ZNF516

Summary

ZNF516 (zinc finger protein 516, HGNC:28990) is a protein-coding gene on chromosome 18q23, encoding Zinc finger protein 516 (Q92618). Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation.

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation.

Source: NCBI Gene 9658 — RefSeq curated summary.

At a glance

• GWAS associations: 20
• Clinical variants (ClinVar): 246 total
• MANE Select transcript: NM_014643

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28990
Approved symbol	ZNF516
Name	zinc finger protein 516
Location	18q23
Locus type	gene with protein product
Status	Approved
Aliases	HsT287, KIAA0222
Ensembl gene	ENSG00000101493
Ensembl biotype	protein_coding
OMIM	615114
Entrez	9658

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000443185, ENST00000532857, ENST00000542818, ENST00000543743, ENST00000617840, ENST00000871208, ENST00000871209, ENST00000871210, ENST00000915360, ENST00000915361, ENST00000915362, ENST00000957637, ENST00000957638, ENST00000957639

RefSeq mRNA: 1 — MANE Select: NM_014643 NM_014643

CCDS: CCDS74234

Canonical transcript exons

ENST00000443185 — 7 exons

Exon	Start	End
ENSE00001409124	76495144	76495242
ENSE00001411234	76463028	76463141
ENSE00001647913	76378855	76380303
ENSE00001663270	76357682	76362557
ENSE00003518162	76370528	76370595
ENSE00003596540	76371467	76371571
ENSE00003668447	76441245	76443211

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 94.63.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.7054 / max 279.0276, expressed in 1454 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
172477	2.4855	1046
172475	1.2682	630
172456	0.8854	460
172478	0.5852	343
172476	0.2233	106
172479	0.1970	70
172457	0.0309	6
172480	0.0298	4

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	94.63	gold quality
endocervix	UBERON:0000458	94.04	gold quality
left testis	UBERON:0004533	92.48	gold quality
body of uterus	UBERON:0009853	92.23	gold quality
right testis	UBERON:0004534	92.15	gold quality
testis	UBERON:0000473	91.03	gold quality
left ovary	UBERON:0002119	91.01	gold quality
right uterine tube	UBERON:0001302	90.82	gold quality
endometrium	UBERON:0001295	90.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.09	gold quality
ectocervix	UBERON:0012249	90.05	gold quality
right ovary	UBERON:0002118	89.84	gold quality
monocyte	CL:0000576	89.64	gold quality
mononuclear cell	CL:0000842	89.40	gold quality
left uterine tube	UBERON:0001303	89.27	gold quality
uterus	UBERON:0000995	89.00	gold quality
leukocyte	CL:0000738	88.93	gold quality
seminal vesicle	UBERON:0000998	88.65	gold quality
blood	UBERON:0000178	88.52	gold quality
ovary	UBERON:0000992	88.44	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.40	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.10	gold quality
decidua	UBERON:0002450	87.92	gold quality
myometrium	UBERON:0001296	87.78	gold quality
adenohypophysis	UBERON:0002196	87.37	gold quality
tibial nerve	UBERON:0001323	86.39	gold quality
lower esophagus mucosa	UBERON:0035834	86.06	gold quality
female reproductive system	UBERON:0000474	85.80	gold quality
pituitary gland	UBERON:0000007	85.74	gold quality
sural nerve	UBERON:0015488	85.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.31

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

304 targeting ZNF516, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-6077	99.99	68.04	2299

Literature-anchored findings (GeneRIF, showing 4)

• one interacting gene pair (RBMS3 versus ZNF516) which, even after Bonferroni correction for multiple testing, showed consistently significant effects on hip bone mineral density. (PMID:23045156)
• ZNF516 promoter methylation was the best biomarker, with both sensitivity and specificity of 90% (AUC = 0.92), results subsequently corroborated in a Prevalence cohort. (PMID:24241165)
• ZNF516 represses EGFR transcription through the interaction with the CtBP/LSD1/CoREST complex. (PMID:28947780)
• MiR-371-5p regulates trophoblast cell proliferation, migration, and invasion by directly targeting ZNF516. (PMID:38761180)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp516	ENSMUSG00000058881
rattus_norvegicus	Zfp516	ENSRNOG00000016258

Paralogs (14): HIVEP2 (ENSG00000010818), HIVEP1 (ENSG00000095951), SALL4 (ENSG00000101115), SALL1 (ENSG00000103449), BCL11A (ENSG00000119866), ZNF831 (ENSG00000124203), RREB1 (ENSG00000124782), HIVEP3 (ENSG00000127124), BCL11B (ENSG00000127152), ZNF219 (ENSG00000165804), SALL2 (ENSG00000165821), ZNF217 (ENSG00000171940), ZNF536 (ENSG00000198597), SALL3 (ENSG00000256463)

Protein

Protein identifiers

Zinc finger protein 516 — Q92618 (reviewed: Q92618)

All UniProt accessions (4): Q92618, A0A087WUJ4, F5H2K2, H0YH41

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress.

