ZNF354A

Summary

ZNF354A (zinc finger protein 354A, HGNC:11628) is a protein-coding gene on chromosome 5q35.3, encoding Zinc finger protein 354A (O60765).

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. Biomarker of in situ carcinoma and seminoma.

Source: NCBI Gene 6940 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 79 total
• MANE Select transcript: NM_005649

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11628
Approved symbol	ZNF354A
Name	zinc finger protein 354A
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Aliases	KID-1, EZNF, HKL1, KID1
Ensembl gene	ENSG00000169131
Ensembl biotype	protein_coding
OMIM	602444
Entrez	6940

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 protein_coding, 1 nonsense_mediated_decay

ENST00000335815, ENST00000518048, ENST00000520331, ENST00000865234, ENST00000865235, ENST00000865236, ENST00000916334, ENST00000916335, ENST00000916336

RefSeq mRNA: 2 — MANE Select: NM_005649 NM_001324339, NM_005649

CCDS: CCDS4438

Canonical transcript exons

ENST00000335815 — 5 exons

Exon	Start	End
ENSE00001194604	178711512	178713621
ENSE00002108682	178730556	178730659
ENSE00002499429	178728990	178729073
ENSE00003832941	178726999	178727125
ENSE00003837177	178725376	178725471

Expression profiles

Bgee: expression breadth ubiquitous, 253 present calls, max score 87.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.9389 / max 208.2473, expressed in 1621 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65181	3.3146	1416
65180	1.6358	1063
65182	0.9885	638

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	87.57	gold quality
oocyte	CL:0000023	87.25	gold quality
cortical plate	UBERON:0005343	87.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.47	gold quality
ganglionic eminence	UBERON:0004023	85.31	gold quality
monocyte	CL:0000576	84.90	gold quality
mononuclear cell	CL:0000842	84.54	gold quality
leukocyte	CL:0000738	84.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.89	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	82.71	gold quality
lower esophagus	UBERON:0013473	82.69	gold quality
metanephros cortex	UBERON:0010533	82.62	gold quality
granulocyte	CL:0000094	82.44	gold quality
body of pancreas	UBERON:0001150	82.39	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.75	gold quality
embryo	UBERON:0000922	81.64	gold quality
ventricular zone	UBERON:0003053	81.25	gold quality
left lobe of thyroid gland	UBERON:0001120	80.93	gold quality
mucosa of stomach	UBERON:0001199	80.81	gold quality
left uterine tube	UBERON:0001303	80.57	gold quality
sigmoid colon	UBERON:0001159	80.56	gold quality
apex of heart	UBERON:0002098	80.49	gold quality
pancreas	UBERON:0001264	80.45	gold quality
spleen	UBERON:0002106	80.34	gold quality
right lobe of thyroid gland	UBERON:0001119	80.24	gold quality
bone marrow	UBERON:0002371	80.13	gold quality
thyroid gland	UBERON:0002046	80.12	gold quality
body of uterus	UBERON:0009853	80.04	gold quality
lower esophagus mucosa	UBERON:0035834	79.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.69

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA1978.1	ZNF354A	More than 3 adjacent zinc fingers
MA1978.2	ZNF354A	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:27852650

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

39 targeting ZNF354A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-489-3P	99.80	66.46	839
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-3913-3P	99.74	66.53	938
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-885-5P	99.59	68.59	879
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-6740-3P	99.48	68.49	1392
HSA-MIR-582-5P	99.47	70.79	2635
HSA-MIR-7151-5P	99.37	67.82	613
HSA-MIR-377-3P	99.37	70.18	1905
HSA-MIR-520F-5P	99.34	70.40	1632
HSA-MIR-133A-3P	99.27	71.53	1270
HSA-MIR-133B	99.27	71.53	1270
HSA-MIR-4721	99.26	66.05	818
HSA-MIR-8065	99.19	70.38	1289
HSA-MIR-10399-5P	99.17	69.87	2610
HSA-MIR-6504-3P	99.17	69.31	2891
HSA-MIR-670-3P	99.03	68.88	2404
HSA-MIR-323A-5P	98.59	65.13	651

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp354a	ENSMUSG00000020364
rattus_norvegicus	Zfp354a	ENSRNOG00000003634

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 354A — O60765 (reviewed: O60765)

Alternative names: Transcription factor 17, Zinc finger protein eZNF

All UniProt accessions (4): O60765, E5RGC2, E5RHT5, V9HWI2

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Nucleus.

