ZNF264

Summary

ZNF264 (zinc finger protein 264, HGNC:13057) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 264 (O43296). May be involved in transcriptional regulation.

This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription.

Source: NCBI Gene 9422 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 115 total
• Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence
• MANE Select transcript: NM_003417

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13057
Approved symbol	ZNF264
Name	zinc finger protein 264
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0412
Ensembl gene	ENSG00000083844
Ensembl biotype	protein_coding
OMIM	604668
Entrez	9422

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000263095, ENST00000594126, ENST00000597447, ENST00000599653, ENST00000600531

RefSeq mRNA: 1 — MANE Select: NM_003417 NM_003417

CCDS: CCDS33127

Canonical transcript exons

ENST00000263095 — 4 exons

Exon	Start	End
ENSE00001306308	57211354	57222846
ENSE00001322591	57191500	57191946
ENSE00002445959	57205397	57205492
ENSE00002470617	57193875	57194001

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 90.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.4549 / max 63.1018, expressed in 1744 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177741	9.5902	1735
177740	0.8647	608

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	90.55	gold quality
nipple	UBERON:0002030	90.00	gold quality
caput epididymis	UBERON:0004358	88.12	gold quality
bronchial epithelial cell	CL:0002328	87.72	gold quality
visceral pleura	UBERON:0002401	87.00	gold quality
parietal pleura	UBERON:0002400	86.94	gold quality
corpus epididymis	UBERON:0004359	86.92	gold quality
calcaneal tendon	UBERON:0003701	86.20	gold quality
pleura	UBERON:0000977	86.17	gold quality
sural nerve	UBERON:0015488	84.55	gold quality
cauda epididymis	UBERON:0004360	84.11	gold quality
epithelium of bronchus	UBERON:0002031	84.08	gold quality
bronchus	UBERON:0002185	84.01	gold quality
mammalian vulva	UBERON:0000997	83.97	gold quality
endothelial cell	CL:0000115	83.68	gold quality
renal medulla	UBERON:0000362	83.62	gold quality
corpus callosum	UBERON:0002336	83.59	gold quality
urethra	UBERON:0000057	83.46	gold quality
inferior vagus X ganglion	UBERON:0005363	83.46	gold quality
postcentral gyrus	UBERON:0002581	83.33	gold quality
adult organism	UBERON:0007023	83.18	gold quality
adrenal tissue	UBERON:0018303	83.15	gold quality
parietal lobe	UBERON:0001872	83.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.08	gold quality
superior surface of tongue	UBERON:0007371	83.04	gold quality
pylorus	UBERON:0001166	82.88	gold quality
lower lobe of lung	UBERON:0008949	82.80	gold quality
medial globus pallidus	UBERON:0002477	82.61	gold quality
tendon	UBERON:0000043	82.59	gold quality
seminal vesicle	UBERON:0000998	82.28	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.94
E-MTAB-7303	no	111.21
E-MTAB-6142	no	18.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

351 targeting ZNF264, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4500	99.99	72.72	2367

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300), ZNF70 (ENSG00000187792)

Protein

Protein identifiers

Zinc finger protein 264 — O43296 (reviewed: O43296)

All UniProt accessions (5): O43296, M0QXF3, M0QZJ4, M0QZT5, M0R146

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Tissue specificity. Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_003408* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (27 total): zinc finger region 13, region of interest 3, compositionally biased region 3, modified residue 3, sequence variant 2, chain 1, domain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43296-F1	66.72	0.10

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 80, 343, 511, 425

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins

MSigDB gene sets: 175 (showing top): MODULE_255, BROWNE_HCMV_INFECTION_8HR_UP, MODULE_317, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP, MORF_ZNF10, BLALOCK_ALZHEIMERS_DISEASE_UP, MODULE_123, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP, MORF_EPHA7, MORF_RAB3A, MORF_BMPR2, MORF_WNT1, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, MORF_IL9

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
RNA Polymerase II Transcription	1
Regulation of endogenous retroelements	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

