ZNF420

Summary

ZNF420 (zinc finger protein 420, HGNC:20649) is a protein-coding gene on chromosome 19q13.12, encoding Zinc finger protein 420 (Q8TAQ5). May be involved in transcriptional regulation.

The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis.

Source: NCBI Gene 147923 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_144689

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20649
Approved symbol	ZNF420
Name	zinc finger protein 420
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ32191
Ensembl gene	ENSG00000197050
Ensembl biotype	protein_coding
OMIM	617216
Entrez	147923

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 11 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000304239, ENST00000337995, ENST00000585862, ENST00000586540, ENST00000587029, ENST00000587082, ENST00000589245, ENST00000589461, ENST00000590332, ENST00000876809, ENST00000876810, ENST00000876811, ENST00000960579, ENST00000960580

RefSeq mRNA: 10 — MANE Select: NM_144689 NM_001329515, NM_001329516, NM_001329517, NM_001329518, NM_001329519, NM_001329520, NM_001329521, NM_001329522, NM_001329524, NM_144689

CCDS: CCDS12498, CCDS86757

Canonical transcript exons

ENST00000337995 — 5 exons

Exon	Start	End
ENSE00001145505	37089039	37089127
ENSE00001145513	37080345	37080388
ENSE00001332353	37127128	37130368
ENSE00001615902	37090995	37091121
ENSE00002778816	37078433	37078570

Expression profiles

Bgee: expression breadth ubiquitous, 258 present calls, max score 95.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.4377 / max 66.4794, expressed in 1317 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175540	3.4267	1316
175538	0.0110	4

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
middle temporal gyrus	UBERON:0002771	95.50	gold quality
endothelial cell	CL:0000115	94.54	gold quality
epithelial cell of pancreas	CL:0000083	94.14	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.91	gold quality
oviduct epithelium	UBERON:0004804	93.71	gold quality
sperm	CL:0000019	92.85	gold quality
medial globus pallidus	UBERON:0002477	91.16	gold quality
buccal mucosa cell	CL:0002336	90.27	gold quality
globus pallidus	UBERON:0001875	89.95	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.37	gold quality
germinal epithelium of ovary	UBERON:0001304	87.24	gold quality
parietal pleura	UBERON:0002400	87.06	gold quality
amniotic fluid	UBERON:0000173	87.00	gold quality
tendon of biceps brachii	UBERON:0008188	86.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.24	gold quality
secondary oocyte	CL:0000655	85.97	gold quality
primary visual cortex	UBERON:0002436	85.93	gold quality
cortical plate	UBERON:0005343	85.45	gold quality
kidney epithelium	UBERON:0004819	85.28	silver quality
visceral pleura	UBERON:0002401	85.23	gold quality
palpebral conjunctiva	UBERON:0001812	85.04	gold quality
lateral globus pallidus	UBERON:0002476	85.01	gold quality
lateral nuclear group of thalamus	UBERON:0002736	84.75	gold quality
occipital lobe	UBERON:0002021	84.67	gold quality
embryo	UBERON:0000922	84.57	gold quality
ganglionic eminence	UBERON:0004023	84.57	gold quality
eye	UBERON:0000970	84.53	gold quality
right testis	UBERON:0004534	84.43	gold quality
tendon	UBERON:0000043	84.18	gold quality
testis	UBERON:0000473	83.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

52 targeting ZNF420, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-200A-5P	99.76	69.10	949
HSA-MIR-200B-5P	99.76	69.05	948
HSA-MIR-1255A	99.74	68.09	744
HSA-MIR-1255B-5P	99.74	68.16	741
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-548M	99.70	68.87	1749
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-513C-5P	99.50	68.42	1730
HSA-MIR-514B-5P	99.50	68.19	1766
HSA-MIR-4666A-5P	99.41	69.72	1887
HSA-MIR-372-5P	99.41	69.11	2299
HSA-MIR-520F-5P	99.34	70.40	1632

Literature-anchored findings (GeneRIF, showing 6)

• Apak (ZNF420 or FLJ32191) is a negative regulator of p53-mediated apoptosis. (PMID:19377469)
• four of seven types of DNA damage signals examined resulted in significant Apak phosphorylation and dissociation of Apak from p53, releasing the inhibition of p53 transcriptional activity (PMID:19629643)
• Apak is differentially regulated in the ARF and ATM-dependent manner in response to oncogenic stress and DNA damage, respectively. (PMID:20713054)
• Apak competes with p53 for binding to inhibit p53AIP1 expression. (PMID:22334068)
• ARF coordinates Apak to regulate ribosome biogenesis upon cellular stress. (PMID:25691462)
• Functional importance of H3K9me3 in hypoxia, apoptosis and repression of APAK. (PMID:25961932)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zgc:66472	ENSDARG00000075916
mus_musculus	Zfp780b	ENSMUSG00000063047
rattus_norvegicus	Zfp780b-ps1	ENSRNOG00000018936
rattus_norvegicus	Zfp780b	ENSRNOG00000029805
drosophila_melanogaster	mld	FBGN0263490

