ZNF267

Summary

ZNF267 (zinc finger protein 267, HGNC:13060) is a protein-coding gene on chromosome 16p11.2, encoding Zinc finger protein 267 (Q14586). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 10308 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 89 total
• MANE Select transcript: NM_003414

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13060
Approved symbol	ZNF267
Name	zinc finger protein 267
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Aliases	HZF2
Ensembl gene	ENSG00000185947
Ensembl biotype	protein_coding
OMIM	604752
Entrez	10308

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000300870, ENST00000394846, ENST00000561814, ENST00000562971, ENST00000566541, ENST00000575471, ENST00000854651

RefSeq mRNA: 2 — MANE Select: NM_003414 NM_001265588, NM_003414

CCDS: CCDS32440

Canonical transcript exons

ENST00000300870 — 4 exons

Exon	Start	End
ENSE00001519790	31914476	31917357
ENSE00002247619	31873807	31873969
ENSE00003472289	31885161	31885256
ENSE00003553376	31884498	31884624

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 94.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 42.9531 / max 2549.6565, expressed in 1795 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
153857	42.9531	1795

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	94.62	gold quality
epithelium of nasopharynx	UBERON:0001951	92.49	gold quality
secondary oocyte	CL:0000655	91.46	gold quality
monocyte	CL:0000576	90.19	gold quality
calcaneal tendon	UBERON:0003701	89.91	gold quality
mononuclear cell	CL:0000842	89.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.62	gold quality
leukocyte	CL:0000738	89.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.81	gold quality
tongue squamous epithelium	UBERON:0006919	87.62	silver quality
colonic epithelium	UBERON:0000397	86.83	gold quality
amniotic fluid	UBERON:0000173	86.39	gold quality
blood	UBERON:0000178	86.33	gold quality
palpebral conjunctiva	UBERON:0001812	86.30	gold quality
bone marrow	UBERON:0002371	85.86	gold quality
vermiform appendix	UBERON:0001154	85.82	gold quality
germinal epithelium of ovary	UBERON:0001304	85.71	gold quality
gingival epithelium	UBERON:0001949	85.71	gold quality
tonsil	UBERON:0002372	84.93	gold quality
gingiva	UBERON:0001828	84.90	gold quality
lymph node	UBERON:0000029	84.05	gold quality
bone marrow cell	CL:0002092	83.60	gold quality
superficial temporal artery	UBERON:0001614	83.41	gold quality
cartilage tissue	UBERON:0002418	83.04	gold quality
islet of Langerhans	UBERON:0000006	83.00	gold quality
squamous epithelium	UBERON:0006914	82.68	gold quality
gall bladder	UBERON:0002110	82.48	gold quality
granulocyte	CL:0000094	82.45	gold quality
visceral pleura	UBERON:0002401	82.20	gold quality
esophagus squamous epithelium	UBERON:0006920	82.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	17.18

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
MMP10	Repression

Upstream regulators (CollecTRI, top): E2F4, HIF1A, NFYA, STAT1

miRNA regulators (miRDB)

48 targeting ZNF267, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-2116-3P	99.74	64.32	889
HSA-MIR-4255	99.72	67.70	1541
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-8061	99.63	69.44	1411
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-4728-3P	99.47	68.94	981
HSA-MIR-642A-3P	99.23	67.67	1258
HSA-MIR-642B-3P	99.23	67.67	1258
HSA-MIR-4478	99.07	65.16	2320

Literature-anchored findings (GeneRIF, showing 5)

• The binding site for NF-Y is critical for ZNF267 gene regulation and, herewith, the activation of this transcriptional factor plays an important role in the activation process of hepatic stellate cells and in liver fibrosis (PMID:15814297)
• ZNF267 as a negative transcriptional regulator of matrix metallopeptidase 10 might promote liver fibrogenesis (PMID:16054593)
• ZNF267 promotes proliferation and migration of hepatocellular carcinoma cells in vitro (PMID:21840307)
• Report increased expression of zinc finger protein 267 in non-alcoholic fatty liver disease. (PMID:22076166)
• LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis. (PMID:36691044)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 267 — Q14586 (reviewed: Q14586)

