ZNF467

Summary

ZNF467 (zinc finger protein 467, HGNC:23154) is a protein-coding gene on chromosome 7q36.1, encoding Zinc finger protein 467 (Q7Z7K2). Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow.

The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes.

Source: NCBI Gene 168544 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 140 total
• MANE Select transcript: NM_207336

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23154
Approved symbol	ZNF467
Name	zinc finger protein 467
Location	7q36.1
Locus type	gene with protein product
Status	Approved
Aliases	EZI, Zfp467
Ensembl gene	ENSG00000181444
Ensembl biotype	protein_coding
OMIM	614040
Entrez	168544

Gene structure

Transcript identifiers

Ensembl transcripts: 34 — 34 protein_coding

ENST00000302017, ENST00000484747, ENST00000882861, ENST00000882862, ENST00000882863, ENST00000882864, ENST00000882865, ENST00000882866, ENST00000882867, ENST00000882868, ENST00000882869, ENST00000882870, ENST00000882871, ENST00000882872, ENST00000882873, ENST00000882874, ENST00000882875, ENST00000882876, ENST00000882877, ENST00000882878, ENST00000882879, ENST00000882880, ENST00000882881, ENST00000882882, ENST00000882883, ENST00000882884, ENST00000882885, ENST00000882886, ENST00000882887, ENST00000882888, ENST00000882889, ENST00000951627, ENST00000951628, ENST00000951629

RefSeq mRNA: 2 — MANE Select: NM_207336 NM_001329856, NM_207336

CCDS: CCDS5899, CCDS87563

Canonical transcript exons

ENST00000302017 — 5 exons

Exon	Start	End
ENSE00001142582	149764182	149766239
ENSE00001339175	149769090	149769200
ENSE00001339178	149770440	149770556
ENSE00001339180	149770999	149771074
ENSE00001882896	149773108	149773588

Expression profiles

Bgee: expression breadth ubiquitous, 195 present calls, max score 92.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.8099 / max 506.9993, expressed in 1224 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86744	9.3380	1205
86742	0.4719	250

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	92.46	gold quality
granulocyte	CL:0000094	92.44	gold quality
leukocyte	CL:0000738	92.43	gold quality
mononuclear cell	CL:0000842	92.40	gold quality
blood	UBERON:0000178	91.84	gold quality
endometrium epithelium	UBERON:0004811	89.25	gold quality
metanephros cortex	UBERON:0010533	82.90	gold quality
spleen	UBERON:0002106	82.62	gold quality
apex of heart	UBERON:0002098	82.38	gold quality
left uterine tube	UBERON:0001303	81.33	gold quality
putamen	UBERON:0001874	80.63	gold quality
body of stomach	UBERON:0001161	80.43	gold quality
bone marrow cell	CL:0002092	79.62	gold quality
upper lobe of left lung	UBERON:0008952	79.49	gold quality
right lobe of thyroid gland	UBERON:0001119	79.43	gold quality
right lung	UBERON:0002167	79.35	gold quality
caudate nucleus	UBERON:0001873	79.27	gold quality
adenohypophysis	UBERON:0002196	79.19	gold quality
left lobe of thyroid gland	UBERON:0001120	78.93	gold quality
right lobe of liver	UBERON:0001114	78.77	gold quality
upper lobe of lung	UBERON:0008948	78.73	gold quality
omental fat pad	UBERON:0010414	78.40	gold quality
peritoneum	UBERON:0002358	78.33	gold quality
bone marrow	UBERON:0002371	78.32	gold quality
thyroid gland	UBERON:0002046	78.05	gold quality
adipose tissue of abdominal region	UBERON:0007808	77.98	gold quality
pancreatic ductal cell	CL:0002079	77.96	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	77.95	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.90	gold quality
stomach	UBERON:0000945	77.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting ZNF467, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4738-3P	98.98	67.98	1846
HSA-MIR-3074-5P	98.82	66.56	1414
HSA-MIR-4686	98.77	66.87	964
HSA-MIR-4297	98.77	66.95	2013
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-6827-5P	98.46	64.88	1256
HSA-MIR-5589-5P	98.34	64.82	1148
HSA-MIR-134-3P	96.83	66.22	1001
HSA-MIR-4296	96.35	63.55	1233
HSA-MIR-4734	88.28	63.44	87

Literature-anchored findings (GeneRIF, showing 3)

• These results identify EZI as a novel cargo protein for importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export. (PMID:17848547)
• ZNF467 gene DNA methylation is importants in the pathogenesis of idiopathic pulmonary fibrosis. (PMID:22700861)
• demonstrate that PCBP2 and ZNF467 impact adipogenic but not osteogenic differentiation, further supporting evidence that AMSCs and BMSCs appear to be adapted to their microenvironment (PMID:32032745)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp467	ENSMUSG00000068551
rattus_norvegicus	Zfp467	ENSRNOG00000007707

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)

Protein

Protein identifiers

Zinc finger protein 467 — Q7Z7K2 (reviewed: Q7Z7K2)

All UniProt accessions (2): C9JAX3, Q7Z7K2

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5’-CTTCTGGGAAGA-3’ of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex.

