ZNF318

Summary

ZNF318 (zinc finger protein 318, HGNC:13578) is a protein-coding gene on chromosome 6p21.1, encoding Zinc finger protein 318 (Q5VUA4). Acts as a transcriptional corepressor for AR-mediated transactivation function.

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in cytosol and nucleoplasm.

Source: NCBI Gene 24149 — RefSeq curated summary.

At a glance

• GWAS associations: 46
• Clinical variants (ClinVar): 340 total
• MANE Select transcript: NM_014345

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13578
Approved symbol	ZNF318
Name	zinc finger protein 318
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	HRIHFB2436, ZFP318
Ensembl gene	ENSG00000171467
Ensembl biotype	protein_coding
OMIM	617512
Entrez	24149

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000361428, ENST00000605935, ENST00000606599, ENST00000607252, ENST00000930865

RefSeq mRNA: 1 — MANE Select: NM_014345 NM_014345

CCDS: CCDS4895

Canonical transcript exons

ENST00000361428 — 10 exons

Exon	Start	End
ENSE00001137777	43336070	43340502
ENSE00001137783	43357126	43357765
ENSE00001172979	43340790	43340908
ENSE00001172987	43342112	43342211
ENSE00001172995	43342676	43342879
ENSE00001173003	43348324	43348625
ENSE00001173011	43352377	43352476
ENSE00001173021	43354664	43356145
ENSE00001612696	43368967	43369647
ENSE00001681665	43365292	43365440

Expression profiles

Bgee: expression breadth ubiquitous, 274 present calls, max score 91.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.9862 / max 101.9156, expressed in 1726 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73679	3.6148	1342
73680	1.8298	1121
73681	1.3229	910
73678	0.9909	447
204000	0.2210	102
73677	0.0068	3

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	91.92	gold quality
right testis	UBERON:0004534	91.60	gold quality
testis	UBERON:0000473	91.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.39	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.35	gold quality
cerebellar hemisphere	UBERON:0002245	86.32	gold quality
granulocyte	CL:0000094	86.28	gold quality
cerebellar cortex	UBERON:0002129	86.19	gold quality
secondary oocyte	CL:0000655	85.77	gold quality
apex of heart	UBERON:0002098	85.70	gold quality
lymph node	UBERON:0000029	85.54	gold quality
sural nerve	UBERON:0015488	85.52	gold quality
endocervix	UBERON:0000458	84.88	gold quality
monocyte	CL:0000576	84.59	gold quality
body of uterus	UBERON:0009853	84.57	gold quality
leukocyte	CL:0000738	84.53	gold quality
mononuclear cell	CL:0000842	84.43	gold quality
cerebellum	UBERON:0002037	84.23	gold quality
sperm	CL:0000019	83.65	gold quality
right lobe of thyroid gland	UBERON:0001119	83.64	gold quality
cortical plate	UBERON:0005343	83.52	gold quality
left lobe of thyroid gland	UBERON:0001120	83.46	gold quality
tibial nerve	UBERON:0001323	83.23	gold quality
ventricular zone	UBERON:0003053	83.11	gold quality
ganglionic eminence	UBERON:0004023	83.03	gold quality
right ovary	UBERON:0002118	82.79	gold quality
islet of Langerhans	UBERON:0000006	82.78	gold quality
thyroid gland	UBERON:0002046	82.61	gold quality
left ovary	UBERON:0002119	82.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.91

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

113 targeting ZNF318, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-12118	100.00	65.88	1270
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-548N	99.98	71.94	4170
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-5688	99.96	73.23	4504

Literature-anchored findings (GeneRIF, showing 1)

• in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively (PMID:16446156)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf318	ENSDARG00000090054
mus_musculus	Zfp318	ENSMUSG00000015597
rattus_norvegicus	Zfp318	ENSRNOG00000018741
drosophila_melanogaster	CG9776	FBGN0027866
caenorhabditis_elegans		WBGENE00017031

Protein

Protein identifiers

Zinc finger protein 318 — Q5VUA4 (reviewed: Q5VUA4)

Alternative names: Endocrine regulatory protein

All UniProt accessions (2): Q5VUA4, U3KQ37

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.

Subunit / interactions. Homodimer. Heterodimer of isoform 1 and isoform 2. Isoform 1 and isoform 2 interact with AR.

Subcellular location. Nucleus.

