ZNF274

Summary

ZNF274 (zinc finger protein 274, HGNC:13068) is a protein-coding gene on chromosome 19q13.43, encoding Neurotrophin receptor-interacting factor homolog (Q96GC6). Probable transcription repressor.

This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals.

Source: NCBI Gene 10782 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 38 total
• Cancer driver (intOGen): activating (oncogene-like) across 1 cancer types
• MANE Select transcript: NM_133502

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13068
Approved symbol	ZNF274
Name	zinc finger protein 274
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	ZKSCAN19, ZSCAN51
Ensembl gene	ENSG00000171606
Ensembl biotype	protein_coding
OMIM	605467
Entrez	10782

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 18 protein_coding, 5 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000326804, ENST00000345813, ENST00000424679, ENST00000594248, ENST00000594839, ENST00000595146, ENST00000597528, ENST00000600704, ENST00000601995, ENST00000610905, ENST00000615675, ENST00000617501, ENST00000619307, ENST00000621145, ENST00000863438, ENST00000930795, ENST00000930796, ENST00000930797, ENST00000930798, ENST00000930799, ENST00000930800, ENST00000930801, ENST00000952034, ENST00000952035, ENST00000952036

RefSeq mRNA: 4 — MANE Select: NM_133502 NM_001278734, NM_016324, NM_016325, NM_133502

CCDS: CCDS74473, CCDS74474, CCDS74475, CCDS74476

Canonical transcript exons

ENST00000617501 — 8 exons

Exon	Start	End
ENSE00003584696	58206720	58207202
ENSE00003593102	58186947	58187042
ENSE00003610358	58209961	58210073
ENSE00003623762	58185712	58185838
ENSE00003632047	58211560	58211686
ENSE00003712961	58212161	58213562
ENSE00003739436	58183061	58183442
ENSE00003744661	58183921	58183998

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 90.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.5227 / max 117.0845, expressed in 1793 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177818	7.2270	1715
177819	4.2957	1594

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	90.28	gold quality
lower esophagus mucosa	UBERON:0035834	90.19	gold quality
cervix squamous epithelium	UBERON:0006922	89.94	silver quality
colonic epithelium	UBERON:0000397	89.82	gold quality
left lobe of thyroid gland	UBERON:0001120	89.58	gold quality
right lobe of thyroid gland	UBERON:0001119	89.49	gold quality
thyroid gland	UBERON:0002046	89.43	gold quality
right ovary	UBERON:0002118	89.33	gold quality
sural nerve	UBERON:0015488	89.21	gold quality
heart right ventricle	UBERON:0002080	89.15	gold quality
pigmented layer of retina	UBERON:0001782	88.74	gold quality
ovary	UBERON:0000992	87.81	gold quality
cardiac ventricle	UBERON:0002082	87.81	gold quality
heart left ventricle	UBERON:0002084	87.80	gold quality
right uterine tube	UBERON:0001302	87.53	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.44	gold quality
cerebellar hemisphere	UBERON:0002245	87.37	gold quality
cerebellar cortex	UBERON:0002129	87.27	gold quality
tongue squamous epithelium	UBERON:0006919	87.23	gold quality
epithelium of nasopharynx	UBERON:0001951	87.19	gold quality
mammary duct	UBERON:0001765	87.18	gold quality
calcaneal tendon	UBERON:0003701	87.15	gold quality
spleen	UBERON:0002106	87.10	gold quality
right lobe of liver	UBERON:0001114	87.09	gold quality
granulocyte	CL:0000094	87.03	gold quality
nipple	UBERON:0002030	87.00	gold quality
germinal epithelium of ovary	UBERON:0001304	86.98	gold quality
epithelium of mammary gland	UBERON:0003244	86.97	gold quality
blood	UBERON:0000178	86.94	gold quality
cerebellum	UBERON:0002037	86.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.69

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

4 targets.

Target	Regulation
CDKN2A
DHCR7	Activation
HBZ
HMGCR	Activation

JASPAR motifs

Motif	Name	Family
MA1592.1	ZNF274	More than 3 adjacent zinc fingers
MA1592.2	ZNF274	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:21170338

Upstream regulators (CollecTRI, top): TRIM28

miRNA regulators (miRDB)

