ZNF295-AS1

Summary

ZNF295-AS1 (ZNF295 antisense RNA 1, HGNC:23130) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23130
Approved symbol	ZNF295-AS1
Name	ZNF295 antisense RNA 1
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRED87
Ensembl gene	ENSG00000237232
Ensembl biotype	lncRNA
Entrez	150142
RNAcentral	URS000075ED2C — lncRNA, 777 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 52 — 52 lncRNA

ENST00000412906, ENST00000429739, ENST00000455701, ENST00000657413, ENST00000665885, ENST00000669320, ENST00000675169, ENST00000675770, ENST00000675924, ENST00000676087, ENST00000676145, ENST00000845081, ENST00000845082, ENST00000845083, ENST00000845084, ENST00000845085, ENST00000845086, ENST00000845087, ENST00000845088, ENST00000845089, ENST00000845090, ENST00000845091, ENST00000845092, ENST00000845093, ENST00000845094, ENST00000845095, ENST00000845096, ENST00000845097, ENST00000845098, ENST00000845099, ENST00000845100, ENST00000845101, ENST00000845102, ENST00000845103, ENST00000845104, ENST00000845105, ENST00000845106, ENST00000845107, ENST00000845108, ENST00000845109, ENST00000845110, ENST00000845111, ENST00000845112, ENST00000845113, ENST00000845114, ENST00000845115, ENST00000845116, ENST00000845117, ENST00000845118, ENST00000845119, ENST00000845120, ENST00000845121

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412906 — 2 exons

Exon	Start	End
ENSE00004272230	42009148	42009584
ENSE00004272274	42024306	42024965

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 91.95.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0163 / max 13.9836, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189271	0.0163	3

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	91.95	gold quality
right uterine tube	UBERON:0001302	91.61	gold quality
right testis	UBERON:0004534	88.39	gold quality
left testis	UBERON:0004533	88.25	gold quality
oviduct epithelium	UBERON:0004804	86.06	gold quality
testis	UBERON:0000473	85.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.68	gold quality
mucosa of paranasal sinus	UBERON:0005030	81.17	gold quality
bronchial epithelial cell	CL:0002328	79.81	gold quality
bone marrow cell	CL:0002092	78.43	gold quality
bronchus	UBERON:0002185	78.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.70	gold quality
fallopian tube	UBERON:0003889	75.76	gold quality
buccal mucosa cell	CL:0002336	75.41	silver quality
cardiac muscle of right atrium	UBERON:0003379	74.88	gold quality
left ventricle myocardium	UBERON:0006566	74.75	gold quality
left adrenal gland	UBERON:0001234	72.68	gold quality
left adrenal gland cortex	UBERON:0035825	72.64	gold quality
adult organism	UBERON:0007023	71.76	gold quality
stromal cell of endometrium	CL:0002255	71.19	gold quality
adrenal cortex	UBERON:0001235	70.21	gold quality
nasal cavity mucosa	UBERON:0001826	70.11	gold quality
adrenal gland	UBERON:0002369	69.62	gold quality
pancreatic ductal cell	CL:0002079	69.37	silver quality
sural nerve	UBERON:0015488	69.21	gold quality
right lobe of liver	UBERON:0001114	69.20	gold quality
calcaneal tendon	UBERON:0003701	69.00	gold quality
superficial temporal artery	UBERON:0001614	68.95	gold quality
right adrenal gland cortex	UBERON:0035827	68.05	gold quality
epithelium of nasopharynx	UBERON:0001951	67.67	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• ZNF295-AS1 inhibits autophagy via the ZNF295-AS1/miR-508-5p/ATG7 axis in AS. (PMID:32633396)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.