TSH9, Q7Z398, Q7Z7L9, Q8BI99, Q8BIQ3, Q8BLB0, Q8IZ26

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	20
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1509 predictions. Top by Δscore:

Variant	Effect	Δscore
12:132986869:GCTGG:G	donor_gain	1.0000
12:132986870:CTGG:C	donor_gain	1.0000
12:132986871:TGGGT:T	donor_loss	1.0000
12:132986872:GG:G	donor_gain	1.0000
12:132986873:GG:G	donor_gain	1.0000
12:132986873:GGTA:G	donor_loss	1.0000
12:132986874:G:GG	donor_gain	1.0000
12:133007165:GTGG:G	donor_gain	1.0000
12:133007166:TGG:T	donor_gain	1.0000
12:133007167:GG:G	donor_gain	1.0000
12:133007167:GGG:G	donor_gain	1.0000
12:133007167:GGGT:G	donor_loss	1.0000
12:133007168:GG:G	donor_gain	1.0000
12:133007168:GGT:G	donor_loss	1.0000
12:133007169:G:GG	donor_gain	1.0000
12:133007170:T:TC	donor_loss	1.0000
12:133010133:TA:T	acceptor_loss	1.0000
12:133010134:A:AG	acceptor_gain	1.0000
12:133010135:G:GC	acceptor_loss	1.0000
12:133010135:G:GG	acceptor_gain	1.0000
12:133010135:GAT:G	acceptor_gain	1.0000
12:132986871:TGG:T	donor_gain	0.9900
12:132986872:GGG:G	donor_gain	0.9900
12:132986875:T:A	donor_loss	0.9900
12:133006691:TTC:T	donor_gain	0.9900
12:133007040:AG:A	acceptor_gain	0.9900
12:133007041:GG:G	acceptor_gain	0.9900
12:133007164:AGTGG:A	donor_gain	0.9900
12:133007165:GTGGG:G	donor_gain	0.9900
12:133007166:TGGGT:T	donor_gain	0.9900

AlphaMissense

3539 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:133011098:T:C	F407L	0.999
12:133011100:C:A	F407L	0.999
12:133011100:C:G	F407L	0.999
12:133011182:T:C	F435L	0.999
12:133011184:T:A	F435L	0.999
12:133011184:T:G	F435L	0.999
12:133011350:T:C	F491L	0.999
12:133011352:C:A	F491L	0.999
12:133011352:C:G	F491L	0.999
12:133010510:T:C	F211L	0.998
12:133010512:C:A	F211L	0.998
12:133010512:C:G	F211L	0.998
12:133010930:T:C	F351L	0.998
12:133010932:C:A	F351L	0.998
12:133010932:C:G	F351L	0.998
12:133011014:T:C	F379L	0.998
12:133011016:T:A	F379L	0.998
12:133011016:T:G	F379L	0.998
12:133010762:T:C	F295L	0.997
12:133010764:T:A	F295L	0.997
12:133010764:T:G	F295L	0.997
12:133011125:C:G	H416D	0.997
12:133011201:T:C	L441P	0.997
12:133011434:T:C	F519L	0.997
12:133011436:C:A	F519L	0.997
12:133011436:C:G	F519L	0.997
12:133010846:T:C	F323L	0.996
12:133010848:T:A	F323L	0.996
12:133010848:T:G	F323L	0.996
12:133011033:T:C	L385P	0.996

dbSNP variants (sampled 300 via entrez): RS1000027385 (12:132994483 T>G), RS1000054008 (12:133014457 G>A), RS1000169556 (12:132992018 C>T), RS1000403976 (12:133014797 C>T), RS1000596262 (12:133009364 G>A), RS1000626431 (12:132992321 T>C), RS1000681054 (12:132998004 G>C), RS1000733206 (12:132998317 C>T), RS1000752402 (12:133003688 A>G), RS1000832698 (12:133026978 T>G), RS1000879036 (12:133021691 C>T), RS1000991559 (12:133021957 G>A,C), RS1001280880 (12:132985992 G>A), RS1001316727 (12:133026396 G>C), RS1001388079 (12:133019891 T>A,G)

Disease associations

OMIM: gene MIM:194537 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
beta-lapachone	increases expression	1
sodium arsenite	increases expression	1
pentabromodiphenyl ether	increases expression	1
2-palmitoylglycerol	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Hydrogen Peroxide	affects cotreatment, decreases expression	1
Oxazolone	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Selenium	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Theophylline	affects cotreatment, decreases expression	1
Thiram	increases expression	1
Urethane	decreases expression	1
Vitamin E	affects cotreatment, decreases expression	1
Cadmium Chloride	increases abundance, increases expression	1
Copper Sulfate	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW25	HEK293 eGFP-ZNF26	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.