31 targeting ZNF274, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-892A	99.54	68.16	1141
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-216A-5P	99.50	68.02	1288
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-410-3P	99.27	69.98	2457
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-4279	99.19	66.70	2437
HSA-MIR-500A-5P	98.76	69.13	1241
HSA-MIR-5094	98.63	67.11	1062
HSA-MIR-3691-5P	98.62	65.88	552
HSA-MIR-7114-5P	98.51	67.87	1349
HSA-MIR-676-5P	98.49	68.87	1492
HSA-MIR-1914-5P	97.83	66.21	807
HSA-MIR-4693-5P	97.35	67.02	1234
HSA-MIR-5694	97.06	67.70	682

Literature-anchored findings (GeneRIF, showing 4)

• KAP1 functions to coordinate activities that dynamically regulate changes in histone modifications and deposition of HP1 to establish a de novo microenvironment of heterochromatin, which is required for repression of gene transcription by KRAB-zfps. (PMID:16954381)
• analysis of a KRAB domain-containing ZNF (ZNF274) that is involved in recruitment of the KAP1 and SETDB1 to specific regions of the human genome (PMID:21170338)
• A proximal promoter construct for the MAS gene was repressed by the SOX [SRY (sex-determining region on the Y chromosome) box] proteins SRY, SOX2, SOX3 and SOX14, of which SRY is known to interact with the KRAB domain. (PMID:24128372)
• Specific ZNF274 binding interference at SNORD116 activates the maternal transcripts in Prader-Willi syndrome neurons. (PMID:32977341)

Cross-species orthologs

12 orthologs

Organism	Symbol	Gene ID
danio_rerio	plagx	ENSDARG00000036855
danio_rerio	ovol1a	ENSDARG00000076472
danio_rerio	plagl2	ENSDARG00000076657
danio_rerio	ovol1b	ENSDARG00000078256
mus_musculus	Zfp369	ENSMUSG00000021514
mus_musculus	Zfp110	ENSMUSG00000058638
rattus_norvegicus	Zfp110	ENSRNOG00000031328
drosophila_melanogaster	hb	FBGN0001180
drosophila_melanogaster	CG12391	FBGN0033581
caenorhabditis_elegans		WBGENE00001824
caenorhabditis_elegans		WBGENE00003033
caenorhabditis_elegans		WBGENE00012385

Paralogs (29): ZNF446 (ENSG00000083838), REST (ENSG00000084093), ZNF174 (ENSG00000103343), OVOL3 (ENSG00000105261), PLAGL1 (ENSG00000118495), ZSCAN18 (ENSG00000121413), ZNF576 (ENSG00000124444), OVOL2 (ENSG00000125850), PLAGL2 (ENSG00000126003), ZSCAN5A (ENSG00000131848), ZSCAN29 (ENSG00000140265), ZSCAN32 (ENSG00000140987), ZSCAN1 (ENSG00000152467), ZNF18 (ENSG00000154957), ZKSCAN2 (ENSG00000155592), ZNF496 (ENSG00000162714), ZNF202 (ENSG00000166261), ZNF641 (ENSG00000167528), ZNF444 (ENSG00000167685), SCAND1 (ENSG00000171222), ZNF131 (ENSG00000172262), OVOL1 (ENSG00000172818), ZNF518A (ENSG00000177853), ZNF518B (ENSG00000178163), PLAG1 (ENSG00000181690), ZSCAN5B (ENSG00000197213), ZNF770 (ENSG00000198146), PEG3 (ENSG00000198300), ZSCAN5C (ENSG00000204532)

Protein

Protein identifiers

Neurotrophin receptor-interacting factor homolog — Q96GC6 (reviewed: Q96GC6)

Alternative names: Zinc finger protein 274, Zinc finger protein HFB101, Zinc finger protein with KRAB and SCAN domains 19, Zinc finger protein zfp2

All UniProt accessions (4): A0A0A0MR47, Q96GC6, M0QXW4, M0QY30

UniProt curated annotations — full annotation on UniProt →

Function. Probable transcription repressor. Specifically binds to the 3’-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3’-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.

Subunit / interactions. Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28.

Subcellular location. Cytoplasm. Nucleus. Nucleolus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q96GC6-1	1, SP2114a	yes
Q96GC6-2	2, ZNF274a
Q96GC6-3	3, ZNF274b
Q96GC6-4	4, SP2114b

RefSeq proteins (4): NP_001265663, NP_057408, NP_057409, NP_598009* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF02023

UniProt features (28 total): region of interest 5, compositionally biased region 5, zinc finger region 5, splice variant 4, sequence conflict 4, domain 3, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96GC6-F1	59.79	0.08