Tissue specificity. Expressed in endocrine tissue.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5VUA4-1	1	yes
Q5VUA4-2	2

RefSeq proteins (1): NP_055160* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003604	Matrin/U1-like-C_Znf_C2H2	Domain
IPR055309	Znf318-like	Family

UniProt features (92 total): modified residue 29, compositionally biased region 20, region of interest 16, sequence variant 8, sequence conflict 7, cross-link 4, coiled-coil region 3, zinc finger region 2, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VUA4-F1	41.32	0.05

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (33): 40, 79, 81, 136, 173, 205, 207, 214, 464, 472, 501, 527, 842, 1010, 1037, 1243, 1267, 1420, 1713, 1856 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (3): negative regulation of DNA-templated transcription (GO:0045892), positive regulation of DNA-templated transcription (GO:0045893), meiotic cell cycle (GO:0051321)

GO Molecular Function (4): nucleic acid binding (GO:0003676), zinc ion binding (GO:0008270), protein homodimerization activity (GO:0042803), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleoplasm (GO:0005654), cytosol (GO:0005829), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	2
regulation of DNA-templated transcription	2
cellular anatomical structure	2
negative regulation of RNA biosynthetic process	1
positive regulation of RNA biosynthetic process	1
cell cycle	1
sexual reproduction	1
reproductive process	1
meiotic nuclear division	1
binding	1
transition metal ion binding	1
identical protein binding	1
protein dimerization activity	1
cation binding	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2428 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF318	ZFP36L2	P47974	669
ZNF318	YLPM1	P49750	557
ZNF318	ZFP36	P26651	524
ZNF318	PPP1CC	P36873	482
ZNF318	ZFP36L1	Q07352	466
ZNF318	HINFP	Q9BQA5	441
ZNF318	SYCE3	A1L190	434
ZNF318	ABCC10	Q5T3U5	417
ZNF318	TEX11	Q8IYF3	411
ZNF318	NCAPD2	Q15021	402
ZNF318	ZFHX4	Q86UP3	389
ZNF318	TESMIN	Q9Y4I5	371
ZNF318	CNR2	P34972	370
ZNF318	RWDD1	Q9H446	357
ZNF318	POU6F1	Q14863	330
ZNF318	ZC3H15	Q8WU90	330

IntAct

108 interactions, top by confidence:

A	B	Type	Score
AXIN1	APC	psi-mi:“MI:0914”(association)	0.850
P4HA3	FAM171A2	psi-mi:“MI:0914”(association)	0.640
rep	SBNO1	psi-mi:“MI:0914”(association)	0.530
DISC1	AP4M1	psi-mi:“MI:0914”(association)	0.530
CPNE2	HIP1	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
BAG4	DNAJC13	psi-mi:“MI:0914”(association)	0.530
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
ZNF318	LRRC59	psi-mi:“MI:0915”(physical association)	0.400
FHIP2B	ZNF318	psi-mi:“MI:0915”(physical association)	0.400
	DENR	psi-mi:“MI:0915”(physical association)	0.400
	TK2	psi-mi:“MI:0915”(physical association)	0.400
Cep135		psi-mi:“MI:0914”(association)	0.350
AP4M1		psi-mi:“MI:0914”(association)	0.350
SGTB	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
EGLN3	FAM168B	psi-mi:“MI:0914”(association)	0.350
NBEAL2	HAX1	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
rep	SBNO1	psi-mi:“MI:0914”(association)	0.350
CEP63	CIT	psi-mi:“MI:0914”(association)	0.350
CEP170	FAM171A2	psi-mi:“MI:0914”(association)	0.350
CEP192	WASL	psi-mi:“MI:0914”(association)	0.350
CEP63	CIBAR1	psi-mi:“MI:0914”(association)	0.350
DYRK1A	TEX13D	psi-mi:“MI:0914”(association)	0.350
SF3A1	HSPA8	psi-mi:“MI:0914”(association)	0.350

BioGRID (169): ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Proximity Label-MS), ZNF318 (Proximity Label-MS), ZNF318 (Proximity Label-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS), ZNF318 (Affinity Capture-MS)

