ZNF502

Summary

ZNF502 (zinc finger protein 502, HGNC:23718) is a protein-coding gene on chromosome 3p21.31, encoding Zinc finger protein 502 (Q8TBZ5). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation by host of viral process and viral release from host cell. Located in nucleus.

Source: NCBI Gene 91392 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_001134442

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23718
Approved symbol	ZNF502
Name	zinc finger protein 502
Location	3p21.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14855, FLJ12515
Ensembl gene	ENSG00000196653
Ensembl biotype	protein_coding
Entrez	91392

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000296091, ENST00000411443, ENST00000436624, ENST00000449836, ENST00000877951, ENST00000877952, ENST00000935001, ENST00000949184

RefSeq mRNA: 5 — MANE Select: NM_001134442 NM_001134440, NM_001134441, NM_001134442, NM_001282880, NM_033210

CCDS: CCDS2719

Canonical transcript exons

ENST00000436624 — 3 exons

Exon	Start	End
ENSE00001078242	44720203	44720316
ENSE00001880323	44712660	44712740
ENSE00001934619	44720873	44723831

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 87.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.1298 / max 32.5324, expressed in 1014 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36341	1.5544	872
36342	0.5754	333

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.82	gold quality
calcaneal tendon	UBERON:0003701	82.48	gold quality
cortical plate	UBERON:0005343	78.02	gold quality
ventricular zone	UBERON:0003053	77.87	gold quality
embryo	UBERON:0000922	77.52	gold quality
ganglionic eminence	UBERON:0004023	77.52	gold quality
islet of Langerhans	UBERON:0000006	76.27	gold quality
endometrium	UBERON:0001295	75.58	gold quality
ovary	UBERON:0000992	75.15	gold quality
right ovary	UBERON:0002118	75.03	gold quality
left ovary	UBERON:0002119	74.76	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.69	gold quality
skeletal muscle tissue	UBERON:0001134	74.63	gold quality
smooth muscle tissue	UBERON:0001135	74.61	gold quality
body of uterus	UBERON:0009853	74.57	gold quality
uterus	UBERON:0000995	74.45	gold quality
pancreas	UBERON:0001264	74.31	gold quality
right uterine tube	UBERON:0001302	74.22	gold quality
cerebellar hemisphere	UBERON:0002245	74.12	gold quality
cerebellar cortex	UBERON:0002129	74.11	gold quality
cerebellum	UBERON:0002037	74.04	gold quality
muscle tissue	UBERON:0002385	73.83	gold quality
body of pancreas	UBERON:0001150	73.75	gold quality
myometrium	UBERON:0001296	73.75	gold quality
prostate gland	UBERON:0002367	73.64	gold quality
fallopian tube	UBERON:0003889	73.50	gold quality
skeletal muscle organ	UBERON:0014892	73.45	gold quality
muscle of leg	UBERON:0001383	73.40	gold quality
adrenal tissue	UBERON:0018303	73.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.74

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

60 targeting ZNF502, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-6848-3P	99.64	66.49	885
HSA-MIR-488-3P	99.61	68.79	1731
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-12122	99.56	69.33	1672
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-20A-3P	99.44	69.10	1575
HSA-MIR-6843-3P	99.26	66.42	915
HSA-MIR-5693	99.24	66.67	1106
HSA-MIR-146A-3P	99.13	68.99	1881
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-10B-3P	99.04	66.98	988

Literature-anchored findings (GeneRIF, showing 2)

• Results present initial characterization of key proteins Cav2 and CFL1 as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 protein which appears to interact with RSV M in the nucleus. (PMID:25556234)
• ENAH-202 promotes cancer progression in oral squamous cell carcinoma by regulating ZNF502/VIM axis. (PMID:37902191)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 502 — Q8TBZ5 (reviewed: Q8TBZ5)

All UniProt accessions (2): C9JLT3, Q8TBZ5

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subunit / interactions. (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) matrix protein; this interaction probably facilitates viral release.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (5): NP_001127912, NP_001127913, NP_001127914, NP_001269809, NP_149987 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF13465

UniProt features (19 total): zinc finger region 14, sequence variant 3, chain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TBZ5-F1	74.30	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 43

