ZNF385D-AS2

Summary

ZNF385D-AS2 (ZNF385D antisense RNA 2, HGNC:42420) is a long non-coding RNA gene on chromosome 3p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42420
Approved symbol	ZNF385D-AS2
Name	ZNF385D antisense RNA 2
Location	3p24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223351
Ensembl biotype	lncRNA
Entrez	100874221
RNAcentral	URS000075F08E — lncRNA, 421 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000436306, ENST00000448980

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436306 — 4 exons

Exon	Start	End
ENSE00001593521	21957136	21957192
ENSE00001606569	21958832	21958923
ENSE00001616929	21978215	21978291
ENSE00001639193	21979631	21979828

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 95.85.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.85	gold quality
right testis	UBERON:0004534	67.55	gold quality
liver	UBERON:0002107	65.66	gold quality
skeletal muscle tissue	UBERON:0001134	65.35	silver quality
kidney	UBERON:0002113	64.61	gold quality
testis	UBERON:0000473	64.37	gold quality
left testis	UBERON:0004533	64.19	gold quality
lung	UBERON:0002048	63.69	gold quality
calcaneal tendon	UBERON:0003701	62.97	gold quality
stomach	UBERON:0000945	59.72	gold quality
islet of Langerhans	UBERON:0000006	59.39	gold quality
monocyte	CL:0000576	57.12	gold quality
intestine	UBERON:0000160	56.30	gold quality
cerebellar cortex	UBERON:0002129	56.19	gold quality
multicellular organism	UBERON:0000468	56.17	gold quality
cerebellar hemisphere	UBERON:0002245	55.86	gold quality
heart	UBERON:0000948	54.99	gold quality
superior frontal gyrus	UBERON:0002661	54.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	54.66	gold quality
left adrenal gland cortex	UBERON:0035825	54.37	gold quality
gastrocnemius	UBERON:0001388	54.22	gold quality
blood	UBERON:0000178	53.93	gold quality
primary visual cortex	UBERON:0002436	53.29	gold quality
adrenal tissue	UBERON:0018303	53.25	gold quality
adrenal gland	UBERON:0002369	52.49	gold quality
left adrenal gland	UBERON:0001234	51.76	gold quality
colon	UBERON:0001155	50.70	gold quality
body of pancreas	UBERON:0001150	50.37	gold quality
right adrenal gland cortex	UBERON:0035827	50.21	gold quality
right adrenal gland	UBERON:0001233	50.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Low lncRNA ZNF385DAS2 expression is associated with liver cancer. (PMID:31322274)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.