ESM2 similar proteins: A0JMU8, A5D7H5, E9Q2Z1, O15014, O15234, O43823, O70305, O75420, P48634, P61129, Q13625, Q1ECZ4, Q3UH68, Q3UIL6, Q569Z6, Q5BJ39, Q5CZI8, Q5M7V8, Q5R4R4, Q5TM26, Q5VK71, Q5VUA4, Q62415, Q68FI1, Q6IQ23, Q6MG48, Q6PJG2, Q6ZQ03, Q7TPM1, Q7TQG1, Q7TSC1, Q8AVJ2, Q8BZ47, Q8CG79, Q8K2F8, Q8K3W3, Q8K3X0, Q8N3X1, Q8ND56, Q96EV2

Diamond homologs: Q5VUA4, Q99PP2

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
ZNF318	“down-regulates activity”	AR	binding
HDAC2	“up-regulates activity”	ZNF318	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 146 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing	13	15.5×	4e-10
mRNA 3’-end processing	7	15.0×	3e-05
Processing of Capped Intron-Containing Pre-mRNA	14	12.5×	7e-10
mRNA Polyadenylation	13	12.4×	4e-09
mRNA Splicing - Minor Pathway	5	12.2×	3e-03
RNA Polymerase II Transcription Termination	5	11.9×	3e-03
mRNA Splicing - Major Pathway	19	11.3×	1e-12
Transport of Mature mRNA derived from an Intron-Containing Transcript	6	9.9×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
mRNA splicing, via spliceosome	17	12.3×	3e-11
mRNA processing	10	6.2×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

340 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	298
Likely benign	20
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

2386 predictions. Top by Δscore:

Variant	Effect	Δscore
6:43307610:A:AC	donor_gain	1.0000
6:43307611:C:CC	donor_gain	1.0000
6:43307611:CTTTT:C	donor_gain	1.0000
6:43308514:T:TA	donor_gain	1.0000
6:43340498:TATTT:T	acceptor_gain	1.0000
6:43340499:ATTT:A	acceptor_gain	1.0000
6:43340499:ATTTC:A	acceptor_loss	1.0000
6:43340500:TTT:T	acceptor_gain	1.0000
6:43340500:TTTC:T	acceptor_loss	1.0000
6:43340501:TT:T	acceptor_gain	1.0000
6:43340502:TC:T	acceptor_loss	1.0000
6:43340503:C:CC	acceptor_gain	1.0000
6:43340504:T:A	acceptor_loss	1.0000
6:43342216:T:C	acceptor_gain	1.0000
6:43342599:T:C	acceptor_gain	1.0000
6:43342599:T:TC	acceptor_gain	1.0000
6:43348635:C:CT	acceptor_gain	1.0000
6:43348636:A:T	acceptor_gain	1.0000
6:43348638:A:AC	acceptor_gain	1.0000
6:43348638:A:C	acceptor_gain	1.0000
6:43348642:C:CT	acceptor_gain	1.0000
6:43348643:A:T	acceptor_gain	1.0000
6:43348645:C:CT	acceptor_gain	1.0000
6:43352371:TGATA:T	donor_loss	1.0000
6:43352372:GATAC:G	donor_loss	1.0000
6:43352374:TACCT:T	donor_loss	1.0000
6:43352376:C:A	donor_loss	1.0000
6:43352473:TAAC:T	acceptor_gain	1.0000
6:43352478:T:C	acceptor_loss	1.0000
6:43357199:T:TA	donor_gain	1.0000

AlphaMissense

14852 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:43342187:A:G	W1101R	1.000
6:43342187:A:T	W1101R	1.000
6:43348553:A:G	L948P	1.000
6:43352391:A:G	L919P	1.000
6:43355547:A:G	L596P	1.000
6:43339295:A:G	L1568P	0.999
6:43339768:A:C	F1410L	0.999
6:43339768:A:T	F1410L	0.999
6:43339770:A:G	F1410L	0.999
6:43339992:A:G	W1336R	0.999
6:43339992:A:T	W1336R	0.999
6:43340459:A:G	L1180P	0.999
6:43340465:C:G	R1178P	0.999
6:43340468:C:G	R1177P	0.999
6:43340795:A:C	Y1164D	0.999
6:43340871:G:C	C1138W	0.999
6:43340873:A:G	C1138R	0.999
6:43342112:C:G	G1126R	0.999
6:43342185:C:A	W1101C	0.999
6:43342185:C:G	W1101C	0.999
6:43342739:G:C	C1071W	0.999
6:43342748:G:C	C1068W	0.999
6:43342749:C:G	C1068S	0.999
6:43342750:A:G	C1068R	0.999
6:43342750:A:T	C1068S	0.999
6:43342753:A:G	W1067R	0.999
6:43342753:A:T	W1067R	0.999
6:43348467:C:G	A977P	0.999
6:43348478:A:G	L973P	0.999
6:43352412:A:G	L912P	0.999