Paralogs (36): ZNF302 (ENSG00000089335), ZNF184 (ENSG00000096654), CTCF (ENSG00000102974), ZNF574 (ENSG00000105732), ZBTB24 (ENSG00000112365), ZNF142 (ENSG00000115568), CTCFL (ENSG00000124092), ZNF473 (ENSG00000142528), ZNF827 (ENSG00000151612), ZNF689 (ENSG00000156853), ZNF208 (ENSG00000160321), ZNF91 (ENSG00000167232), ZNF526 (ENSG00000167625), ZNF764 (ENSG00000169951), ZNF747 (ENSG00000169955), ZNF282 (ENSG00000170265), ZNF160 (ENSG00000170949), ZNF497 (ENSG00000174586), ZBTB34 (ENSG00000177125), ZNF771 (ENSG00000179965), ZNF48 (ENSG00000180035), ZNF594 (ENSG00000180626), ZBTB37 (ENSG00000185278), ZFP92 (ENSG00000189420), ZNF107 (ENSG00000196247), ZNF729 (ENSG00000196350), ZNF569 (ENSG00000196437), ZNF785 (ENSG00000197162), ZNF665 (ENSG00000197497), ZNF181 (ENSG00000197841), ZNF347 (ENSG00000197937), ZNF84 (ENSG00000198040), ZBTB48 (ENSG00000204859), ZNF845 (ENSG00000213799), ZNF99 (ENSG00000213973), ZNF688 (ENSG00000229809)

Protein

Protein identifiers

Zinc finger protein 420 — Q8TAQ5 (reviewed: Q8TAQ5)

All UniProt accessions (7): Q8TAQ5, K7EJW2, K7ELF6, K7EPG0, K7EQC9, K7ERS3, K7ESJ1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8TAQ5-1	1	yes
Q8TAQ5-2	2

RefSeq proteins (10): NP_001316444, NP_001316445, NP_001316446, NP_001316447, NP_001316448, NP_001316449, NP_001316450, NP_001316451, NP_001316453, NP_653290* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050589	Ikaros_C2H2-ZF	Family

Pfam: PF00096, PF01352, PF13465

UniProt features (24 total): zinc finger region 19, splice variant 2, chain 1, domain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TAQ5-F1	77.84	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 298

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

MSigDB gene sets: 94 (showing top): GGAMTNNNNNTCCY_UNKNOWN, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, TGGAAA_NFAT_Q4_01, STAT1_02, YKACATTT_UNKNOWN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, CHENG_IMPRINTED_BY_ESTRADIOL, STAT1_03, GRYDER_PAX3FOXO1_ENHANCERS_KO_DOWN, MYC_UP.V1_UP, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53, REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES, REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
RNA Polymerase II Transcription	1
TP53 Regulates Transcription of Cell Death Genes	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

468 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF420	ATM	Q13315	532
ZNF420	PRDM2	Q13029	393
ZNF420	RB1CC1	Q8TDY2	370
ZNF420	TP53AIP1	Q9HCN2	351
ZNF420	HHLA1	C9JL84	323
ZNF420	SETDB1	Q15047	319
ZNF420	KATNBL1	Q9H079	317
ZNF420	FAM120A2P	Q5T035	305
ZNF420	TRIM28	Q13263	296
ZNF420	C1orf159	Q96HA4	296
ZNF420	OR10AG1	Q8NH19	291
ZNF420	ITPRID2	P28290	288
ZNF420	ZFHX2	Q9C0A1	280
ZNF420	TTLL2	Q9BWV7	276
ZNF420	KDM4E	B2RXH2	274

IntAct

46 interactions, top by confidence:

A	B	Type	Score
ZNF420	CDKN2A	psi-mi:“MI:0407”(direct interaction)	0.640
CDKN2A	ZNF420	psi-mi:“MI:0915”(physical association)	0.640
ZNF420	CDKN2A	psi-mi:“MI:0403”(colocalization)	0.640
ZNF420	CDKN2A	psi-mi:“MI:0915”(physical association)	0.640
ZNF420	TP53	psi-mi:“MI:0407”(direct interaction)	0.590
TP53	ZNF420	psi-mi:“MI:0915”(physical association)	0.590
ZNF420	TP53	psi-mi:“MI:0914”(association)	0.590
ZNF420	TP53	psi-mi:“MI:0915”(physical association)	0.590
AIRIM	ZNF420	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF420	psi-mi:“MI:0915”(physical association)	0.560
ZNF420	CEP19	psi-mi:“MI:0915”(physical association)	0.560
ZNF420	EXOSC5	psi-mi:“MI:0915”(physical association)	0.560
ZNF420	AIRIM	psi-mi:“MI:0915”(physical association)	0.560
ZNF76	ZNF420	psi-mi:“MI:0915”(physical association)	0.560
ZNF420	H2AX	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
ZNF420	CYP51A1	psi-mi:“MI:0915”(physical association)	0.370
SLC1A7	ZNF420	psi-mi:“MI:0915”(physical association)	0.370
ZNF420	TNFRSF1B	psi-mi:“MI:0915”(physical association)	0.370
TRIM28	ZNF420	psi-mi:“MI:0915”(physical association)	0.370
ZNF420	CYP4V2	psi-mi:“MI:0915”(physical association)	0.370
CDK2AP1	ZNF420	psi-mi:“MI:0915”(physical association)	0.370
HAX1	ZNF420	psi-mi:“MI:0915”(physical association)	0.370
ZNF420	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	ZNF420	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (47): MDM2 (Affinity Capture-Western), ZNF420 (Affinity Capture-Western), CDKN2A (Affinity Capture-Western), ZNF420 (Reconstituted Complex), ZNF420 (Reconstituted Complex), UBE2I (Affinity Capture-Western), ZNF420 (Affinity Capture-Western), ZNF420 (Reconstituted Complex), SENP1 (Affinity Capture-Western), SAV1 (Affinity Capture-MS), ZNF420 (Affinity Capture-MS), STK3 (Affinity Capture-MS), H2AFX (Affinity Capture-MS), ZNF420 (Proximity Label-MS), ZNF420 (Affinity Capture-MS)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0A1W2PQL4, A2RRD8, A2VDQ7, A6NHJ4, A6NK75, A6NN14, A6NNF4, A6NP11, B4DX44, B4DXR9, E9PW05, O14628, O43345, O75290, O75346, O75373, O75820, P0CB33, P0CJ79, P0DKX0, P10755, P17032, P17035, P52738, Q02386, Q03923, Q03936, Q05481, Q08AN1, Q09FC8, Q0VGE8, Q14586, Q14593, Q147U1, Q15928, Q3MIS6, Q3SXZ3, Q494X3, Q4R6C2, Q5HY98

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
ZNF420	“down-regulates activity”	TP53BP1	binding
ATM	“down-regulates activity”	ZNF420	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1109 predictions. Top by Δscore:

Variant	Effect	Δscore
19:37080336:T:TA	acceptor_gain	1.0000
19:37127119:A:AG	acceptor_gain	1.0000
19:37127120:T:G	acceptor_gain	1.0000
19:37127124:TCAG:T	acceptor_loss	1.0000
19:37127124:TCAGA:T	acceptor_gain	1.0000
19:37127125:CAGA:C	acceptor_gain	1.0000
19:37127126:A:AG	acceptor_gain	1.0000
19:37127127:G:GC	acceptor_gain	1.0000
19:37127127:GA:G	acceptor_gain	1.0000
19:37127127:GAC:G	acceptor_gain	1.0000
19:37127127:GACT:G	acceptor_gain	1.0000
19:37127127:GACTT:G	acceptor_gain	1.0000
19:37078566:TCAAG:T	donor_loss	0.9900
19:37078567:CAAGG:C	donor_loss	0.9900
19:37078568:AAGG:A	donor_loss	0.9900
19:37078569:AGG:A	donor_loss	0.9900
19:37078570:GGTAG:G	donor_loss	0.9900
19:37078572:T:A	donor_loss	0.9900
19:37080389:G:GA	donor_loss	0.9900
19:37080390:T:A	donor_loss	0.9900
19:37090988:GTTTC:G	acceptor_loss	0.9900
19:37090990:TTCA:T	acceptor_loss	0.9900
19:37090992:CA:C	acceptor_loss	0.9900
19:37090993:A:AG	acceptor_gain	0.9900
19:37090994:G:GG	acceptor_gain	0.9900
19:37090994:GA:G	acceptor_gain	0.9900
19:37090994:GAA:G	acceptor_gain	0.9900
19:37091117:ACTAG:A	donor_loss	0.9900
19:37091120:AG:A	donor_loss	0.9900
19:37091121:GG:G	donor_loss	0.9900

