ZNF345

Summary

ZNF345 (zinc finger protein 345, HGNC:16367) is a protein-coding gene on chromosome 19q13.12, encoding Zinc finger protein 345 (Q14585). May be involved in transcriptional regulation.

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 25850 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 34 total
• MANE Select transcript: NM_001242472

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16367
Approved symbol	ZNF345
Name	zinc finger protein 345
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	HZF10
Ensembl gene	ENSG00000251247
Ensembl biotype	protein_coding
OMIM	621272
Entrez	25850

Gene structure

Transcript identifiers

Ensembl transcripts: 34 — 29 protein_coding, 5 protein_coding_CDS_not_defined

ENST00000331800, ENST00000420450, ENST00000432005, ENST00000525851, ENST00000526123, ENST00000529555, ENST00000529989, ENST00000532141, ENST00000534729, ENST00000585396, ENST00000586646, ENST00000586933, ENST00000589046, ENST00000706174, ENST00000868513, ENST00000868514, ENST00000868515, ENST00000868516, ENST00000868517, ENST00000868518, ENST00000868519, ENST00000868520, ENST00000868521, ENST00000868522, ENST00000914790, ENST00000914791, ENST00000914792, ENST00000914793, ENST00000963970, ENST00000963971, ENST00000963972, ENST00000963973, ENST00000963974, ENST00000963975

RefSeq mRNA: 5 — MANE Select: NM_001242472 NM_001242472, NM_001242474, NM_001242475, NM_001242476, NM_003419

CCDS: CCDS12497

Canonical transcript exons

ENST00000420450 — 3 exons

Exon	Start	End
ENSE00001681945	36876785	36879575
ENSE00001705454	36851830	36851904
ENSE00002821052	36850876	36850968

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 89.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0752 / max 94.3440, expressed in 1312 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175530	3.3009	1184
175529	0.6903	373
175528	0.0743	21
175531	0.0096	3

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	89.05	gold quality
left testis	UBERON:0004533	88.65	gold quality
testis	UBERON:0000473	84.81	gold quality
sperm	CL:0000019	83.63	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.33	gold quality
colonic epithelium	UBERON:0000397	82.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.72	gold quality
cortical plate	UBERON:0005343	80.84	gold quality
male germ cell	CL:0000015	80.80	gold quality
calcaneal tendon	UBERON:0003701	79.04	gold quality
ganglionic eminence	UBERON:0004023	78.65	gold quality
right ovary	UBERON:0002118	78.29	gold quality
popliteal artery	UBERON:0002250	78.13	gold quality
tibial artery	UBERON:0007610	78.13	gold quality
ventricular zone	UBERON:0003053	78.00	gold quality
left ovary	UBERON:0002119	77.70	gold quality
aorta	UBERON:0000947	77.31	gold quality
descending thoracic aorta	UBERON:0002345	77.01	gold quality
tibial nerve	UBERON:0001323	76.82	gold quality
lower esophagus	UBERON:0013473	76.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.52	gold quality
thoracic aorta	UBERON:0001515	76.45	gold quality
muscle layer of sigmoid colon	UBERON:0035805	76.45	gold quality
ascending aorta	UBERON:0001496	76.39	gold quality
right lung	UBERON:0002167	76.33	gold quality
body of uterus	UBERON:0009853	76.32	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.32	gold quality
mucosa of stomach	UBERON:0001199	76.31	gold quality
right coronary artery	UBERON:0001625	76.31	gold quality
stromal cell of endometrium	CL:0002255	76.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.12

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

105 targeting ZNF345, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp11	ENSMUSG00000051034
rattus_norvegicus	Zfp11	ENSRNOG00000051442

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 345 — Q14585 (reviewed: Q14585)

Alternative names: Zinc finger protein HZF10

All UniProt accessions (7): E9PLT7, Q14585, F8W8R5, K7EKZ8, K7EM63, K7EQ01, K7ESK8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (5): NP_001229401, NP_001229403, NP_001229404, NP_001229405, NP_003410 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF13465

UniProt features (16 total): zinc finger region 15, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14585-F1	81.72	0.57

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 73 (showing top): GOBP_TRANSCRIPTION_BY_RNA_POLYMERASE_III, MODULE_123, MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_III, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOMF_DNA_BINDING_TRANSCRIPTION_ACTIVATOR_ACTIVITY, IL21_UP.V1_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, DYRK1A_TARGET_GENES, ZFP28_TARGET_GENES, ZFP3_TARGET_GENES, ZNF2_TARGET_GENES

GO Biological Process (7): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), regulation of transcription by RNA polymerase III (GO:0006359), transcription by RNA polymerase II (GO:0006366), transcription by RNA polymerase III (GO:0006383), regulation of DNA-templated transcription (GO:0006355), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), zinc ion binding (GO:0008270), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	3
DNA-templated transcription	3
regulation of transcription by RNA polymerase II	2
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
negative regulation of DNA-templated transcription	1
transcription by RNA polymerase III	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
positive regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

376 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF345	TFPI2	P48307	414
ZNF345	ZC3H11B	A0A1B0GTU1	400
ZNF345	ZNF608	Q9ULD9	340
ZNF345	BEST3	Q8N1M1	334
ZNF345	TFF3	Q07654	324
ZNF345	CCDC180	Q9P1Z9	322
ZNF345	BEST2	Q8NFU1	318
ZNF345	OGFRL1	Q5TC84	310
ZNF345	PTPN20	Q4JDL3	308
ZNF345	CCDC18	Q5T9S5	305
ZNF345	CIBAR1	A1XBS5	302
ZNF345	DUS4L	O95620	296
ZNF345	SBNO1	A3KN83	291
ZNF345	RWDD2B	P57060	287
ZNF345	RUNDC3B	Q96NL0	272