Subunit / interactions. Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001316785, NP_997219* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050717	C2H2-ZF_Transcription_Reg	Family

Pfam: PF00096

UniProt features (19 total): zinc finger region 12, region of interest 2, cross-link 2, chain 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z7K2-F1	65.99	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 97, 368

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation

MSigDB gene sets: 142 (showing top): REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, SANSOM_APC_TARGETS_DN, GNF2_HCK, MULLIGHAN_NPM1_SIGNATURE_3_DN, WALLACE_PROSTATE_CANCER_RACE_DN, ACEVEDO_LIVER_CANCER_UP, IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP, WGGAATGY_TEF1_Q6, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, CHENG_IMPRINTED_BY_ESTRADIOL, MARTENS_TRETINOIN_RESPONSE_UP, DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Adipogenesis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

664 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF467	TTYH3	Q9C0H2	412
ZNF467	ZNF395	Q9H8N7	365
ZNF467	C7orf33	Q8WU49	348
ZNF467	PWWP3B	Q5H9M0	324
ZNF467	DRC11L	A6NCM1	323
ZNF467	ZNF638	Q14966	321
ZNF467	WDR86	Q86TI4	316
ZNF467	A0A087WTJ2	A0A087WTJ2	301
ZNF467	ZNF862	O60290	294
ZNF467	ZBED10P	Q96FA7	290
ZNF467	ATP6V0E2	Q8NHE4	289
ZNF467	KRABD3	A5PL33	285
ZNF467	SLC37A1	P57057	272
ZNF467	PGBD4	Q96DM1	270
ZNF467	LRRC61	Q9BV99	267

IntAct

19 interactions, top by confidence:

A	B	Type	Score
KRTAP12-3	ZNF467	psi-mi:“MI:0915”(physical association)	0.560
	ZNF467	psi-mi:“MI:0915”(physical association)	0.560
LMO4	ZNF467	psi-mi:“MI:0915”(physical association)	0.560
TLE5	ZNF467	psi-mi:“MI:0915”(physical association)	0.560
ZNF467	L3MBTL2	psi-mi:“MI:0915”(physical association)	0.560
	ZNF467	psi-mi:“MI:0915”(physical association)	0.370
ZNF467	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF467	TARBP2	psi-mi:“MI:0914”(association)	0.350
ZNF467	KRTAP12-3	psi-mi:“MI:0915”(physical association)	0.000
ZNF467		psi-mi:“MI:0915”(physical association)	0.000
LMO4	ZNF467	psi-mi:“MI:0915”(physical association)	0.000
ZNF467	TLE5	psi-mi:“MI:0915”(physical association)	0.000
L3MBTL2	ZNF467	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (175): ZNF467 (Affinity Capture-MS), ZNF467 (Affinity Capture-MS), ZNF467 (Affinity Capture-MS), ZNF467 (Affinity Capture-RNA), ZNF467 (Affinity Capture-MS), ZNF467 (Two-hybrid), ZNF467 (Two-hybrid), ZNF467 (Two-hybrid), ZNF467 (Two-hybrid), KRTAP12-3 (Two-hybrid), STRBP (Affinity Capture-MS), GTPBP4 (Affinity Capture-MS), DDX55 (Affinity Capture-MS), ZNF317 (Affinity Capture-MS), YTHDC2 (Affinity Capture-MS)

ESM2 similar proteins: A2CE44, A6NFI3, A6NM28, A8K8V0, O15370, O70218, O95201, P0CJ78, P10075, P10754, P28698, P70338, Q04890, Q07120, Q14V87, Q19A40, Q569E7, Q58DK7, Q5DWN0, Q5FWU5, Q5RJR4, Q5T619, Q5TEC3, Q6DD87, Q6IQX8, Q6PD29, Q6PGE4, Q6ZMY9, Q7Z7K2, Q80VM4, Q8BIF9, Q8JZL0, Q8N8E2, Q8NAF0, Q8NCA9, Q8TD94, Q8WUU4, Q96C55, Q96H86, Q96MX3

Diamond homologs: Q5RJR4, Q6A085, Q7Z7K2, Q8BI67, Q8JZL0, Q9UDV6, A6QR00, P0CG23, P18735, Q569E7, Q5TEC3, Q6H236, Q6ZNH5, Q8BI66, Q8BI73, Q8NF99, Q8TF50, Q9H7R5, Q9NSD4, Q8NAF0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

140 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	127
Likely benign	9
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1041 predictions. Top by Δscore:

Variant	Effect	Δscore
7:149766240:C:CC	acceptor_gain	1.0000
7:149766235:CTCTC:C	acceptor_gain	0.9900
7:149766237:CTC:C	acceptor_gain	0.9900
7:149766237:CTCCT:C	acceptor_loss	0.9900
7:149766238:TC:T	acceptor_gain	0.9900
7:149766239:CC:C	acceptor_gain	0.9900
7:149766240:C:CG	acceptor_loss	0.9900
7:149766241:T:A	acceptor_loss	0.9900
7:149766236:TCTC:T	acceptor_gain	0.9800
7:149766237:CTCC:C	acceptor_gain	0.9800
7:149766238:TCCT:T	acceptor_gain	0.9800
7:149766249:C:CT	acceptor_gain	0.9800
7:149773102:CCTTA:C	donor_loss	0.9800
7:149773103:CTTA:C	donor_loss	0.9800
7:149773104:TTAC:T	donor_loss	0.9800
7:149773105:TACCT:T	donor_loss	0.9800
7:149773106:ACCTG:A	donor_loss	0.9800
7:149773107:CCTGG:C	donor_gain	0.9800
7:149770997:AC:A	donor_gain	0.9600
7:149770998:CC:C	donor_gain	0.9600
7:149776090:GG:G	donor_gain	0.9600
7:149776091:GG:G	donor_gain	0.9600
7:149773101:CCCTT:C	donor_loss	0.9500
7:149776344:AGGC:A	acceptor_gain	0.9500
7:149776345:GGCG:G	acceptor_gain	0.9500
7:149770993:GCTCA:G	donor_loss	0.9400
7:149770994:CTCA:C	donor_loss	0.9400
7:149770995:T:TA	donor_loss	0.9400
7:149770996:C:CA	donor_loss	0.9400
7:149770997:A:AC	donor_gain	0.9400

AlphaMissense

3876 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:149765575:G:C	F309L	1.000
7:149765575:G:T	F309L	1.000
7:149765576:A:G	F309S	1.000
7:149765577:A:G	F309L	1.000
7:149765659:A:C	F281L	1.000
7:149765659:A:T	F281L	1.000
7:149765660:A:G	F281S	1.000
7:149765661:A:G	F281L	1.000
7:149765716:G:C	H262Q	1.000
7:149765716:G:T	H262Q	1.000
7:149765718:G:C	H262D	1.000
7:149765743:G:C	F253L	1.000
7:149765743:G:T	F253L	1.000
7:149765744:A:G	F253S	1.000
7:149765745:A:G	F253L	1.000
7:149765827:G:C	F225L	1.000
7:149765827:G:T	F225L	1.000
7:149765829:A:G	F225L	1.000
7:149764846:G:C	F552L	0.999
7:149764846:G:T	F552L	0.999
7:149764848:A:G	F552L	0.999
7:149764930:G:C	F524L	0.999
7:149764930:G:T	F524L	0.999
7:149764932:A:G	F524L	0.999
7:149765014:G:C	F496L	0.999
7:149765014:G:T	F496L	0.999
7:149765016:A:G	F496L	0.999
7:149765548:G:C	H318Q	0.999
7:149765548:G:T	H318Q	0.999
7:149765577:A:T	F309I	0.999

dbSNP variants (sampled 300 via entrez): RS1000114805 (7:149778201 C>G,T), RS1000397745 (7:149778514 G>A), RS1000880283 (7:149771777 C>T), RS1000934386 (7:149776173 G>A), RS1001655446 (7:149773984 G>A), RS1001748341 (7:149767237 G>A), RS1002125428 (7:149775898 A>G), RS1002460619 (7:149774768 C>T), RS1002471966 (7:149777557 C>A,G,T), RS1002625543 (7:149772083 C>T), RS1002700966 (7:149767997 G>C,T), RS1002743566 (7:149774965 G>A,T), RS1002777916 (7:149769547 C>A,G,T), RS1003141688 (7:149767627 T>C), RS1004138378 (7:149773417 C>A)

Disease associations

OMIM: gene MIM:614040 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST006626_28	Pulse pressure	2.000000e-11
GCST009698_126	Metabolite levels	2.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0005059	acylcarnitine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, increases methylation, affects cotreatment, decreases expression	7
entinostat	decreases expression, affects cotreatment	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Cisplatin	affects expression, decreases expression	2
Estradiol	decreases expression, affects cotreatment	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
TAK-243	affects sumoylation	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
geraniol	increases expression	1
lead acetate	decreases expression	1
sodium arsenate	decreases expression, increases abundance	1
afimoxifene	decreases expression, decreases reaction	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
clothianidin	increases expression	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
gardiquimod	decreases expression, decreases reaction	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Decitabine	affects expression	1
Zoledronic Acid	increases expression	1
Vorinostat	decreases expression	1
Acetaminophen	decreases expression	1
Arsenic	decreases expression, increases abundance	1
Atrazine	increases expression	1
Benzo(a)pyrene	decreases methylation, affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.