ZNF362

Summary

ZNF362 (zinc finger protein 362, HGNC:18079) is a protein-coding gene on chromosome 1p35.1, encoding Zinc finger protein 362 (Q5T0B9). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 149076 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 54 total
• Transcription factor: yes — 25 downstream targets (CollecTRI)
• MANE Select transcript: NM_152493

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18079
Approved symbol	ZNF362
Name	zinc finger protein 362
Location	1p35.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ25476, lin-29, RN
Ensembl gene	ENSG00000160094
Ensembl biotype	protein_coding
Entrez	149076

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000373428, ENST00000477934, ENST00000483388, ENST00000490959, ENST00000539719, ENST00000926820

RefSeq mRNA: 2 — MANE Select: NM_152493 NM_001370212, NM_152493

CCDS: CCDS377

Canonical transcript exons

ENST00000539719 — 9 exons

Exon	Start	End
ENSE00000916665	33294937	33295015
ENSE00000956969	33295147	33295305
ENSE00001049709	33276348	33276594
ENSE00001066034	33280124	33280457
ENSE00001066037	33281587	33281811
ENSE00001733539	33298930	33300719
ENSE00002257162	33256492	33256654
ENSE00003572143	33270487	33270612
ENSE00003603550	33276100	33276163

Expression profiles

Bgee: expression breadth ubiquitous, 265 present calls, max score 95.10.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.8134 / max 117.1677, expressed in 1759 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
2056	17.6466	1759
2057	0.1668	60

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	95.10	gold quality
pigmented layer of retina	UBERON:0001782	94.92	gold quality
nipple	UBERON:0002030	93.98	gold quality
cortical plate	UBERON:0005343	93.97	gold quality
caput epididymis	UBERON:0004358	93.90	gold quality
cauda epididymis	UBERON:0004360	93.66	gold quality
corpus epididymis	UBERON:0004359	92.86	gold quality
ascending aorta	UBERON:0001496	92.55	gold quality
descending thoracic aorta	UBERON:0002345	92.55	gold quality
thoracic aorta	UBERON:0001515	92.54	gold quality
right coronary artery	UBERON:0001625	92.45	gold quality
saphenous vein	UBERON:0007318	92.28	gold quality
aorta	UBERON:0000947	92.25	gold quality
urethra	UBERON:0000057	92.16	gold quality
ganglionic eminence	UBERON:0004023	92.12	gold quality
popliteal artery	UBERON:0002250	92.03	gold quality
tibial artery	UBERON:0007610	92.02	gold quality
renal medulla	UBERON:0000362	91.96	gold quality
primary visual cortex	UBERON:0002436	91.88	gold quality
tibia	UBERON:0000979	91.83	gold quality
cerebellar vermis	UBERON:0004720	91.77	gold quality
mammalian vulva	UBERON:0000997	91.75	gold quality
skin of hip	UBERON:0001554	91.59	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	91.21	gold quality
Brodmann (1909) area 23	UBERON:0013554	91.15	gold quality
medial globus pallidus	UBERON:0002477	90.95	gold quality
vena cava	UBERON:0004087	90.87	gold quality
trabecular bone tissue	UBERON:0002483	90.86	gold quality
entorhinal cortex	UBERON:0002728	90.83	gold quality
apex of heart	UBERON:0002098	90.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.81

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

25 targets.

Target	Regulation
AATF
ACAT1
CAT
CIITA
CNTN2
CRH
FGFR1
GSTP1
HBB
HRAS
HTR1A
IFNB1
IGF1
KDR
MBP
MDM2
MMP10
NODAL
PSG5
REG1A
RNASE2
SLC4A1
SUPT7L
TIMP1
U2AF1

JASPAR motifs

Motif	Name	Family
MA2593.1	ZNF362	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

miRNA regulators (miRDB)

146 targeting ZNF362, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf362a	ENSDARG00000060900
danio_rerio	znf362b	ENSDARG00000062231
mus_musculus	Zfp362	ENSMUSG00000028799
rattus_norvegicus	Zfp362	ENSRNOG00000043364

Paralogs (36): ZBTB32 (ENSG00000011590), SNAI2 (ENSG00000019549), PRDM1 (ENSG00000057657), PRDM6 (ENSG00000061455), ZNF76 (ENSG00000065029), PATZ1 (ENSG00000100105), MAZ (ENSG00000103495), ZBTB16 (ENSG00000109906), ZNF451 (ENSG00000112200), ZBTB45 (ENSG00000119574), ZNF410 (ENSG00000119725), SNAI1 (ENSG00000124216), ZNF384 (ENSG00000126746), ZBTB1 (ENSG00000126804), VEZF1 (ENSG00000136451), PRDM14 (ENSG00000147596), ZNF276 (ENSG00000158805), ZNF653 (ENSG00000161914), ZNF281 (ENSG00000162702), ZNF148 (ENSG00000163848), ZNF143 (ENSG00000166478), HIC2 (ENSG00000169635), PRDM10 (ENSG00000170325), ZNF296 (ENSG00000170684), ZNF692 (ENSG00000171163), ZNF575 (ENSG00000176472), HIC1 (ENSG00000177374), ZBTB18 (ENSG00000179456), ZBTB42 (ENSG00000179627), ZBTB20 (ENSG00000181722), ZBTB7C (ENSG00000184828), SNAI3 (ENSG00000185669), ZFP91 (ENSG00000186660), MTF1 (ENSG00000188786), SCRT2 (ENSG00000215397), SCRT1 (ENSG00000261678)