Subunit / interactions. Interacts with PRDM16; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific genes. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_055458* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR051967	Krueppel_C2H2-ZF	Family

Pfam: PF00096

UniProt features (35 total): compositionally biased region 11, zinc finger region 10, region of interest 7, cross-link 4, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92618-F1	51.85	0.04

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 643, 681, 1043, 1062

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 212 (showing top): GOBP_RESPONSE_TO_COLD, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, TOMLINS_PROSTATE_CANCER_DN, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN, GOBP_BROWN_FAT_CELL_DIFFERENTIATION, MODULE_123, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP, GOBP_FAT_CELL_DIFFERENTIATION, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS, GOBP_CONNECTIVE_TISSUE_DEVELOPMENT, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP, GOBP_TEMPERATURE_HOMEOSTASIS, GOBP_ADIPOSE_TISSUE_DEVELOPMENT

GO Biological Process (7): regulation of DNA-templated transcription (GO:0006355), response to cold (GO:0009409), positive regulation of DNA-templated transcription (GO:0045893), brown fat cell differentiation (GO:0050873), adipose tissue development (GO:0060612), positive regulation of cold-induced thermogenesis (GO:0120162), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), cis-regulatory region sequence-specific DNA binding (GO:0000987), zinc ion binding (GO:0008270), DNA-binding transcription factor binding (GO:0140297), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	2
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of gene expression	1
regulation of RNA biosynthetic process	1
response to stress	1
response to temperature stimulus	1
positive regulation of RNA biosynthetic process	1
fat cell differentiation	1
animal organ development	1
connective tissue development	1
positive regulation of multicellular organismal process	1
cold-induced thermogenesis	1
regulation of cold-induced thermogenesis	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription cis-regulatory region binding	1
transition metal ion binding	1
transcription factor binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

732 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF516	RCOR1	Q9UKL0	888
ZNF516	PRDM16	Q9HAZ2	826
ZNF516	CTBP1	Q13363	803
ZNF516	CTBP2	P56545	684
ZNF516	KLF3	P57682	648
ZNF516	KDM1A	O60341	643
ZNF516	ZNF217	O75362	637
ZNF516	MBOAT2	Q6ZWT7	636
ZNF516	NRIP1	P48552	614
ZNF516	CBX2	Q14781	546
ZNF516	MEX3C	Q5U5Q3	539
ZNF516	ZMYM2	Q9UBW7	535
ZNF516	ZMYM3	Q14202	515
ZNF516	ZFPM1	Q8IX07	497
ZNF516	SLC66A2	Q8N2U9	488

IntAct

75 interactions, top by confidence:

A	B	Type	Score
ZNF516	CTBP1	psi-mi:“MI:0915”(physical association)	0.880
ZNF516	HDAC1	psi-mi:“MI:0915”(physical association)	0.880
S100B	S100A4	psi-mi:“MI:0914”(association)	0.870
HDAC1	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
CTBP1	ZEB2	psi-mi:“MI:0914”(association)	0.800
CTBP1	KDM1A	psi-mi:“MI:0914”(association)	0.790
HDAC1	TNRC18	psi-mi:“MI:0914”(association)	0.790
MED23	MED19	psi-mi:“MI:2364”(proximity)	0.770
HDAC1	ZNF609	psi-mi:“MI:0914”(association)	0.730
CTBP1	CBX4	psi-mi:“MI:0914”(association)	0.700
ZNF516	CTBP2	psi-mi:“MI:0915”(physical association)	0.660
ZNF516	HDAC2	psi-mi:“MI:0915”(physical association)	0.660
ZNF516	RCOR1	psi-mi:“MI:0915”(physical association)	0.660
ZBTB18	HSPA8	psi-mi:“MI:0914”(association)	0.640
DCAF7	PFDN6	psi-mi:“MI:2364”(proximity)	0.570
ZNF516	KDM1A	psi-mi:“MI:0914”(association)	0.560
ZNF516	KDM1A	psi-mi:“MI:0915”(physical association)	0.560
ZBTB42	MID1	psi-mi:“MI:0914”(association)	0.530

