ZNF512

Summary

ZNF512 (zinc finger protein 512, HGNC:29380) is a protein-coding gene on chromosome 2p23.3, encoding Zinc finger protein 512 (Q96ME7). Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation.

This gene encodes a protein containing four putative zinc finger motifs. Zinc finger motifs may bind to proteins or nucleic acids. Zinc finger-containing proteins are involved in a variety of processes, including regulation of transcription. Alternative splicing results in multiple transcript variants for this gene.

Source: NCBI Gene 84450 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_032434

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29380
Approved symbol	ZNF512
Name	zinc finger protein 512
Location	2p23.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1805
Ensembl gene	ENSG00000243943
Ensembl biotype	protein_coding
OMIM	620921
Entrez	84450

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 10 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000355467, ENST00000379717, ENST00000413371, ENST00000416005, ENST00000461705, ENST00000488055, ENST00000494548, ENST00000556601, ENST00000879762, ENST00000879763, ENST00000937483, ENST00000937484, ENST00000948674

RefSeq mRNA: 6 — MANE Select: NM_032434 NM_001271286, NM_001271287, NM_001271288, NM_001271289, NM_001271318, NM_032434

CCDS: CCDS1758, CCDS59428, CCDS59429

Canonical transcript exons

ENST00000355467 — 14 exons

Exon	Start	End
ENSE00000963018	27600691	27600815
ENSE00003463012	27607845	27608039
ENSE00003502538	27598067	27598254
ENSE00003509846	27616262	27616324
ENSE00003511102	27601356	27601442
ENSE00003514025	27602463	27602561
ENSE00003514964	27617473	27617571
ENSE00003573781	27615168	27615269
ENSE00003637863	27583658	27583716
ENSE00003650236	27603140	27603307
ENSE00003715179	27599583	27599678
ENSE00003733227	27599970	27600053
ENSE00003841385	27621153	27623217
ENSE00003842873	27583042	27583142

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 95.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.1890 / max 1516.1399, expressed in 1778 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19380	16.1353	1776
19379	0.7257	409
19381	0.3120	118
19382	0.0159	2

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	95.79	gold quality
ganglionic eminence	UBERON:0004023	94.73	gold quality
ventricular zone	UBERON:0003053	93.60	gold quality
ileal mucosa	UBERON:0000331	93.39	gold quality
left ovary	UBERON:0002119	92.94	gold quality
tibialis anterior	UBERON:0001385	92.65	silver quality
right ovary	UBERON:0002118	92.61	gold quality
ovary	UBERON:0000992	92.30	gold quality
body of uterus	UBERON:0009853	92.00	gold quality
endocervix	UBERON:0000458	91.90	gold quality
calcaneal tendon	UBERON:0003701	91.74	gold quality
cauda epididymis	UBERON:0004360	91.49	gold quality
pancreatic ductal cell	CL:0002079	91.47	gold quality
smooth muscle tissue	UBERON:0001135	91.46	gold quality
corpus epididymis	UBERON:0004359	91.32	gold quality
popliteal artery	UBERON:0002250	90.77	gold quality
tibial artery	UBERON:0007610	90.77	gold quality
sural nerve	UBERON:0015488	90.73	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.66	silver quality
caput epididymis	UBERON:0004358	90.66	gold quality
islet of Langerhans	UBERON:0000006	90.57	gold quality
right uterine tube	UBERON:0001302	90.52	gold quality
right coronary artery	UBERON:0001625	90.49	gold quality
adenohypophysis	UBERON:0002196	90.22	gold quality
aorta	UBERON:0000947	90.12	gold quality
tibial nerve	UBERON:0001323	90.11	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.09	gold quality
lymph node	UBERON:0000029	89.93	gold quality
thyroid gland	UBERON:0002046	89.92	gold quality
left uterine tube	UBERON:0001303	89.86	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-100618	yes	542.85
E-ANND-3	yes	3.99

