ZNF317

Summary

ZNF317 (zinc finger protein 317, HGNC:13507) is a protein-coding gene on chromosome 19p13.2, encoding Zinc finger protein 317 (Q96PQ6). May function as a transcription factor. It is a selective cancer dependency (DepMap: 10.8% of cell lines).

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus.

Source: NCBI Gene 57693 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 98 total
• Cancer dependency (DepMap): dependent in 10.8% of screened cell lines
• MANE Select transcript: NM_020933

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13507
Approved symbol	ZNF317
Name	zinc finger protein 317
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000130803
Ensembl biotype	protein_coding
OMIM	613864
Entrez	57693

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 13 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000247956, ENST00000360385, ENST00000419608, ENST00000590152, ENST00000591278, ENST00000591508, ENST00000891822, ENST00000891823, ENST00000933872, ENST00000933873, ENST00000933874, ENST00000933875, ENST00000933876, ENST00000949134, ENST00000949135, ENST00000949136

RefSeq mRNA: 2 — MANE Select: NM_020933 NM_001190791, NM_020933

CCDS: CCDS12210, CCDS54213

Canonical transcript exons

ENST00000247956 — 7 exons

Exon	Start	End
ENSE00001345511	9155925	9156041
ENSE00001683836	9157268	9157394
ENSE00002754690	9140397	9140592
ENSE00002874668	9160114	9163413
ENSE00003561007	9156612	9156748
ENSE00003686568	9158826	9158908
ENSE00003688506	9157980	9158075

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 90.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 20.2788 / max 124.1033, expressed in 1816 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173692	10.3239	1791
173691	9.9549	1792

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	90.84	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.40	silver quality
upper arm skin	UBERON:0004263	90.11	gold quality
left ventricle myocardium	UBERON:0006566	89.96	silver quality
kidney epithelium	UBERON:0004819	89.66	silver quality
mucosa of transverse colon	UBERON:0004991	89.54	gold quality
ileal mucosa	UBERON:0000331	89.17	gold quality
cortical plate	UBERON:0005343	89.15	gold quality
lower esophagus mucosa	UBERON:0035834	88.36	gold quality
embryo	UBERON:0000922	87.76	gold quality
ganglionic eminence	UBERON:0004023	87.76	gold quality
ventricular zone	UBERON:0003053	87.75	gold quality
islet of Langerhans	UBERON:0000006	87.17	gold quality
skin of abdomen	UBERON:0001416	86.75	gold quality
spleen	UBERON:0002106	86.56	gold quality
apex of heart	UBERON:0002098	86.48	gold quality
skin of leg	UBERON:0001511	86.31	gold quality
leukocyte	CL:0000738	86.21	gold quality
monocyte	CL:0000576	85.82	gold quality
zone of skin	UBERON:0000014	85.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.06	gold quality
pancreas	UBERON:0001264	85.03	gold quality
right lobe of liver	UBERON:0001114	85.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	84.99	gold quality
lower esophagus	UBERON:0013473	84.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.93	gold quality
small intestine Peyer’s patch	UBERON:0003454	84.63	gold quality
adenohypophysis	UBERON:0002196	84.57	gold quality
body of pancreas	UBERON:0001150	84.47	gold quality
body of stomach	UBERON:0001161	84.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.18

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA1593.1	ZNF317	More than 3 adjacent zinc fingers
MA1593.2	ZNF317	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:28273063

miRNA regulators (miRDB)

46 targeting ZNF317, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-4320	99.75	65.80	793
HSA-MIR-8084	99.73	69.57	1760
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-6740-3P	99.48	68.49	1392
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-3915	99.45	68.49	1905
HSA-MIR-650	99.45	65.77	1309
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-6882-5P	99.35	71.13	1206
HSA-MIR-5693	99.24	66.67	1106
HSA-MIR-6071	99.16	67.77	1780
HSA-MIR-323B-3P	99.14	68.89	725
HSA-MIR-198	98.70	67.32	920
HSA-MIR-7977	98.65	66.18	2590

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 10.8% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• molecular cloning and characterization of isoforms (PMID:11688974)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp317	ENSMUSG00000057551
rattus_norvegicus	Zfp317	ENSRNOG00000006684

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 317 — Q96PQ6 (reviewed: Q96PQ6)

All UniProt accessions (3): Q96PQ6, K7EKT9, K7ERD6

UniProt curated annotations — full annotation on UniProt →

Function. May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Subcellular location. Nucleus.