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 150 (showing top): RRAGTTGT_UNKNOWN, SHIPP_DLBCL_CURED_VS_FATAL_DN, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, ROSS_LEUKEMIA_WITH_MLL_FUSIONS, BLALOCK_ALZHEIMERS_DISEASE_UP, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, HE_PTEN_TARGETS_UP, PID_P75_NTR_PATHWAY, GOBP_CHROMATIN_REMODELING, DANG_BOUND_BY_MYC, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_NEUROTROPHIN_SIGNALING_PATHWAY, OSMAN_BLADDER_CANCER_DN, ACTWSNACTNY_UNKNOWN

GO Biological Process (4): negative regulation of transcription by RNA polymerase II (GO:0000122), chromatin remodeling (GO:0006338), regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (9): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), chromatin binding (GO:0003682), zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleolus (GO:0005730), cytoplasm (GO:0005737), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
binding	2
negative regulation of DNA-templated transcription	1
chromatin organization	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
DNA binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
cation binding	1
nuclear lumen	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

970 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF274	SETDB1	Q15047	970
ZNF274	TRIM28	Q13263	846
ZNF274	GATA2	P23769	675
ZNF274	SPI1	P17947	630
ZNF274	YIPF2	Q9BWQ6	593
ZNF274	ZNF75D	P51815	585
ZNF274	WDR33	Q9C0J8	583
ZNF274	CRBN	Q96SW2	557
ZNF274	ABL1	P00519	498
ZNF274	DDB1	Q16531	496
ZNF274	ETV6	P41212	488
ZNF274	CTBP1	Q13363	480
ZNF274	CTCF	P49711	473
ZNF274	ZZZ3	Q8IYH5	451
ZNF274	YIPF1	Q9Y548	447
ZNF274	CPSF4	O95639	447

IntAct

10 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ZNF274	SCAND1	psi-mi:“MI:0914”(association)	0.530
GRB2	ZNF274	psi-mi:“MI:0915”(physical association)	0.400
ZNF274	DIRAS1	psi-mi:“MI:0915”(physical association)	0.400
ZNF274	S	psi-mi:“MI:0915”(physical association)	0.370
CBX5	ZNF568	psi-mi:“MI:0914”(association)	0.350
ZNF274	ZNF24	psi-mi:“MI:0914”(association)	0.350
ZNF274	RPS27A	psi-mi:“MI:0914”(association)	0.350

BioGRID (37): ZNF274 (Affinity Capture-Western), ZNF274 (Affinity Capture-Western), TRIM28 (Affinity Capture-MS), RPS27A (Affinity Capture-MS), HIST1H1A (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), MRPL27 (Affinity Capture-MS), MRPS14 (Affinity Capture-MS), MDM2 (Affinity Capture-MS), MALSU1 (Affinity Capture-MS), MRPL27 (Affinity Capture-MS), MRPL30 (Affinity Capture-MS), RPS27A (Affinity Capture-MS), HIST1H1A (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS)

ESM2 similar proteins: A1A5P9, A2AVR2, A6QPT6, B2KFW1, O14978, P17029, P17040, P17098, P25233, P70503, Q13342, Q14D33, Q3SYK4, Q3V3Q4, Q4KLI1, Q4R8H9, Q4V8E9, Q5PPP4, Q5R670, Q5R7U0, Q5VWK0, Q61066, Q63HK3, Q68CQ1, Q6PCZ4, Q7TS72, Q80ZG2, Q8BGS3, Q8CF60, Q8IWY8, Q8N660, Q8NDZ0, Q8TD17, Q921B4, Q923B3, Q96D09, Q96GC6, Q96JL9, Q96M43, Q99608

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Cancer significance

From intOGen — cancer-driver classification: activating (oncogene-like) across 1 cancer types — MBL.

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1429 predictions. Top by Δscore:

Variant	Effect	Δscore
19:58183440:CGGGT:C	donor_loss	1.0000
19:58183441:GG:G	donor_gain	1.0000
19:58183441:GGGTG:G	donor_loss	1.0000
19:58183442:GG:G	donor_gain	1.0000
19:58183442:GGTG:G	donor_loss	1.0000
19:58183443:GTG:G	donor_loss	1.0000
19:58183444:T:A	donor_loss	1.0000
19:58185668:T:TA	acceptor_gain	1.0000
19:58185669:G:A	acceptor_gain	1.0000
19:58185799:G:GT	donor_gain	1.0000
19:58185799:G:T	donor_gain	1.0000
19:58185835:G:GG	donor_gain	1.0000
19:58185837:GG:G	donor_gain	1.0000
19:58185838:GG:G	donor_gain	1.0000
19:58186945:A:AG	acceptor_gain	1.0000
19:58186946:G:GG	acceptor_gain	1.0000
19:58206710:T:TA	acceptor_gain	1.0000
19:58206717:CAG:C	acceptor_gain	1.0000
19:58206718:A:AG	acceptor_gain	1.0000
19:58206718:AGA:A	acceptor_gain	1.0000
19:58206719:G:GA	acceptor_gain	1.0000
19:58206719:GA:G	acceptor_gain	1.0000
19:58206719:GAG:G	acceptor_gain	1.0000
19:58206719:GAGT:G	acceptor_gain	1.0000
19:58207198:GGAAG:G	donor_gain	1.0000
19:58207199:GAAG:G	donor_gain	1.0000
19:58207199:GAAGG:G	donor_gain	1.0000
19:58207200:AAG:A	donor_gain	1.0000
19:58207201:AG:A	donor_gain	1.0000
19:58207202:GG:G	donor_gain	1.0000

