ZNF503-AS1

Summary

ZNF503-AS1 (ZNF503 antisense RNA 1, HGNC:27370) is a long non-coding RNA gene on chromosome 10q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27370
Approved symbol	ZNF503-AS1
Name	ZNF503 antisense RNA 1
Location	10q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	uc.286
Ensembl gene	ENSG00000226051
Ensembl biotype	lncRNA
Entrez	253264
RNAcentral	URS000075A5BB — lncRNA, 1867 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 57 — 57 lncRNA

ENST00000416398, ENST00000524517, ENST00000526759, ENST00000528121, ENST00000530606, ENST00000531808, ENST00000533822, ENST00000649714, ENST00000656537, ENST00000660346, ENST00000660657, ENST00000661189, ENST00000661246, ENST00000661449, ENST00000663224, ENST00000663601, ENST00000665971, ENST00000666247, ENST00000668415, ENST00000668572, ENST00000668612, ENST00000669449, ENST00000670172, ENST00000670946, ENST00000671219, ENST00000701551, ENST00000701852, ENST00000734865, ENST00000734866, ENST00000734867, ENST00000734868, ENST00000734869, ENST00000734870, ENST00000734871, ENST00000734872, ENST00000734873, ENST00000734874, ENST00000734875, ENST00000734876, ENST00000734877, ENST00000734878, ENST00000734879, ENST00000734880, ENST00000734881, ENST00000734882, ENST00000734883, ENST00000734884, ENST00000734885, ENST00000734886, ENST00000734887, ENST00000734888, ENST00000734889, ENST00000734890, ENST00000734891, ENST00000734892, ENST00000734893, ENST00000734894

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416398 — 3 exons

Exon	Start	End
ENSE00001634376	75358510	75359049
ENSE00004067370	75360621	75361680
ENSE00004067382	75296369	75296651

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 94.04.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1275 / max 29.7483, expressed in 63 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105623	0.0514	24
105622	0.0391	19
105624	0.0371	11

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	94.04	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.50	gold quality
epithelial cell of pancreas	CL:0000083	93.45	gold quality
left ventricle myocardium	UBERON:0006566	93.24	gold quality
pancreatic ductal cell	CL:0002079	88.12	silver quality
sperm	CL:0000019	85.09	gold quality
upper arm skin	UBERON:0004263	82.37	silver quality
esophagus squamous epithelium	UBERON:0006920	80.27	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.90	gold quality
gingival epithelium	UBERON:0001949	78.74	silver quality
lower esophagus mucosa	UBERON:0035834	78.34	gold quality
body of pancreas	UBERON:0001150	77.01	gold quality
right lung	UBERON:0002167	76.05	gold quality
rectum	UBERON:0001052	76.02	gold quality
esophagus mucosa	UBERON:0002469	75.56	gold quality
pancreas	UBERON:0001264	74.00	gold quality
duodenum	UBERON:0002114	73.45	gold quality
sural nerve	UBERON:0015488	73.32	gold quality
myocardium	UBERON:0002349	72.95	gold quality
gingiva	UBERON:0001828	72.67	silver quality
mucosa of paranasal sinus	UBERON:0005030	72.17	gold quality
mucosa of transverse colon	UBERON:0004991	71.31	gold quality
jejunal mucosa	UBERON:0000399	71.17	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	70.79	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.14	gold quality
islet of Langerhans	UBERON:0000006	69.95	gold quality
calcaneal tendon	UBERON:0003701	69.89	gold quality
muscle tissue	UBERON:0002385	69.75	gold quality
palpebral conjunctiva	UBERON:0001812	69.34	gold quality
upper lobe of left lung	UBERON:0008952	69.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.50

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca(2+) concentration via transcription factor GATA6. (PMID:33001357)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.