742 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF264	USP29	Q9HBJ7	449
ZNF264	ZNF704	Q6ZNC4	399
ZNF264	LYSMD1	Q96S90	348
ZNF264	SLC67A1	Q96BI1	305
ZNF264	C2CD2	Q9Y426	305
ZNF264	ANKIB1	Q9P2G1	300
ZNF264	ZC3H12C	Q9C0D7	295
ZNF264	CAMSAP2	Q08AD1	288
ZNF264	C2CD4C	Q8TF44	288
ZNF264	INTS2	Q9H0H0	287
ZNF264	MRPS12	O15235	277
ZNF264	KIAA1549L	Q6ZVL6	276
ZNF264	TMEM101	Q96IK0	274
ZNF264	BTF3L4	Q96K17	271
ZNF264	N4BP2L2	Q92802	267

IntAct

55 interactions, top by confidence:

A	B	Type	Score
ZNF264	TRIM41	psi-mi:“MI:0915”(physical association)	0.740
ZNF264	CEP70	psi-mi:“MI:0915”(physical association)	0.600
ZNF264	ZNF175	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	KRTAP10-6	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	MCC	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.560
GOLGA6L9	ZNF264	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	KRTAP10-8	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	ZNF526	psi-mi:“MI:0915”(physical association)	0.560
IPO8	ZNF264	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	PICK1	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	MDFI	psi-mi:“MI:0915”(physical association)	0.560
ZNF264	DVL3	psi-mi:“MI:0915”(physical association)	0.560
	ZNF264	psi-mi:“MI:0915”(physical association)	0.560
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
KRTAP10-1	ZNF264	psi-mi:“MI:0915”(physical association)	0.370
ZNF264	TRIM24	psi-mi:“MI:0914”(association)	0.350
CBX5	ZNF568	psi-mi:“MI:0914”(association)	0.350
ZNF264	CEP70	psi-mi:“MI:0915”(physical association)	0.000
ZNF264	ZNF175	psi-mi:“MI:0915”(physical association)	0.000
ZNF264	KRTAP10-6	psi-mi:“MI:0915”(physical association)	0.000
ZNF264	MCC	psi-mi:“MI:0915”(physical association)	0.000
ZNF264	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.000
ZNF264	GOLGA6L9	psi-mi:“MI:0915”(physical association)	0.000
ZNF264		psi-mi:“MI:0915”(physical association)	0.000
ZNF264	KRTAP10-8	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (60): ZNF264 (Two-hybrid), ZNF264 (Two-hybrid), ZNF264 (Two-hybrid), NDEL1 (Two-hybrid), TRIM41 (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP10-1 (Two-hybrid), KRTAP10-5 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZYG11A (Affinity Capture-MS), CENPB (Affinity Capture-MS), TRIM24 (Affinity Capture-MS), GOPC (Affinity Capture-MS), ZNF805 (Affinity Capture-MS), TRIM41 (Affinity Capture-MS)

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A6QLU5, B2RUI1, D3ZVT0, O14709, O43296, O75123, P10072, P15621, P17020, P17097, P51814, P85977, Q08ER8, Q0VGE8, Q14590, Q32KN0, Q3KQV3, Q4V8A8, Q5CZA5, Q5RBX0, Q5RCD9, Q5VIY5, Q61116, Q61967, Q6GQR8, Q6P9A3, Q6ZMS4, Q7TSH9, Q7TSI0, Q7Z3I7, Q86UD4, Q86WZ6, Q8BFS8, Q8IZ26, Q8N9F8, Q8TAF7

Diamond homologs: A6NDX5, A6NN14, A6QLU5, A7MBI1, A8MQ14, B4DU55, B4DX44, O43296, O60765, O75290, O75346, O75437, O95780, P10072, P10078, P17014, P17030, P17032, P17097, P17098, P51523, P51814, P52736, P52738, P52742, Q05481, Q06730, Q06732, Q14586, Q14929, Q15928, Q16587, Q29RZ4, Q2KI58, Q3KNS6, Q3V080, Q3ZCX4, Q49AA0, Q4R6C2, Q4V8A8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 20 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	5	17.4×	4e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

115 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	97
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1011 predictions. Top by Δscore:

Variant	Effect	Δscore
19:57193874:GGT:G	acceptor_gain	1.0000
19:57193874:GGTGT:G	acceptor_gain	1.0000
19:57193962:G:GT	donor_gain	1.0000
19:57194000:GG:G	donor_gain	1.0000
19:57194000:GGGTA:G	donor_loss	1.0000
19:57194001:GG:G	donor_gain	1.0000
19:57194002:G:C	donor_loss	1.0000
19:57194002:G:GG	donor_gain	1.0000
19:57194003:T:G	donor_loss	1.0000
19:57191944:CAGG:C	donor_loss	0.9900
19:57191945:AGG:A	donor_loss	0.9900
19:57191946:GGTG:G	donor_loss	0.9900
19:57191947:GTG:G	donor_loss	0.9900
19:57191948:T:A	donor_loss	0.9900
19:57193871:CCAG:C	acceptor_loss	0.9900
19:57193873:A:AG	acceptor_gain	0.9900
19:57193873:AG:A	acceptor_gain	0.9900
19:57193873:AGGT:A	acceptor_gain	0.9900
19:57193873:AGGTG:A	acceptor_loss	0.9900
19:57193874:G:GA	acceptor_gain	0.9900
19:57193874:GG:G	acceptor_gain	0.9900
19:57193874:GGTG:G	acceptor_gain	0.9900
19:57192548:G:GG	donor_gain	0.9800
19:57192554:A:T	donor_gain	0.9800
19:57193864:T:TA	acceptor_gain	0.9800
19:57191949:GAGTG:G	donor_loss	0.9700
19:57193968:A:AG	donor_gain	0.9700
19:57194000:GGGT:G	donor_gain	0.9600
19:57194001:GGT:G	donor_gain	0.9600
19:57205846:C:G	donor_gain	0.9600

AlphaMissense

4149 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:57212487:T:C	F464L	0.999
19:57212489:T:A	F464L	0.999
19:57212489:T:G	F464L	0.999
19:57212506:T:C	L470P	0.999
19:57212655:T:C	F520L	0.999
19:57212657:T:A	F520L	0.999
19:57212657:T:G	F520L	0.999
19:57212739:T:C	F548L	0.999
19:57212741:C:A	F548L	0.999
19:57212741:C:G	F548L	0.999
19:57211899:T:C	F268L	0.998
19:57211901:C:A	F268L	0.998
19:57211901:C:G	F268L	0.998
19:57211983:T:C	F296L	0.998
19:57211985:C:A	F296L	0.998
19:57211985:C:G	F296L	0.998
19:57212319:T:C	F408L	0.998
19:57212321:C:A	F408L	0.998
19:57212321:C:G	F408L	0.998
19:57212403:T:C	F436L	0.998
19:57212405:C:A	F436L	0.998
19:57212405:C:G	F436L	0.998
19:57212512:G:C	R472P	0.998
19:57212516:C:A	H473Q	0.998
19:57212516:C:G	H473Q	0.998
19:57212571:T:C	F492L	0.998
19:57212573:C:A	F492L	0.998
19:57212573:C:G	F492L	0.998
19:57212674:T:C	L526P	0.998
19:57212680:G:C	R528P	0.998

dbSNP variants (sampled 300 via entrez): RS1000200469 (19:57190972 G>C,T), RS1000206519 (19:57195919 A>G), RS1000223729 (19:57203983 G>A), RS1000328406 (19:57195987 A>T), RS1000411689 (19:57201397 C>T), RS1000436330 (19:57201361 C>A), RS1000468149 (19:57190627 C>G), RS1000477650 (19:57222867 C>G), RS1000610861 (19:57206451 C>G,T), RS1000799265 (19:57218256 G>A,C), RS1000849887 (19:57218596 A>G), RS1000890220 (19:57201667 C>A), RS1000915614 (19:57196975 C>T), RS1001186434 (19:57212416 C>G,T), RS1001191587 (19:57200373 A>G)

Disease associations

OMIM: gene MIM:604668 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001144_10	Dupuytren’s disease	7.000000e-14
GCST004858_25	Dupuytren’s disease	2.000000e-17
GCST008823_1	Body mass index	2.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004229	Dupuytren Contracture
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	increases methylation, affects methylation	2
Tetrachlorodibenzodioxin	increases expression, affects expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	increases phosphorylation	1
testosterone enanthate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	affects cotreatment, increases methylation	1
geraniol	increases expression	1
terbufos	increases methylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
bazedoxifene	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
jinfukang	decreases expression, affects cotreatment	1
NSC 689534	affects binding, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Cisplatin	affects cotreatment, decreases expression	1
Copper	increases expression, affects binding	1
Doxorubicin	decreases expression	1
Fonofos	increases methylation	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	decreases expression	1
Gallic Acid	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD17	HEK293 eGFP-ZNF264	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.