ZNF433-AS1

Summary

ZNF433-AS1 (ZNF433 and ZNF878 antisense RNA 1, HGNC:53776) is a long non-coding RNA gene on chromosome 19p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53776
Approved symbol	ZNF433-AS1
Name	ZNF433 and ZNF878 antisense RNA 1
Location	19p13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000219665
Ensembl biotype	lncRNA
Entrez	101928464
RNAcentral	URS0000A76F75 — lncRNA, 1273 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 7 lncRNA, 2 retained_intron

ENST00000406892, ENST00000476474, ENST00000489336, ENST00000495324, ENST00000588047, ENST00000589551, ENST00000591838, ENST00000591898, ENST00000592187

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000406892 — 3 exons

Exon	Start	End
ENSE00001551231	12026194	12027194
ENSE00001559670	11987617	11987823
ENSE00001562925	12001774	12001822

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 86.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1233 / max 254.4711, expressed in 1593 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173977	5.9820	1479
173978	2.8393	1228
173976	0.3021	155

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	86.99	gold quality
right testis	UBERON:0004534	85.99	gold quality
left testis	UBERON:0004533	85.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.71	gold quality
colonic epithelium	UBERON:0000397	84.63	gold quality
apex of heart	UBERON:0002098	84.51	gold quality
pancreatic ductal cell	CL:0002079	83.53	silver quality
testis	UBERON:0000473	83.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	82.86	gold quality
lower esophagus	UBERON:0013473	82.80	gold quality
granulocyte	CL:0000094	82.70	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.14	gold quality
left adrenal gland cortex	UBERON:0035825	82.07	gold quality
leukocyte	CL:0000738	81.79	gold quality
monocyte	CL:0000576	81.74	gold quality
right adrenal gland cortex	UBERON:0035827	81.70	gold quality
right adrenal gland	UBERON:0001233	81.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.32	gold quality
left adrenal gland	UBERON:0001234	81.18	gold quality
stromal cell of endometrium	CL:0002255	80.90	gold quality
adrenal cortex	UBERON:0001235	80.47	gold quality
islet of Langerhans	UBERON:0000006	80.26	gold quality
bone marrow	UBERON:0002371	80.13	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.78	gold quality
lymph node	UBERON:0000029	79.75	gold quality
adrenal gland	UBERON:0002369	79.48	gold quality
right atrium auricular region	UBERON:0006631	79.39	gold quality
right ovary	UBERON:0002118	79.09	gold quality
esophagus	UBERON:0001043	78.88	gold quality
gastrocnemius	UBERON:0001388	78.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.