ZNF263

Summary

ZNF263 (zinc finger protein 263, HGNC:13056) is a protein-coding gene on chromosome 16p13.3, encoding Zinc finger protein 263 (O14978). Transcription factor that binds to the consensus sequence 5’-TCCTCCC-3’ and acts as a transcriptional repressor.

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus.

Source: NCBI Gene 10127 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 120 total
• Transcription factor: yes — 12 downstream targets (CollecTRI)
• MANE Select transcript: NM_005741

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13056
Approved symbol	ZNF263
Name	zinc finger protein 263
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FPM315, ZKSCAN12, ZSCAN44
Ensembl gene	ENSG00000006194
Ensembl biotype	protein_coding
OMIM	604191
Entrez	10127

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000219069, ENST00000572748, ENST00000573578, ENST00000574253, ENST00000574674, ENST00000575332, ENST00000575823, ENST00000703449

RefSeq mRNA: 2 — MANE Select: NM_005741 NM_001411015, NM_005741

CCDS: CCDS10499, CCDS92094

Canonical transcript exons

ENST00000219069 — 6 exons

Exon	Start	End
ENSE00000830618	3289393	3291460
ENSE00002640130	3286023	3286149
ENSE00002653913	3283491	3284205
ENSE00003994561	3288454	3288570
ENSE00003994562	3285059	3285239
ENSE00003994565	3285681	3285754

Expression profiles

Bgee: expression breadth ubiquitous, 276 present calls, max score 91.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.5344 / max 56.0358, expressed in 1790 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
152417	11.2785	1788
152411	2.8462	770
152418	0.2559	101

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	91.38	gold quality
granulocyte	CL:0000094	89.90	gold quality
left ovary	UBERON:0002119	89.86	gold quality
cortical plate	UBERON:0005343	89.82	gold quality
left uterine tube	UBERON:0001303	89.06	gold quality
right ovary	UBERON:0002118	89.03	gold quality
sural nerve	UBERON:0015488	88.95	gold quality
right uterine tube	UBERON:0001302	88.69	gold quality
ventricular zone	UBERON:0003053	88.68	gold quality
mucosa of stomach	UBERON:0001199	88.50	gold quality
ganglionic eminence	UBERON:0004023	88.41	gold quality
body of stomach	UBERON:0001161	88.40	gold quality
right coronary artery	UBERON:0001625	88.34	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.27	gold quality
popliteal artery	UBERON:0002250	88.22	gold quality
tibial artery	UBERON:0007610	88.22	gold quality
islet of Langerhans	UBERON:0000006	88.05	gold quality
pituitary gland	UBERON:0000007	88.01	gold quality
adenohypophysis	UBERON:0002196	87.94	gold quality
body of uterus	UBERON:0009853	87.81	gold quality
cerebellar hemisphere	UBERON:0002245	87.60	gold quality
descending thoracic aorta	UBERON:0002345	87.55	gold quality
cerebellar cortex	UBERON:0002129	87.51	gold quality
aorta	UBERON:0000947	87.47	gold quality
skin of leg	UBERON:0001511	87.39	gold quality
ovary	UBERON:0000992	87.35	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.34	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.28	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.24	gold quality
stomach	UBERON:0000945	87.21	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-75367	yes	82.66
E-MTAB-6142	no	80.10
E-ANND-3	no	4.25

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

12 targets.

Target	Regulation
ALOX5
ASXL1
COL11A2
FOXA1	Repression
GAD1
NFKB
NT5E
RELN
RGS19
SART3
TPM1
ZFP42

JASPAR motifs

Motif	Name	Family
MA0528.1	ZNF263	More than 3 adjacent zinc fingers
MA0528.2	ZNF263	More than 3 adjacent zinc fingers
MA0528.3	ZNF263	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:19887448

Literature-anchored findings (GeneRIF, showing 8)

• Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. (PMID:19887448)
• The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. (PMID:32051553)
• ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. (PMID:32277030)
• Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p. (PMID:34514002)
• Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263. (PMID:37353617)
• Zinc finger protein 263 upregulates interleukin 33 and suppresses autophagy to accelerate the malignant progression of non-small cell lung cancer. (PMID:37821764)
• Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma. (PMID:38335093)
• Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance. (PMID:39294234)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp263	ENSMUSG00000022529
rattus_norvegicus	Zfp263	ENSRNOG00000007678

