ZNF407-AS1

Summary

ZNF407-AS1 (ZNF407 antisense RNA 1, HGNC:44331) is a long non-coding RNA gene on chromosome 18q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44331
Approved symbol	ZNF407-AS1
Name	ZNF407 antisense RNA 1
Location	18q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000264247
Ensembl biotype	lncRNA
Entrez	400657
RNAcentral	URS000075BFAB — lncRNA, 3474 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000577806, ENST00000580048, ENST00000581192, ENST00000585279, ENST00000652782, ENST00000654728, ENST00000657978, ENST00000664604, ENST00000669094, ENST00000670940, ENST00000827606

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577806 — 2 exons

Exon	Start	End
ENSE00004239687	74592840	74593839
ENSE00004239688	74597258	74597581

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 92.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.2049 / max 55.4940, expressed in 1681 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
172434	2.8717	1436
172433	2.0877	1066
172435	0.2456	87

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	92.56	gold quality
epithelial cell of pancreas	CL:0000083	89.59	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.39	gold quality
tibialis anterior	UBERON:0001385	87.36	gold quality
ventricular zone	UBERON:0003053	85.78	gold quality
ileal mucosa	UBERON:0000331	85.76	gold quality
spinal cord	UBERON:0002240	85.47	gold quality
endothelial cell	CL:0000115	85.29	gold quality
granulocyte	CL:0000094	85.24	gold quality
calcaneal tendon	UBERON:0003701	84.85	gold quality
left ventricle myocardium	UBERON:0006566	84.59	gold quality
deltoid	UBERON:0001476	84.41	gold quality
tendon	UBERON:0000043	84.21	gold quality
putamen	UBERON:0001874	83.99	gold quality
caudate nucleus	UBERON:0001873	83.47	gold quality
cardiac muscle of right atrium	UBERON:0003379	83.22	silver quality
Brodmann (1909) area 9	UBERON:0013540	83.22	gold quality
muscle of leg	UBERON:0001383	83.09	gold quality
gastrocnemius	UBERON:0001388	82.94	gold quality
spleen	UBERON:0002106	82.87	gold quality
hypothalamus	UBERON:0001898	82.72	gold quality
amygdala	UBERON:0001876	82.67	gold quality
cortical plate	UBERON:0005343	82.59	gold quality
right frontal lobe	UBERON:0002810	82.58	gold quality
prefrontal cortex	UBERON:0000451	82.56	gold quality
lymph node	UBERON:0000029	82.46	gold quality
cerebellar hemisphere	UBERON:0002245	82.07	gold quality
nucleus accumbens	UBERON:0001882	82.06	gold quality
cerebellar cortex	UBERON:0002129	82.04	gold quality
ganglionic eminence	UBERON:0004023	81.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00909 could act as a ceRNA to interact with miR-194 and thereby up-regulate the expression of MUC1-C. (PMID:31132669)
• LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4. (PMID:38504385)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.