ZNF326

Summary

ZNF326 (zinc finger protein 326, HGNC:14104) is a protein-coding gene on chromosome 1p22.2, encoding DBIRD complex subunit ZNF326 (Q5BKZ1). Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongati….

Enables RNA polymerase II complex binding activity. Involved in regulation of DNA-templated transcription elongation and regulation of RNA splicing. Located in nucleoplasm. Part of DBIRD complex.

Source: NCBI Gene 284695 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 83 total
• MANE Select transcript: NM_182976

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14104
Approved symbol	ZNF326
Name	zinc finger protein 326
Location	1p22.2
Locus type	gene with protein product
Status	Approved
Aliases	Zfp326, ZAN75, FLJ20403, ZIRD
Ensembl gene	ENSG00000162664
Ensembl biotype	protein_coding
OMIM	614601
Entrez	284695

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 nonsense_mediated_decay

ENST00000340281, ENST00000361911, ENST00000370447, ENST00000394583, ENST00000902215, ENST00000902216, ENST00000902217, ENST00000918480, ENST00000918481, ENST00000971818

RefSeq mRNA: 4 — MANE Select: NM_182976 NM_001320185, NM_181781, NM_182975, NM_182976

CCDS: CCDS727, CCDS728, CCDS81351

Canonical transcript exons

ENST00000340281 — 12 exons

Exon	Start	End
ENSE00001452743	90027354	90035533
ENSE00001631587	89995110	89995273
ENSE00001667126	90005133	90005244
ENSE00001673235	90007345	90007750
ENSE00001700064	90005003	90005038
ENSE00003458730	90017317	90017464
ENSE00003488602	90020792	90020922
ENSE00003542153	90018685	90018784
ENSE00003543739	90010088	90010286
ENSE00003566160	90022250	90022345
ENSE00003658791	89998110	89998154
ENSE00003662522	90013126	90013237

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 96.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.1250 / max 651.2898, expressed in 1815 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
3991	33.1250	1815

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.53	gold quality
spinal cord	UBERON:0002240	94.99	gold quality
medial globus pallidus	UBERON:0002477	92.55	gold quality
ventricular zone	UBERON:0003053	92.19	gold quality
pigmented layer of retina	UBERON:0001782	91.94	gold quality
ganglionic eminence	UBERON:0004023	91.73	gold quality
globus pallidus	UBERON:0001875	91.16	gold quality
cortical plate	UBERON:0005343	91.11	gold quality
tendon of biceps brachii	UBERON:0008188	91.09	gold quality
substantia nigra	UBERON:0002038	90.89	gold quality
subthalamic nucleus	UBERON:0001906	90.81	gold quality
body of pancreas	UBERON:0001150	90.53	gold quality
inferior vagus X ganglion	UBERON:0005363	90.49	gold quality
midbrain	UBERON:0001891	90.28	gold quality
corpus callosum	UBERON:0002336	90.14	gold quality
cartilage tissue	UBERON:0002418	89.97	gold quality
amygdala	UBERON:0001876	89.82	gold quality
epithelial cell of pancreas	CL:0000083	89.50	gold quality
endometrium	UBERON:0001295	89.43	gold quality
left ovary	UBERON:0002119	89.15	gold quality
hypothalamus	UBERON:0001898	89.13	gold quality
pancreatic ductal cell	CL:0002079	89.07	gold quality
rectum	UBERON:0001052	89.00	gold quality
colonic epithelium	UBERON:0000397	88.58	gold quality
tendon	UBERON:0000043	88.41	gold quality
ovary	UBERON:0000992	88.32	gold quality
Ammon’s horn	UBERON:0001954	88.28	gold quality
thymus	UBERON:0002370	88.19	gold quality
right ovary	UBERON:0002118	88.08	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-11121	yes	889.21
E-GEOD-137537	yes	17.59
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

267 targeting ZNF326, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593

Literature-anchored findings (GeneRIF, showing 8)