IntAct

23 interactions, top by confidence:

A	B	Type	Score
ZNF345	RNPS1	psi-mi:“MI:0915”(physical association)	0.560
ZNF250	ZNF345	psi-mi:“MI:0915”(physical association)	0.560
EFEMP2	ZNF345	psi-mi:“MI:0915”(physical association)	0.560
ZNF345	DMWD	psi-mi:“MI:0915”(physical association)	0.560
LMNA	ZNF345	psi-mi:“MI:0915”(physical association)	0.560
TSC1	ZNF345	psi-mi:“MI:0915”(physical association)	0.560
ZNF345	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
RNPS1	ZNF345	psi-mi:“MI:0915”(physical association)	0.000
ZNF250	ZNF345	psi-mi:“MI:0915”(physical association)	0.000
EFEMP2	ZNF345	psi-mi:“MI:0915”(physical association)	0.000
ZNF345	serS	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): ZNF345 (Two-hybrid), ZNF345 (Two-hybrid), ZNF345 (Two-hybrid), ZNF345 (Two-hybrid), ZNF345 (Two-hybrid), ZNF345 (Affinity Capture-RNA), ZNF345 (Cross-Linking-MS (XL-MS)), ZNF345 (Affinity Capture-RNA)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A8MQ14, O75290, Q14585, Q3SYV7, Q4R6C2, Q5R5Q6, Q6J6I6, Q6JLC9, Q6P9Y7, Q6PG37, Q7Z3V5, Q86UE3, Q8N141, Q8N7M2, Q8N9K5, Q8NA42, Q8NB42, Q8TAF7, Q95K52, Q969W8, Q96NG8, Q9HCL3, Q9Y6R6, P52738, A0A1W2PQL4, A2RRD8, A2VDP4, A2VDQ7, A6NHJ4, A8MTY0, A8MUV8, B4DX44, B4DXR9, E9PW05, O75820, P08042, P0CJ79, P10755, P16373, P16374

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	19
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

809 predictions. Top by Δscore:

Variant	Effect	Δscore
19:36908327:CCTTA:C	donor_loss	1.0000
19:36908328:CTTAC:C	donor_loss	1.0000
19:36908329:TTAC:T	donor_loss	1.0000
19:36908330:TA:T	donor_loss	1.0000
19:36908331:A:AG	donor_loss	1.0000
19:36908331:AC:A	donor_gain	1.0000
19:36908332:C:G	donor_loss	1.0000
19:36908332:CC:C	donor_gain	1.0000
19:36908332:CCCA:C	donor_gain	1.0000
19:36908335:A:AC	donor_gain	1.0000
19:36908336:C:CC	donor_gain	1.0000
19:36908371:T:TA	donor_gain	1.0000
19:36872532:T:G	acceptor_gain	0.9900
19:36876779:TTTCA:T	acceptor_loss	0.9900
19:36876780:TTCA:T	acceptor_loss	0.9900
19:36876781:TCAG:T	acceptor_loss	0.9900
19:36876783:AGA:A	acceptor_loss	0.9900
19:36876784:GACT:G	acceptor_gain	0.9900
19:36892467:CAGAT:C	acceptor_gain	0.9900
19:36892468:AGATC:A	acceptor_loss	0.9900
19:36892469:GATCT:G	acceptor_loss	0.9900
19:36892470:ATCTG:A	acceptor_loss	0.9900
19:36892471:TCT:T	acceptor_loss	0.9900
19:36892472:C:CA	acceptor_loss	0.9900
19:36892472:C:CC	acceptor_gain	0.9900
19:36892473:T:G	acceptor_loss	0.9900
19:36907924:CTT:C	donor_loss	0.9900
19:36907926:TACCT:T	donor_loss	0.9900
19:36907927:A:C	donor_loss	0.9900
19:36907928:C:CA	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000141647 (19:36857443 A>G), RS1000316464 (19:36849642 C>A,T), RS1000366600 (19:36890588 C>G,T), RS1000440391 (19:36890854 T>C), RS1000515009 (19:36857329 C>T), RS1000581958 (19:36876711 TC>T), RS1000659712 (19:36868641 T>TTG), RS1000729807 (19:36876056 T>C), RS1000803515 (19:36876357 C>G), RS1000917358 (19:36851158 TAG>T), RS1000964003 (19:36861842 G>A), RS1000995264 (19:36862246 G>A), RS1001085538 (19:36888437 C>G,T), RS1001188367 (19:36869374 GGT>G), RS1001224815 (19:36856441 G>A)

Disease associations

OMIM: gene MIM:621272 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90002383_279	Hematocrit	5.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004348	hematocrit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation	4
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation, affects cotreatment	1
methylselenic acid	increases expression	1
terbufos	increases methylation	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	affects methylation	1
methacrylaldehyde	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	increases reaction, affects binding	1
2-palmitoylglycerol	increases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	decreases methylation, affects cotreatment	1
Acrolein	affects cotreatment, decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Fonofos	increases methylation	1
Estradiol	decreases expression	1
Ozone	affects cotreatment, decreases expression	1
Parathion	increases methylation	1
Smoke	decreases expression, increases abundance	1
Testosterone	increases expression	1
Cyclosporine	decreases expression	1
Antirheumatic Agents	increases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.