Tissue specificity. Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q96PQ6-1	2, ZNF317-2	yes
Q96PQ6-2	1, ZNF317-1
Q96PQ6-3	3, ZNF317-3
Q96PQ6-4	4, ZNF317-4

RefSeq proteins (2): NP_001177720, NP_065984* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096, PF01352

UniProt features (20 total): zinc finger region 13, splice variant 2, chain 1, domain 1, region of interest 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96PQ6-F1	68.10	0.05

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins

MSigDB gene sets: 74 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, WANG_CISPLATIN_RESPONSE_AND_XPC_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, SENESE_HDAC1_TARGETS_UP, ZHANG_BREAST_CANCER_PROGENITORS_UP, chr19p13, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GCM_DENR, REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ASH1L_TARGET_GENES

GO Biological Process (3): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
RNA Polymerase II Transcription	1
Regulation of endogenous retroelements	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

576 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF317	OR4N4C	A0A096LPK9	507
ZNF317	CARM1	Q86X55	488
ZNF317	CNDP2	Q96KP4	393
ZNF317	PRR12	Q9ULL5	377
ZNF317	GTF3C5	Q9Y5Q8	375
ZNF317	DNAJC5G	Q8N7S2	355
ZNF317	CTPS2	Q9NRF8	352
ZNF317	DHX15	O43143	298
ZNF317	STX16	O14662	286
ZNF317	SETD5	Q9C0A6	270
ZNF317	ATMIN	O43313	263
ZNF317	TOP1	P11387	258
ZNF317	KCNAB2	Q13303	253
ZNF317	TRIM28	Q13263	249
ZNF317	PRMT2	P55345	242

IntAct

89 interactions, top by confidence:

A	B	Type	Score
NKAPD1	ZNF317	psi-mi:“MI:0915”(physical association)	0.780
ZNF317	NKAPD1	psi-mi:“MI:0915”(physical association)	0.780
ZNF317	RBMY1A1	psi-mi:“MI:0915”(physical association)	0.740
RBMY1A1	ZNF317	psi-mi:“MI:0915”(physical association)	0.740
AEN	ZNF317	psi-mi:“MI:0915”(physical association)	0.670
ZNF317	AEN	psi-mi:“MI:0915”(physical association)	0.670
ZNF837	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
RBMY1F	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
RBM10	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
RBMY1A1	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
ZNF317	ZNF408	psi-mi:“MI:0915”(physical association)	0.560
ZNF317	CIB3	psi-mi:“MI:0915”(physical association)	0.560
ZNF524	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
CLK2	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
ZBTB48	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
ZNF648	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
BAHD1	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
RSBN1	SETD1A	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530

BioGRID (93): ZNF317 (Two-hybrid), ZNF317 (Two-hybrid), AEN (Two-hybrid), KRT40 (Two-hybrid), KRTAP10-9 (Two-hybrid), RPL26L1 (Affinity Capture-MS), RPL26 (Affinity Capture-MS), RPS3A (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), TUBA8 (Affinity Capture-MS), RPL13 (Affinity Capture-MS), MRPS18A (Affinity Capture-MS), RBMY1A1 (Two-hybrid), TUBA8 (Affinity Capture-MS), ZNF317 (Affinity Capture-MS)

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A6QLU5, B2RUI1, D3ZVT0, O14709, O43296, O75123, P10072, P15621, P17020, P17097, P51814, P85977, Q08ER8, Q0VGE8, Q14590, Q32KN0, Q3KQV3, Q4V8A8, Q5CZA5, Q5RBX0, Q5RCD9, Q5VIY5, Q61116, Q61967, Q6GQR8, Q6P9A3, Q6ZMS4, Q7TSH9, Q7TSI0, Q7Z3I7, Q86UD4, Q86WZ6, Q8BFS8, Q8IZ26, Q8N9F8, Q8TAF7

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 62 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	7	30.6×	7e-08
Viral mRNA Translation	7	30.6×	7e-08
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	7	30.3×	7e-08
Selenocysteine synthesis	7	29.0×	7e-08
Eukaryotic Translation Termination	7	29.0×	7e-08
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	7	28.4×	7e-08
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	7	28.4×	7e-08
SRP-dependent cotranslational protein targeting to membrane	8	27.6×	3e-08