Paralogs (30): ZNF213 (ENSG00000085644), ZNF500 (ENSG00000103199), ZKSCAN1 (ENSG00000106261), ZNF205 (ENSG00000122386), ZSCAN9 (ENSG00000137185), PGBD1 (ENSG00000137338), ZNF215 (ENSG00000149054), ZSCAN12 (ENSG00000158691), ZNF394 (ENSG00000160908), ZNF75A (ENSG00000162086), ZSCAN21 (ENSG00000166529), ZNF232 (ENSG00000167840), ZNF24 (ENSG00000172466), ZNF449 (ENSG00000173275), ZSCAN4 (ENSG00000180532), ZSCAN22 (ENSG00000182318), ZNF75D (ENSG00000186376), ZNF396 (ENSG00000186496), ZNF397 (ENSG00000186812), ZSCAN30 (ENSG00000186814), ZKSCAN4 (ENSG00000187626), ZSCAN23 (ENSG00000187987), ZKSCAN3 (ENSG00000189298), ZSCAN16 (ENSG00000196812), ZSCAN25 (ENSG00000197037), ZSCAN26 (ENSG00000197062), ZNF165 (ENSG00000197279), ZKSCAN8 (ENSG00000198315), ZSCAN31 (ENSG00000235109), ZNF853 (ENSG00000236609)

Protein

Protein identifiers

Zinc finger protein 263 — O14978 (reviewed: O14978)

Alternative names: Zinc finger protein FPM315, Zinc finger protein with KRAB and SCAN domains 12

All UniProt accessions (7): O14978, B4DI05, D3DUC1, I3L0N0, I3L2X3, I3L393, I3NI39

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor that binds to the consensus sequence 5’-TCCTCCC-3’ and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.

Subunit / interactions. Interacts with a number of proteins involved in chromatin modification and transcriptional corepression including DNMT1, DNMT3A, HDAC2, PHF8, TRIM28/KAP1, SETDB1, EZH2, UHRF1, CBX3/HP1-gamma, and CBX5/HP1-alpha; recruits these proteins to the SIX3 promoter region, leading to SIX3 transcriptional repression. Interacts with MAPK3/ERK1 and MAPK1/ERK2.

Subcellular location. Nucleus.

Tissue specificity. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.

Post-translational modifications. Ubiquitinated, leading to proteasomal degradation.

Miscellaneous. May be involved in the EGFR-mediated promotion of invasion and anchorage-independent growth in glioblastomas via silencing of SIX3. May act as a prognostic indicator in glioblastoma patients, with increased expression correlating with poor prognosis.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001397944, NP_005732* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF02023, PF13465

UniProt features (30 total): zinc finger region 9, cross-link 7, sequence variant 4, region of interest 3, domain 2, modified residue 2, chain 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14978-F1	61.19	0.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 166, 178, 17, 157, 285, 299, 376, 573, 582

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 107 (showing top): ENK_UV_RESPONSE_KERATINOCYTE_UP, DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, BROWNE_HCMV_INFECTION_12HR_UP, PAX2_01, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_UP, GATA1_03, SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UP, MODULE_204, MYB_Q5_01, RIZKI_TUMOR_INVASIVENESS_3D_UP, BROWNE_HCMV_INFECTION_14HR_UP, LAIHO_COLORECTAL_CANCER_SERRATED_DN, GENTILE_UV_LOW_DOSE_UP, MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING

GO Biological Process (4): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (11): transcription cis-regulatory region binding (GO:0000976), RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	3
transcription by RNA polymerase II	3
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of DNA-templated transcription	2
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
positive regulation of DNA-templated transcription	1
transcription regulatory region nucleic acid binding	1
sequence-specific double-stranded DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
DNA binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1536 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF263	FOXA1	P55317	543
ZNF263	RAD21	O60216	528
ZNF263	STAT3	P40763	510
ZNF263	SMC3	Q9UQE7	505
ZNF263	JUN	P05412	486
ZNF263	MEFV	O15553	479
ZNF263	ZKSCAN2	Q63HK3	462
ZNF263	FOXA2	Q9Y261	453
ZNF263	TAL1	P17542	445
ZNF263	SPI1	P17947	442
ZNF263	HOXB13	Q92826	440
ZNF263	TIGD7	Q6NT04	431
ZNF263	GATB	O75879	429
ZNF263	NFKB1	P19838	429
ZNF263	L3MBTL4	Q8NA19	425

