ZNF444

Summary

ZNF444 (zinc finger protein 444, HGNC:16052) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 444 (Q8N0Y2). Transcriptional regulator.

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 55311 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 56 total
• MANE Select transcript: NM_018337

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16052
Approved symbol	ZNF444
Name	zinc finger protein 444
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	ZSCAN17, FLJ11137, EZF2
Ensembl gene	ENSG00000167685
Ensembl biotype	protein_coding
OMIM	607874
Entrez	55311

Gene structure

Transcript identifiers

Ensembl transcripts: 47 — 43 protein_coding, 3 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000337080, ENST00000586123, ENST00000587195, ENST00000587236, ENST00000587467, ENST00000587664, ENST00000588203, ENST00000588358, ENST00000591564, ENST00000592171, ENST00000592949, ENST00000593100, ENST00000875358, ENST00000875359, ENST00000875360, ENST00000875361, ENST00000875362, ENST00000875363, ENST00000875364, ENST00000875365, ENST00000875366, ENST00000875367, ENST00000875368, ENST00000875369, ENST00000875370, ENST00000875371, ENST00000875372, ENST00000875373, ENST00000875374, ENST00000875375, ENST00000875376, ENST00000875377, ENST00000924374, ENST00000924375, ENST00000924376, ENST00000924377, ENST00000924378, ENST00000924379, ENST00000924380, ENST00000924381, ENST00000924382, ENST00000924383, ENST00000924384, ENST00000969530, ENST00000969531, ENST00000969532, ENST00000969533

RefSeq mRNA: 2 — MANE Select: NM_018337 NM_001253792, NM_018337

CCDS: CCDS12939, CCDS59426

Canonical transcript exons

ENST00000337080 — 5 exons

Exon	Start	End
ENSE00001342684	56159624	56160893
ENSE00001422903	56146247	56146420
ENSE00001423682	56141287	56141357
ENSE00003498985	56158494	56158602
ENSE00003619213	56146890	56147208

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 95.19.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.3255 / max 66.4794, expressed in 1729 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177699	5.5581	1638
177702	1.3987	759
177698	1.1809	788
177700	0.9478	656
177701	0.2399	120

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
type B pancreatic cell	CL:0000169	95.19	gold quality
olfactory bulb	UBERON:0002264	94.88	gold quality
vena cava	UBERON:0004087	94.57	gold quality
right uterine tube	UBERON:0001302	94.03	gold quality
right lobe of liver	UBERON:0001114	93.99	gold quality
cerebellar vermis	UBERON:0004720	93.88	gold quality
body of pancreas	UBERON:0001150	93.17	gold quality
diaphragm	UBERON:0001103	92.17	silver quality
cervix squamous epithelium	UBERON:0006922	92.11	gold quality
cingulate cortex	UBERON:0003027	92.08	gold quality
anterior cingulate cortex	UBERON:0009835	92.06	gold quality
pancreatic ductal cell	CL:0002079	91.92	silver quality
fundus of stomach	UBERON:0001160	91.89	gold quality
putamen	UBERON:0001874	91.81	gold quality
nucleus accumbens	UBERON:0001882	91.77	gold quality
amygdala	UBERON:0001876	91.69	gold quality
body of stomach	UBERON:0001161	91.65	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	91.50	gold quality
pituitary gland	UBERON:0000007	91.42	gold quality
right frontal lobe	UBERON:0002810	91.40	gold quality
adenohypophysis	UBERON:0002196	91.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	91.31	gold quality
lower esophagus	UBERON:0013473	91.29	gold quality
tongue squamous epithelium	UBERON:0006919	91.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	91.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	91.01	gold quality
caudate nucleus	UBERON:0001873	90.86	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	90.84	gold quality
right lobe of thyroid gland	UBERON:0001119	90.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.42

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
SCARF1	Activation

miRNA regulators (miRDB)

61 targeting ZNF444, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6751-5P	99.56	64.99	1145
HSA-MIR-486-3P	99.51	66.82	1901