Protein

Protein identifiers

Zinc finger protein 362 — Q5T0B9 (reviewed: Q5T0B9)

All UniProt accessions (2): Q5T0B9, F5H055

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001357141, NP_689706* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (16 total): zinc finger region 6, region of interest 4, modified residue 2, chain 1, compositionally biased region 1, cross-link 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T0B9-F1	57.63	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 162, 404, 198

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 241 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, E2F_Q4, E2F_Q4_01, FREAC2_01, E2F4DP1_01, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, AAGCCAT_MIR135A_MIR135B, MAZ_Q6, GTCTACC_MIR379, MEF2_02, GGCNKCCATNK_UNKNOWN, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, IRF7_01, E2F1DP1_01, E2F_Q3

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

742 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF362	TRIM71	Q2Q1W2	724
ZNF362	ZNF512	Q96ME7	651
ZNF362	ZNF451	Q9Y4E5	572
ZNF362	SDAD1	Q9NVU7	552
ZNF362	LIN28A	Q9H9Z2	544
ZNF362	AJM1	C9J069	523
ZNF362	SRBD1	Q8N5C6	490
ZNF362	LCN9	Q8WX39	480
ZNF362	TTLL11	Q8NHH1	476
ZNF362	Q5T8A5	Q5T8A5	461
ZNF362	SACK1E	Q2M2I3	456
ZNF362	UNC119	Q13432	450
ZNF362	NIPBL	Q6KC79	436
ZNF362	RRP15	Q9Y3B9	435
ZNF362	RAD21	O60216	427

IntAct

11 interactions, top by confidence:

A	B	Type	Score
ZNF362	ANKRA2	psi-mi:“MI:0407”(direct interaction)	0.440
ARHGEF19	NUP42	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
H2BC10	SMCHD1	psi-mi:“MI:2364”(proximity)	0.270
AR	MED6	psi-mi:“MI:2364”(proximity)	0.270
CDC14B	PES1	psi-mi:“MI:2364”(proximity)	0.270
TLK2	PES1	psi-mi:“MI:2364”(proximity)	0.270
ZMYM2	ZBTB5	psi-mi:“MI:2364”(proximity)	0.270
ZMYM3	TAF4	psi-mi:“MI:2364”(proximity)	0.270
SUMO1	CHD2	psi-mi:“MI:0914”(association)	0.000

BioGRID (43): ZNF362 (Proximity Label-MS), ZNF362 (Proximity Label-MS), ZNF362 (Affinity Capture-RNA), ZNF362 (Affinity Capture-MS), ZNF362 (Proximity Label-MS), ZNF362 (Proximity Label-MS), ZNF362 (Proximity Label-MS), ZNF362 (Proximity Label-MS), ZNF362 (Affinity Capture-MS), ZNF362 (Proximity Label-MS), ZNF362 (Affinity Capture-MS), ZNF362 (Affinity Capture-MS), ZNF362 (Affinity Capture-MS), ZNF362 (Affinity Capture-MS), ZNF362 (Proximity Label-MS)

ESM2 similar proteins: A0JPB4, A1L1J6, A2VDW9, A4IFJ6, O00409, O08876, O08900, O13089, O15060, O15062, O42410, O57415, O60315, O75626, O89091, P14404, P25932, P36197, P37275, P55878, P55879, P81183, Q03267, Q0VDT2, Q13422, Q33BP8, Q3BJS3, Q3UH06, Q499D0, Q5R9W9, Q5T0B9, Q5ZLR2, Q5ZM39, Q60636, Q62255, Q62947, Q64318, Q6DBW0, Q6NRM0, Q6XDT4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1454 predictions. Top by Δscore:

Variant	Effect	Δscore
1:33256717:A:T	donor_gain	1.0000
1:33276343:C:A	acceptor_gain	1.0000
1:33276343:CGCA:C	acceptor_loss	1.0000
1:33276344:GCA:G	acceptor_loss	1.0000
1:33276345:CA:C	acceptor_loss	1.0000
1:33276346:A:AG	acceptor_gain	1.0000
1:33276346:A:AT	acceptor_loss	1.0000
1:33276346:AGCT:A	acceptor_gain	1.0000
1:33276346:AGCTG:A	acceptor_gain	1.0000
1:33276347:G:GA	acceptor_gain	1.0000
1:33276347:GC:G	acceptor_gain	1.0000
1:33276347:GCT:G	acceptor_gain	1.0000
1:33276347:GCTG:G	acceptor_gain	1.0000
1:33276347:GCTGG:G	acceptor_gain	1.0000
1:33276591:ACAG:A	donor_loss	1.0000
1:33276593:AGGTA:A	donor_loss	1.0000
1:33276595:GTAG:G	donor_loss	1.0000
1:33276596:T:G	donor_loss	1.0000
1:33281809:CAGG:C	donor_loss	1.0000
1:33281810:AGG:A	donor_loss	1.0000
1:33281812:G:GA	donor_loss	1.0000
1:33281813:T:G	donor_loss	1.0000
1:33295143:ACAGT:A	acceptor_loss	1.0000
1:33295144:CA:C	acceptor_loss	1.0000
1:33295145:A:AG	acceptor_gain	1.0000
1:33295145:A:C	acceptor_loss	1.0000
1:33295146:G:GA	acceptor_gain	1.0000
1:33295146:GT:G	acceptor_gain	1.0000
1:33295146:GTC:G	acceptor_gain	1.0000
1:33295146:GTCT:G	acceptor_gain	1.0000

AlphaMissense

2718 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:33281588:T:C	C229R	1.000
1:33281597:T:C	C232R	1.000
1:33281599:C:G	C232W	1.000
1:33281672:T:C	C257R	1.000
1:33281683:C:G	C260W	1.000
1:33281693:T:C	F264L	1.000
1:33281695:T:A	F264L	1.000
1:33281695:T:G	F264L	1.000
1:33281712:T:C	L270P	1.000
1:33281720:C:G	H273D	1.000
1:33281722:C:A	H273Q	1.000
1:33281722:C:G	H273Q	1.000
1:33281724:T:C	L274P	1.000
1:33281756:T:C	C285R	1.000
1:33281777:T:C	F292L	1.000
1:33281779:C:A	F292L	1.000
1:33281779:C:G	F292L	1.000
1:33281796:T:C	L298P	1.000
1:33294965:T:C	C313R	1.000
1:33294992:T:C	F322L	1.000
1:33294994:C:A	F322L	1.000
1:33294994:C:G	F322L	1.000
1:33295011:T:C	L328P	1.000
1:33295150:C:G	H331D	1.000
1:33295186:T:C	C343R	1.000
1:33281588:T:A	C229S	0.999
1:33281589:G:C	C229S	0.999
1:33281590:T:G	C229W	0.999
1:33281597:T:A	C232S	0.999
1:33281598:G:A	C232Y	0.999

dbSNP variants (sampled 300 via entrez): RS1000048917 (1:33148566 T>C,G), RS1000051694 (1:33234981 A>C), RS1000067945 (1:33287141 A>C), RS1000068851 (1:33280536 C>T), RS1000082373 (1:33162597 C>G,T), RS1000109418 (1:33272033 C>G,T), RS1000114862 (1:33162839 G>A), RS1000143709 (1:33147927 A>G), RS1000152233 (1:33195227 A>G), RS1000157417 (1:33186994 G>A), RS1000173646 (1:33231137 G>A,C), RS1000177490 (1:33295571 A>G), RS1000182130 (1:33195589 C>A), RS1000190113 (1:33286928 G>A), RS1000197274 (1:33151423 A>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006810_10	Self-reported risk-taking behaviour	4.000000e-09
GCST008794_40	Urinary albumin-to-creatinine ratio	4.000000e-08
GCST90002381_571	Eosinophil count	6.000000e-14

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008579	risk-taking behaviour
EFO:0007778	urinary albumin to creatinine ratio
EFO:0004842	eosinophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases methylation	7
Benzo(a)pyrene	decreases methylation, decreases expression	5
sodium arsenite	decreases expression, increases abundance, increases expression	4
Cyclosporine	decreases expression	2
Aflatoxin B1	decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol A	increases expression	1
butyraldehyde	decreases expression	1
coumarin	increases phosphorylation	1
S-(1,2-dichlorovinyl)cysteine	decreases expression, affects response to substance, increases expression, affects cotreatment	1
beta-methylcholine	affects expression	1
monomethylarsonous acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
ON 01910	increases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Acetaminophen	increases expression	1
Arsenic	increases abundance, increases expression	1
Azathioprine	decreases expression	1
Cadmium	decreases expression, increases abundance	1
Caffeine	affects phosphorylation	1
Calcitriol	decreases expression	1
Hydrogen Peroxide	affects expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression, affects cotreatment	1
Plant Extracts	affects cotreatment, decreases expression	1
Quercetin	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW37	HEK293 eGFP-ZNF362	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.