IntAct

61 interactions, top by confidence:

A	B	Type	Score
ZNF263	TRIM41	psi-mi:“MI:0915”(physical association)	0.800
ZNF263	SCAND1	psi-mi:“MI:0915”(physical association)	0.800
CLK2	ZNF263	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	CLK3	psi-mi:“MI:0915”(physical association)	0.560
GPATCH2L	ZNF263	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	TCAF1	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	CLK2	psi-mi:“MI:0915”(physical association)	0.560
TCAF1	ZNF263	psi-mi:“MI:0915”(physical association)	0.560
CLK3	ZNF263	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	GPATCH2L	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	ZNF165	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	PPL	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	JAKMIP2	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	ZSCAN22	psi-mi:“MI:0915”(physical association)	0.560
ZNF263	LNX1	psi-mi:“MI:0915”(physical association)	0.560
SUFU	ZNF263	psi-mi:“MI:0915”(physical association)	0.550
ZNF263	SUFU	psi-mi:“MI:0915”(physical association)	0.550
ZNF263	AHCYL1	psi-mi:“MI:0914”(association)	0.530
PCBD1	ZNF263	psi-mi:“MI:0915”(physical association)	0.370
ZNF263	ZSCAN1	psi-mi:“MI:0915”(physical association)	0.370
ZNF263	EFEMP2	psi-mi:“MI:0915”(physical association)	0.370
ZNF263	ZNF446	psi-mi:“MI:0915”(physical association)	0.370
ZNF263	SPG21	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (213): ZNF263 (Two-hybrid), ZNF263 (Two-hybrid), ZNF263 (Two-hybrid), GPATCH2L (Two-hybrid), ZNF263 (Affinity Capture-MS), ZNF263 (Affinity Capture-MS), EFEMP2 (Two-hybrid), ZNF446 (Two-hybrid), SPG21 (Two-hybrid), TRIM41 (Two-hybrid), SCAND1 (Two-hybrid), ZNF263 (Two-hybrid), NME7 (Two-hybrid), SUFU (Two-hybrid), PLEKHF2 (Two-hybrid)

ESM2 similar proteins: A1A5P9, A2AVR2, A6QPT6, B2KFW1, O14978, P17029, P17040, P17098, P25233, P70503, Q13342, Q14D33, Q3SYK4, Q3V3Q4, Q4KLI1, Q4R8H9, Q4V8E9, Q5PPP4, Q5R670, Q5R7U0, Q5VWK0, Q61066, Q63HK3, Q68CQ1, Q6PCZ4, Q7TS72, Q80ZG2, Q8BGS3, Q8CF60, Q8IWY8, Q8N660, Q8NDZ0, Q8TD17, Q921B4, Q923B3, Q96D09, Q96GC6, Q96JL9, Q96M43, Q99608

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

120 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	106
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

971 predictions. Top by Δscore:

Variant	Effect	Δscore
16:3300638:A:T	acceptor_gain	1.0000
16:3284203:CAGGT:C	donor_loss	0.9900
16:3284204:AGG:A	donor_loss	0.9900
16:3284206:GTGA:G	donor_loss	0.9900
16:3284207:T:A	donor_loss	0.9900
16:3285223:GGCT:G	donor_gain	0.9900
16:3285224:GCTG:G	donor_gain	0.9900
16:3285234:A:T	donor_gain	0.9900
16:3285235:GAGGG:G	donor_gain	0.9900
16:3285237:GGG:G	donor_gain	0.9900
16:3285238:GGG:G	donor_gain	0.9900
16:3286021:A:AG	acceptor_gain	0.9900
16:3286022:G:GA	acceptor_gain	0.9900
16:3286123:A:T	donor_gain	0.9900
16:3289388:A:AG	acceptor_gain	0.9900
16:3289389:C:G	acceptor_gain	0.9900
16:3289389:CCA:C	acceptor_loss	0.9900
16:3289390:CA:C	acceptor_loss	0.9900
16:3289391:A:AC	acceptor_loss	0.9900
16:3289391:A:AG	acceptor_gain	0.9900
16:3289392:G:GG	acceptor_gain	0.9900
16:3289392:GGA:G	acceptor_gain	0.9900
16:3285763:G:T	donor_gain	0.9800
16:3289388:ACCAG:A	acceptor_gain	0.9800
16:3300637:C:CT	acceptor_gain	0.9800
16:3284170:GA:G	donor_gain	0.9700
16:3289392:GGAGA:G	acceptor_gain	0.9700
16:3285215:G:T	donor_gain	0.9600
16:3289391:AG:A	acceptor_gain	0.9500
16:3289392:GG:G	acceptor_gain	0.9500