Literature-anchored findings (GeneRIF, showing 2)

• regulates the human gene encoding the scavenger receptor expressed by endothelial cells (PMID:11978792)
• t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 is associated with soft tissue myoepithelial carcinoma. (PMID:19760602)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	plagx	ENSDARG00000036855
danio_rerio	ovol1a	ENSDARG00000076472
danio_rerio	plagl2	ENSDARG00000076657
danio_rerio	ovol1b	ENSDARG00000078256
mus_musculus	Zfp444	ENSMUSG00000044876
rattus_norvegicus	Zfp444	ENSRNOG00000015517
drosophila_melanogaster	hb	FBGN0001180
drosophila_melanogaster	CG12391	FBGN0033581
caenorhabditis_elegans		WBGENE00001824
caenorhabditis_elegans		WBGENE00003033
caenorhabditis_elegans		WBGENE00012385

Paralogs (29): ZNF446 (ENSG00000083838), REST (ENSG00000084093), ZNF174 (ENSG00000103343), OVOL3 (ENSG00000105261), PLAGL1 (ENSG00000118495), ZSCAN18 (ENSG00000121413), ZNF576 (ENSG00000124444), OVOL2 (ENSG00000125850), PLAGL2 (ENSG00000126003), ZSCAN5A (ENSG00000131848), ZSCAN29 (ENSG00000140265), ZSCAN32 (ENSG00000140987), ZSCAN1 (ENSG00000152467), ZNF18 (ENSG00000154957), ZKSCAN2 (ENSG00000155592), ZNF496 (ENSG00000162714), ZNF202 (ENSG00000166261), ZNF641 (ENSG00000167528), SCAND1 (ENSG00000171222), ZNF274 (ENSG00000171606), ZNF131 (ENSG00000172262), OVOL1 (ENSG00000172818), ZNF518A (ENSG00000177853), ZNF518B (ENSG00000178163), PLAG1 (ENSG00000181690), ZSCAN5B (ENSG00000197213), ZNF770 (ENSG00000198146), PEG3 (ENSG00000198300), ZSCAN5C (ENSG00000204532)

Protein

Protein identifiers

Zinc finger protein 444 — Q8N0Y2 (reviewed: Q8N0Y2)

Alternative names: Endothelial zinc finger protein 2, Zinc finger and SCAN domain-containing protein 17

All UniProt accessions (7): Q8N0Y2, K7EJ91, K7EJH4, K7EK55, K7ELZ3, K7EMV5, K7ESL2

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional regulator. Binds to the 5’-flanking critical region of the SCARF1 promoter.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N0Y2-1	1	yes
Q8N0Y2-2	2

RefSeq proteins (2): NP_001240721, NP_060807* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily

Pfam: PF00096, PF02023

UniProt features (20 total): modified residue 4, zinc finger region 4, compositionally biased region 3, region of interest 3, cross-link 2, chain 1, domain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N0Y2-F1	69.09	0.03

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 1, 18, 104, 235, 8, 190

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 109 (showing top): CACCAGC_MIR138, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5, MODULE_205, BLALOCK_ALZHEIMERS_DISEASE_UP, MODULE_206, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, SANSOM_APC_MYC_TARGETS, SANSOM_APC_TARGETS_REQUIRE_MYC, GOCC_NUCLEOLUS, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D, BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING, GCM_RAB10

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

860 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF444	SCARF1	Q14162	789
ZNF444	EWSR1	Q01844	772
ZNF444	PBX1	P40424	625
ZNF444	CLEC7A	Q9BXN2	586
ZNF444	PBX3	P40426	542
ZNF444	SCARB2	Q14108	502
ZNF444	CD36	P16671	502
ZNF444	SCARB1	Q8WTV0	475
ZNF444	NR4A3	Q92570	461
ZNF444	POU5F1	P31359	450
ZNF444	FUS	P35637	439
ZNF444	SMARCB1	Q12824	373
ZNF444	TLR2	O60603	351
ZNF444	TEK	Q02763	337
ZNF444	DUX4L2	P0CJ85	327

