ZNF432

Summary

ZNF432 (zinc finger protein 432, HGNC:20810) is a protein-coding gene on chromosome 19q13.41, encoding Zinc finger protein 432 (O94892). Homologous recombination repressor that functions as a poly(ADP-ribose) (PAR) reader regulating DNA damage response and PARP inhibition.

Enables damaged DNA binding activity and protein-macromolecule adaptor activity. Involved in DNA damage response. Located in nucleoplasm.

Source: NCBI Gene 9668 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 109 total
• MANE Select transcript: NM_014650

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20810
Approved symbol	ZNF432
Name	zinc finger protein 432
Location	19q13.41
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0798
Ensembl gene	ENSG00000256087
Ensembl biotype	protein_coding
OMIM	620554
Entrez	9668

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000221315, ENST00000594154, ENST00000597273, ENST00000598446, ENST00000598745, ENST00000600368, ENST00000601310, ENST00000913743

RefSeq mRNA: 3 — MANE Select: NM_014650 NM_001322284, NM_001322285, NM_014650

CCDS: CCDS12848

Canonical transcript exons

ENST00000221315 — 5 exons

Exon	Start	End
ENSE00001124026	52046854	52047060
ENSE00001283222	52031378	52035440
ENSE00001509756	52048695	52048838
ENSE00002463048	52040488	52040583
ENSE00002515591	52041480	52041606

Expression profiles

Bgee: expression breadth ubiquitous, 280 present calls, max score 95.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 1.9136 / max 58.5584, expressed in 995 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182516	10.1273	1720
182515	1.4143	823
182514	0.4993	263

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	95.22	gold quality
pancreatic ductal cell	CL:0002079	93.01	gold quality
choroid plexus epithelium	UBERON:0003911	90.41	gold quality
calcaneal tendon	UBERON:0003701	89.16	gold quality
hair follicle	UBERON:0002073	87.06	gold quality
body of pancreas	UBERON:0001150	86.81	gold quality
Brodmann (1909) area 23	UBERON:0013554	86.31	gold quality
cervix squamous epithelium	UBERON:0006922	85.95	gold quality
sural nerve	UBERON:0015488	85.60	gold quality
bronchial epithelial cell	CL:0002328	85.46	gold quality
periodontal ligament	UBERON:0008266	85.09	gold quality
tendon	UBERON:0000043	85.07	gold quality
germinal epithelium of ovary	UBERON:0001304	84.52	gold quality
pleura	UBERON:0000977	84.26	gold quality
parietal pleura	UBERON:0002400	84.19	gold quality
visceral pleura	UBERON:0002401	84.10	gold quality
epithelium of bronchus	UBERON:0002031	83.76	gold quality
oviduct epithelium	UBERON:0004804	83.66	gold quality
epithelial cell of pancreas	CL:0000083	83.43	gold quality
ventricular zone	UBERON:0003053	83.33	gold quality
bronchus	UBERON:0002185	83.24	gold quality
pigmented layer of retina	UBERON:0001782	83.22	gold quality
caput epididymis	UBERON:0004358	83.00	gold quality
prostate gland	UBERON:0002367	82.59	gold quality
pancreas	UBERON:0001264	82.57	gold quality
blood vessel layer	UBERON:0004797	82.52	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.46	gold quality
ganglionic eminence	UBERON:0004023	82.05	gold quality
tibia	UBERON:0000979	82.02	gold quality
endometrium	UBERON:0001295	81.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

96 targeting ZNF432, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4500	99.99	72.72	2367
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-181B-2-3P	99.81	70.06	1646

Literature-anchored findings (GeneRIF, showing 2)

• Inhaled corticosteroids appear to modulate the association of bronchodilator response with variant(s) in the ZNF432 gene among adults and children with asthma. (PMID:24280104)
• ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance. (PMID:37823600)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 432 — O94892 (reviewed: O94892)

All UniProt accessions (5): O94892, M0QZ71, M0R0E2, M0R0H8, M0R258

UniProt curated annotations — full annotation on UniProt →

Function. Homologous recombination repressor that functions as a poly(ADP-ribose) (PAR) reader regulating DNA damage response and PARP inhibition. Once recruited to DNA lesions via DNA-, in a PAR-dependent mechanism, stimulates PARP1 activity. Binds preferentially ssDNA and inhibits EXO1-mediated resection, probably through a PAR-independent DNA-binding mechanism.

