ZNF395

Summary

ZNF395 (zinc finger protein 395, HGNC:18737) is a protein-coding gene on chromosome 8p21.1, encoding Zinc finger protein 395 (Q9H8N7). Plays a role in papillomavirus genes transcription.

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nuclear speck.

Source: NCBI Gene 55893 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 82 total
• Cancer driver (intOGen): activating (oncogene-like) across 1 cancer types
• MANE Select transcript: NM_018660

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18737
Approved symbol	ZNF395
Name	zinc finger protein 395
Location	8p21.1
Locus type	gene with protein product
Status	Approved
Aliases	PRF-1, HDBP2, PBF, DKFZp434K1210
Ensembl gene	ENSG00000186918
Ensembl biotype	protein_coding
OMIM	609494
Entrez	55893

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 36 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000344423, ENST00000517372, ENST00000517459, ENST00000519730, ENST00000520290, ENST00000520535, ENST00000521185, ENST00000521912, ENST00000522795, ENST00000523095, ENST00000523202, ENST00000887379, ENST00000887380, ENST00000887381, ENST00000887382, ENST00000887383, ENST00000887384, ENST00000887385, ENST00000887386, ENST00000887387, ENST00000887388, ENST00000887389, ENST00000887390, ENST00000887391, ENST00000887392, ENST00000887393, ENST00000887394, ENST00000887395, ENST00000887396, ENST00000887397, ENST00000887398, ENST00000914548, ENST00000942495, ENST00000942496, ENST00000942497, ENST00000942498, ENST00000942499, ENST00000942500

RefSeq mRNA: 1 — MANE Select: NM_018660 NM_018660

CCDS: CCDS6067

Canonical transcript exons

ENST00000344423 — 10 exons

Exon	Start	End
ENSE00001414788	28345590	28348830
ENSE00001420932	28386393	28386460
ENSE00003505029	28356670	28356779
ENSE00003516537	28352573	28352673
ENSE00003543568	28353173	28353408
ENSE00003618611	28351495	28351807
ENSE00003641016	28359592	28359824
ENSE00003653368	28350064	28350156
ENSE00003676492	28360885	28361182
ENSE00003683775	28349125	28349228

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 96.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.9241 / max 128.3385, expressed in 1619 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92527	4.5593	1424
92531	1.5832	1034
92529	0.2951	136
92526	0.2729	136
92528	0.1975	67
92532	0.0161	6

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nipple	UBERON:0002030	96.02	gold quality
parietal pleura	UBERON:0002400	95.15	gold quality
tendon of biceps brachii	UBERON:0008188	95.10	gold quality
secondary oocyte	CL:0000655	94.78	gold quality
tongue squamous epithelium	UBERON:0006919	94.77	gold quality
germinal epithelium of ovary	UBERON:0001304	94.63	gold quality
left ovary	UBERON:0002119	94.48	gold quality
mucosa of stomach	UBERON:0001199	94.26	gold quality
pericardium	UBERON:0002407	94.25	gold quality
cartilage tissue	UBERON:0002418	94.06	gold quality
ovary	UBERON:0000992	94.05	gold quality
tonsil	UBERON:0002372	94.01	gold quality
esophagus squamous epithelium	UBERON:0006920	93.99	gold quality
tibia	UBERON:0000979	93.96	gold quality
right ovary	UBERON:0002118	93.90	gold quality
palpebral conjunctiva	UBERON:0001812	93.82	gold quality
tibial artery	UBERON:0007610	93.81	gold quality
popliteal artery	UBERON:0002250	93.80	gold quality
parotid gland	UBERON:0001831	93.78	gold quality
upper leg skin	UBERON:0004262	93.71	gold quality
body of pancreas	UBERON:0001150	93.62	gold quality
saphenous vein	UBERON:0007318	93.62	gold quality
cervix squamous epithelium	UBERON:0006922	93.58	gold quality
squamous epithelium	UBERON:0006914	93.52	gold quality
epithelium of esophagus	UBERON:0001976	93.36	gold quality
ventricular zone	UBERON:0003053	93.27	gold quality
sural nerve	UBERON:0015488	93.25	gold quality
esophagus mucosa	UBERON:0002469	93.18	gold quality
skin of leg	UBERON:0001511	93.10	gold quality
zone of skin	UBERON:0000014	93.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

8 targets.

