ZNF346

Summary

ZNF346 (zinc finger protein 346, HGNC:16403) is a protein-coding gene on chromosome 5q35.2, encoding Zinc finger protein 346 (Q9UL40). Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants.

Source: NCBI Gene 23567 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_012279

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16403
Approved symbol	ZNF346
Name	zinc finger protein 346
Location	5q35.2
Locus type	gene with protein product
Status	Approved
Aliases	JAZ, Zfp346
Ensembl gene	ENSG00000113761
Ensembl biotype	protein_coding
OMIM	605308
Entrez	23567

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 27 protein_coding, 2 retained_intron, 2 nonsense_mediated_decay

ENST00000358149, ENST00000503039, ENST00000503425, ENST00000504600, ENST00000506693, ENST00000508155, ENST00000510933, ENST00000511834, ENST00000512315, ENST00000513587, ENST00000883438, ENST00000883439, ENST00000883440, ENST00000883441, ENST00000883442, ENST00000883443, ENST00000883444, ENST00000883445, ENST00000883446, ENST00000883447, ENST00000883448, ENST00000883449, ENST00000921160, ENST00000921161, ENST00000921162, ENST00000921163, ENST00000921164, ENST00000921165, ENST00000947036, ENST00000947037, ENST00000947038

RefSeq mRNA: 10 — MANE Select: NM_012279 NM_001308213, NM_001308214, NM_001308215, NM_001308216, NM_001308218, NM_001308219, NM_001308221, NM_001308223, NM_001363713, NM_012279

CCDS: CCDS4409, CCDS78094, CCDS83052, CCDS83053, CCDS83054, CCDS87353

Canonical transcript exons

ENST00000358149 — 7 exons

Exon	Start	End
ENSE00001095546	177041778	177041870
ENSE00001095551	177044389	177044533
ENSE00001412343	177022696	177022913
ENSE00001426578	177064512	177067985
ENSE00003501605	177041126	177041229
ENSE00003575048	177062058	177062151
ENSE00003617799	177050751	177050936

Expression profiles

Bgee: expression breadth ubiquitous, 217 present calls, max score 90.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.2069 / max 270.4276, expressed in 1811 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60443	21.5134	1811
60444	0.6934	438

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	90.13	gold quality
buccal mucosa cell	CL:0002336	89.76	gold quality
cortical plate	UBERON:0005343	89.46	gold quality
ventricular zone	UBERON:0003053	89.09	gold quality
sural nerve	UBERON:0015488	89.04	gold quality
ganglionic eminence	UBERON:0004023	88.95	gold quality
tendon of biceps brachii	UBERON:0008188	87.25	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.55	gold quality
calcaneal tendon	UBERON:0003701	86.48	gold quality
tendon	UBERON:0000043	85.66	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.02	gold quality
tibialis anterior	UBERON:0001385	84.86	silver quality
adrenal tissue	UBERON:0018303	84.54	gold quality
epithelial cell of pancreas	CL:0000083	84.44	silver quality
right hemisphere of cerebellum	UBERON:0014890	83.95	gold quality
cerebellar hemisphere	UBERON:0002245	83.90	gold quality
cerebellar cortex	UBERON:0002129	83.87	gold quality
cerebellum	UBERON:0002037	83.78	gold quality
colonic epithelium	UBERON:0000397	83.62	gold quality
prefrontal cortex	UBERON:0000451	83.61	gold quality
left ovary	UBERON:0002119	83.44	gold quality
right ovary	UBERON:0002118	83.21	gold quality
oocyte	CL:0000023	82.92	gold quality
left lobe of thyroid gland	UBERON:0001120	82.69	gold quality
smooth muscle tissue	UBERON:0001135	82.66	gold quality
thyroid gland	UBERON:0002046	82.59	gold quality
blood	UBERON:0000178	82.53	gold quality
tonsil	UBERON:0002372	82.34	gold quality
islet of Langerhans	UBERON:0000006	82.32	gold quality
bone marrow cell	CL:0002092	82.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.40

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

124 targeting ZNF346, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-5682	99.89	72.56	1005
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4447	99.85	67.81	2900

Literature-anchored findings (GeneRIF, showing 4)

• JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism (PMID:15254228)
• JAZ directly binds E2F1 in vitro in a dsRNA-independent manner, and JAZ’s dsRNA binding ZF domains, which are necessary for localizing JAZ to the nucleus, are required for repression of transcriptional activity in vivo. (PMID:21715977)
• This detection method can be readily extended to multiplex detection of miRNAs with only one ALP-conjugated JAZ probe due to its nonsequence-specific binding character (PMID:28208259)
• ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma. (PMID:36834567)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf346	ENSDARG00000060695
mus_musculus	Zfp346	ENSMUSG00000021481
rattus_norvegicus	Zfp346	ENSRNOG00000016867
drosophila_melanogaster	CG1231	FBGN0035134
drosophila_melanogaster	dbf	FBGN0287630

Paralogs (9): ZNF385B (ENSG00000144331), ZMAT2 (ENSG00000146007), ZNF385D (ENSG00000151789), ZNF385A (ENSG00000161642), ZMAT4 (ENSG00000165061), ZMAT1 (ENSG00000166432), KRCC1 (ENSG00000172086), ZMAT3 (ENSG00000172667), ZNF385C (ENSG00000187595)

Protein

Protein identifiers

Zinc finger protein 346 — Q9UL40 (reviewed: Q9UL40)

Alternative names: Just another zinc finger protein

All UniProt accessions (6): Q9UL40, B7Z4J8, B7Z4N4, B7Z6B6, B7Z6Q2, D6RJ07

UniProt curated annotations — full annotation on UniProt →

Function. Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins.

Subunit / interactions. Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.

Subcellular location. Nucleus. Nucleolus. Cytoplasm.

Domain organisation. The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9UL40-1	1	yes
Q9UL40-2	2
Q9UL40-3	3

RefSeq proteins (10): NP_001295142, NP_001295143, NP_001295144, NP_001295145, NP_001295147, NP_001295148, NP_001295150, NP_001295152, NP_001350642, NP_036411* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003604	Matrin/U1-like-C_Znf_C2H2	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR051868	ZN346_ZMAT4	Family

Pfam: PF12874

UniProt features (29 total): binding site 8, zinc finger region 4, cross-link 2, splice variant 2, turn 2, strand 2, helix 2, region of interest 2, compositionally biased region 2, chain 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
2MKD	SOLUTION NMR
2MKN	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UL40-F1	67.17	0.10

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 78; 91; 97; 136; 139; 152; 158; 75

Post-translational modifications (3): 1, 114, 170

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 89 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, MAYBURD_RESPONSE_TO_L663536_UP, PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_DN, GOCC_NUCLEOLUS, GOMF_MIRNA_BINDING, GEORGES_TARGETS_OF_MIR192_AND_MIR215, GOMF_REGULATORY_RNA_BINDING, BANP_TARGET_GENES, DYRK1A_TARGET_GENES, FEV_TARGET_GENES, HOXB4_TARGET_GENES, ID2_TARGET_GENES, IRF5_TARGET_GENES, NFE2L1_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (8): RNA binding (GO:0003723), double-stranded RNA binding (GO:0003725), zinc ion binding (GO:0008270), enzyme binding (GO:0019899), miRNA binding (GO:0035198), nucleic acid binding (GO:0003676), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
nuclear lumen	2
cellular anatomical structure	2
nucleic acid binding	1
RNA binding	1
transition metal ion binding	1
protein binding	1
regulatory RNA binding	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

980 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF346	MYC	P01106	986
ZNF346	ICE2	Q659A1	947
ZNF346	MT-CO1	P00395	899
ZNF346	SKP1	P34991	841
ZNF346	HBS1L	Q9Y450	822
ZNF346	CUL1	Q13616	750
ZNF346	A0A087WZY1	A0A087WZY1	720
ZNF346	EIF2AK2	P19525	715
ZNF346	PRH1	P02810	715
ZNF346	SFRP4	Q6FHJ7	696
ZNF346	ETF1	P46055	695
ZNF346	ICE1	Q9Y2F5	667
ZNF346	LOX	P28300	575
ZNF346	RBX1	P62877	572
ZNF346	MYBL2	P10244	571

IntAct

128 interactions, top by confidence:

A	B	Type	Score
ZNF346	TARBP2	psi-mi:“MI:0915”(physical association)	0.720
TARBP2	ZNF346	psi-mi:“MI:0915”(physical association)	0.720
ZNF346	EIF2AK2	psi-mi:“MI:0915”(physical association)	0.710
NKRF	ZNF346	psi-mi:“MI:0915”(physical association)	0.670
STRBP	ZNF346	psi-mi:“MI:0915”(physical association)	0.560
RNF8	ZNF346	psi-mi:“MI:0915”(physical association)	0.560
ADARB1	ZNF346	psi-mi:“MI:0915”(physical association)	0.560
LNX1	ZNF346	psi-mi:“MI:0915”(physical association)	0.560
ZNF346	YWHAG	psi-mi:“MI:0915”(physical association)	0.560
BAG6	ZNF346	psi-mi:“MI:0915”(physical association)	0.560
KLF11	ZNF346	psi-mi:“MI:0915”(physical association)	0.560
ZNF346	SETDB1	psi-mi:“MI:0915”(physical association)	0.560
ZNF346	KAT5	psi-mi:“MI:0915”(physical association)	0.560
LMO3	ZNF346	psi-mi:“MI:0915”(physical association)	0.560
HNRNPD	HNRNPDL	psi-mi:“MI:0914”(association)	0.560
N	NOP56	psi-mi:“MI:0914”(association)	0.530

BioGRID (444): ZNF346 (Two-hybrid), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS), ZNF346 (Affinity Capture-MS)

ESM2 similar proteins: A2RV29, A4QP16, B0JZ85, F4I7L1, O23463, O48772, O64571, P43243, P43244, Q0VD35, Q10KL8, Q28EG9, Q32NW2, Q3KQ71, Q569K4, Q5R4W8, Q5ZDJ6, Q66IH2, Q6AXX3, Q6NPP4, Q6PBT9, Q7XHR2, Q8BXJ8, Q8GSA7, Q8K310, Q8LMR2, Q8S9H7, Q90Y35, Q94AD9, Q9C682, Q9D8C3, Q9ERV1, Q9FFH1, Q9FH37, Q9FYG2, Q9H000, Q9H6B1, Q9H898, Q9LES2, Q9LES3

Diamond homologs: A2RV29, B0JZ85, O08781, O54836, Q0IIC4, Q0VD35, Q28EG9, Q5H9K5, Q5R4W8, Q8AVN9, Q8BZ94, Q9H898, Q9HA38, Q9R0B7, Q9UL40, O88532, Q5REX3, Q5U231, Q6GPM1, Q96KR1, Q17QQ9, Q5PPL1, Q5R6I3, Q99JT5, Q9NPI7, Q3V0C1, A0A096LPI5, A6NJG6, F2Z398, Q09FC8, Q68CZ1, Q8IV13, Q8N9N2, Q8TDM0, Q92918, Q96J02, Q96MD7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 127 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	8	30.5×	5e-09
Cap-dependent Translation Initiation	8	30.5×	5e-09
SARS-CoV-1 modulates host translation machinery	8	30.5×	5e-09
Eukaryotic Translation Elongation	8	27.5×	1e-08
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	8	26.9×	1e-08
Nonsense-Mediated Decay (NMD)	8	23.0×	3e-08
SARS-CoV-2 modulates host translation machinery	8	22.1×	4e-08
Influenza Viral RNA Transcription and Replication	8	21.3×	6e-08

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	12	20.8×	3e-10
ribosomal small subunit biogenesis	9	19.1×	2e-07
RNA processing	6	12.3×	1e-03
translation	12	11.5×	2e-07
rRNA processing	7	9.3×	1e-03
negative regulation of translation	5	9.2×	9e-03
mRNA splicing, via spliceosome	7	6.0×	8e-03
RNA splicing	7	5.8×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	35
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1526 predictions. Top by Δscore:

Variant	Effect	Δscore
5:177041121:TATA:T	acceptor_loss	1.0000
5:177041122:ATAGT:A	acceptor_gain	1.0000
5:177041123:T:G	acceptor_gain	1.0000
5:177041124:A:AC	acceptor_loss	1.0000
5:177041124:A:AG	acceptor_gain	1.0000
5:177041124:AGT:A	acceptor_gain	1.0000
5:177041124:AGTG:A	acceptor_gain	1.0000
5:177041125:G:A	acceptor_loss	1.0000
5:177041125:G:GT	acceptor_gain	1.0000
5:177041125:GT:G	acceptor_gain	1.0000
5:177041125:GTG:G	acceptor_gain	1.0000
5:177041125:GTGG:G	acceptor_gain	1.0000
5:177041125:GTGGA:G	acceptor_gain	1.0000
5:177041226:CCAG:C	donor_loss	1.0000
5:177041227:CAG:C	donor_loss	1.0000
5:177041229:GGTAT:G	donor_loss	1.0000
5:177041230:G:A	donor_loss	1.0000
5:177041231:T:A	donor_loss	1.0000
5:177041766:G:A	acceptor_gain	1.0000
5:177041777:GAGC:G	acceptor_gain	1.0000
5:177044383:A:AG	acceptor_gain	1.0000
5:177044384:A:G	acceptor_gain	1.0000
5:177044388:GA:G	acceptor_gain	1.0000
5:177064400:A:T	donor_gain	1.0000
5:177041122:A:AG	acceptor_gain	0.9900
5:177041172:GT:G	donor_gain	0.9900
5:177041765:T:TA	acceptor_gain	0.9900
5:177041772:TTGCA:T	acceptor_loss	0.9900
5:177041773:TGCA:T	acceptor_loss	0.9900
5:177041774:GCA:G	acceptor_loss	0.9900

AlphaMissense

1947 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:177041159:T:C	F70S	1.000
5:177041173:T:A	C75S	1.000
5:177041173:T:C	C75R	1.000
5:177041174:G:C	C75S	1.000
5:177041175:T:G	C75W	1.000
5:177041182:T:C	C78R	1.000
5:177041183:G:A	C78Y	1.000
5:177041184:C:G	C78W	1.000
5:177041221:C:A	H91N	1.000
5:177041221:C:G	H91D	1.000
5:177041223:T:A	H91Q	1.000
5:177041223:T:G	H91Q	1.000
5:177041224:T:G	Y92D	1.000
5:177041789:T:A	H97Q	1.000
5:177041789:T:G	H97Q	1.000
5:177044431:T:C	C139R	1.000
5:177044470:C:G	H152D	1.000
5:177044472:C:A	H152Q	1.000
5:177044472:C:G	H152Q	1.000
5:177044480:G:A	G155E	1.000
5:177050792:T:C	C187R	1.000
5:177062114:T:G	Y254D	1.000
5:177041158:T:C	F70L	0.999
5:177041160:C:A	F70L	0.999
5:177041160:C:G	F70L	0.999
5:177041174:G:A	C75Y	0.999
5:177041174:G:T	C75F	0.999
5:177041180:T:A	V77D	0.999
5:177041182:T:A	C78S	0.999
5:177041183:G:C	C78S	0.999

dbSNP variants (sampled 300 via entrez): RS1000081300 (5:177067063 CAAAAT>C), RS1000097001 (5:177058909 T>G), RS1000129732 (5:177058586 T>C,G), RS1000153445 (5:177037423 C>CTA), RS1000185971 (5:177042109 A>G), RS1000211613 (5:177061047 G>C,T), RS1000240271 (5:177023456 A>G), RS1000321140 (5:177035572 T>C), RS1000324859 (5:177078237 G>A), RS1000347644 (5:177078866 G>A), RS1000358683 (5:177049233 C>T), RS1000369643 (5:177064885 C>T), RS1000371845 (5:177035806 C>T), RS1000409765 (5:177053009 A>T), RS1000576018 (5:177054201 T>G)

Disease associations

OMIM: gene MIM:605308 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST005956_15	Waist-to-hip ratio adjusted for BMI	1.000000e-07
GCST005957_13	Waist-to-hip ratio adjusted for BMI (age <50)	3.000000e-07
GCST005962_42	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	1.000000e-08
GCST006462_28	Uterine fibroids	2.000000e-09
GCST007847_86	Type 2 diabetes	4.000000e-10
GCST008163_436	Height	3.000000e-06
GCST008163_499	Height	1.000000e-06
GCST008839_14	Height	1.000000e-11
GCST009158_5	Uterine fibroids	1.000000e-11

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	4
bisphenol A	affects cotreatment, increases methylation, decreases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Arsenic	affects methylation	1
Atrazine	decreases expression	1
Cannabidiol	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
T-2 Toxin	increases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Antirheumatic Agents	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW35	HEK293 eGFP-ZNF346	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.