ZNF266

Summary

ZNF266 (zinc finger protein 266, HGNC:13059) is a protein-coding gene on chromosome 19p13.2, encoding Zinc finger protein 266 (Q14584). May be involved in transcriptional regulation.

This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene.

Source: NCBI Gene 10781 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 101 total
• MANE Select transcript: NM_001370374

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13059
Approved symbol	ZNF266
Name	zinc finger protein 266
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	HZF1
Ensembl gene	ENSG00000174652
Ensembl biotype	protein_coding
OMIM	604751
Entrez	10781

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 31 protein_coding, 2 retained_intron

ENST00000588221, ENST00000588933, ENST00000590306, ENST00000591213, ENST00000592292, ENST00000592904, ENST00000648978, ENST00000651268, ENST00000859744, ENST00000859745, ENST00000859746, ENST00000859747, ENST00000859748, ENST00000859749, ENST00000859750, ENST00000859751, ENST00000859752, ENST00000859753, ENST00000859754, ENST00000859755, ENST00000859756, ENST00000859757, ENST00000859758, ENST00000927991, ENST00000927992, ENST00000927993, ENST00000948585, ENST00000948586, ENST00000948587, ENST00000948588, ENST00000948589, ENST00000948590, ENST00000948591

RefSeq mRNA: 29 — MANE Select: NM_001370374 NM_001271314, NM_001370374, NM_001370375, NM_001370376, NM_001370377, NM_001370378, NM_001370379, NM_001370380, NM_001370381, NM_001370382, NM_001370383, NM_001370384, NM_001370385, NM_001370386, NM_001370387, NM_001370388, NM_001370389, NM_001370390, NM_001370391, NM_001370392, NM_001370393, NM_001370394, NM_001370395, NM_001370396, NM_001370397, NM_001370398, NM_001370399, NM_001370400, NM_006631

CCDS: CCDS12213, CCDS92507

Canonical transcript exons

ENST00000592904 — 11 exons

Exon	Start	End
ENSE00001199937	9415654	9415742
ENSE00001215203	9435108	9435193
ENSE00001516774	9433668	9433786
ENSE00001516775	9434075	9434235
ENSE00001741110	9417828	9417908
ENSE00002923295	9434798	9434859
ENSE00003832112	9419217	9419299
ENSE00003834677	9412429	9414720
ENSE00003837314	9420065	9420218
ENSE00003839325	9435284	9435573
ENSE00003840867	9418505	9418631

Expression profiles

Bgee: expression breadth ubiquitous, 289 present calls, max score 96.63.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.7799 / max 137.5736, expressed in 1765 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179003	8.1676	1689
179004	5.6123	1605

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.63	gold quality
visceral pleura	UBERON:0002401	94.54	gold quality
tibia	UBERON:0000979	94.10	gold quality
pleura	UBERON:0000977	93.75	gold quality
spleen	UBERON:0002106	93.57	gold quality
parietal pleura	UBERON:0002400	93.44	gold quality
mucosa of stomach	UBERON:0001199	93.32	gold quality
superficial temporal artery	UBERON:0001614	93.31	gold quality
trabecular bone tissue	UBERON:0002483	92.65	gold quality
hair follicle	UBERON:0002073	92.55	gold quality
corpus epididymis	UBERON:0004359	92.47	gold quality
lower esophagus mucosa	UBERON:0035834	92.36	gold quality
cardia of stomach	UBERON:0001162	92.25	gold quality
small intestine Peyer’s patch	UBERON:0003454	92.20	gold quality
lymph node	UBERON:0000029	92.18	gold quality
germinal epithelium of ovary	UBERON:0001304	92.11	gold quality
body of uterus	UBERON:0009853	91.88	gold quality
skin of hip	UBERON:0001554	91.57	gold quality
left ovary	UBERON:0002119	91.49	gold quality
right lobe of thyroid gland	UBERON:0001119	91.47	gold quality
right ovary	UBERON:0002118	91.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	91.36	gold quality
left lobe of thyroid gland	UBERON:0001120	91.26	gold quality
skin of abdomen	UBERON:0001416	91.20	gold quality
skin of leg	UBERON:0001511	91.11	gold quality
rectum	UBERON:0001052	90.97	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.89	gold quality
epithelium of nasopharynx	UBERON:0001951	90.88	gold quality
lower esophagus	UBERON:0013473	90.88	gold quality
left uterine tube	UBERON:0001303	90.86	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-CURD-89	no	321.61
E-ANND-3	no	4.16

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
KIT
ZNF266

Upstream regulators (CollecTRI, top): MEF2A, ZNF266

miRNA regulators (miRDB)

55 targeting ZNF266, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-7845-5P	99.88	64.88	771
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-4527	99.66	67.43	714
HSA-MIR-6503-5P	99.62	66.96	597