Target	Regulation
HTT
IFIT1
PRF1
SAP30
SLC16A2
SLC5A5
SUPT7L
TP53

JASPAR motifs

Motif	Name	Family
MA2566.1	ZNF395	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:14625278

miRNA regulators (miRDB)

179 targeting ZNF395, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502

Literature-anchored findings (GeneRIF, showing 12)

• HDBP1 and HDBP2 are novel transcription factors shuttling between nucleus and cytoplasm and bind to the specific GCCGGCG, which is an essential cis-element for HD gene expression in neuronal cells (PMID:14625278)
• PBF is an osteosarcoma-associated antigen recognized by autologous cytotoxic T-lymphocyte clone in the context of HLA-B*5502. (PMID:15289353)
• PBF is a new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth (PMID:17531190)
• PBF binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex (PMID:17897615)
• colocalization of PBF and Scythe/BAT3 in the nucleus might be an important factor for survival of osteosarcoma cells. (PMID:19018758)
• ZNF395 coordinate the transcriptional regulatory pathway with PPARG2, which may be necessary for the genesis of adipocytes. (PMID:23142027)
• Studies indicate that ZNF395 was strongly expressed in adipocytes, and suggest a role for ZNF395 as a modulator of adipogenesis. (PMID:23760207)
• IkBalpha kinase (IKK)-signaling is necessary to allow ZNF395 to activate transcription and simultaneously enhances its proteolytic degradation. (PMID:24086395)
• miR-525-3p promotes liver cancer cell migration and invasion by directly targeting ZNF395. (PMID:24599008)
• The transcriptional activation of CXCL10 and CXCL11 by ZNF395 was abolished after inhibition of IKK by BMS-345541, which increased the stability of ZNF395. ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low. (PMID:28316371)
• epigenomic profiling of clear cell renal cell carcinoma (ccRCC) establishes a compendium of somatically altered cis-regulatory elements, uncovering new potential targets including ZNF395. Loss of VHL, a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes (PMID:28893800)
• Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential. (PMID:33794543)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf395b	ENSDARG00000024195
danio_rerio	znf395a	ENSDARG00000060113
mus_musculus	Zfp395	ENSMUSG00000034522
rattus_norvegicus	Zfp395	ENSRNOG00000014191
drosophila_melanogaster	Glut4EF	FBGN0267336

Paralogs (2): SLC2A4RG (ENSG00000125520), ZNF704 (ENSG00000164684)

Protein

Protein identifiers

Zinc finger protein 395 — Q9H8N7 (reviewed: Q9H8N7)

Alternative names: HD-regulating factor 2, Huntington disease gene regulatory region-binding protein 2, Papillomavirus regulatory factor 1, Papillomavirus-binding factor

All UniProt accessions (7): Q9H8N7, A0A0C4DGD9, E5RFV4, E5RG59, E5RGF1, E5RH90, H0YAN1

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in papillomavirus genes transcription.

Subunit / interactions. Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8).

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Widely expressed.

RefSeq proteins (1): NP_061130* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR031940	ZNF395/ZNF704_N	Domain
IPR052253	CR1/CR2-DNA-binding_regulator	Family

Pfam: PF15997

UniProt features (20 total): compositionally biased region 5, mutagenesis site 4, modified residue 3, region of interest 3, sequence conflict 2, chain 1, zinc finger region 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H8N7-F1	59.53	0.18

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 248, 376, 449

Mutagenesis-validated functional residues (4):