Alternative names: Zinc finger protein HZF2

All UniProt accessions (5): Q14586, H3BMG2, H3BNA3, H3BPW2, I3L4I6

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001252517, NP_003405* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (24 total): zinc finger region 15, sequence conflict 3, cross-link 2, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14586-F1	61.27	0.17

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 66, 135

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 143 (showing top): PAL_PRMT5_TARGETS_UP, MODULE_308, CAGCTG_AP4_Q5, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, WEI_MYCN_TARGETS_WITH_E_BOX, LINDSTEDT_DENDRITIC_CELL_MATURATION_B, ONKEN_UVEAL_MELANOMA_UP, FISCHER_G2_M_CELL_CYCLE, chr16p11, MODULE_123, DODD_NASOPHARYNGEAL_CARCINOMA_UP, FISCHER_DREAM_TARGETS, ZHANG_BREAST_CANCER_PROGENITORS_UP, PODAR_RESPONSE_TO_ADAPHOSTIN_UP, CHEN_HOXA5_TARGETS_9HR_UP

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

514 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF267	MCM10	Q7L590	472
ZNF267	NLRC5	Q86WI3	454
ZNF267	GDPD3	Q7L5L3	418
ZNF267	ABLIM2	Q6H8Q1	408
ZNF267	CCDC137	Q6PK04	394
ZNF267	NFIC	P08651	381
ZNF267	CDCA2	Q69YH5	376
ZNF267	OLIG3	Q7RTU3	353
ZNF267	PDGFC	Q9NRA1	353
ZNF267	SPRY1	O43609	351
ZNF267	CEP78	Q5JTW2	324
ZNF267	SMN1	Q16637	323
ZNF267	ZGPAT	Q8N5A5	317
ZNF267	MS4A15	Q8N5U1	316
ZNF267	SLC6A1	P30531	295

IntAct

20 interactions, top by confidence:

A	B	Type	Score
CACNG5	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ADORA2B	ZNF267	psi-mi:“MI:0915”(physical association)	0.370
ZNF267	ATP6V0A1	psi-mi:“MI:0915”(physical association)	0.370
EPHA7	ZNF267	psi-mi:“MI:0915”(physical association)	0.370
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
ZNF267	DNAJB6	psi-mi:“MI:0914”(association)	0.350
ZNF460	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF418	ZNF195	psi-mi:“MI:0914”(association)	0.350
CDK11A	PRPF40A	psi-mi:“MI:0914”(association)	0.350
FHIP1B	MED19	psi-mi:“MI:2364”(proximity)	0.270
TRIM54	ZNF267	psi-mi:“MI:0915”(physical association)	0.000
ZNF267	gerKA	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (18): ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Two-hybrid), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-MS), ZNF267 (Affinity Capture-RNA), ZNF267 (Affinity Capture-RNA), ZNF267 (Two-hybrid)

ESM2 similar proteins: A2VDP4, A6NHJ4, O94892, P0CJ79, P17014, P17021, P17025, P17032, P17035, P18733, P51508, P51814, Q06730, Q06732, Q09FC8, Q0VGE8, Q14586, Q32M78, Q3MIS6, Q5JVG2, Q5R4K8, Q5R9S5, Q5RBQ3, Q5RCJ2, Q5RER9, Q5TYW1, Q5VIY5, Q6P560, Q6PDB4, Q6ZMW2, Q6ZN06, Q6ZNA1, Q76KX8, Q7L2R6, Q86Y25, Q8N184, Q8N823, Q8N883, Q8N8J6, Q8NEP9

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
ZNF267	“down-regulates quantity by repression”	MMP10	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	79
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

963 predictions. Top by Δscore:

Variant	Effect	Δscore
16:31873967:ATGGT:A	donor_loss	1.0000
16:31873969:GGTG:G	donor_loss	1.0000
16:31884494:TCA:T	acceptor_loss	1.0000
16:31884496:A:C	acceptor_loss	1.0000
16:31884496:AG:A	acceptor_gain	1.0000
16:31884497:GG:G	acceptor_gain	1.0000
16:31884585:G:GT	donor_gain	1.0000
16:31884621:CTGGG:C	donor_loss	1.0000
16:31884622:TGGGT:T	donor_loss	1.0000
16:31884623:GG:G	donor_gain	1.0000
16:31884623:GGGTG:G	donor_loss	1.0000
16:31884624:GG:G	donor_gain	1.0000
16:31884624:GGT:G	donor_loss	1.0000
16:31873967:ATG:A	donor_gain	0.9900
16:31873968:TG:T	donor_gain	0.9900
16:31873969:GG:G	donor_gain	0.9900
16:31873970:G:GG	donor_gain	0.9900
16:31873971:T:G	donor_loss	0.9900
16:31884496:A:AG	acceptor_gain	0.9900
16:31884496:AGG:A	acceptor_gain	0.9900
16:31884497:G:GG	acceptor_gain	0.9900
16:31884497:GGG:G	acceptor_gain	0.9900
16:31884497:GGGA:G	acceptor_gain	0.9900
16:31884497:GGGAC:G	acceptor_gain	0.9900
16:31884625:G:GG	donor_gain	0.9900
16:31884626:T:TC	donor_loss	0.9900
16:31884658:C:G	donor_gain	0.9900
16:31914475:GAT:G	acceptor_gain	0.9900
16:31914475:GATGT:G	acceptor_gain	0.9900
16:31873935:C:G	donor_gain	0.9800

AlphaMissense

4961 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:31916170:T:C	F641L	0.998
16:31916172:C:A	F641L	0.998
16:31916172:C:G	F641L	0.998
16:31916254:T:C	F669L	0.997
16:31916256:C:A	F669L	0.997
16:31916256:C:G	F669L	0.997
16:31916338:T:C	F697L	0.997
16:31916340:C:A	F697L	0.997
16:31916340:C:G	F697L	0.997
16:31916002:T:C	F585L	0.996
16:31916004:T:A	F585L	0.996
16:31916004:T:G	F585L	0.996
16:31916086:T:C	F613L	0.996
16:31916088:T:A	F613L	0.996
16:31916088:T:G	F613L	0.996
16:31916422:T:C	F725L	0.996
16:31916424:T:A	F725L	0.996
16:31916424:T:G	F725L	0.996
16:31915918:T:C	F557L	0.995
16:31915920:T:A	F557L	0.995
16:31915920:T:G	F557L	0.995
16:31915952:G:C	R568P	0.995
16:31916036:G:C	R596P	0.995
16:31915582:T:C	F445L	0.993
16:31915584:T:A	F445L	0.993
16:31915584:T:G	F445L	0.993
16:31915750:T:C	F501L	0.992
16:31915752:T:A	F501L	0.992
16:31915752:T:G	F501L	0.992
16:31916189:T:C	L647P	0.992

dbSNP variants (sampled 300 via entrez): RS1000095786 (16:31899532 A>C), RS1000194665 (16:31876133 A>G), RS1000247034 (16:31876497 G>T), RS1000478820 (16:31886372 T>C), RS1000496547 (16:31896970 A>G), RS1000579809 (16:31894784 T>C), RS1000612738 (16:31890583 T>C,G), RS1000651854 (16:31894480 T>C), RS1000671107 (16:31905746 T>C), RS1000850646 (16:31874136 C>T), RS1000872634 (16:31916858 CAG>C), RS1000910809 (16:31912502 A>G), RS1000955495 (16:31905608 A>C,T), RS1001182961 (16:31896635 A>G), RS1001253359 (16:31912115 T>C)

Disease associations

OMIM: gene MIM:604752 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression	3
Arsenic	decreases expression, decreases methylation, increases abundance, increases expression	3
Nickel	increases expression	3
Acetaminophen	increases expression	2
Benzo(a)pyrene	affects methylation, decreases expression	2
Formaldehyde	increases expression, decreases expression	2
Tobacco Smoke Pollution	increases expression	2
Tretinoin	decreases expression, increases expression	2
Cadmium Chloride	increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	increases expression	1
FR900359	decreases phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
methylselenic acid	increases expression	1
zinc chromate	increases abundance, increases expression	1
manganese chloride	increases abundance, increases expression	1
tamibarotene	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
abrine	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
jinfukang	decreases expression	1
MT19c compound	increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Air Pollutants, Occupational	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TZ37	HAP1 ZNF267 (-) 1	Cancer cell line	Male
CVCL_TZ38	HAP1 ZNF267 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.