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp266	ENSMUSG00000060510
rattus_norvegicus	Zfp266	ENSRNOG00000034037
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300), ZNF70 (ENSG00000187792)

Protein

Protein identifiers

Zinc finger protein 266 — Q14584 (reviewed: Q14584)

Alternative names: Zinc finger protein HZF1

All UniProt accessions (2): Q14584, A0A3F2YPB8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (29): NP_001258243, NP_001357303, NP_001357304, NP_001357305, NP_001357306, NP_001357307, NP_001357308, NP_001357309, NP_001357310, NP_001357311, NP_001357312, NP_001357313, NP_001357314, NP_001357315, NP_001357316, NP_001357317, NP_001357318, NP_001357319, NP_001357320, NP_001357321, NP_001357322, NP_001357323, NP_001357324, NP_001357325, NP_001357326, NP_001357327, NP_001357328, NP_001357329, NP_006622 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096

UniProt features (19 total): zinc finger region 14, chain 1, domain 1, region of interest 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14584-F1	68.88	0.27

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 136 (showing top): MORF_MSH3, MORF_BRCA1, MORF_RAD51L3, MODULE_313, MODULE_205, CADWELL_ATG16L1_TARGETS_DN, MORF_ATF2, MORF_BCL2L11, IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR, MILI_PSEUDOPODIA_CHEMOTAXIS_DN, BROWNE_HCMV_INFECTION_14HR_UP, MORF_PTEN, MORF_KDR, chr19p13, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING

GO Biological Process (3): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872), sequence-specific double-stranded DNA binding (GO:1990837)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

598 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF266	CCDC163	A0A0D9SF12	594
ZNF266	ZPR1	O75312	559
ZNF266	GPR15	P49685	442
ZNF266	CLLU1-AS1	Q5K130	414
ZNF266	SP140L	Q9H930	391
ZNF266	YJEFN3	A6XGL0	374
ZNF266	SLFN5	Q08AF3	367
ZNF266	ZNF738	Q8NE65	359
ZNF266	SAMD10	Q9BYL1	359
ZNF266	NOAZFP	Q9Y3S2	348
ZNF266	TMEM161A	Q9NX61	336
ZNF266	ZNF414	Q96IQ9	330
ZNF266	ZMYND11	Q15326	326
ZNF266	CCDC126	Q96EE4	324
ZNF266	WDR54	Q9H977	322

IntAct

54 interactions, top by confidence:

A	B	Type	Score
CEP70	ZNF266	psi-mi:“MI:0915”(physical association)	0.720
ZNF266	MDFI	psi-mi:“MI:0915”(physical association)	0.720
ZNF266	CEP70	psi-mi:“MI:0915”(physical association)	0.720
MDFI	ZNF266	psi-mi:“MI:0915”(physical association)	0.720
ZNF266	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
TRIM41	ZNF266	psi-mi:“MI:0915”(physical association)	0.600
ZNF266	TRIM41	psi-mi:“MI:0915”(physical association)	0.600
ZNF266	RANGRF	psi-mi:“MI:0915”(physical association)	0.590
KRTAP5-9	ZNF266	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF266	psi-mi:“MI:0915”(physical association)	0.560
ZNF266	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
KRT40	ZNF266	psi-mi:“MI:0915”(physical association)	0.560
ZNF266		psi-mi:“MI:0915”(physical association)	0.560

BioGRID (19): ZNF266 (Two-hybrid), ZNF266 (Two-hybrid), CEP70 (Two-hybrid), TRIM41 (Two-hybrid), KRT40 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-3 (Two-hybrid), RANGRF (Affinity Capture-MS), ZNF266 (Two-hybrid), ZNF266 (Two-hybrid), ZNF266 (Two-hybrid), ZNF266 (Two-hybrid), KRTAP10-8 (Two-hybrid), CYSRT1 (Two-hybrid), RANGRF (Affinity Capture-MS)

ESM2 similar proteins: A2VDP4, A6NHJ4, D3ZVT0, O60765, O75123, P17097, P51508, P52738, Q02975, Q06730, Q0VGE8, Q14584, Q14590, Q2M218, Q2M3W8, Q2M3X9, Q2TL60, Q32KN0, Q3MIS6, Q4V8A8, Q5HY98, Q5HYK9, Q5MYW4, Q5RBX0, Q5VIY5, Q61751, Q61967, Q6GQR8, Q6P2D0, Q7TSH9, Q7Z3I7, Q86UD4, Q86Y25, Q8BFS8, Q8BQC8, Q8IZ26, Q8N184, Q8N782, Q8N9F8, Q8TF47

Diamond homologs: A0JPL0, A1L1L7, A2A761, A2VDP4, A3KN36, A6QLU5, A6QPT6, A7MBI1, A8MT65, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, O95780, P10076, P17014, P17023, P17025, P17030, P17032, P17098, P51523, P51814, P52736, P52742, P58317, Q02975, Q06730, Q06732, Q08DG8, Q0VCB0, Q13360, Q14584, Q14587, Q14590, Q147U1, Q16587, Q29RZ4, Q2M218