Position	Phenotype
109	no change in subcellular location; when associated with a-113.
113	no change in subcellular location; when associated with a-109.
169	no shuttle from the nucleus to the cytoplasm; when associated with a-172.
172	no shuttle from the nucleus to the cytoplasm; when associated with a-169.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 239 (showing top): TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, MITSIADES_RESPONSE_TO_APLIDIN_DN, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_UP, MODULE_205, chr8p21, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, RIGGI_EWING_SARCOMA_PROGENITOR_DN, MODULE_301, AIYAR_COBRA1_TARGETS_DN, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, HOOI_ST7_TARGETS_DN, P300_01

GO Biological Process (3): regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), cis-regulatory region sequence-specific DNA binding (GO:0000987), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), nuclear speck (GO:0016607)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription cis-regulatory region binding	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
regulation of transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
nucleic acid binding	1
transcription regulator activity	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
nuclear ribonucleoprotein granule	1

Protein interactions and networks

STRING

1766 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF395	DYNC1I1	O14576	547
ZNF395	GTF3A	Q92664	541
ZNF395	MINK1	Q8N4C8	517
ZNF395	LCP1	P13796	497
ZNF395	TUBB2A	Q13885	484
ZNF395	PTOV1	Q86YD1	473
ZNF395	GAPDH	P00354	459
ZNF395	ZNF638	Q14966	446
ZNF395	ZNF773	Q6PK81	437
ZNF395	TUBB	P05218	437
ZNF395	PLS3	P13797	436
ZNF395	S100A6	P06703	433
ZNF395	REST	Q13127	428
ZNF395	ZNF671	Q8TAW3	426
ZNF395	PML	P29590	425

IntAct

19 interactions, top by confidence:

A	B	Type	Score
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
ZNF395	YWHAG	psi-mi:“MI:0914”(association)	0.530
YWHAB	ZNF395	psi-mi:“MI:0914”(association)	0.530
YWHAQ	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
ZNF395	H3-4	psi-mi:“MI:0915”(physical association)	0.400
ZNF395	H2AC4	psi-mi:“MI:0915”(physical association)	0.400
ZNF395	Nfkbia	psi-mi:“MI:0915”(physical association)	0.400
ZNF395	Ikbkb	psi-mi:“MI:0915”(physical association)	0.400
WASL	ZNF395	psi-mi:“MI:0915”(physical association)	0.370
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
YWHAE	DEPDC5	psi-mi:“MI:0914”(association)	0.350
YWHAG	BRAF	psi-mi:“MI:0914”(association)	0.350
YWHAB	FOXO6	psi-mi:“MI:0914”(association)	0.350
YWHAQ	FOXO6	psi-mi:“MI:0914”(association)	0.350
CREB3L2	PLEKHG3	psi-mi:“MI:0914”(association)	0.350

BioGRID (31): ZNF395 (Affinity Capture-MS), ZNF395 (Affinity Capture-MS), ZNF395 (Affinity Capture-MS), ZNF395 (Affinity Capture-Western), ZNF395 (Affinity Capture-Western), ZNF395 (Affinity Capture-MS), ZNF395 (Proximity Label-MS), ZNF395 (Proximity Label-MS), ZNF395 (Affinity Capture-MS), ZNF395 (Proximity Label-MS), ZNF395 (Proximity Label-MS), BTRC (Affinity Capture-MS), ZNF395 (Affinity Capture-MS), FBXW11 (Affinity Capture-MS), YWHAH (Affinity Capture-MS)

ESM2 similar proteins: A0JNG6, A2AKB4, A7YWL5, B0BN13, O35181, O43734, O70142, O70240, O88286, O88566, P0DPB3, P0DPB4, P56975, P70298, P86174, P97303, Q00IB7, Q1LY51, Q2M3C6, Q2T9L4, Q3TY60, Q498S6, Q4V7B1, Q568Z1, Q5HZN9, Q5JTD0, Q5SYB0, Q5U5E5, Q5VT97, Q69ZB8, Q6PG95, Q6UXB0, Q6ZU67, Q76N89, Q80YE4, Q86XD5, Q8BWU3, Q8BZB3, Q8CD60, Q8N365

