ZNF430

Summary

ZNF430 (zinc finger protein 430, HGNC:20808) is a protein-coding gene on chromosome 19p12, encoding Zinc finger protein 430 (Q9H8G1). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in substantia nigra development. Predicted to be located in nucleus.

Source: NCBI Gene 80264 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 76 total
• MANE Select transcript: NM_025189

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20808
Approved symbol	ZNF430
Name	zinc finger protein 430
Location	19p12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ13659
Ensembl gene	ENSG00000118620
Ensembl biotype	protein_coding
Entrez	80264

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 retained_intron

ENST00000261560, ENST00000594110, ENST00000595401, ENST00000595833, ENST00000597922, ENST00000599548, ENST00000935026

RefSeq mRNA: 2 — MANE Select: NM_025189 NM_001172671, NM_025189

CCDS: CCDS32978

Canonical transcript exons

ENST00000261560 — 5 exons

Exon	Start	End
ENSE00000799661	21056631	21060050
ENSE00001593150	21033456	21033582
ENSE00001623868	21034086	21034184
ENSE00001670932	21020657	21020803
ENSE00003471620	21022789	21022881

Expression profiles

Bgee: expression breadth ubiquitous, 268 present calls, max score 90.64.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.0231 / max 139.8894, expressed in 1712 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174876	11.6412	1689
174877	2.3819	1017

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mammalian vulva	UBERON:0000997	90.64	gold quality
corpus epididymis	UBERON:0004359	90.56	gold quality
superficial temporal artery	UBERON:0001614	89.91	gold quality
buccal mucosa cell	CL:0002336	89.58	gold quality
oral cavity	UBERON:0000167	88.97	gold quality
bone marrow	UBERON:0002371	88.15	gold quality
skin of hip	UBERON:0001554	87.53	gold quality
upper leg skin	UBERON:0004262	87.26	gold quality
corpus callosum	UBERON:0002336	86.74	gold quality
cauda epididymis	UBERON:0004360	86.69	gold quality
bone marrow cell	CL:0002092	86.28	gold quality
nipple	UBERON:0002030	86.27	gold quality
amniotic fluid	UBERON:0000173	85.61	gold quality
lower lobe of lung	UBERON:0008949	85.44	gold quality
trabecular bone tissue	UBERON:0002483	84.69	gold quality
caput epididymis	UBERON:0004358	83.67	gold quality
cortical plate	UBERON:0005343	83.59	gold quality
calcaneal tendon	UBERON:0003701	83.36	gold quality
ganglionic eminence	UBERON:0004023	83.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.14	gold quality
superior surface of tongue	UBERON:0007371	83.14	gold quality
inferior vagus X ganglion	UBERON:0005363	83.06	gold quality
thymus	UBERON:0002370	82.69	gold quality
pericardium	UBERON:0002407	82.61	gold quality
pons	UBERON:0000988	82.54	gold quality
adrenal tissue	UBERON:0018303	82.54	gold quality
cranial nerve II	UBERON:0000941	82.25	gold quality
lymph node	UBERON:0000029	82.07	gold quality
colonic epithelium	UBERON:0000397	81.88	gold quality
oocyte	CL:0000023	81.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

100 targeting ZNF430, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-548AZ-5P	99.83	69.94	3230
HSA-MIR-548T-5P	99.83	69.91	3220
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000099025

Paralogs (18): ZNF92 (ENSG00000146757), ZNF66 (ENSG00000160229), ZNF22 (ENSG00000165512), ZNF680 (ENSG00000173041), ZNF114 (ENSG00000178150), ZFP41 (ENSG00000181638), ZNF730 (ENSG00000183850), ZNF479 (ENSG00000185177), ZNF626 (ENSG00000188171), ZNF431 (ENSG00000196705), ZNF100 (ENSG00000197020), ZNF257 (ENSG00000197134), ZNF98 (ENSG00000197360), ZNF675 (ENSG00000197372), ZNF273 (ENSG00000198039), ZNF737 (ENSG00000237440), ZNF253 (ENSG00000256771), ZNF723 (ENSG00000268696)

Protein

Protein identifiers

Zinc finger protein 430 — Q9H8G1 (reviewed: Q9H8G1)