dbSNP variants (sampled 300 via entrez): RS1000024783 (6:43369594 C>A,G,T), RS1000079955 (6:43360491 C>T), RS1000325969 (6:43354008 G>A), RS1000366317 (6:43371339 T>G), RS1000401212 (6:43354360 T>C), RS1000432787 (6:43357028 A>T), RS1000448600 (6:43365522 G>C), RS1000596621 (6:43339392 C>T), RS1000609991 (6:43348196 C>A,G), RS1000659884 (6:43352472 A>G), RS1000710939 (6:43369789 C>G,T), RS1000731553 (6:43352791 T>C), RS1000773188 (6:43365824 T>A,C), RS1000879762 (6:43335988 A>G), RS1000909595 (6:43346378 G>A)

Disease associations

OMIM: gene MIM:617512 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

46 associations (top):

Study	Trait	p-value
GCST003272_2	Systolic blood pressure	2.000000e-16
GCST004521_164	Autism spectrum disorder or schizophrenia	3.000000e-08
GCST004775_24	Pulse pressure	7.000000e-07
GCST004776_25	Systolic blood pressure	3.000000e-06
GCST005956_58	Waist-to-hip ratio adjusted for BMI	7.000000e-26
GCST005957_1	Waist-to-hip ratio adjusted for BMI (age <50)	2.000000e-14
GCST005958_2	Waist-to-hip ratio adjusted for BMI (age >50)	2.000000e-19
GCST005962_2	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	3.000000e-31
GCST005983_48	Serum uric acid levels	1.000000e-11
GCST006168_31	Pulse pressure x alcohol consumption interaction (2df test)	2.000000e-16
GCST006168_46	Pulse pressure x alcohol consumption interaction (2df test)	5.000000e-10
GCST006259_53	Systolic blood pressure	5.000000e-09
GCST006434_17	Systolic blood pressure x alcohol consumption interaction (2df test)	2.000000e-22
GCST006434_84	Systolic blood pressure x alcohol consumption interaction (2df test)	3.000000e-11
GCST006979_279	Heel bone mineral density	6.000000e-09
GCST007096_154	Pulse pressure	4.000000e-08
GCST007096_193	Pulse pressure	3.000000e-06
GCST007099_135	Systolic blood pressure	1.000000e-09
GCST007099_208	Systolic blood pressure	4.000000e-10
GCST007267_216	Systolic blood pressure	3.000000e-24
GCST007269_248	Pulse pressure	4.000000e-14
GCST007576_192	Chronotype	3.000000e-09
GCST007703_123	Systolic blood pressure	3.000000e-10
GCST007704_49	Diastolic blood pressure	7.000000e-07
GCST007705_7	Pulse pressure	4.000000e-06
GCST007706_82	Mean arterial pressure	2.000000e-09
GCST007707_44	Hypertension	4.000000e-07
GCST007725_36	Serum uric acid levels	2.000000e-13
GCST007928_43	Medication use (diuretics)	6.000000e-11
GCST007929_73	Medication use (calcium channel blockers)	3.000000e-10

EFO canonical traits (18, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0005763	pulse pressure measurement
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004761	uric acid measurement
EFO:0004329	alcohol drinking
EFO:0009270	heel bone mineral density
EFO:0008328	chronotype measurement
EFO:0006336	diastolic blood pressure
EFO:0006340	mean arterial pressure
EFO:0009928	Diuretic use measurement
EFO:0009930	Calcium channel blocker use measurement
EFO:0009931	Agents acting on the renin-angiotensin system use measurement
EFO:0004531	urate measurement
EFO:1001976	cardioembolic stroke
EFO:0008039	BMI-adjusted hip circumference
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	affects phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression, increases abundance	1
butyraldehyde	decreases expression	1
coumarin	affects phosphorylation	1
testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	affects expression	1
deguelin	decreases expression	1
ICG 001	increases expression	1
Temozolomide	increases expression	1
Vorinostat	decreases expression	1
Leflunomide	decreases expression	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Caffeine	affects phosphorylation	1
Dimethyl Sulfoxide	increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Quercetin	decreases phosphorylation	1
Dronabinol	increases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
Cyclosporine	decreases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	decreases expression, increases abundance	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.