Diamond homologs: Q1LY51, Q6DFC8, Q6ZNC4, Q9ERQ3, Q9H8N7, Q9NR83

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 17 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	6	304.5×	8e-13
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	6	268.7×	1e-12
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	6	268.7×	1e-12
Activation of BH3-only proteins	6	198.6×	7e-12
RHO GTPases activate PKNs	6	126.9×	9e-11
Intrinsic Pathway for Apoptosis	6	117.1×	1e-10
SARS-CoV-1-host interactions	6	70.3×	3e-09
Apoptosis	6	67.2×	3e-09

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	122.1×	5e-08
intracellular protein localization	6	41.9×	2e-07

Disease & clinical

Cancer significance

From intOGen — cancer-driver classification: activating (oncogene-like) across 1 cancer types — NSCLC.

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	68
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2016 predictions. Top by Δscore:

Variant	Effect	Δscore
8:28348826:CTTTC:C	acceptor_gain	1.0000
8:28349227:ACC:A	acceptor_loss	1.0000
8:28349234:C:CT	acceptor_gain	1.0000
8:28351739:T:TA	donor_gain	1.0000
8:28351807:CCTG:C	acceptor_gain	1.0000
8:28352570:TA:T	donor_loss	1.0000
8:28352571:A:C	donor_loss	1.0000
8:28352571:AC:A	donor_gain	1.0000
8:28352571:ACC:A	donor_gain	1.0000
8:28352572:CC:C	donor_gain	1.0000
8:28352572:CCC:C	donor_gain	1.0000
8:28352669:GAGTT:G	acceptor_gain	1.0000
8:28352670:AGTT:A	acceptor_gain	1.0000
8:28352671:GTT:G	acceptor_gain	1.0000
8:28352672:TT:T	acceptor_gain	1.0000
8:28352672:TTCTA:T	acceptor_loss	1.0000
8:28352674:C:CA	acceptor_loss	1.0000
8:28352674:C:CC	acceptor_gain	1.0000
8:28356787:C:CT	acceptor_gain	1.0000
8:28359591:CCT:C	donor_gain	1.0000
8:28359820:TAAAC:T	acceptor_gain	1.0000
8:28359821:AAAC:A	acceptor_gain	1.0000
8:28359822:AAC:A	acceptor_gain	1.0000
8:28359823:AC:A	acceptor_gain	1.0000
8:28359824:CC:C	acceptor_gain	1.0000
8:28359824:CCT:C	acceptor_loss	1.0000
8:28359825:C:CA	acceptor_loss	1.0000
8:28359825:C:CC	acceptor_gain	1.0000
8:28360946:T:TA	donor_gain	1.0000
8:28348827:TTTC:T	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000097506 (8:28381360 T>C), RS1000172920 (8:28359133 A>C), RS1000261658 (8:28347775 A>G), RS1000273344 (8:28365356 C>T), RS1000283474 (8:28352916 T>C), RS1000405495 (8:28381674 T>C), RS1000460609 (8:28383453 C>A), RS1000466018 (8:28377232 T>C), RS1000536592 (8:28385055 C>G), RS1000561976 (8:28376945 T>C), RS1000603211 (8:28383728 C>A), RS1000693725 (8:28350850 T>G), RS1000723310 (8:28365141 C>T), RS1000748903 (8:28371622 T>C), RS1000836005 (8:28359319 G>A,T)

Disease associations

OMIM: gene MIM:609494 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

61 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation, increases expression	5
Benzo(a)pyrene	decreases expression, decreases methylation, increases expression	4
bisphenol A	affects expression, affects cotreatment, increases expression	2
Estradiol	affects cotreatment, decreases expression, affects expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Cyclosporine	decreases expression	2
Aflatoxin B1	decreases expression	2
Particulate Matter	increases expression, decreases expression, increases abundance, affects cotreatment	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
methylmercuric chloride	decreases expression	1
propionaldehyde	decreases expression	1
trichostatin A	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	decreases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	increases expression	1
ferrous chloride	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
perfluorobutanesulfonic acid	increases expression	1
bisphenol S	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	increases methylation	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Carbamazepine	affects expression	1
Coumestrol	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HA02	K562 eGFP-ZNF395	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.