AlphaMissense

4490 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:3289917:T:C	F471L	0.999
16:3289919:C:A	F471L	0.999
16:3289919:C:G	F471L	0.999
16:3290001:T:C	F499L	0.999
16:3290003:T:A	F499L	0.999
16:3290003:T:G	F499L	0.999
16:3290020:T:C	L505P	0.999
16:3290028:C:G	H508D	0.999
16:3290085:T:C	F527L	0.999
16:3290087:C:A	F527L	0.999
16:3290087:C:G	F527L	0.999
16:3290340:T:C	F612L	0.999
16:3290342:C:A	F612L	0.999
16:3290342:C:G	F612L	0.999
16:3290371:A:C	Q622P	0.999
16:3290424:T:C	F640L	0.999
16:3290426:C:A	F640L	0.999
16:3290426:C:G	F640L	0.999
16:3289833:T:C	F443L	0.998
16:3289835:C:A	F443L	0.998
16:3289835:C:G	F443L	0.998
16:3289867:G:C	R454P	0.998
16:3289936:T:C	L477P	0.998
16:3289944:C:G	H480D	0.998
16:3289946:C:A	H480Q	0.998
16:3289946:C:G	H480Q	0.998
16:3289958:C:A	H484Q	0.998
16:3289958:C:G	H484Q	0.998
16:3290002:T:C	F499S	0.998
16:3290030:C:A	H508Q	0.998

dbSNP variants (sampled 300 via entrez): RS1000184372 (16:3292719 G>A,T), RS1000360526 (16:3287300 C>T), RS1000455546 (16:3287204 G>A,C), RS1000743295 (16:3294549 T>C), RS1000762091 (16:3294088 G>C,T), RS1000792025 (16:3288170 T>C,G), RS1000921371 (16:3293956 C>T), RS1001357154 (16:3293052 G>A), RS1001378029 (16:3283208 T>C), RS1001487363 (16:3287571 C>G), RS1001521469 (16:3287851 T>C), RS1001576701 (16:3288633 G>A,T), RS1001627804 (16:3283232 A>T), RS1001633526 (16:3294214 C>T), RS1001750157 (16:3282856 G>A)

Disease associations

OMIM: gene MIM:604191 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	increases expression	2
Aflatoxin B1	decreases methylation, increases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	increases phosphorylation	1
bisphenol F	affects cotreatment, decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
geraniol	increases expression	1
sodium arsenite	increases expression	1
tamibarotene	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Cadmium	increases abundance, increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Diazinon	increases methylation	1
Fluorouracil	affects expression	1
Indomethacin	affects cotreatment, decreases expression	1
Lead	affects expression	1
Plant Extracts	affects cotreatment, increases expression	1
Silver	increases expression	1
Smoke	decreases expression	1
Dronabinol	decreases expression	1
Thiram	increases expression	1
Tretinoin	decreases expression	1
Valproic Acid	increases expression	1
Zinc	affects cotreatment, increases expression	1

Cellosaurus cell lines

4 cell lines: 3 embryonic stem cell, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A8F6	SEES3-1V human ZNF263, clone1	Embryonic stem cell	Male
CVCL_A8F7	SEES3-1V human ZNF263, clone2	Embryonic stem cell	Male
CVCL_A8F8	SEES3-1V human ZNF263, clone3	Embryonic stem cell	Male
CVCL_D9W2	Ubigene HEK293 ZNF263 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.