Tissue specificity. Expressed in kidney and inner ear.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001311268, NP_005640* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (23 total): zinc finger region 13, cross-link 5, chain 1, domain 1, region of interest 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60765-F1	68.73	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 110, 121, 139, 171, 268

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins

MSigDB gene sets: 82 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, YAGI_AML_WITH_INV_16_TRANSLOCATION, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, NKX25_02, WOO_LIVER_CANCER_RECURRENCE_UP, GOBP_SENSORY_PERCEPTION, IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM, GOCC_NUCLEOLUS, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, PGF_UP.V1_UP, REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_129_MOUSE_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CEBPZ_TARGET_GENES

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), sensory perception of sound (GO:0007605), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
RNA Polymerase II Transcription	1
Regulation of endogenous retroelements	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
nuclear lumen	2
cellular anatomical structure	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
sensory perception of mechanical stimulus	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
cytoplasm	1

Protein interactions and networks

STRING

674 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF354A	USP50	Q70EL3	701
ZNF354A	FRG2C	A6NGY1	700
ZNF354A	LIN54	Q6MZP7	581
ZNF354A	EML3	Q32P44	509
ZNF354A	SPICE1	Q8N0Z3	478
ZNF354A	ZMYM6	O95789	474
ZNF354A	CACHD1	Q5VU97	461
ZNF354A	DCTPP1	Q9H773	454
ZNF354A	SRY	Q05066	451
ZNF354A	UBAC2	Q8NBM4	438
ZNF354A	SNRPF	P62306	435
ZNF354A	CMTM3	Q96MX0	433
ZNF354A	GTF2H1	P32780	430
ZNF354A	RAB30	Q15771	424
ZNF354A	ARPP19	P56211	418

IntAct

48 interactions, top by confidence:

A	B	Type	Score
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
ZNF331	USP9Y	psi-mi:“MI:0914”(association)	0.530
ZNF71	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
ZC3HAV1	KHNYN	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
H1-4	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL8	ZBTB24	psi-mi:“MI:0914”(association)	0.530
ZNF354A	ECE1	psi-mi:“MI:0915”(physical association)	0.370
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350
PPAN	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
RPL28	SDCBP	psi-mi:“MI:0914”(association)	0.350
ZC3HAV1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
GPATCH4	NOP56	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
rl3_rl3l_human	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
RPS19	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF467	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL36	GTPBP10	psi-mi:“MI:0914”(association)	0.350
RPL28	GTPBP10	psi-mi:“MI:0914”(association)	0.350
ADARB1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
OASL	ZNF316	psi-mi:“MI:0914”(association)	0.350

BioGRID (52): ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), HDAC4 (Reconstituted Complex), ZNF354A (Proximity Label-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS), ZNF354A (Affinity Capture-MS)

ESM2 similar proteins: A1YEP8, A1YFW2, A2RRD8, A2T6E3, A2T6V8, A2T7D2, A2T7F4, A2T812, A6NHJ4, O14709, O43309, O60765, P17036, P17097, P51814, P52738, Q02975, Q08ER8, Q0VGE8, Q12901, Q2M218, Q2M3X9, Q3KNS6, Q4V8A8, Q5RBX0, Q5RCD9, Q5VIY5, Q61751, Q6GQR8, Q6ZMS4, Q7TSH9, Q86Y25, Q8BQC8, Q8IYX0, Q8IZ26, Q8N9F8, Q8NF99, Q8TF39, Q8TF47, Q96N58

Diamond homologs: A2A761, A2VDP4, A3KN32, A6QLU5, A6QPT6, A7MBI1, A8MT65, B4DU55, E9PYI1, O60765, O95780, P15622, P17014, P17032, P17098, P21506, P51508, P51814, P52736, P52738, P52742, Q02975, Q06730, Q06732, Q0VCB0, Q14587, Q16587, Q2KI58, Q2M3W8, Q3V080, Q49AA0, Q4R6C2, Q4V8A8, Q571J5, Q5HYK9, Q5JUW0, Q5JVG2, Q5MCW4, Q5MYW4, Q5R4K8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 52 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	10	40.9×	8e-13
Viral mRNA Translation	10	40.9×	8e-13
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	10	40.5×	8e-13
Selenocysteine synthesis	10	38.8×	8e-13
Eukaryotic Translation Termination	10	38.8×	8e-13
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	10	38.0×	8e-13
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	10	38.0×	8e-13
Formation of a pool of free 40S subunits	10	36.1×	1e-12

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	10	40.3×	1e-11
translation	11	24.6×	7e-11
rRNA processing	7	21.6×	3e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

717 predictions. Top by Δscore:

Variant	Effect	Δscore
5:178725371:CTTA:C	donor_loss	1.0000
5:178725372:TTAC:T	donor_loss	1.0000
5:178725373:TA:T	donor_loss	1.0000
5:178726993:CCTTA:C	donor_loss	1.0000
5:178726994:CTTA:C	donor_loss	1.0000
5:178726995:TTACC:T	donor_loss	1.0000
5:178726996:TACCC:T	donor_loss	1.0000
5:178726997:A:AC	donor_gain	1.0000
5:178726997:A:AT	donor_loss	1.0000
5:178726997:AC:A	donor_gain	1.0000
5:178726997:ACC:A	donor_gain	1.0000
5:178726998:C:CC	donor_gain	1.0000
5:178726998:CC:C	donor_gain	1.0000
5:178726998:CCC:C	donor_gain	1.0000
5:178726998:CCCA:C	donor_gain	1.0000
5:178727123:CAC:C	acceptor_gain	1.0000
5:178727123:CACCT:C	acceptor_loss	1.0000
5:178727125:CCTG:C	acceptor_loss	1.0000
5:178727126:C:CC	acceptor_gain	1.0000
5:178727126:CTGTA:C	acceptor_loss	1.0000
5:178727127:T:G	acceptor_loss	1.0000
5:178727217:T:TA	donor_gain	1.0000
5:178727218:C:A	donor_gain	1.0000
5:178728984:GCTCA:G	donor_loss	1.0000
5:178728985:CTCA:C	donor_loss	1.0000
5:178728986:TCA:T	donor_loss	1.0000
5:178728987:CA:C	donor_loss	1.0000
5:178728988:A:AG	donor_loss	1.0000
5:178728989:CCT:C	donor_loss	1.0000
5:178730558:C:A	donor_gain	1.0000

AlphaMissense

3986 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:178712621:A:C	F419L	0.999
5:178712621:A:T	F419L	0.999
5:178712623:A:G	F419L	0.999
5:178712705:G:C	F391L	0.998
5:178712705:G:T	F391L	0.998
5:178712707:A:G	F391L	0.998
5:178712342:G:C	H512Q	0.997
5:178712342:G:T	H512Q	0.997
5:178712604:A:G	L425P	0.997
5:178712617:A:G	S421P	0.997
5:178712622:A:G	F419S	0.997
5:178712678:A:C	H400Q	0.997
5:178712678:A:T	H400Q	0.997
5:178712680:G:C	H400D	0.997
5:178712201:A:C	F559L	0.996
5:178712201:A:T	F559L	0.996
5:178712203:A:G	F559L	0.996
5:178712344:G:C	H512D	0.996
5:178712369:G:C	F503L	0.996
5:178712369:G:T	F503L	0.996
5:178712371:A:G	F503L	0.996
5:178712453:G:C	F475L	0.996
5:178712453:G:T	F475L	0.996
5:178712455:A:G	F475L	0.996
5:178712688:A:G	L397P	0.996
5:178712285:A:C	F531L	0.995
5:178712285:A:T	F531L	0.995
5:178712287:A:G	F531L	0.995
5:178712426:A:C	H484Q	0.995
5:178712426:A:T	H484Q	0.995

dbSNP variants (sampled 300 via entrez): RS1000180053 (5:178716542 T>C), RS1000247933 (5:178727500 T>C), RS1000261226 (5:178721621 A>G), RS1000316196 (5:178716192 G>A), RS1000350002 (5:178716743 A>C), RS1000383336 (5:178722653 T>C,G), RS1000519013 (5:178717851 G>A), RS1000953408 (5:178718220 T>C), RS1001249948 (5:178711343 C>T), RS1001261077 (5:178728868 G>A,T), RS1001318455 (5:178714705 G>A), RS1001669308 (5:178720603 A>C), RS1001722286 (5:178730888 A>G), RS1001822874 (5:178723331 T>C), RS1002427658 (5:178724728 C>A)

Disease associations

OMIM: gene MIM:602444 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002337_127	Amyotrophic lateral sclerosis (sporadic)	3.000000e-07
GCST007676_10	3-month functional outcome in ischaemic stroke (modified Rankin score)	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009603	stroke outcome severity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Cyclosporine	increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
geraniol	increases expression	1
mono-(2-ethylhexyl)phthalate	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
abrine	decreases expression	1
Benzo(a)pyrene	increases methylation, affects methylation	1
Coumestrol	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	affects cotreatment, decreases expression	1
Phenobarbital	affects expression	1
Smoke	decreases expression	1
Sulindac	increases expression	1
Theophylline	affects cotreatment, decreases expression	1
Urethane	increases expression	1
Valproic Acid	increases expression, increases methylation	1
Aflatoxin M1	decreases expression	1
Asbestos, Crocidolite	decreases methylation	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.