Subunit / interactions. Interacts with PARP1 and several chromatin remodeling proteins; the interaction with PARP1 reshapes ZNF432 interacting proteins. Interacts with TRIM28; the interaction is independent of PARP1.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (3): NP_001309213, NP_001309214, NP_055465* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (26 total): zinc finger region 16, modified residue 6, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O94892-F1	72.56	0.18

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 41, 139, 164, 246, 330, 414

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 71 (showing top): GOBP_DNA_DAMAGE_RESPONSE, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, LIAO_METASTASIS, MODULE_397, CHEN_HOXA5_TARGETS_9HR_UP, GOCC_NUCLEOLUS, PHONG_TNF_RESPONSE_NOT_VIA_P38, ATF2_UP.V1_DN, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, STK33_SKM_UP, CIITA_TARGET_GENES, NFE2L1_TARGET_GENES, ZNF274_TARGET_GENES, ZNF350_TARGET_GENES, ZNF766_TARGET_GENES

GO Biological Process (2): regulation of DNA-templated transcription (GO:0006355), DNA damage response (GO:0006974)

GO Molecular Function (6): damaged DNA binding (GO:0003684), zinc ion binding (GO:0008270), protein-macromolecule adaptor activity (GO:0030674), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cellular response to stress	1
DNA binding	1
transition metal ion binding	1
protein binding	1
molecular adaptor activity	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

662 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF432	GRIP2	Q9C0E4	470
ZNF432	IRAK2	O43187	408
ZNF432	RHPN2	Q8IUC4	405
ZNF432	PSMA2	P25787	380
ZNF432	OR4C5	Q8NGB2	378
ZNF432	ACAP1	Q15027	376
ZNF432	LILRA4	P59901	369
ZNF432	KCTD1	Q719H9	366
ZNF432	PAQR3	Q6TCH7	355
ZNF432	APMAP	Q9HDC9	325
ZNF432	KIAA1671	Q9BY89	316
ZNF432	IL36A	Q9UHA7	311
ZNF432	C2CD4C	Q8TF44	305
ZNF432	LRRC4C	Q9HCJ2	290
ZNF432	PRKAR1B	P31321	280

IntAct

11 interactions, top by confidence:

A	B	Type	Score
ZNF432	DCDC2	psi-mi:“MI:0915”(physical association)	0.560
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
SLC9A8	ZNF432	psi-mi:“MI:0914”(association)	0.530
ZNF432	PGRMC1	psi-mi:“MI:0915”(physical association)	0.400
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF248	SYN3	psi-mi:“MI:0914”(association)	0.350
SLC9A8	AP1G1	psi-mi:“MI:0914”(association)	0.350
NDEL1	ZNF432	psi-mi:“MI:0915”(physical association)	0.000
ZNF432	DCDC2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (13): ZNF432 (Affinity Capture-MS), ZNF432 (Two-hybrid), ZNF432 (Proximity Label-MS), ZNF432 (Affinity Capture-MS), ZNF432 (Affinity Capture-MS), ZNF432 (Affinity Capture-MS), ZNF432 (Affinity Capture-MS), ZNF432 (Affinity Capture-MS), HSPE1 (Cross-Linking-MS (XL-MS)), ZNF432 (Affinity Capture-MS), ZNF432 (Affinity Capture-RNA), ZNF432 (Proximity Label-MS), ZNF432 (Proximity Label-MS)

ESM2 similar proteins: A2VDP4, A6NHJ4, O94892, P0CJ79, P17014, P17021, P17025, P17032, P17035, P18733, P51508, P51814, Q06730, Q06732, Q09FC8, Q0VGE8, Q14586, Q32M78, Q3MIS6, Q5JVG2, Q5R4K8, Q5R9S5, Q5RBQ3, Q5RCJ2, Q5RER9, Q5TYW1, Q5VIY5, Q6P560, Q6PDB4, Q6ZMW2, Q6ZN06, Q6ZNA1, Q76KX8, Q7L2R6, Q86Y25, Q8N184, Q8N823, Q8N883, Q8N8J6, Q8NEP9

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

109 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	97
Likely benign	6
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1213 predictions. Top by Δscore:

Variant	Effect	Δscore
19:52035441:C:CC	acceptor_gain	1.0000
19:52040483:CATA:C	donor_loss	1.0000
19:52040579:ATAAC:A	acceptor_gain	1.0000
19:52040580:TAAC:T	acceptor_gain	1.0000
19:52040581:AAC:A	acceptor_gain	1.0000
19:52040582:AC:A	acceptor_gain	1.0000
19:52040583:CC:C	acceptor_gain	1.0000
19:52040583:CCTGT:C	acceptor_loss	1.0000
19:52040584:C:CC	acceptor_gain	1.0000
19:52040588:T:C	acceptor_gain	1.0000
19:52040588:T:TC	acceptor_gain	1.0000
19:52040592:G:T	acceptor_gain	1.0000
19:52041474:CCTCA:C	donor_loss	1.0000
19:52041475:CTCA:C	donor_loss	1.0000
19:52041476:TCACC:T	donor_loss	1.0000
19:52041477:CACCC:C	donor_loss	1.0000
19:52041478:A:AC	donor_gain	1.0000
19:52041478:A:AG	donor_loss	1.0000
19:52041478:AC:A	donor_gain	1.0000
19:52041479:C:CC	donor_gain	1.0000
19:52041479:C:CG	donor_loss	1.0000
19:52041479:CC:C	donor_gain	1.0000
19:52041602:AATTC:A	acceptor_gain	1.0000
19:52041603:ATTC:A	acceptor_gain	1.0000
19:52041604:TTC:T	acceptor_gain	1.0000
19:52041605:TC:T	acceptor_gain	1.0000
19:52041606:CC:C	acceptor_gain	1.0000
19:52041607:C:CC	acceptor_gain	1.0000
19:52076951:T:A	donor_gain	1.0000
19:52076953:CTCA:C	donor_loss	1.0000

AlphaMissense

4378 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:52034333:C:G	R449P	0.998
19:52034669:C:G	R337P	0.998
19:52034701:G:C	F326L	0.998
19:52034701:G:T	F326L	0.998
19:52034703:A:G	F326L	0.998
19:52034081:C:G	R533P	0.997
19:52034113:A:C	F522L	0.997
19:52034113:A:T	F522L	0.997
19:52034115:A:G	F522L	0.997
19:52034197:G:C	F494L	0.997
19:52034197:G:T	F494L	0.997
19:52034199:A:G	F494L	0.997
19:52034365:A:C	F438L	0.997
19:52034365:A:T	F438L	0.997
19:52034367:A:G	F438L	0.997
19:52034449:A:C	F410L	0.997
19:52034449:A:T	F410L	0.997
19:52034451:A:G	F410L	0.997
19:52034785:G:C	F298L	0.997
19:52034785:G:T	F298L	0.997
19:52034787:A:G	F298L	0.997
19:52034165:C:G	R505P	0.996
19:52034249:C:G	R477P	0.996
19:52034281:G:C	F466L	0.996
19:52034281:G:T	F466L	0.996
19:52034283:A:G	F466L	0.996
19:52034533:G:C	F382L	0.996
19:52034533:G:T	F382L	0.996
19:52034535:A:G	F382L	0.996
19:52034672:T:G	Q336P	0.996

dbSNP variants (sampled 300 via entrez): RS1000031777 (19:52049378 T>C), RS1000040430 (19:52042653 T>A), RS1000083441 (19:52049191 G>T), RS1000140259 (19:52039571 C>T), RS1000325427 (19:52043991 C>A,G,T), RS1000380485 (19:52031251 C>T), RS1001114381 (19:52032441 T>TG), RS1001589927 (19:52045480 C>T), RS1001695135 (19:52050421 G>C), RS1001773783 (19:52045924 C>T), RS1001829200 (19:52041230 A>G), RS1001864533 (19:52040535 TCTC>T), RS1002328473 (19:52046765 A>G), RS1002335983 (19:52047546 C>A,T), RS1002487654 (19:52040836 G>A)

Disease associations

OMIM: gene MIM:620554 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002291_2	Bronchodilator response in asthma (inhaled corticosteroid treatment interaction)	2.000000e-09
GCST007277_24	Tourette syndrome	9.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs3752120	ZNF432		0.00	0

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression	3
arsenite	affects binding, decreases reaction, increases methylation	2
Air Pollutants	decreases expression, affects expression, increases abundance	2
Particulate Matter	decreases expression, increases abundance	2
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
pentabromodiphenyl ether	increases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
theaflavin-3,3’-digallate	affects expression	1
Resveratrol	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Vehicle Emissions	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Catechin	affects cotreatment, decreases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Plant Oils	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Aflatoxin B1	increases methylation	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E0TC	Ubigene HeLa ZNF432 KO	Cancer cell line	Female
CVCL_E1E0	Ubigene U2OS ZNF432 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.