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 44 (showing top): GOBP_MODULATION_OF_PROCESS_OF_ANOTHER_ORGANISM, GOBP_HOST_MEDIATED_PERTURBATION_OF_VIRAL_PROCESS, SOX9_B1, GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERACTION_WITH_HOST, GOBP_VIRAL_LIFE_CYCLE, GOBP_HOST_MEDIATED_ACTIVATION_OF_VIRAL_PROCESS, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, RGAGGAARY_PU1_Q6, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, TGGAAA_NFAT_Q4_01, MZF1_01, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, WANG_CISPLATIN_RESPONSE_AND_XPC_UP, chr3p21, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY

GO Biological Process (4): regulation of DNA-templated transcription (GO:0006355), viral release from host cell (GO:0019076), host-mediated activation of viral process (GO:0044794), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
viral process	1
viral life cycle	1
exit from host cell	1
host-mediated perturbation of viral process	1
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

288 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF502	KAT8	Q9H7Z6	410
ZNF502	NKAPL	Q5M9Q1	391
ZNF502	STYXL1	Q9Y6J8	360
ZNF502	VMA22	Q96NT0	355
ZNF502	XRRA1	Q6P2D8	349
ZNF502	DYNLT5	Q8N7M0	348
ZNF502	TMEM91	Q6ZNR0	348
ZNF502	SEC14L4	Q9UDX3	317
ZNF502	LRRC14	Q15048	313
ZNF502	OGFRL1	Q5TC84	310
ZNF502	ZNF518B	Q9C0D4	293
ZNF502	RHOXF1	Q8NHV9	290
ZNF502	PGBD1	Q96JS3	290
ZNF502	RUNDC3B	Q96NL0	290
ZNF502	DCAF16	Q9NXF7	287

IntAct

12 interactions, top by confidence:

A	B	Type	Score
ZNF502	TRAF1	psi-mi:“MI:0915”(physical association)	0.780
TRAF1	ZNF502	psi-mi:“MI:0915”(physical association)	0.780
M	ZNF502	psi-mi:“MI:0915”(physical association)	0.560
ZNF502	M	psi-mi:“MI:0403”(colocalization)	0.560
TLX2	ZNF502	psi-mi:“MI:0915”(physical association)	0.370
ZNF502	TRAF1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (4): ZNF502 (Two-hybrid), ZNF502 (Affinity Capture-MS), ZNF502 (Two-hybrid), ZNF502 (Two-hybrid)

ESM2 similar proteins: A2VDP4, A6NHJ4, O94892, P0CJ79, P17014, P17021, P17025, P17032, P17035, P18733, P51508, P51814, Q06730, Q06732, Q09FC8, Q0VGE8, Q14586, Q32M78, Q3MIS6, Q5JVG2, Q5R4K8, Q5R9S5, Q5RBQ3, Q5RCJ2, Q5RER9, Q5TYW1, Q5VIY5, Q6P560, Q6PDB4, Q6ZMW2, Q6ZN06, Q6ZNA1, Q76KX8, Q7L2R6, Q86Y25, Q8N184, Q8N823, Q8N883, Q8N8J6, Q8NEP9

Diamond homologs: B0K011, B0X9H6, E9Q6W4, O75362, O77459, P28698, P31509, P60319, P80944, P86413, Q01798, Q02026, Q02027, Q08DS3, Q0IHB8, Q292R5, Q29419, Q32NK7, Q3T135, Q3US17, Q567J8, Q5SVQ8, Q5XJQ7, Q66JF8, Q6AY34, Q6ZNH5, Q811F1, Q8BX22, Q8BY46, Q8N2R0, Q8TAX0, Q8TBZ5, Q8WUU4, Q91ZD1, Q99PV8, Q9C0K0, Q9H165, Q9H4T2, Q9QX96, Q9QYE3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

562 predictions. Top by Δscore:

Variant	Effect	Δscore
3:44712741:G:GG	donor_gain	1.0000
3:44714689:G:GG	donor_gain	1.0000
3:44720317:G:A	donor_loss	1.0000
3:44720318:T:A	donor_loss	1.0000
3:44720867:TTTCA:T	acceptor_loss	1.0000
3:44720868:TTCAG:T	acceptor_loss	1.0000
3:44720869:TCAG:T	acceptor_loss	1.0000
3:44720870:CAGGC:C	acceptor_loss	1.0000
3:44720871:A:AC	acceptor_loss	1.0000
3:44720871:A:AG	acceptor_gain	1.0000
3:44720871:AGGCT:A	acceptor_gain	1.0000
3:44720872:G:GG	acceptor_gain	1.0000
3:44720872:G:GT	acceptor_loss	1.0000
3:44720872:GGCT:G	acceptor_gain	1.0000
3:44720872:GGCTG:G	acceptor_gain	1.0000
3:44712722:A:T	donor_gain	0.9900
3:44712739:CA:C	donor_gain	0.9900
3:44712761:G:GT	donor_gain	0.9900
3:44712762:G:T	donor_gain	0.9900
3:44719694:G:GG	donor_gain	0.9900
3:44720183:C:G	acceptor_gain	0.9900
3:44720195:A:AG	acceptor_gain	0.9900
3:44720195:AT:A	acceptor_gain	0.9900
3:44720196:T:G	acceptor_gain	0.9900
3:44720196:T:TA	acceptor_gain	0.9900
3:44720201:A:AG	acceptor_gain	0.9900
3:44720201:AG:A	acceptor_gain	0.9900
3:44720201:AGG:A	acceptor_gain	0.9900
3:44720202:G:GA	acceptor_gain	0.9900
3:44720202:GG:G	acceptor_gain	0.9900

AlphaMissense

3653 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:44721979:T:C	F388L	0.999
3:44721981:T:A	F388L	0.999
3:44721981:T:G	F388L	0.999
3:44722147:T:C	F444L	0.999
3:44722149:T:A	F444L	0.999
3:44722149:T:G	F444L	0.999
3:44721391:T:C	F192L	0.998
3:44721393:T:A	F192L	0.998
3:44721393:T:G	F192L	0.998
3:44721475:T:C	F220L	0.998
3:44721477:T:A	F220L	0.998
3:44721477:T:G	F220L	0.998
3:44721559:T:C	F248L	0.998
3:44721561:C:A	F248L	0.998
3:44721561:C:G	F248L	0.998
3:44721643:T:C	F276L	0.998
3:44721645:C:A	F276L	0.998
3:44721645:C:G	F276L	0.998
3:44721895:T:C	F360L	0.998
3:44721897:T:A	F360L	0.998
3:44721897:T:G	F360L	0.998
3:44722063:T:C	F416L	0.998
3:44722065:C:A	F416L	0.998
3:44722065:C:G	F416L	0.998
3:44722148:T:C	F444S	0.998
3:44722166:T:C	L450P	0.998
3:44722231:T:C	F472L	0.998
3:44722233:T:A	F472L	0.998
3:44722233:T:G	F472L	0.998
3:44721578:T:C	L254P	0.997

dbSNP variants (sampled 300 via entrez): RS1000390923 (3:44720078 G>C), RS1000892095 (3:44711835 G>A), RS1000920632 (3:44718826 C>T), RS1001082922 (3:44712219 G>C), RS1001122342 (3:44718614 G>A), RS1001132071 (3:44717940 C>T), RS1001513101 (3:44717124 T>C), RS1001663217 (3:44710676 G>A), RS1001722365 (3:44716778 T>C,G), RS1001963600 (3:44717634 C>T), RS1002323747 (3:44717311 C>T), RS1002920355 (3:44715492 A>G), RS1003131960 (3:44715154 C>G,T), RS1003193644 (3:44715715 T>G), RS1003275537 (3:44715932 A>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST008103_52	Bipolar disorder	3.000000e-07
GCST008128_1	Body mass index	6.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
quercitrin	increases expression	1
beta-lapachone	increases expression	1
mono-(2-ethylhexyl)phthalate	increases abundance, increases methylation	1
potassium chromate(VI)	decreases expression	1
2-palmitoylglycerol	increases expression	1
clothianidin	increases expression	1
bisphenol S	affects methylation	1
jinfukang	decreases expression	1
Acetaminophen	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation, increases methylation	1
Caffeine	decreases phosphorylation	1
Diethylhexyl Phthalate	increases abundance, increases methylation	1
Folic Acid	decreases expression	1
Antirheumatic Agents	increases expression	1
S-Nitrosoglutathione	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.