ZNF367

Summary

ZNF367 (zinc finger protein 367, HGNC:18320) is a protein-coding gene on chromosome 9q22.32, encoding Zinc finger protein 367 (Q7RTV3). Transcriptional activator.

Enables DNA-binding transcription factor activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleoplasm.

Source: NCBI Gene 195828 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 18 total
• MANE Select transcript: NM_153695

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18320
Approved symbol	ZNF367
Name	zinc finger protein 367
Location	9q22.32
Locus type	gene with protein product
Status	Approved
Aliases	FLJ33970
Ensembl gene	ENSG00000165244
Ensembl biotype	protein_coding
OMIM	610160
Entrez	195828

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000375256

RefSeq mRNA: 1 — MANE Select: NM_153695 NM_153695

CCDS: CCDS6718

Canonical transcript exons

ENST00000375256 — 5 exons

Exon	Start	End
ENSE00001091583	96398164	96398314
ENSE00001091585	96394823	96394942
ENSE00001091590	96392398	96392536
ENSE00001466452	96385941	96388459
ENSE00001466459	96417613	96418370

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 86.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.1215 / max 73.9056, expressed in 1140 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101595	2.4696	936
101596	0.8432	514
101594	0.6019	347
101597	0.2067	81

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	86.98	gold quality
ventricular zone	UBERON:0003053	86.44	gold quality
trabecular bone tissue	UBERON:0002483	84.46	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.20	gold quality
bone marrow	UBERON:0002371	84.20	gold quality
ileal mucosa	UBERON:0000331	82.99	gold quality
ganglionic eminence	UBERON:0004023	82.74	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.84	gold quality
mucosa of sigmoid colon	UBERON:0004993	75.30	gold quality
monocyte	CL:0000576	74.27	gold quality
leukocyte	CL:0000738	74.11	gold quality
stromal cell of endometrium	CL:0002255	73.70	gold quality
colonic mucosa	UBERON:0000317	72.65	gold quality
skin of hip	UBERON:0001554	72.48	gold quality
tibia	UBERON:0000979	72.32	gold quality
cartilage tissue	UBERON:0002418	72.32	silver quality
vermiform appendix	UBERON:0001154	72.15	gold quality
bone marrow cell	CL:0002092	72.10	gold quality
rectum	UBERON:0001052	71.86	gold quality
calcaneal tendon	UBERON:0003701	71.45	gold quality
smooth muscle tissue	UBERON:0001135	69.93	gold quality
islet of Langerhans	UBERON:0000006	68.04	gold quality
mucosa of transverse colon	UBERON:0004991	67.98	gold quality
lymph node	UBERON:0000029	67.77	gold quality
granulocyte	CL:0000094	67.64	gold quality
tibialis anterior	UBERON:0001385	67.50	silver quality
buccal mucosa cell	CL:0002336	67.07	silver quality
popliteal artery	UBERON:0002250	67.03	gold quality
tibial artery	UBERON:0007610	67.01	gold quality
heart left ventricle	UBERON:0002084	66.74	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-110499	no	356.21
E-ANND-3	no	2.79

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2552.1	ZNF367

JASPAR matrix evidence (PMIDs): PMID:39605320

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

268 targeting ZNF367, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684

Literature-anchored findings (GeneRIF, showing 7)

• molecular cloning of ZFF29 (zinc-finger protein of human fetal liver erythroid cells 29), from human fetal liver erythroid cells (PMID:15344908)
• ZNF367 is overexpressed in a variety of endocrine cancers and that it inhibits in vitro and in vivo growth, cellular invasion, migration, and adhesion. ZNF367 overexpression is associated with the loss of miR-195 expression. (PMID:25047265)
• Over-expression of MiR-24 could significantly promoted cell migration and invasion (p<0.05). ZNF367 was a downstream target of MiR-24 and down-regulated by MiR-24. Knockdown of ZNF367 remarkably promoted NSCLC cell proliferation (p<0.05). (PMID:30570867)
• Validation of the OncoMasTR Risk Score in Estrogen Receptor-Positive/HER2-Negative Patients: A TransATAC study. (PMID:31641007)
• ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer. (PMID:32549756)
• Inhibition of zinc finger protein 367 exerts a tumor suppressive role in colorectal cancer by affecting the activation of oncogenic YAP1 signaling. (PMID:34351699)
• Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade. (PMID:38880190)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf367	ENSDARG00000021086
mus_musculus	Zfp367	ENSMUSG00000044934
rattus_norvegicus	Zfp367	ENSRNOG00000027234
drosophila_melanogaster	klu	FBGN0013469
drosophila_melanogaster	CG4318	FBGN0030455
caenorhabditis_elegans	klu-2	WBGENE00022592