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

101 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1358 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9415647:ATCTT:A	donor_loss	1.0000
19:9415648:TCTTA:T	donor_loss	1.0000
19:9415649:CTTA:C	donor_loss	1.0000
19:9415650:TTACC:T	donor_loss	1.0000
19:9415651:T:TG	donor_loss	1.0000
19:9415652:A:AC	donor_gain	1.0000
19:9415652:A:C	donor_loss	1.0000
19:9415653:C:CC	donor_gain	1.0000
19:9415743:C:CC	acceptor_gain	1.0000
19:9417825:CA:C	donor_loss	1.0000
19:9417826:A:AT	donor_loss	1.0000
19:9417905:TATC:T	acceptor_gain	1.0000
19:9417908:CC:C	acceptor_loss	1.0000
19:9417908:CCTG:C	acceptor_gain	1.0000
19:9417909:C:CC	acceptor_gain	1.0000
19:9418504:CCTA:C	donor_gain	1.0000
19:9419299:CCTCA:C	acceptor_gain	1.0000
19:9419303:A:C	acceptor_gain	1.0000
19:9435100:GTACT:G	donor_loss	1.0000
19:9435102:ACT:A	donor_loss	1.0000
19:9435103:CTC:C	donor_loss	1.0000
19:9435104:TCAC:T	donor_loss	1.0000
19:9435105:CACCG:C	donor_loss	1.0000
19:9435106:A:AC	donor_gain	1.0000
19:9435106:ACC:A	donor_loss	1.0000
19:9435107:C:CC	donor_gain	1.0000
19:9435107:CCG:C	donor_gain	1.0000
19:9414717:CTAT:C	acceptor_gain	0.9900
19:9415637:AT:A	donor_gain	0.9900
19:9415738:TGAAG:T	acceptor_gain	0.9900

AlphaMissense

4097 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9413674:A:C	F417L	0.999
19:9413674:A:T	F417L	0.999
19:9413676:A:G	F417L	0.999
19:9413563:G:C	H454Q	0.998
19:9413563:G:T	H454Q	0.998
19:9413590:A:C	F445L	0.998
19:9413590:A:T	F445L	0.998
19:9413592:A:G	F445L	0.998
19:9413758:A:C	F389L	0.998
19:9413758:A:T	F389L	0.998
19:9413760:A:G	F389L	0.998
19:9413842:G:C	F361L	0.998
19:9413842:G:T	F361L	0.998
19:9413844:A:G	F361L	0.998
19:9413338:G:C	F529L	0.997
19:9413338:G:T	F529L	0.997
19:9413340:A:G	F529L	0.997
19:9413390:C:G	R512P	0.997
19:9413422:G:C	F501L	0.997
19:9413422:G:T	F501L	0.997
19:9413424:A:G	F501L	0.997
19:9413565:G:C	H454D	0.997
19:9413565:G:T	H454N	0.997
19:9413899:G:C	H342Q	0.997
19:9413899:G:T	H342Q	0.997
19:9413926:A:C	F333L	0.997
19:9413926:A:T	F333L	0.997
19:9413928:A:G	F333L	0.997
19:9413506:A:C	F473L	0.996
19:9413506:A:T	F473L	0.996

dbSNP variants (sampled 300 via entrez): RS1000051022 (19:9433810 A>C), RS1000112821 (19:9420207 G>T), RS1000181362 (19:9425905 G>T), RS1000236665 (19:9412573 CT>C), RS1000364053 (19:9425278 C>G), RS1000419430 (19:9431403 T>C,G), RS1000473944 (19:9423505 G>C), RS1000481146 (19:9433465 A>C), RS1000517731 (19:9421752 T>C), RS1000729504 (19:9426790 T>C,G), RS1000757637 (19:9432679 A>C), RS1000786774 (19:9424795 T>C), RS1001096007 (19:9415488 G>A,C), RS1001334767 (19:9417164 A>T), RS1001471723 (19:9416917 C>T)

Disease associations

OMIM: gene MIM:604751 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, decreases methylation	3
Valproic Acid	decreases expression, decreases methylation	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
bisphenol F	affects cotreatment, decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
cupric oxide	increases expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Catechin	affects cotreatment, decreases expression	1
Dexamethasone	decreases expression, affects cotreatment	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Fluorouracil	affects reaction, decreases expression	1
Formaldehyde	increases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Thiram	increases expression	1
Zinc	affects cotreatment, increases expression	1
1-Methyl-3-isobutylxanthine	decreases expression, affects cotreatment	1
Cyclosporine	increases methylation	1
Lithium Chloride	decreases expression	1
Lactic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW26	HEK293 eGFP-ZNF266	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.