• data indicate that the DBIRD complex (consisting of DBC1 and ZNF326) acts at the interface between mRNP particles and RNAPII, integrating transcript elongation with the regulation of alternative splicing (PMID:22446626)
• involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response (PMID:22666313)
• Data indicate that ZNF326 is an interaction partner and substrate of the PRMT5/WDR77 complex. (PMID:28977470)
• Data provide evidence that the high nuclear expression of ZNF326 in breast cancer was closely related to advanced pTNM staging, positive lymph node metastasis, and poor prognosis in patients with breast cancer. ZNF326 promotes proliferation, invasiveness, and xenograft formation by upregulating MMP7, EMT, and cell cycle-related factors by interacting with DBC1. (PMID:30175866)
• Studied role of zinc finger protein 326 (ZNF326) in promotion of excision repair cross-complementation group 1 (ERCC1) expression in non-small cell lung cancer (NSCLC) cells. (PMID:30401956)
• High ZNF326 expression is associated with glioma. (PMID:30691485)
• Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma. (PMID:31930344)
• MicroRNA-136-5p regulates gemcitabine resistance in pancreatic cancer via down-regulating ZNF32. (PMID:33155203)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf326	ENSDARG00000098348
mus_musculus	Zfp326	ENSMUSG00000029290
rattus_norvegicus	Zfp326	ENSRNOG00000047761

Paralogs (2): AKAP8L (ENSG00000011243), AKAP8 (ENSG00000105127)

Protein

Protein identifiers

DBIRD complex subunit ZNF326 — Q5BKZ1 (reviewed: Q5BKZ1)

Alternative names: Zinc finger protein 326, Zinc finger protein interacting with mRNPs and DBC1

All UniProt accessions (3): A0A0A0MRN4, E2QRN4, Q5BKZ1

UniProt curated annotations — full annotation on UniProt →

Function. Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.

Subunit / interactions. Component of the DBIRD complex. Interacts with CCAR2; the interaction is direct.

Subcellular location. Nucleus matrix.

Similarity. Belongs to the AKAP95 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q5BKZ1-1	1	yes
Q5BKZ1-2	2
Q5BKZ1-3	3

RefSeq proteins (4): NP_001307114, NP_861446, NP_892020, NP_892021* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007071	AKAP95	Family
IPR034736	ZF_C2H2_AKAP95	Domain

Pfam: PF04988

UniProt features (42 total): modified residue 19, cross-link 8, compositionally biased region 4, region of interest 4, zinc finger region 2, splice variant 2, chain 1, sequence conflict 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5BKZ1-F1	54.04	0.08

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (27): 48, 56, 63, 69, 81, 82, 91, 106, 114, 118, 121, 137, 173, 212, 235, 247, 249, 251, 270, 140 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 181 (showing top): CAGCTG_AP4_Q5, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_RNA_SPLICING, GATA1_02, chr1p22, GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION, GOBP_REGULATION_OF_RNA_SPLICING, NUYTTEN_EZH2_TARGETS_DN, E2A_Q2, CCAWNWWNNNGGC_UNKNOWN, AAGWWRNYGGC_UNKNOWN, NUYTTEN_NIPP1_TARGETS_DN, GOMF_RNA_POLYMERASE_BINDING, GOMF_RNA_POLYMERASE_CORE_ENZYME_BINDING, GOMF_BASAL_TRANSCRIPTION_MACHINERY_BINDING

GO Biological Process (4): mRNA processing (GO:0006397), RNA splicing (GO:0008380), regulation of DNA-templated transcription elongation (GO:0032784), regulation of RNA splicing (GO:0043484)

GO Molecular Function (6): RNA polymerase II complex binding (GO:0000993), DNA binding (GO:0003677), RNA binding (GO:0003723), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), nuclear matrix (GO:0016363), DBIRD complex (GO:0044609)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
nucleic acid binding	2
nuclear lumen	2
cellular anatomical structure	2
mRNA metabolic process	1
DNA-templated transcription elongation	1
regulation of DNA-templated transcription	1
RNA splicing	1
regulation of gene expression	1
regulation of primary metabolic process	1
RNA polymerase core enzyme binding	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular protein-containing complex	1

Protein interactions and networks

STRING

1190 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF326	CCAR2	Q8N163	808
ZNF326	ALDH18A1	P54886	525
ZNF326	MATR3	P43243	511
ZNF326	GPANK1	O95872	495
ZNF326	TARS2	Q9BW92	476
ZNF326	HNRNPA1	P09651	475
ZNF326	CPNE5	Q9HCH3	474
ZNF326	GANAB	Q14697	474
ZNF326	WDR77	Q9BQA1	454
ZNF326	ZMYM3	Q14202	442
ZNF326	KHSRP	Q92945	442
ZNF326	LRRFIP1	Q32MZ4	438
ZNF326	TUBA1B	P04687	404
ZNF326	H1-1	Q02539	398
ZNF326	ABCC12	Q96J65	386

IntAct

196 interactions, top by confidence:

A	B	Type	Score
PIK3CA	PIK3R2	psi-mi:“MI:0914”(association)	0.900
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
NCBP1	KPNA3	psi-mi:“MI:0914”(association)	0.640
IGF2BP1	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
ZNF326	HNRNPA1	psi-mi:“MI:0914”(association)	0.600
ZNF326	BRINP1	psi-mi:“MI:0914”(association)	0.580
ZNF326	BRINP1	psi-mi:“MI:0915”(physical association)	0.580
BRINP1	ZNF326	psi-mi:“MI:0915”(physical association)	0.580
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
KHDRBS3	ZNF326	psi-mi:“MI:0915”(physical association)	0.560
VMAC	ZNF326	psi-mi:“MI:0915”(physical association)	0.560
	ZNF326	psi-mi:“MI:0915”(physical association)	0.560
GYS1	ZNF326	psi-mi:“MI:0915”(physical association)	0.560
GEMIN4	ZNF326	psi-mi:“MI:0915”(physical association)	0.560
SPTA1	ZNF326	psi-mi:“MI:0915”(physical association)	0.560
KPNA5	ZNF326	psi-mi:“MI:0915”(physical association)	0.560
FOXP3	FOXP2	psi-mi:“MI:0914”(association)	0.530
BCOR	CBX4	psi-mi:“MI:0914”(association)	0.530
PCGF1	CBX4	psi-mi:“MI:0914”(association)	0.530
NCBP3	SAP18	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
SNRNP70	GTPBP1	psi-mi:“MI:0914”(association)	0.530
ELAVL2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530

BioGRID (280): ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Affinity Capture-MS), ZNF326 (Proximity Label-MS), ZNF326 (Proximity Label-MS), ZNF326 (Proximity Label-MS), ZNF326 (Proximity Label-MS), ZNF326 (Proximity Label-MS), ZNF326 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IZ84, A2CEZ5, A2RV70, D3YXK2, F1MJM0, O15047, O43823, O60293, O88291, O88453, P41073, P43243, P43244, P61129, P61406, P78332, P97868, Q08D57, Q14151, Q15424, Q1LY77, Q28F29, Q2HJG4, Q3TLH4, Q498L2, Q5BKZ1, Q5F3P8, Q5R452, Q5RAK6, Q5RCA4, Q5U236, Q5VK71, Q5ZJ02, Q63014, Q66HC1, Q66J90, Q7YZA2, Q7Z6E9, Q80YR5, Q86US8

Diamond homologs: A2CEZ5, A2RV70, F1MJM0, O43823, O88291, Q28F29, Q5BKZ1, Q5RCA4, Q5VK71, Q5ZJ02, Q63014, Q9DBR0, Q9R0L7, Q9ULX6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 208 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Polyadenylation	26	16.1×	1e-21
mRNA Splicing	18	13.9×	7e-14
RNA Polymerase II Transcription Termination	9	13.9×	1e-06
Processing of Capped Intron-Containing Pre-mRNA	24	13.9×	1e-18
Transport of Mature Transcript to Cytoplasm	5	13.4×	2e-03
mRNA Splicing - Major Pathway	30	11.5×	3e-21
mRNA 3’-end processing	8	11.1×	4e-05
Dengue Virus-Host Interactions	25	8.0×	7e-14

GO biological processes:

GO term	Partners	Fold	FDR
regulation of mRNA splicing, via spliceosome	5	24.9×	2e-04
negative regulation of mRNA splicing, via spliceosome	5	21.5×	4e-04
alternative mRNA splicing, via spliceosome	5	18.9×	5e-04
U2-type prespliceosome assembly	5	17.5×	7e-04
spliceosomal snRNP assembly	5	16.3×	9e-04
regulation of alternative mRNA splicing, via spliceosome	10	13.7×	8e-07
mRNA splicing, via spliceosome	24	12.3×	2e-16
negative regulation of translation	10	11.0×	5e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

83 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1894 predictions. Top by Δscore:

Variant	Effect	Δscore
1:89995269:GGACG:G	donor_gain	1.0000
1:89995270:GACG:G	donor_gain	1.0000
1:89995270:GACGG:G	donor_gain	1.0000
1:89995272:CGG:C	donor_loss	1.0000
1:89995273:GGTAA:G	donor_loss	1.0000
1:89995274:G:GG	donor_gain	1.0000
1:89995274:GT:G	donor_loss	1.0000
1:89998095:A:G	acceptor_gain	1.0000
1:89998153:TG:T	donor_gain	1.0000
1:89998153:TGGT:T	donor_loss	1.0000
1:89998154:GG:G	donor_gain	1.0000
1:89998154:GGT:G	donor_loss	1.0000
1:89998155:G:GG	donor_gain	1.0000
1:89998156:T:A	donor_loss	1.0000
1:90004997:TTTTA:T	acceptor_loss	1.0000
1:90004998:TTTAG:T	acceptor_loss	1.0000
1:90004999:TTAG:T	acceptor_loss	1.0000
1:90005000:TAGGA:T	acceptor_loss	1.0000
1:90005001:A:AG	acceptor_gain	1.0000
1:90005002:G:GG	acceptor_gain	1.0000
1:90005002:GGA:G	acceptor_gain	1.0000
1:90007327:ACTGT:A	acceptor_gain	1.0000
1:90007334:A:AG	acceptor_gain	1.0000
1:90007335:A:G	acceptor_gain	1.0000
1:90007342:CAG:C	acceptor_loss	1.0000
1:90007344:G:GT	acceptor_loss	1.0000
1:90007746:GAGGA:G	donor_gain	1.0000
1:90007747:AGGA:A	donor_gain	1.0000
1:90007748:GGA:G	donor_gain	1.0000
1:90007748:GGAG:G	donor_gain	1.0000

AlphaMissense

3869 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:90013199:A:C	R296S	1.000
1:90013199:A:T	R296S	1.000
1:90013202:A:C	R297S	1.000
1:90013202:A:T	R297S	1.000
1:90017330:T:A	C314S	1.000
1:90017330:T:C	C314R	1.000
1:90017331:G:A	C314Y	1.000
1:90017331:G:C	C314S	1.000
1:90017331:G:T	C314F	1.000
1:90017332:T:G	C314W	1.000
1:90017339:T:A	C317S	1.000
1:90017339:T:C	C317R	1.000
1:90017340:G:A	C317Y	1.000
1:90017340:G:C	C317S	1.000
1:90017340:G:T	C317F	1.000
1:90017341:T:G	C317W	1.000
1:90017378:C:A	H330N	1.000
1:90017378:C:G	H330D	1.000
1:90017380:T:A	H330Q	1.000
1:90017380:T:G	H330Q	1.000
1:90017382:T:C	L331P	1.000
1:90017396:C:A	H336N	1.000
1:90017396:C:G	H336D	1.000
1:90017398:T:A	H336Q	1.000
1:90017398:T:G	H336Q	1.000
1:90017418:T:A	I343K	1.000
1:90017418:T:G	I343R	1.000
1:90017456:T:C	F356L	1.000
1:90017457:T:C	F356S	1.000
1:90017458:T:A	F356L	1.000

dbSNP variants (sampled 300 via entrez): RS1000049871 (1:90022973 G>A), RS1000101916 (1:90022666 C>T), RS1000315164 (1:90025760 A>T), RS1000354824 (1:90012519 G>A), RS1000360162 (1:89993174 A>T), RS1000407378 (1:90010555 AATAG>A), RS1000571175 (1:89999389 A>G), RS1000647286 (1:90033875 G>A), RS1000657613 (1:90030685 C>T), RS1000699664 (1:90033628 A>G), RS1000726549 (1:90006159 G>C), RS1000751322 (1:90002743 C>G), RS1000798687 (1:90006503 G>A), RS1000799458 (1:90008265 G>A), RS1000942660 (1:90005885 C>G,T)

Disease associations

OMIM: gene MIM:614601 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST000615_1	Brain structure (hippocampal volume)	2.000000e-06
GCST003434_11	Obsessive-compulsive symptoms	8.000000e-06
GCST006041_41	Major depressive disorder	3.000000e-06
GCST006210_1	Thiopurine-induced digestive symptoms in inflammatory bowel disease	7.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005035	hippocampal volume
EFO:0007802	obsessive-compulsive symptom measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	2
sodium arsenite	increases expression, decreases expression, increases abundance	2
Arsenic	increases abundance, increases expression, affects methylation	2
Valproic Acid	affects expression, increases expression	2
FR900359	affects phosphorylation	1
TAK-243	decreases sumoylation	1
dicrotophos	decreases expression	1
geldanamycin	increases expression	1
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
bisphenol B	increases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Cadmium	increases expression, increases abundance	1
Caffeine	affects phosphorylation	1
Dinitrochlorobenzene	affects binding	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Silicon Dioxide	increases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2LU	Abcam HeLa ZNF326 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.