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	8	26.9×	1e-07
translation	7	13.1×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	79
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1217 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9140588:GTCGT:G	donor_gain	1.0000
19:9140591:GT:G	donor_gain	1.0000
19:9140593:G:GG	donor_gain	1.0000
19:9143041:A:T	donor_gain	1.0000
19:9157393:GG:G	donor_gain	1.0000
19:9157394:GG:G	donor_gain	1.0000
19:9157394:GGTAA:G	donor_loss	1.0000
19:9157395:G:GA	donor_loss	1.0000
19:9157395:G:GG	donor_gain	1.0000
19:9158824:A:AG	acceptor_gain	1.0000
19:9158824:AGATT:A	acceptor_gain	1.0000
19:9158825:G:GA	acceptor_gain	1.0000
19:9158825:GATT:G	acceptor_gain	1.0000
19:9158825:GATTG:G	acceptor_gain	1.0000
19:9158905:GATG:G	donor_gain	1.0000
19:9158906:ATGGT:A	donor_loss	1.0000
19:9158908:GGT:G	donor_loss	1.0000
19:9158909:G:GG	donor_gain	1.0000
19:9158909:G:T	donor_loss	1.0000
19:9158910:TAAGA:T	donor_loss	1.0000
19:9140589:TCGT:T	donor_gain	0.9900
19:9140589:TCGTG:T	donor_loss	0.9900
19:9140590:CGTG:C	donor_loss	0.9900
19:9140591:GTGTA:G	donor_loss	0.9900
19:9140593:G:T	donor_loss	0.9900
19:9140594:T:TC	donor_loss	0.9900
19:9156735:GT:G	donor_gain	0.9900
19:9156742:TTCCC:T	donor_gain	0.9900
19:9156881:G:GT	donor_gain	0.9900
19:9158820:TTTCA:T	acceptor_loss	0.9900

AlphaMissense

3979 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9161260:T:C	F539L	1.000
19:9161262:C:A	F539L	1.000
19:9161262:C:G	F539L	1.000
19:9160336:T:C	F231L	0.999
19:9160338:C:A	F231L	0.999
19:9160338:C:G	F231L	0.999
19:9160420:T:C	F259L	0.999
19:9160422:C:A	F259L	0.999
19:9160422:C:G	F259L	0.999
19:9160672:T:C	F343L	0.999
19:9160674:C:A	F343L	0.999
19:9160674:C:G	F343L	0.999
19:9160756:T:C	F371L	0.999
19:9160758:C:A	F371L	0.999
19:9160758:C:G	F371L	0.999
19:9161008:T:C	F455L	0.999
19:9161010:C:A	F455L	0.999
19:9161010:C:G	F455L	0.999
19:9161210:G:C	R522P	0.999
19:9161294:G:C	R550P	0.999
19:9161344:T:C	F567L	0.999
19:9161346:C:A	F567L	0.999
19:9161346:C:G	F567L	0.999
19:9160504:T:C	F287L	0.998
19:9160506:C:A	F287L	0.998
19:9160506:C:G	F287L	0.998
19:9160701:C:A	H352Q	0.998
19:9160701:C:G	H352Q	0.998
19:9160924:T:C	F427L	0.998
19:9160926:C:A	F427L	0.998

dbSNP variants (sampled 300 via entrez): RS1000307709 (19:9148251 C>T), RS1000470452 (19:9153741 T>C), RS1000595559 (19:9143300 T>G), RS1000667158 (19:9141887 C>T), RS1000700621 (19:9149304 T>G), RS1000708398 (19:9138593 C>A,G), RS1000763855 (19:9138884 T>G), RS1001049821 (19:9143949 T>G), RS1001209288 (19:9155307 C>G), RS1001387537 (19:9153144 TTGTTTTTGTTTG>T), RS1001390777 (19:9139034 G>A), RS1001442905 (19:9153480 G>A), RS1001575779 (19:9161549 G>A), RS1001603147 (19:9138461 G>A), RS1001629552 (19:9161209 C>G,T)

Disease associations

OMIM: gene MIM:613864 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003542_87	Night sleep phenotypes	5.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
bisphenol A	increases expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	increases expression	1
zinc chromate	increases abundance, increases expression	1
chromium hexavalent ion	increases abundance, increases expression	1
abrine	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, decreases reaction	1
Sunitinib	increases expression	1
Vehicle Emissions	decreases expression, decreases reaction	1
Dexamethasone	affects cotreatment, increases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Methotrexate	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Oils	increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	increases expression	1
Valproic Acid	increases methylation	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Asbestos, Crocidolite	decreases expression	1
Cadmium Chloride	increases expression	1
Particulate Matter	decreases expression, decreases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.