BioGRID (79): ZNF516 (Affinity Capture-MS), ZNF516 (Proximity Label-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Affinity Capture-RNA), ZNF516 (Proximity Label-MS), ZNF516 (Affinity Capture-MS), ZNF516 (Proximity Label-MS), ZNF516 (Proximity Label-MS), ZNF516 (Proximity Label-MS)

ESM2 similar proteins: A0A2Z4LIS9, A6QPM6, A7X8B3, A7X8B5, A7X8B7, A7X8C4, A7X8C7, A7X8C9, A7XW16, A7XW20, A7XW25, O08664, O15054, O43151, O70218, O89113, P09066, P14652, P17542, P19419, P19622, P22091, P23683, P49640, P70061, P78412, P82976, P97503, Q00587, Q04890, Q05916, Q05917, Q12950, Q15270, Q17QW1, Q3U133, Q5JPB2, Q5NCY0, Q6ZW13, Q80WY3

Diamond homologs: A1L2U9, A2A884, A2ANX9, B0X0K1, B0X9H6, B0XS89, B1WAZ8, B1WBU4, E9PZZ1, E9Q6W4, G5EBU4, O15090, O60315, O62836, O73694, O75362, O77459, P08048, P10925, P15822, P17010, P17012, P20662, P26635, P28166, P28575, P28698, P31509, P31629, P36197, P52739, P53243, P60319, P78871, P80944, Q00453, Q00900, Q01800, Q02026, Q02027

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 71 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Negative Regulation of CDH1 Gene Transcription	8	20.5×	1e-06
Regulation of PTEN gene transcription	5	19.0×	8e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

246 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	211
Likely benign	16
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

3172 predictions. Top by Δscore:

Variant	Effect	Δscore
18:76443210:ACCT:A	acceptor_loss	1.0000
18:76443218:C:CT	acceptor_gain	1.0000
18:76454219:A:C	acceptor_gain	1.0000
18:76370316:AGAC:A	donor_gain	0.9900
18:76370596:C:CC	acceptor_gain	0.9900
18:76371619:G:C	acceptor_gain	0.9900
18:76371625:G:C	acceptor_gain	0.9900
18:76371625:G:GC	acceptor_gain	0.9900
18:76371634:C:CT	acceptor_gain	0.9900
18:76371642:C:CT	acceptor_gain	0.9900
18:76371643:G:T	acceptor_gain	0.9900
18:76380299:TCCCC:T	acceptor_gain	0.9900
18:76380300:CCCC:C	acceptor_gain	0.9900
18:76380300:CCCCC:C	acceptor_gain	0.9900
18:76380301:CCC:C	acceptor_gain	0.9900
18:76380301:CCCC:C	acceptor_gain	0.9900
18:76380302:CC:C	acceptor_gain	0.9900
18:76380302:CCC:C	acceptor_gain	0.9900
18:76380303:CC:C	acceptor_gain	0.9900
18:76380304:C:CC	acceptor_gain	0.9900
18:76380304:C:G	acceptor_loss	0.9900
18:76443207:AGCAC:A	acceptor_gain	0.9900
18:76443208:GCAC:G	acceptor_gain	0.9900
18:76443209:CAC:C	acceptor_gain	0.9900
18:76443209:CACC:C	acceptor_gain	0.9900
18:76443210:AC:A	acceptor_gain	0.9900
18:76443211:CC:C	acceptor_gain	0.9900
18:76443212:C:CC	acceptor_gain	0.9900
18:76443219:A:T	acceptor_gain	0.9900
18:76454218:C:CT	acceptor_gain	0.9900