AlphaMissense

4581 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:37127601:T:C	F204L	0.998
19:37127603:T:A	F204L	0.998
19:37127603:T:G	F204L	0.998
19:37128693:T:C	F568L	0.998
19:37128695:T:A	F568L	0.998
19:37128695:T:G	F568L	0.998
19:37128777:T:C	F596L	0.997
19:37128779:T:A	F596L	0.997
19:37128779:T:G	F596L	0.997
19:37128861:T:C	F624L	0.997
19:37128863:T:A	F624L	0.997
19:37128863:T:G	F624L	0.997
19:37127517:T:C	F176L	0.996
19:37127519:T:A	F176L	0.996
19:37127519:T:G	F176L	0.996
19:37128525:T:C	F512L	0.996
19:37128527:T:A	F512L	0.996
19:37128527:T:G	F512L	0.996
19:37127685:T:C	F232L	0.995
19:37127687:T:A	F232L	0.995
19:37127687:T:G	F232L	0.995
19:37128105:T:C	F372L	0.995
19:37128107:T:A	F372L	0.995
19:37128107:T:G	F372L	0.995
19:37128273:T:C	F428L	0.995
19:37128275:T:A	F428L	0.995
19:37128275:T:G	F428L	0.995
19:37128727:G:C	R579P	0.995
19:37127937:T:C	F316L	0.994
19:37127939:T:A	F316L	0.994

dbSNP variants (sampled 300 via entrez): RS1000046487 (19:37118271 T>A), RS1000067100 (19:37072655 G>T), RS1000071744 (19:37099350 C>T), RS1000076432 (19:37044223 C>T), RS1000109660 (19:37086108 G>A,T), RS1000120577 (19:37126095 C>G,T), RS1000129685 (19:37016953 C>A), RS1000197929 (19:37079971 G>A,T), RS1000236552 (19:37023659 C>T), RS1000238610 (19:37092803 C>G), RS1000260103 (19:37024929 C>T), RS1000264723 (19:37058962 G>A), RS1000270097 (19:37079641 G>A), RS1000285311 (19:37012991 C>A,G,T), RS1000328802 (19:37038062 A>G)

Disease associations

OMIM: gene MIM:617216 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): breast ductal adenocarcinoma (MONDO:0005590)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST004639_16	Prudent dietary pattern	3.000000e-06
GCST90000025_565	Appendicular lean mass	8.000000e-19
GCST90002382_463	Eosinophil percentage of white cells	9.000000e-16
GCST90002400_283	Plateletcrit	1.000000e-09
GCST90020024_566	A body shape index	6.000000e-09
GCST90020025_1646	Waist-to-hip ratio adjusted for BMI	5.000000e-09
GCST90020027_317	Waist-hip index	3.000000e-08
GCST90020028_1330	Hip circumference adjusted for BMI	2.000000e-08

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement
EFO:0004980	appendicular lean mass
EFO:0007991	eosinophil percentage of leukocytes
EFO:0007985	platelet crit
EFO:0007789	BMI-adjusted waist circumference
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008039	BMI-adjusted hip circumference

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D018270	Carcinoma, Ductal, Breast	C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	decreases expression, increases abundance, increases expression	2
Valproic Acid	decreases expression, increases expression	2
Particulate Matter	increases expression, decreases expression, increases abundance	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
oxybenzone	increases expression	1
triphenyl phosphate	affects expression	1
arsenite	decreases methylation	1
sodium arsenite	affects expression	1
monomethylarsonous acid	increases expression	1
jinfukang	decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Amiodarone	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Succimer	affects cotreatment, decreases expression	1
Estradiol	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Urethane	increases expression	1
Cadmium Chloride	decreases expression	1
Magnetite Nanoparticles	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03414970	PHASE3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	PHASE2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999	PHASE2	NOT_YET_RECRUITING	Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT00637364	PHASE1/PHASE2	SUSPENDED	High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
NCT02779855	PHASE1/PHASE2	COMPLETED	Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
NCT01753908	EARLY_PHASE1	COMPLETED	Broccoli Sprout Extract in Treating Patients With Breast Cancer
NCT01796041	EARLY_PHASE1	COMPLETED	Intraoperative Imaging of Breast Cancer With Indocyanine Green
NCT01208974	Not specified	ACTIVE_NOT_RECRUITING	Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
NCT01875198	Not specified	TERMINATED	Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
NCT03543397	Not specified	UNKNOWN	MRI in Ductal Carcinoma in Situ (DCIS)
NCT03834532	Not specified	COMPLETED	Living Well After Breast Surgery