Paralogs (4): ZNF740 (ENSG00000139651), ZBTB5 (ENSG00000168795), ZBTB43 (ENSG00000169155), ZBTB7A (ENSG00000178951)

Protein

Protein identifiers

Zinc finger protein 367 — Q7RTV3 (reviewed: Q7RTV3)

Alternative names: C2H2 zinc finger protein ZFF29

All UniProt accessions (1): Q7RTV3

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q7RTV3-1	1, ZFF29B	yes
Q7RTV3-2	2, ZFF29A

RefSeq proteins (1): NP_710162* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF13912

UniProt features (10 total): zinc finger region 2, region of interest 2, compositionally biased region 2, chain 1, coiled-coil region 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7RTV3-F1	60.75	0.03

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 310

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 281 (showing top): ATF_B, GCACCTT_MIR18A_MIR18B, E2F_Q4, E2F_Q4_01, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, E2F4DP1_01, FISCHER_G1_S_CELL_CYCLE, TGCACTT_MIR519C_MIR519B_MIR519A, GCANCTGNY_MYOD_Q6, CREBP1_Q2, CREB_Q4, E2F1DP1_01, E2F_Q3, E2F1DP2_01

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

992 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF367	PRXL2C	Q7RTV5	568
ZNF367	UBOX5	O94941	529
ZNF367	J3KS56	J3KS56	526
ZNF367	HABP4	Q5JVS0	506
ZNF367	CCDC150	Q8NCX0	489
ZNF367	DEPDC1B	Q8WUY9	487
ZNF367	CCDC77	Q9BR77	476
ZNF367	GALNT12	Q8IXK2	475
ZNF367	AP5S1	Q9NUS5	461
ZNF367	NEMP1	O14524	458
ZNF367	CEP15	Q9HBI5	455
ZNF367	SMYD1	Q8NB12	447
ZNF367	ZBTB3	Q9H5J0	445
ZNF367	LZTS3	O60299	439
ZNF367	CCDC34	Q96HJ3	437

IntAct

2 interactions, top by confidence:

A	B	Type	Score
KLHL22	TRAV18	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): ZNF367 (Affinity Capture-MS), ZNF367 (Affinity Capture-RNA), ZNF367 (Affinity Capture-RNA)

ESM2 similar proteins: A1L020, A1L3F4, A7X8B3, A7X8B5, A7X8B7, A7X8B9, A7X8C2, A7X8C4, A7X8C7, A7X8C9, A7X8D2, A7X8D4, A7XW25, O97775, O97776, O97952, O97960, P06401, P10275, P84550, P84551, P89463, Q01JD1, Q05A36, Q0VDT2, Q3UE17, Q5PQQ7, Q5U5Q3, Q69Z36, Q6QT55, Q6ZK57, Q6ZN04, Q71FD5, Q7RTV3, Q7TSJ6, Q7XQN1, Q7XT42, Q84SL2, Q86XN8, Q8BQ89

Diamond homologs: A0A9P4XV22, A2ANX9, B1H2Q6, O62836, P08048, P0CJ78, P10925, P17010, P17012, P20662, P27705, P28698, P52288, P80944, Q01611, Q03081, Q03125, Q0VDT2, Q29419, Q3U3I9, Q52V16, Q567C6, Q5U2Z0, Q6B4Z5, Q7RTV3, Q95LI3, Q966L8, Q96EG3, Q9UDV6, Q9UL36, Q9Y462, A0A5K4F1D0, B0YDH7, J9VE33, J9VX63, O35738, O60315, O77027, P08151, P10070

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

18 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	15
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

687 predictions. Top by Δscore:

Variant	Effect	Δscore
9:96388457:TAC:T	acceptor_gain	1.0000
9:96388458:ACC:A	acceptor_loss	1.0000
9:96388459:CCTA:C	acceptor_gain	1.0000
9:96388460:C:CC	acceptor_gain	1.0000
9:96388461:T:G	acceptor_loss	1.0000
9:96388462:A:AC	acceptor_gain	1.0000
9:96388462:A:C	acceptor_gain	1.0000
9:96388464:G:C	acceptor_gain	1.0000
9:96392391:T:A	donor_gain	1.0000
9:96394807:A:C	donor_gain	1.0000
9:96398159:CTTA:C	donor_loss	1.0000
9:96398160:TTACC:T	donor_loss	1.0000
9:96398161:TACCT:T	donor_loss	1.0000
9:96398162:A:AC	donor_gain	1.0000
9:96398162:ACCTG:A	donor_loss	1.0000
9:96398163:C:CC	donor_gain	1.0000
9:96398310:CCATC:C	acceptor_gain	1.0000
9:96398311:CATC:C	acceptor_gain	1.0000
9:96398311:CATCC:C	acceptor_gain	1.0000
9:96398312:ATCC:A	acceptor_loss	1.0000
9:96398313:TC:T	acceptor_gain	1.0000
9:96398313:TCCT:T	acceptor_loss	1.0000
9:96398314:CC:C	acceptor_gain	1.0000
9:96398315:C:CC	acceptor_gain	1.0000
9:96398315:C:G	acceptor_loss	1.0000
9:96398316:T:A	acceptor_loss	1.0000
9:96417608:CTCA:C	donor_loss	1.0000
9:96417609:TCA:T	donor_loss	1.0000
9:96417610:CACCT:C	donor_loss	1.0000
9:96417611:ACCTT:A	donor_loss	1.0000

AlphaMissense

2269 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:96394896:A:C	F206L	1.000
9:96394896:A:T	F206L	1.000
9:96394898:A:G	F206L	1.000
9:96394910:A:G	C202R	1.000
9:96394923:A:C	C197W	1.000
9:96394924:C:G	C197S	1.000
9:96394925:A:G	C197R	1.000
9:96394925:A:T	C197S	1.000
9:96398219:A:C	C172W	1.000
9:96398220:C:G	C172S	1.000
9:96398220:C:T	C172Y	1.000
9:96398221:A:G	C172R	1.000
9:96398221:A:T	C172S	1.000
9:96398229:C:G	C169S	1.000
9:96398230:A:G	C169R	1.000
9:96398230:A:T	C169S	1.000
9:96392520:G:C	F236L	0.999
9:96392520:G:T	F236L	0.999
9:96392522:A:G	F236L	0.999
9:96394833:A:C	C227W	0.999
9:96394834:C:G	C227S	0.999
9:96394835:A:G	C227R	0.999
9:96394835:A:T	C227S	0.999
9:96394839:A:C	F225L	0.999
9:96394839:A:T	F225L	0.999
9:96394841:A:G	F225L	0.999
9:96394871:G:C	H215D	0.999
9:96394897:A:C	F206C	0.999
9:96394897:A:G	F206S	0.999
9:96394898:A:T	F206I	0.999

dbSNP variants (sampled 300 via entrez): RS1000084483 (9:96405406 C>T), RS1000085524 (9:96402595 A>G,T), RS1000373990 (9:96388701 A>G), RS1000389186 (9:96388285 G>A), RS1000404958 (9:96419565 G>A), RS1000529028 (9:96403547 A>C), RS1000562784 (9:96411656 A>T), RS1000601696 (9:96405128 C>T), RS1000689736 (9:96418567 A>C,G), RS1000713684 (9:96418378 C>G,T), RS1000839509 (9:96419358 T>G), RS1000875767 (9:96393462 A>C,G), RS1000984591 (9:96386387 T>C), RS1000990935 (9:96400636 T>G), RS1001038946 (9:96417374 T>C)

Disease associations

OMIM: gene MIM:610160 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001956_67	Height	2.000000e-12
GCST003818_3	Resting heart rate	6.000000e-06
GCST012226_93	Waist circumference adjusted for body mass index	1.000000e-14
GCST012226_94	Waist circumference adjusted for body mass index	2.000000e-08
GCST012227_436	Hip circumference adjusted for BMI	1.000000e-19
GCST90020028_387	Hip circumference adjusted for BMI	3.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007789	BMI-adjusted waist circumference
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

56 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	2
Nickel	increases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	affects expression	1
methylparaben	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
butyraldehyde	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, increases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	increases expression, affects cotreatment	1
cupric chloride	increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
pentanal	decreases expression	1
diethyl malate	increases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
deguelin	decreases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	increases expression	1
bazedoxifene	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Leflunomide	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Calcitriol	decreases expression, affects cotreatment	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TZ39	HAP1 ZNF367 (-) 1	Cancer cell line	Male
CVCL_XV32	HAP1 ZNF367 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.