AlphaMissense

7603 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:76441483:G:C	F524L	1.000
18:76441483:G:T	F524L	1.000
18:76441485:A:G	F524L	1.000
18:76442173:G:C	H294Q	1.000
18:76442173:G:T	H294Q	1.000
18:76442175:G:C	H294D	1.000
18:76442200:G:C	F285L	1.000
18:76442200:G:T	F285L	1.000
18:76442201:A:G	F285S	1.000
18:76442202:A:G	F285L	1.000
18:76442223:A:G	C278R	1.000
18:76442815:G:C	H80Q	1.000
18:76442815:G:T	H80Q	1.000
18:76442817:G:C	H80D	1.000
18:76442825:A:G	L77P	1.000
18:76442865:A:G	C64R	1.000
18:76442887:G:C	H56Q	1.000
18:76442887:G:T	H56Q	1.000
18:76442894:C:G	R54P	1.000
18:76442895:G:T	R54S	1.000
18:76442899:G:C	H52Q	1.000
18:76442899:G:T	H52Q	1.000
18:76442901:G:C	H52D	1.000
18:76442901:G:T	H52N	1.000
18:76442926:G:C	F43L	1.000
18:76442926:G:T	F43L	1.000
18:76442928:A:G	F43L	1.000
18:76441456:G:C	H533Q	0.999
18:76441456:G:T	H533Q	0.999
18:76441458:G:C	H533D	0.999

dbSNP variants (sampled 300 via entrez): RS1000006694 (18:76468673 G>C), RS1000033709 (18:76378176 C>T), RS1000033933 (18:76468273 A>G), RS1000062357 (18:76399046 C>G), RS1000104321 (18:76408147 G>A), RS1000134828 (18:76357966 T>C,G), RS1000140998 (18:76465392 G>GA), RS1000149698 (18:76451748 G>A), RS1000213952 (18:76439408 G>A,C), RS1000222000 (18:76429787 C>A,T), RS1000225494 (18:76450164 T>C), RS1000270973 (18:76431733 CCTTG>C), RS1000274487 (18:76439368 T>C), RS1000275184 (18:76396201 G>C), RS1000288116 (18:76391632 T>C)

Disease associations

OMIM: gene MIM:615114 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

20 associations (top):

Study	Trait	p-value
GCST000785_7	Longevity	1.000000e-06
GCST001713_28	Dental caries	4.000000e-06
GCST001871_1	Renal transplant outcome	4.000000e-08
GCST002688_4	Very long-chain saturated fatty acid levels (fatty acid 22:0)	6.000000e-06
GCST004608_128	Granulocyte percentage of myeloid white cells	5.000000e-15
GCST004609_89	Monocyte percentage of white cells	3.000000e-18
GCST005580_107	Intraocular pressure	1.000000e-11
GCST006073_52	Tenofovir clearance in HIV infection	4.000000e-06
GCST006394_81	Intraocular pressure	4.000000e-08
GCST006412_126	Intraocular pressure	2.000000e-08
GCST006626_9	Pulse pressure	1.000000e-12
GCST010002_143	Refractive error	3.000000e-08
GCST012490_295	Femur bone mineral density x serum urate levels interaction	7.000000e-10
GCST012490_449	Femur bone mineral density x serum urate levels interaction	2.000000e-10
GCST90002393_624	Monocyte count	1.000000e-15
GCST90002394_426	Monocyte percentage of white cells	5.000000e-46
GCST90002398_96	Neutrophil count	9.000000e-19
GCST90002399_259	Neutrophil percentage of white cells	9.000000e-13
GCST90002404_198	Red cell distribution width	2.000000e-10
GCST90002407_170	White blood cell count	2.000000e-13

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0005199	renal transplant outcome measurement
EFO:0006796	very long-chain saturated fatty acid measurement
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes
EFO:0004695	intraocular pressure measurement
EFO:0005763	pulse pressure measurement
EFO:0004531	urate measurement
EFO:0005091	monocyte count
EFO:0004833	neutrophil count
EFO:0007990	neutrophil percentage of leukocytes
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, affects methylation, decreases methylation	3
Air Pollutants	affects expression, increases abundance, increases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
Valproic Acid	increases expression, increases methylation	2
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	increases expression	1
sodium arsenite	affects methylation	1
potassium chromate(VI)	decreases expression	1
aflatoxin B2	decreases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
monomethylarsonous acid	increases expression	1
Arsenic Trioxide	increases expression	1
Leflunomide	increases expression	1
Arsenic	affects methylation	1
Caffeine	increases phosphorylation	1
Doxorubicin	decreases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression	1
Ozone	affects expression, increases abundance	1
Tobacco Smoke Pollution	increases expression	1
Urethane	increases expression	1
Cyclosporine	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	increases expression	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.