All UniProt accessions (5): Q9H8G1, M0QXG3, M0QYF1, M0R0L5, M0R392

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001166142, NP_079465* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (16 total): zinc finger region 12, chain 1, domain 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H8G1-F1	70.44	0.15

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 73 (showing top): GOBP_NEURAL_NUCLEUS_DEVELOPMENT, GOBP_SUBSTANTIA_NIGRA_DEVELOPMENT, GOBP_MIDBRAIN_DEVELOPMENT, chr19p12, GOBP_HEAD_DEVELOPMENT, TGGAAA_NFAT_Q4_01, NUYTTEN_EZH2_TARGETS_DN, HAMAI_APOPTOSIS_VIA_TRAIL_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, ERBB2_UP.V1_DN, NFE2L2.V2, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CEBPZ_TARGET_GENES, FOXN3_TARGET_GENES

GO Biological Process (3): regulation of DNA-templated transcription (GO:0006355), substantia nigra development (GO:0021762), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
midbrain development	1
neural nucleus development	1
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

434 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF430	C19orf44	Q9H6X5	436
ZNF430	WIPF1	O43516	419
ZNF430	CREG2	Q8IUH2	412
ZNF430	P2RX1	P51575	407
ZNF430	SREK1IP1	Q8N9Q2	405
ZNF430	SFXN3	Q9BWM7	383
ZNF430	RBM44	Q6ZP01	375
ZNF430	LEMD3	Q9Y2U8	373
ZNF430	GNG12	Q9UBI6	363
ZNF430	ATAD3C	Q5T2N8	353
ZNF430	ATAD3B	Q5T9A4	351
ZNF430	ATAD3A	Q9NVI7	351
ZNF430	PDE6B	P35913	341
ZNF430	BTBD3	Q9Y2F9	324
ZNF430	PUDP	Q08623	299

IntAct

35 interactions, top by confidence:

A	B	Type	Score
NEUROG3	GXYLT2	psi-mi:“MI:0914”(association)	0.640
POLR2F	POLR3A	psi-mi:“MI:0914”(association)	0.640
VWCE	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF223	PPM1G	psi-mi:“MI:0914”(association)	0.530
HRC	ZNF791	psi-mi:“MI:0914”(association)	0.530
FBL	ZNF316	psi-mi:“MI:0914”(association)	0.530
TIMM50	ZNF724	psi-mi:“MI:0914”(association)	0.530
CLEC3A	ZZEF1	psi-mi:“MI:0914”(association)	0.530
ZNF223	CENPB	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ECE1	ZNF430	psi-mi:“MI:0915”(physical association)	0.370
FBL	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CLEC3A	ZNF593	psi-mi:“MI:0914”(association)	0.350
RPS14	RRP8	psi-mi:“MI:0914”(association)	0.350
RPL27A	ZNF320	psi-mi:“MI:0914”(association)	0.350
FBLN5	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF460	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
SPANXN2	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF677	ZNF320	psi-mi:“MI:0914”(association)	0.350
ABT1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
UBALD2	A2ML1	psi-mi:“MI:0914”(association)	0.350
PRKRA	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
ZNF726	TRIM24	psi-mi:“MI:0914”(association)	0.350
RPS14	NVL	psi-mi:“MI:0914”(association)	0.350

BioGRID (40): ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-RNA), ZNF430 (Proximity Label-MS), ZNF430 (Two-hybrid), HGS (Two-hybrid), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS)

ESM2 similar proteins: A6NDX5, A6NK75, A6NNF4, A6NP11, B4DXR9, B7Z6K7, C9JN71, O43361, O75290, O75373, P0CJ79, P0DKX0, P17019, P17021, P17035, P17039, P35789, Q02386, Q03938, Q08AN1, Q13106, Q15928, Q3ZCX4, Q5R9F0, Q5SXM1, Q68EA5, Q6P9A1, Q6PDB4, Q6ZN06, Q6ZN08, Q6ZNG1, Q76KX8, Q86V71, Q86XN6, Q8IYB9, Q8N4W9, Q8NEP9, Q8TBZ8, Q8TC21, Q8TF32

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	72
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

742 predictions. Top by Δscore:

Variant	Effect	Δscore
19:21056629:A:AG	acceptor_gain	1.0000
19:21056630:G:GG	acceptor_gain	1.0000
19:21056630:GTT:G	acceptor_gain	1.0000
19:21056630:GTTAC:G	acceptor_gain	1.0000
19:21020790:G:GT	donor_gain	0.9900
19:21020802:TGG:T	donor_loss	0.9900
19:21020803:GGTG:G	donor_loss	0.9900
19:21020804:G:GG	donor_gain	0.9900
19:21020804:GTG:G	donor_loss	0.9900
19:21020805:T:A	donor_loss	0.9900
19:21033450:TTTCA:T	acceptor_loss	0.9900
19:21033451:TTCA:T	acceptor_loss	0.9900
19:21033452:TCA:T	acceptor_loss	0.9900
19:21033453:CA:C	acceptor_loss	0.9900
19:21033454:AGG:A	acceptor_gain	0.9900
19:21033455:GGG:G	acceptor_gain	0.9900
19:21033578:CTTGG:C	donor_loss	0.9900
19:21033582:GGTGA:G	donor_loss	0.9900
19:21033583:G:GA	donor_loss	0.9900
19:21033584:T:TG	donor_loss	0.9900
19:21033585:GA:G	donor_loss	0.9900
19:21034079:A:AG	acceptor_gain	0.9900
19:21056626:TTCA:T	acceptor_loss	0.9900
19:21056627:TCA:T	acceptor_loss	0.9900
19:21056628:CAG:C	acceptor_loss	0.9900
19:21056630:G:GT	acceptor_loss	0.9900
19:21056630:GT:G	acceptor_gain	0.9900
19:21056630:GTTA:G	acceptor_gain	0.9900
19:21020769:C:G	donor_gain	0.9800
19:21020807:A:T	donor_gain	0.9800

AlphaMissense

3784 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:21057200:T:C	F298L	0.988
19:21057202:T:A	F298L	0.988
19:21057202:T:G	F298L	0.988
19:21057284:T:C	F326L	0.988
19:21057286:T:A	F326L	0.988
19:21057286:T:G	F326L	0.988
19:21057536:T:C	F410L	0.983
19:21057538:T:A	F410L	0.983
19:21057538:T:G	F410L	0.983
19:21057291:G:C	R328P	0.980
19:21057207:G:C	R300P	0.977
19:21057116:T:C	F270L	0.976
19:21057118:T:A	F270L	0.976
19:21057118:T:G	F270L	0.976
19:21057368:T:C	F354L	0.976
19:21057370:T:A	F354L	0.976
19:21057370:T:G	F354L	0.976
19:21057620:T:C	F438L	0.973
19:21057622:T:A	F438L	0.973
19:21057622:T:G	F438L	0.973
19:21057704:T:C	F466L	0.972
19:21057706:T:A	F466L	0.972
19:21057706:T:G	F466L	0.972
19:21057219:T:C	L304P	0.967
19:21057639:T:C	L444P	0.962
19:21057452:T:C	F382L	0.957
19:21057454:T:A	F382L	0.957
19:21057454:T:G	F382L	0.957
19:21057788:T:C	F494L	0.957
19:21057790:T:A	F494L	0.957

dbSNP variants (sampled 300 via entrez): RS1000066724 (19:21026266 G>A,T), RS1000106837 (19:21044631 C>G), RS1000114095 (19:21051230 C>G,T), RS1000159168 (19:21021282 A>G), RS1000193014 (19:21042271 A>C), RS1000260887 (19:21048776 C>A,G,T), RS1000417238 (19:21057642 C>T), RS1000465848 (19:21033611 A>G), RS1000526642 (19:21024873 G>A), RS1000538611 (19:21043263 T>G), RS1000620226 (19:21040698 G>A), RS1000675903 (19:21027758 T>A), RS1000725386 (19:21055772 A>G), RS1000777710 (19:21048627 C>T), RS1001107296 (19:21046413 A>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
chloropicrin	increases expression	2
Formaldehyde	decreases expression, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, decreases expression	1
arsenite	affects binding, decreases reaction	1
cobaltous chloride	increases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	increases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
jinfukang	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Benzo(a)pyrene	increases expression	1
Coal	decreases expression, increases abundance	1
Dexamethasone	affects cotreatment, decreases expression	1
Succimer	increases expression, affects cotreatment	1
Dimethyl Sulfoxide	increases expression	1
Estradiol	affects expression	1
Ethyl Methanesulfonate	increases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, decreases expression	1
Manganese	increases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.