IntAct

38 interactions, top by confidence:

A	B	Type	Score
PPP2CB	CEP43	psi-mi:“MI:0914”(association)	0.730
P4HA3	FAM171A2	psi-mi:“MI:0914”(association)	0.640
GPR156	PLD2	psi-mi:“MI:0914”(association)	0.640
CHCHD10	CLPX	psi-mi:“MI:0914”(association)	0.640
VWCE	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZSCAN32	ZNF197	psi-mi:“MI:0914”(association)	0.530
ZNF397	ZNF197	psi-mi:“MI:0914”(association)	0.530
PNLIP	LAMC1	psi-mi:“MI:0914”(association)	0.530
ZNF263	AHCYL1	psi-mi:“MI:0914”(association)	0.530
CCDC6	LZTS3	psi-mi:“MI:0914”(association)	0.530
ZNF444	SRPK1	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
	AP3B1	psi-mi:“MI:0914”(association)	0.350
HTRA4	PSMD12	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
FBLN5	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LRP3	TMEM131L	psi-mi:“MI:0914”(association)	0.350
SHISA3	ZNF316	psi-mi:“MI:0914”(association)	0.350
EFEMP1	ZNF316	psi-mi:“MI:0914”(association)	0.350
ZNF174	FAM171A2	psi-mi:“MI:0914”(association)	0.350
PRM2	IPO5	psi-mi:“MI:0914”(association)	0.350
PTX3	POLRMT	psi-mi:“MI:0914”(association)	0.350
ZNF232	ZNF197	psi-mi:“MI:0914”(association)	0.350
MZF1	ZNF213	psi-mi:“MI:0914”(association)	0.350
TNFRSF19	PLD2	psi-mi:“MI:0914”(association)	0.350
ZNF263	PPP1R12A	psi-mi:“MI:0914”(association)	0.350
ZNF444	AHCYL1	psi-mi:“MI:0914”(association)	0.350
RNH1	DUSP11	psi-mi:“MI:0914”(association)	0.350
BCL10	VAPB	psi-mi:“MI:0914”(association)	0.350

BioGRID (159): ZNF444 (Affinity Capture-MS), ZNF444 (Affinity Capture-MS), ZNF444 (Affinity Capture-MS), ZNF444 (Affinity Capture-MS), CCDC6 (Affinity Capture-MS), STRN4 (Affinity Capture-MS), KLHL15 (Affinity Capture-MS), MIA3 (Affinity Capture-MS), RBM22 (Affinity Capture-MS), YBEY (Affinity Capture-MS), STRN3 (Affinity Capture-MS), ZKSCAN8 (Affinity Capture-MS), ZNF174 (Affinity Capture-MS), ZNF446 (Affinity Capture-MS), SCAND1 (Affinity Capture-MS)

ESM2 similar proteins: A2T7E6, A4D1S0, A6NGW2, B2RU40, C9JH25, C9JTQ0, D4A9R4, F2YMG0, O15533, O43593, O70146, O94761, P03971, P03972, P0CW18, P0DPE3, P27106, P49000, P79295, Q15569, Q17RM4, Q1JPB9, Q28616, Q3UM83, Q4TUC0, Q5M844, Q5R732, Q5TJE4, Q63572, Q6NZ36, Q6PZD2, Q6ZS72, Q6ZV89, Q7RTU9, Q866Y3, Q86YV9, Q8CAI1, Q8N0Y2, Q8N4L8, Q8N729

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1320 predictions. Top by Δscore:

Variant	Effect	Δscore
19:56155854:C:G	donor_gain	1.0000
19:56158542:G:GT	donor_gain	1.0000
19:56146888:A:AG	acceptor_gain	0.9900
19:56146889:G:GG	acceptor_gain	0.9900
19:56146889:GGC:G	acceptor_gain	0.9900
19:56147143:GCC:G	donor_gain	0.9900
19:56147207:GG:G	donor_gain	0.9900
19:56147208:GG:G	donor_gain	0.9900
19:56158488:TTTCA:T	acceptor_loss	0.9900
19:56158490:TCAG:T	acceptor_loss	0.9900
19:56158491:CAGG:C	acceptor_loss	0.9900
19:56158492:A:AG	acceptor_gain	0.9900
19:56158492:A:C	acceptor_loss	0.9900
19:56158492:AG:A	acceptor_gain	0.9900
19:56158492:AGG:A	acceptor_gain	0.9900
19:56158493:G:GG	acceptor_gain	0.9900
19:56158493:GG:G	acceptor_gain	0.9900
19:56158493:GGG:G	acceptor_gain	0.9900
19:56158571:TGGA:T	donor_gain	0.9900
19:56158578:G:GT	donor_gain	0.9900
19:56158600:TAGG:T	donor_loss	0.9900
19:56158602:GGT:G	donor_loss	0.9900
19:56158603:G:GA	donor_loss	0.9900
19:56158604:T:A	donor_loss	0.9900
19:56159622:AGCAG:A	acceptor_gain	0.9900
19:56159623:GCA:G	acceptor_gain	0.9900
19:56159623:GCAGG:G	acceptor_gain	0.9900
19:56159624:CAG:C	acceptor_loss	0.9900
19:56159625:A:AC	acceptor_loss	0.9900
19:56159625:A:AG	acceptor_gain	0.9900

AlphaMissense

2082 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:56159863:T:C	F216L	1.000
19:56159865:T:A	F216L	1.000
19:56159865:T:G	F216L	1.000
19:56159992:T:C	F259L	1.000
19:56159994:C:A	F259L	1.000
19:56159994:C:G	F259L	1.000
19:56160076:T:C	F287L	1.000
19:56160078:C:A	F287L	1.000
19:56160078:C:G	F287L	1.000
19:56159864:T:C	F216S	0.999
19:56160019:C:A	H268N	0.999
19:56160019:C:G	H268D	0.999
19:56160021:C:A	H268Q	0.999
19:56160021:C:G	H268Q	0.999
19:56160033:C:A	H272Q	0.999
19:56160033:C:G	H272Q	0.999
19:56160077:T:C	F287S	0.999
19:56160103:C:A	H296N	0.999
19:56160103:C:G	H296D	0.999
19:56147114:T:C	F68S	0.998
19:56159806:C:A	H197N	0.998
19:56159806:C:G	H197D	0.998
19:56159863:T:A	F216I	0.998
19:56159890:C:A	H225N	0.998
19:56159890:C:G	H225D	0.998
19:56159993:T:C	F259S	0.998
19:56160011:T:C	L265P	0.998
19:56160031:C:G	H272D	0.998
19:56160049:T:C	F278L	0.998
19:56160051:T:A	F278L	0.998

dbSNP variants (sampled 300 via entrez): RS1000017491 (19:56133828 T>A,G), RS1000018935 (19:56160708 TG>T), RS1000155870 (19:56160488 C>G,T), RS1000170673 (19:56131716 T>C), RS1000228577 (19:56152622 G>A), RS1000307036 (19:56159380 C>T), RS1000317050 (19:56156689 C>T), RS1000356894 (19:56141651 A>G), RS1000435056 (19:56159218 T>C), RS1000455297 (19:56142751 G>A), RS1000483096 (19:56154927 G>A,T), RS1000533586 (19:56137873 G>A), RS1000669242 (19:56147266 C>T), RS1000712044 (19:56153271 AGTTT>A), RS1001019325 (19:56132359 T>C)

Disease associations

OMIM: gene MIM:607874 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003253_2	Microalbuminuria	5.000000e-06
GCST005991_73	Platelet count	2.000000e-17

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	2
Acetaminophen	decreases expression	2
Valproic Acid	decreases expression, decreases methylation	2
Cadmium Chloride	increases expression	2
FR900359	increases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
eprenetapopt	affects expression, affects reaction	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	decreases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Estradiol	decreases expression	1
Plant Extracts	decreases expression, affects cotreatment	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.