ZNF337

Summary

ZNF337 (zinc finger protein 337, HGNC:15809) is a protein-coding gene on chromosome 20p11.21, encoding Zinc finger protein 337 (Q9Y3M9). May be involved in transcriptional regulation.

This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 26152 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 130 total
• MANE Select transcript: NM_015655

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15809
Approved symbol	ZNF337
Name	zinc finger protein 337
Location	20p11.21
Locus type	gene with protein product
Status	Approved
Aliases	dJ694B14.1
Ensembl gene	ENSG00000130684
Ensembl biotype	protein_coding
Entrez	26152

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 15 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000252979, ENST00000376436, ENST00000481610, ENST00000878466, ENST00000878467, ENST00000878468, ENST00000878469, ENST00000878470, ENST00000878471, ENST00000878472, ENST00000878473, ENST00000912968, ENST00000912969, ENST00000954845, ENST00000954846, ENST00000954847

RefSeq mRNA: 2 — MANE Select: NM_015655 NM_001290261, NM_015655

CCDS: CCDS13174

Canonical transcript exons

ENST00000252979 — 5 exons

Exon	Start	End
ENSE00001796964	25685996	25686122
ENSE00001886932	25696759	25696853
ENSE00003483333	25686391	25686466
ENSE00003530440	25685567	25685662
ENSE00003849082	25673195	25677037

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 95.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.8143 / max 104.1237, expressed in 1721 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
186811	5.9856	1639
186810	1.6286	1002
186809	1.2001	785

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	95.42	gold quality
cerebellar cortex	UBERON:0002129	95.36	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.35	gold quality
tendon of biceps brachii	UBERON:0008188	94.47	gold quality
cerebellum	UBERON:0002037	94.46	gold quality
cortical plate	UBERON:0005343	93.28	gold quality
right uterine tube	UBERON:0001302	92.66	gold quality
ganglionic eminence	UBERON:0004023	91.18	gold quality
cerebellar vermis	UBERON:0004720	91.03	gold quality
left ovary	UBERON:0002119	89.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.39	gold quality
lower esophagus	UBERON:0013473	89.36	gold quality
diaphragm	UBERON:0001103	89.33	gold quality
right ovary	UBERON:0002118	88.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.75	gold quality
granulocyte	CL:0000094	88.66	gold quality
ventricular zone	UBERON:0003053	88.57	gold quality
thymus	UBERON:0002370	88.53	gold quality
superficial temporal artery	UBERON:0001614	88.52	gold quality
body of uterus	UBERON:0009853	88.36	gold quality
endocervix	UBERON:0000458	88.15	gold quality
embryo	UBERON:0000922	87.88	gold quality
adenohypophysis	UBERON:0002196	87.70	gold quality
ovary	UBERON:0000992	87.65	gold quality
left uterine tube	UBERON:0001303	87.64	gold quality
endothelial cell	CL:0000115	87.54	gold quality
pituitary gland	UBERON:0000007	87.52	gold quality
olfactory bulb	UBERON:0002264	87.43	silver quality
right frontal lobe	UBERON:0002810	87.42	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-100618	no	660.89
E-ANND-3	no	1.51

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

73 targeting ZNF337, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-8076	99.78	68.52	1170
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-4719	99.73	72.10	3329
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-5093	99.67	69.26	2291
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-10394-5P	99.65	66.83	1852
HSA-MIR-1205	99.65	66.76	1826
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-4666B	99.64	68.69	1282

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp78	ENSMUSG00000055150
rattus_norvegicus		ENSRNOG00000083797
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300), ZNF70 (ENSG00000187792)

Protein

Protein identifiers

Zinc finger protein 337 — Q9Y3M9 (reviewed: Q9Y3M9)

All UniProt accessions (1): Q9Y3M9

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y3M9-1	1	yes
Q9Y3M9-2	2

RefSeq proteins (2): NP_001277190, NP_056470* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (30 total): zinc finger region 20, sequence variant 2, sequence conflict 2, chain 1, domain 1, region of interest 1, compositionally biased region 1, cross-link 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3M9-F1	75.18	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 458