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

111 targeting ZNF512, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-6077	99.99	68.04	2299
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-9-3P	99.96	70.88	2068

Literature-anchored findings (GeneRIF, showing 2)

• MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. (PMID:27301951)
• risk (C) allele of the SNP (rs2275294) in the ZNF512B gene, cervical flexor muscle power and body weight index might have clinical potential for amyotrophic lateral sclerosis prognostication (PMID:30567526)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf512	ENSDARG00000041910
mus_musculus	Zfp512	ENSMUSG00000062761
rattus_norvegicus	Zfp512	ENSRNOG00000039815
drosophila_melanogaster	Vajk3	FBGN0028544
drosophila_melanogaster	Vajk2	FBGN0032538
drosophila_melanogaster	nahoda	FBGN0034797
drosophila_melanogaster	Vajk4	FBGN0050101
caenorhabditis_elegans		WBGENE00007479

Paralogs (2): GGN (ENSG00000179168), ZNF512B (ENSG00000196700)

Protein

Protein identifiers

Zinc finger protein 512 — Q96ME7 (reviewed: Q96ME7)

All UniProt accessions (2): Q96ME7, G3XAG1

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation.

Subunit / interactions. Interacts with SUV39H1 and SUV39H2; this interaction initiates heterochromatin formation.

Subcellular location. Chromosome. Nucleus.

Domain organisation. Has an atypical organization of its zinc-fingers, with long linkers separating them, providing flexibility for recognizing non-consecutive 3-nucleotide triplets targeted by each zinc finger.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96ME7-1	1	yes
Q96ME7-2	2
Q96ME7-3	3

RefSeq proteins (6): NP_001258215, NP_001258216, NP_001258217, NP_001258218, NP_001258247, NP_115810* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR048403	ZNF512_znf-C2H2	Domain
IPR048408	ZNF512_C2HC	Domain
IPR052274	Krueppel_C2H2_Zn-finger	Family

Pfam: PF00096, PF21276, PF21367

UniProt features (27 total): compositionally biased region 5, zinc finger region 4, cross-link 4, splice variant 3, helix 3, region of interest 3, strand 2, chain 1, sequence conflict 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2CTD	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96ME7-F1	62.76	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 18, 84, 227, 333

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 102 (showing top): WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN, GCM_GSPT1, GGGTGGRR_PAX4_03, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, GCM_NUMA1, LASTOWSKA_COAMPLIFIED_WITH_MYCN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, MAF_Q6, GCM_NF2, GOBP_CHROMATIN_REMODELING, GOBP_HETEROCHROMATIN_ORGANIZATION, AGCTCCT_MIR28, GOBP_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, NKX3A_01, GCM_RBM8A

GO Biological Process (2): constitutive heterochromatin formation (GO:0140719), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), pericentric heterochromatin (GO:0005721)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
heterochromatin formation	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transcription cis-regulatory region binding	1
regulation of DNA-templated transcription	1
transcription regulator activity	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
chromosome, centromeric region	1
heterochromatin	1

Protein interactions and networks

STRING

1070 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF512	SPATA31H1	Q68DN1	766
ZNF512	CCDC121	Q6ZUS5	729
ZNF512	ZNF362	Q5T0B9	651
ZNF512	SDAD1	Q9NVU7	623
ZNF512	KRTCAP3	Q53RY4	605
ZNF512	FNDC4	Q9H6D8	594
ZNF512	NRBP1	Q9UHY1	581
ZNF512	GPN1	Q9HCN4	578
ZNF512	C4orf17	Q53FE4	578
ZNF512	ZNF451	Q9Y4E5	570
ZNF512	GCKR	Q14397	541
ZNF512	NIPBL	Q6KC79	520
ZNF512	IFT172	Q9UG01	519
ZNF512	RRP15	Q9Y3B9	519
ZNF512	SPDYE11	P0DTA3	479

IntAct

210 interactions, top by confidence:

A	B	Type	Score
HDAC2	KDM1A	psi-mi:“MI:0914”(association)	0.890
TUBG1	TUBG1	psi-mi:“MI:2364”(proximity)	0.760
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NOL12	RRP8	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
KANK2	ZNF512	psi-mi:“MI:0915”(physical association)	0.560
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
BCOR	CBX4	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
RSBN1	SETD1A	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
RPL8	RRP8	psi-mi:“MI:0914”(association)	0.530
RPF1	ZNF324	psi-mi:“MI:0914”(association)	0.530
MED27	POLR2D	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF71	DKC1	psi-mi:“MI:0914”(association)	0.530
MKI67	ZC3H11A	psi-mi:“MI:0914”(association)	0.480

BioGRID (344): ZNF512 (Affinity Capture-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Proximity Label-MS), ZNF512 (Proximity Label-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Affinity Capture-MS), ZNF512 (Proximity Label-MS), ZNF273 (Affinity Capture-MS), ZNF724P (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8GR68, A0JPQ7, A4FV61, F7AQ22, O62666, O62674, O62676, O62678, O75151, O75152, P49140, P53349, P97432, Q13233, Q14596, Q15047, Q1LY51, Q3ZC82, Q4R6F6, Q53F19, Q5F3Z9, Q5R6F3, Q5SUE8, Q5XJV7, Q5ZJJ1, Q60698, Q60974, Q62925, Q69Z61, Q69Z99, Q6AI12, Q6NXK2, Q6PJT7, Q6ZNC4, Q7TMD5, Q80VG1, Q80XA6, Q86XL3, Q8BG81, Q8BJ05

Diamond homologs: A4FV61, Q5R6F3, Q69Z99, Q95JV5, Q96KM6, Q96ME7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 206 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	27	24.6×	1e-28
Viral mRNA Translation	27	24.6×	1e-28
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	27	24.4×	1e-28
Selenocysteine synthesis	27	23.4×	3e-28
Eukaryotic Translation Termination	27	23.4×	3e-28
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	27	22.9×	4e-28
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	27	22.9×	4e-28
Formation of a pool of free 40S subunits	27	21.8×	1e-27

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	28	27.7×	3e-30
ribosomal large subunit biogenesis	7	16.6×	4e-05
translation	29	15.9×	4e-24
ribosomal small subunit biogenesis	11	13.4×	1e-07
rRNA processing	16	12.1×	9e-11
regulation of alternative mRNA splicing, via spliceosome	6	7.8×	9e-03
nucleosome assembly	8	6.0×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2271 predictions. Top by Δscore:

Variant	Effect	Δscore
2:27583140:GCC:G	donor_gain	1.0000
2:27583143:G:GG	donor_gain	1.0000
2:27598065:A:AG	acceptor_gain	1.0000
2:27598066:G:GG	acceptor_gain	1.0000
2:27599568:T:TA	acceptor_gain	1.0000
2:27599571:A:AG	acceptor_gain	1.0000
2:27599571:AT:A	acceptor_gain	1.0000
2:27599571:ATG:A	acceptor_gain	1.0000
2:27599572:T:G	acceptor_gain	1.0000
2:27599572:T:TA	acceptor_gain	1.0000
2:27599573:G:A	acceptor_gain	1.0000
2:27599576:A:AG	acceptor_gain	1.0000
2:27599577:C:G	acceptor_gain	1.0000
2:27599579:TCAG:T	acceptor_loss	1.0000
2:27599581:A:AG	acceptor_gain	1.0000
2:27599581:AG:A	acceptor_gain	1.0000
2:27599581:AGG:A	acceptor_gain	1.0000
2:27599582:G:GA	acceptor_gain	1.0000
2:27599582:GG:G	acceptor_gain	1.0000
2:27599582:GGG:G	acceptor_gain	1.0000
2:27599582:GGGT:G	acceptor_gain	1.0000
2:27599582:GGGTC:G	acceptor_gain	1.0000
2:27599678:GGTAA:G	donor_loss	1.0000
2:27599679:G:GG	donor_gain	1.0000
2:27599679:GT:G	donor_loss	1.0000
2:27599684:G:GT	donor_gain	1.0000
2:27600689:A:AG	acceptor_gain	1.0000
2:27600690:G:GG	acceptor_gain	1.0000
2:27600690:GGCA:G	acceptor_gain	1.0000
2:27600811:AGCAG:A	donor_loss	1.0000