AlphaMissense

4297 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:58213063:T:C	F628L	1.000
19:58213065:C:A	F628L	1.000
19:58213065:C:G	F628L	1.000
19:58212811:T:C	F544L	0.999
19:58212813:T:A	F544L	0.999
19:58212813:T:G	F544L	0.999
19:58212895:T:C	F572L	0.999
19:58212897:C:A	F572L	0.999
19:58212897:C:G	F572L	0.999
19:58212979:T:C	F600L	0.999
19:58212981:C:A	F600L	0.999
19:58212981:C:G	F600L	0.999
19:58213064:T:C	F628S	0.999
19:58212924:C:A	H581Q	0.998
19:58212924:C:G	H581Q	0.998
19:58213006:C:G	H609D	0.998
19:58213008:T:A	H609Q	0.998
19:58213008:T:G	H609Q	0.998
19:58213082:T:C	L634P	0.998
19:58212812:T:C	F544S	0.997
19:58213092:C:A	H637Q	0.997
19:58213092:C:G	H637Q	0.997
19:58212830:T:C	L550P	0.996
19:58212840:T:A	H553Q	0.996
19:58212840:T:G	H553Q	0.996
19:58212842:A:C	Q554P	0.996
19:58212980:T:C	F600S	0.996
19:58212998:T:C	L606P	0.996
19:58213006:C:A	H609N	0.996
19:58213010:A:C	Q610P	0.996

dbSNP variants (sampled 300 via entrez): RS1000012764 (19:58209034 G>A), RS1000087855 (19:58193186 G>A), RS1000116566 (19:58199691 T>C), RS1000181152 (19:58184293 T>TG), RS1000205213 (19:58187329 C>A,T), RS1000367741 (19:58204591 T>G), RS1000416833 (19:58193476 G>A), RS1000500197 (19:58189195 T>G), RS1000768237 (19:58211927 C>G), RS1000865080 (19:58195246 T>C), RS1000874552 (19:58188360 G>C), RS1001107900 (19:58183380 C>T), RS1001546246 (19:58185013 G>A,C,T), RS1001638007 (19:58204211 G>A), RS1001640879 (19:58185421 C>G)

Disease associations

OMIM: gene MIM:605467 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002896_47	Cholesterol, total	5.000000e-08
GCST002898_42	LDL cholesterol	1.000000e-08
GCST007239_26	Ovarian cancer	5.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004574	total cholesterol measurement
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	increases expression, affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	increases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
triphenyl phosphate	affects expression	1
geraniol	increases expression	1
methylselenic acid	increases expression	1
beta-lapachone	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
cupric oxide	increases expression	1
beta-methylcholine	affects expression	1
diethyl malate	increases expression	1
di-n-butylphosphoric acid	affects expression	1
deguelin	increases expression	1
2-palmitoylglycerol	increases expression	1
K 7174	increases expression	1
abrine	increases expression	1
picoxystrobin	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Gemcitabine	increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Piroxicam	affects cotreatment, decreases expression	1
Selenium	affects cotreatment, decreases expression	1

Cellosaurus cell lines

6 cell lines: 3 embryonic stem cell, 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A8F9	SEES3-1V human ZNF274, clone1	Embryonic stem cell	Male
CVCL_A8G0	SEES3-1V human ZNF274, clone2	Embryonic stem cell	Male
CVCL_A8G1	SEES3-1V human ZNF274, clone3	Embryonic stem cell	Male
CVCL_E2PS	HAP1 ZNF274 (-) 1	Cancer cell line	Male
CVCL_E2PT	HAP1 ZNF274 (-) 2	Cancer cell line	Male
CVCL_XW27	HEK293 eGFP-ZNF274	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.