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 79 (showing top): MORF_SNRP70, PUJANA_CHEK2_PCC_NETWORK, MODULE_205, BLALOCK_ALZHEIMERS_DISEASE_UP, MORF_PDPK1, MORF_ORC1L, MORF_MYST2, chr20p11, MORF_CNTN1, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP, IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_UP, CSR_EARLY_UP.V1_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CHAF1B_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

722 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF337	PCMTD2	Q9NV79	470
ZNF337	DRC5	Q5JU00	466
ZNF337	ANKRA2	Q9H9E1	391
ZNF337	PRR32	B1ATL7	378
ZNF337	DEFB115	Q30KQ5	370
ZNF337	TLCD2	A6NGC4	350
ZNF337	CCDC125	Q86Z20	350
ZNF337	ZNF518A	Q6AHZ1	348
ZNF337	GATD1	Q8NB37	348
ZNF337	PARP8	Q8N3A8	345
ZNF337	ANKRD30B	Q9BXX2	327
ZNF337	TASOR2	Q5VWN6	324
ZNF337	TXNDC15	Q96J42	323
ZNF337	RAB6B	Q9NRW1	310
ZNF337	PACRG	Q96M98	306

IntAct

31 interactions, top by confidence:

A	B	Type	Score
ZNF337	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
CALCOCO2	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
KRT40	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
HMBOX1	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
RPGRIP1	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
ZNF337	CALCOCO2	psi-mi:“MI:0915”(physical association)	0.560
ZNF337	RPGRIP1	psi-mi:“MI:0915”(physical association)	0.560
ZNF337	KRT40	psi-mi:“MI:0915”(physical association)	0.560
CCDC125	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
GNMT	ZNF337	psi-mi:“MI:0915”(physical association)	0.560
ZNF337	PTGER4	psi-mi:“MI:0915”(physical association)	0.370
CCDC85B	ZNF337	psi-mi:“MI:0915”(physical association)	0.370
ZNF337	IPO8	psi-mi:“MI:0914”(association)	0.350
ZNF460	ZNF320	psi-mi:“MI:0914”(association)	0.350
MRFAP1L1	MYO9A	psi-mi:“MI:0914”(association)	0.350
ZNF337	CCDC125	psi-mi:“MI:0915”(physical association)	0.000
GNMT	ZNF337	psi-mi:“MI:0915”(physical association)	0.000
COMMD3	ZNF337	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (19): ZNF337 (Two-hybrid), ZNF337 (Two-hybrid), RPGRIP1 (Two-hybrid), HMBOX1 (Two-hybrid), KRT40 (Two-hybrid), KRTAP10-7 (Two-hybrid), ZNF337 (Two-hybrid), ZNF337 (Two-hybrid), ZNF337 (Two-hybrid), CCDC125 (Two-hybrid), ZNF337 (Two-hybrid), ZNF337 (Affinity Capture-MS), ZNF337 (Affinity Capture-MS), ZNF337 (Affinity Capture-MS), ZNF337 (Affinity Capture-MS)

ESM2 similar proteins: A6QLU5, O75820, P08043, P10076, P10755, P16374, P16415, P17014, P17021, P17027, P17039, P51786, Q08AN1, Q14588, Q3KP31, Q3ZCX4, Q52M93, Q5MCW4, Q5R5Q6, Q5R5S6, Q5R5Y7, Q5RB30, Q5REA0, Q5REI6, Q6P3V2, Q6P9Y7, Q6ZNA1, Q7TSH9, Q7TSI0, Q7Z3V5, Q80W31, Q86UE3, Q86YE8, Q8BPP0, Q8N141, Q8N4W9, Q8N9F8, Q8NDQ6, Q8TBZ5, Q96ND8

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

130 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	125
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

534 predictions. Top by Δscore:

Variant	Effect	Δscore
20:25685990:GCTTA:G	donor_loss	1.0000
20:25685991:CTTA:C	donor_loss	1.0000
20:25685992:TTA:T	donor_loss	1.0000
20:25685993:TACCT:T	donor_loss	1.0000
20:25685995:C:CA	donor_loss	1.0000
20:25685994:A:AC	donor_gain	0.9900
20:25685995:C:CC	donor_gain	0.9900
20:25686119:AAGCC:A	acceptor_loss	0.9900
20:25686123:C:CA	acceptor_loss	0.9900
20:25686124:TGTAA:T	acceptor_loss	0.9900
20:25686693:CATCA:C	donor_gain	0.9900
20:25677033:TATTC:T	acceptor_gain	0.9800
20:25686125:G:C	acceptor_loss	0.9800
20:25686385:TCTCA:T	donor_loss	0.9800
20:25686386:CTCAC:C	donor_loss	0.9800
20:25686387:TCACC:T	donor_loss	0.9800
20:25686388:CACC:C	donor_loss	0.9800
20:25686389:AC:A	donor_loss	0.9800
20:25686390:C:CT	donor_loss	0.9800
20:25677964:T:A	donor_gain	0.9700
20:25686123:C:CC	acceptor_gain	0.9700
20:25686390:CCTGT:C	donor_gain	0.9700
20:25685995:CCTA:C	donor_gain	0.9600
20:25686035:C:A	donor_gain	0.9600
20:25686692:A:AC	donor_gain	0.9600
20:25686693:C:CC	donor_gain	0.9600
20:25685734:C:T	acceptor_gain	0.9500
20:25686121:GC:G	acceptor_gain	0.9500
20:25686122:CC:C	acceptor_gain	0.9500
20:25677037:CCT:C	acceptor_loss	0.9400

AlphaMissense

4951 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:25676049:A:C	F413L	0.998
20:25676049:A:T	F413L	0.998
20:25676051:A:G	F413L	0.998
20:25675293:G:C	F665L	0.997
20:25675293:G:T	F665L	0.997
20:25675295:A:G	F665L	0.997
20:25675377:G:C	F637L	0.997
20:25675377:G:T	F637L	0.997
20:25675379:A:G	F637L	0.997
20:25675461:A:C	F609L	0.997
20:25675461:A:T	F609L	0.997
20:25675463:A:G	F609L	0.997
20:25675545:G:C	F581L	0.997
20:25675545:G:T	F581L	0.997
20:25675547:A:G	F581L	0.997
20:25675881:A:C	F469L	0.997
20:25675881:A:T	F469L	0.997
20:25675883:A:G	F469L	0.997
20:25675965:A:C	F441L	0.997
20:25675965:A:T	F441L	0.997
20:25675967:A:G	F441L	0.997
20:25676108:G:C	H394D	0.997
20:25676133:A:C	F385L	0.997
20:25676133:A:T	F385L	0.997
20:25676135:A:G	F385L	0.997
20:25676385:A:C	F301L	0.997
20:25676385:A:T	F301L	0.997
20:25676387:A:G	F301L	0.997
20:25675713:A:C	F525L	0.996
20:25675713:A:T	F525L	0.996

dbSNP variants (sampled 300 via entrez): RS1000259050 (20:25688111 T>C), RS1000464402 (20:25689201 G>T), RS1000505133 (20:25683234 T>G), RS1000506668 (20:25689360 C>A), RS1000563850 (20:25683635 T>G), RS1000599568 (20:25689381 C>T), RS1000679481 (20:25695575 G>A,T), RS1000903655 (20:25676192 G>A), RS1000946526 (20:25696217 C>T), RS1001167666 (20:25677409 A>G), RS1001188028 (20:25689191 C>G), RS1001302120 (20:25677648 C>G,T), RS1001389721 (20:25678212 GAAAA>G,GAAA,GAAAAA), RS1001486801 (20:25684823 C>T), RS1001516553 (20:25684496 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST006481_37	Lung function (FEV1)	2.000000e-07
GCST006481_6	Lung function (FEV1)	3.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004314	forced expiratory volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	affects expression, decreases expression, increases expression	3
Aflatoxin B1	increases expression	2
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
perfluorooctanoic acid	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
perfluorohexanesulfonic acid	decreases expression	1
PCI 5002	increases expression, affects cotreatment	1
Decitabine	affects expression	1
Acetaminophen	increases expression	1
Adenine	decreases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases expression	1
Caffeine	decreases phosphorylation	1
Colchicine	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Hydrogen Peroxide	affects expression	1
Methyl Methanesulfonate	increases expression	1
Quercetin	increases expression	1
Selenium	decreases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triiodothyronine	increases expression	1
Valproic Acid	decreases expression	1
Vitamin E	decreases expression	1
Zinc	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.