AlphaMissense

3726 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:27600744:T:C	C171R	1.000
2:27600787:T:C	L185S	1.000
2:27615169:T:C	L378S	1.000
2:27615174:T:C	Y380H	1.000
2:27615174:T:G	Y380D	1.000
2:27615222:T:A	W396R	1.000
2:27615222:T:C	W396R	1.000
2:27615258:T:A	C408S	1.000
2:27615258:T:C	C408R	1.000
2:27615259:G:C	C408S	1.000
2:27615260:T:G	C408W	1.000
2:27616265:T:A	C413S	1.000
2:27616265:T:C	C413R	1.000
2:27616266:G:A	C413Y	1.000
2:27616266:G:C	C413S	1.000
2:27616296:T:C	L423P	1.000
2:27616308:T:C	L427P	1.000
2:27616316:T:C	C430R	1.000
2:27616317:G:A	C430Y	1.000
2:27616318:T:G	C430W	1.000
2:27617500:T:A	C442S	1.000
2:27617500:T:C	C442R	1.000
2:27617501:G:C	C442S	1.000
2:27617502:T:G	C442W	1.000
2:27617509:T:A	C445S	1.000
2:27617509:T:C	C445R	1.000
2:27617510:G:A	C445Y	1.000
2:27617510:G:C	C445S	1.000
2:27617511:T:G	C445W	1.000
2:27617521:T:C	F449L	1.000

dbSNP variants (sampled 300 via entrez): RS1000131716 (2:27585386 A>C,G), RS1000218101 (2:27620190 AATT>A), RS1000298168 (2:27619410 A>AT), RS1000315913 (2:27617738 T>C), RS1000410750 (2:27617067 C>A), RS1000461368 (2:27585852 T>A), RS1000608739 (2:27596656 T>C), RS1000665125 (2:27593070 A>G), RS1000703363 (2:27609972 C>T), RS1000765950 (2:27603432 G>A), RS1000857703 (2:27623440 T>C), RS1000914084 (2:27599469 T>G), RS1000957859 (2:27587278 T>C), RS1001058531 (2:27606383 GAC>G), RS1001064670 (2:27584019 C>T)

Disease associations

OMIM: gene MIM:620921 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST001006_4	Waist Circumference - Triglycerides (WC-TG)	5.000000e-09
GCST001841_15	Palmitoleic acid (16:1n-7) levels	1.000000e-09
GCST001905_4	Hypertriglyceridemia	2.000000e-13
GCST003858_1	Oral cavity cancer	4.000000e-08
GCST005308_2	Nonalcoholic fatty liver disease	1.000000e-06
GCST008103_38	Bipolar disorder	1.000000e-07
GCST008985_2	Triglycerides	7.000000e-12
GCST008985_3	Triglycerides	7.000000e-07
GCST010060_6	Cholesterol	3.000000e-08
GCST011320_40	Type 2 diabetes or prostate cancer (pleiotropy)	1.000000e-08
GCST90000025_804	Appendicular lean mass	5.000000e-13

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0000195	metabolic syndrome
EFO:0004530	triglyceride measurement
EFO:0004574	total cholesterol measurement
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, decreases methylation	6
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
methylmercuric chloride	decreases expression	1
trichostatin A	decreases expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cupric oxide	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Leflunomide	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Ethanol	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	increases expression, affects cotreatment	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Rotenone	decreases expression	1
Smoke	increases abundance, increases expression	1
Urethane	decreases expression	1
Cyclosporine	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HA03	K562 eGFP-ZNF512	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.